Book The Best Hotels in Syracuse, MO for 2026 from CA $80 - Fully Refundable Options

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Our top choices for Syracuse hotels

A spacious lobby with a high ceiling, ornate chandeliers, and classic furniture.

A wall with a decorative mirror, two wall sconces, and a vase with red flowers on a wooden console table.

A building entrance with a classic architectural design, featuring a large arched entrance and two potted plants on either side.

A spacious kitchen with wooden cabinets, a dining area with a round table and chairs, and a bar area with stools.

1. Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel

Sedalia Downtown Historic District

Pamela

CA $172

CA $196 total

includes taxes & fees

Oct 20 - Oct 21

An indoor swimming pool with lounge chairs and a hot tub, surrounded by wooden walls and windows.

A hotel room with a desk, computer, and a sofa. There is a dining area in the background with chairs and tables.

A hotel lobby with a sofa, chairs, a table, and a patterned carpet.

A hotel with an indoor pool, featuring a prominent sign and a brick facade.

2. Quality Inn & Suites Boonville - Columbia

Boonville

Makayla

CA $141

CA $161 total

includes taxes & fees

Nov 12 - Nov 13

A gazebo in a snow-covered garden with benches and a building in the background.

A kitchen with wooden cabinets, a wooden island with stools, a refrigerator, and various kitchen appliances.

A white two-story house with a covered porch and a small garden area with a bench and a gazebo.

A traditional bedroom with a large bed, two armchairs, a desk, and a standing fan.

3. Hawthorne Inn

Versailles

Jean

CA $123

CA $133 total

includes taxes & fees

Oct 15 - Oct 16

A hotel room with a bed, a sofa, a television, and a large window with curtains.

A motel with a covered parking area, multiple rooms, and a visible sign for a nearby Super 8 motel.

A hotel lobby with a reception desk, a framed welcome sign, and a large window with curtains.

A hotel room with a bed, two bedside tables, a window with curtains, a wall-mounted air conditioner, and a large picture of a boat on the wall.

4. Super 8 by Wyndham Boonville

Boonville

Robert

CA $98

CA $112 total

includes taxes & fees

Nov 9 - Nov 10

A swimming pool area with a covered bench, a chair, and a sign indicating pool rules.

A coffee station with two coffee machines and a variety of coffee pods and cups.

A modern room with a blue wall, a gray sofa, a wooden coffee table, and a yellow chair.

A hotel room with a large bed, two bedside tables with lamps, a desk with a chair, a television, and a wardrobe.

5. Holiday Inn Express Boonville by IHG

Boonville

CA $192

CA $248 total

includes taxes & fees

Oct 26 - Oct 27

A Sedalia Station building with a covered walkway, outdoor seating, and flower planters.

A hotel room with a bed, a desk with a television, a chair, a lamp, and a small table.

An indoor swimming pool with clear water, a diving board, and lounge chairs.

A spacious living area with a large TV, comfortable seating, and a sign reading "MISSOURI".

6. Comfort Inn Sedalia Station

Sedalia

LESLIE

CA $169

CA $192 total

includes taxes & fees

Oct 20 - Oct 21

A spacious indoor area with a high ceiling and wooden beams, featuring multiple dining tables and a central counter with a display of colorful items.

A spacious living area with a herringbone floor pattern, a fireplace, and a large window offering a view of the outdoors.

A modern living room with a sofa, ottoman, and bench, a herringbone wood floor, and a large TV on the wall.

A modern building with a landscaped front yard, a Best Western sign, and a brick facade.

7. Best Western State Fair Inn

Sedalia

Russell

CA $175

CA $199 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with two single beds, a nightstand with a lamp, and a chair.

A neatly made bed with a grey quilt, two bedside tables with lamps, and a wooden nightstand with a remote control.

A compact kitchenette with a refrigerator, microwave, and coffee maker.

A compact living space with a kitchenette, a flat-screen TV mounted on the wall, a sofa, a dining table, and a chair.

8. Western Hills Motel

Versailles

Shon

CA $103

CA $112 total

includes taxes & fees

Oct 22 - Oct 23

A grand staircase with a red carpet leading to a balcony with ornate railings.

A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.

A spacious living room with a high ceiling, a large flat-screen TV, and a red patterned carpet.

A swimming pool with a stone wall and a hot tub.

9. Econo Lodge Truman Inn

Sedalia

John

CA $100

CA $113 total

includes taxes & fees

Oct 27 - Oct 28

A reception area with a stone wall, a welcome mat, a desk, a computer, and a pendant light.

A compact kitchen with wooden cabinets, a refrigerator, and a dining table with chairs.

A hotel room with a flat-screen TV mounted on the wall, a small desk with drawers, a microwave, and a trash bin.

A motel with a row of rooms, each with a window and a bench outside.

10. Budget Inn

Sedalia

Amber

CA $92

CA $105 total

includes taxes & fees

Oct 18 - Oct 19

A landscaped area with white pebbles, shrubs, and a fountain.

A reception desk with a black and white patterned tile design, a framed picture above it, and a colorful rug in front.

A hotel room with a desk, a black office chair, a television mounted on the wall, a microwave, a coffee maker, and a lamp.

A large, rustic building surrounded by dense greenery.

11. American Inn Sedalia

Sedalia

Joshua

CA $70

CA $80 total

includes taxes & fees

Nov 6 - Nov 7

A hotel room with two beds, a desk, a chair, a TV, and a window with a view of the outside.

A laundry area with three front-loading washing machines and a refrigerator.

A small kitchenette with a microwave, refrigerator, and a flat-screen TV mounted on the wall. There are two chairs in front of a desk with a telephone and a small table with a box.

A room with a flat-screen TV mounted on the wall, a small wooden table with items on it, and a patterned carpet.

12. Motel 6 Sedalia, MO

Sedalia

Steven

CA $76

CA $86 total

includes taxes & fees

Nov 6 - Nov 7

A reception area with a chandelier, a wall clock, and a signboard.

A covered corridor with a row of windows and doors, a bench, and a parked car.

A motel with a neon sign indicating 'NO VACANCY' and a Coca-Cola vending machine.

A hotel room with two beds, each with a red bedspread and white pillows. There are two wall-mounted lamps on either side of the beds.

13. Super 7 Motel Sedalia

Sedalia

Kiley

CA $72

CA $80 total

includes taxes & fees

Nov 1 - Nov 2

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Top Syracuse Hotel Reviews

Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel

8/10 Good

"The hotel itself is a classic - it was built in the 1920s and renovated about 30 years ago. Good restaurants close by. I would have rated it higher but the water pressure was not good, making a shower sort of an effort. the Staff was amazing, and the lobby and lounge/restaurant are really cool"

Best Western State Fair Inn

10/10 Excellent

"It was great"

Comfort Inn Sedalia Station

10/10 Excellent

"I didn't like the shampoo,conditioner,body wash or lotion dispensors."

Quality Inn & Suites Boonville - Columbia

10/10 Excellent

"The whole hotel and room were very clean. Breakfast was pretty good. Staff were very kind and helpful. Parking was no issue."

Super 8 by Wyndham Boonville

8/10 Good

"Staff was very friendly and helpful. I was working nights on the highway and needed to find a place that would allow me to check in at 5:00am and after calling multiple hotels this was the only that would accommodate me. The room was clean and slightly updated. Only complaint was the bed frame was all metal and made a lot of noise when moving around on the bed. Overall I would stay here again."

Hawthorne Inn

10/10 Excellent

"The location is awesome, the rooms are nice and the amenities are great."

4 Bedroom Comfortable Cottage

10/10 Excellent

"Very family and pet friendly! The house and location was perfect for what we needed!! Nice communication.."

Holiday Inn Express Boonville by IHG

8/10 Good

"."

Scarlet Suite

10/10 Excellent

"N"

More cheap stays in Syracuse

American Inn Sedalia

1217 S Limit Ave Sedalia MO

CA $70

CA $80 total

Nov 6 - Nov 7

includes taxes & fees

5.4/10 (274 reviews)

Motel 6 Sedalia, MO

3402 W Broadway Blvd Sedalia MO

CA $76

CA $86 total

Nov 6 - Nov 7

includes taxes & fees

5.6/10 (763 reviews)

Econo Lodge Truman Inn

3501 W Broadway Blvd Sedalia MO

CA $100

CA $113 total

Oct 27 - Oct 28

includes taxes & fees

5.8/10 (872 reviews)

Quality Inn & Suites Boonville - Columbia

2427 Mid America Industrial Dr Boonville MO

CA $141

CA $161 total

Nov 12 - Nov 13

includes taxes & fees

7.4/10 Good! (641 reviews)

Comfort Inn Sedalia Station

3600 W Broadway Blvd Sedalia MO

CA $169

CA $192 total

Oct 20 - Oct 21

includes taxes & fees

9.2/10 Wonderful! (674 reviews)

Days Inn by Wyndham Boonville

2401 Pioneer St Boonville MO

Get rates

5.6/10 (1,004 reviews)

Hotels in Syracuse with star rating

Frequently asked questions

What is the best area to stay in Syracuse?

The best area to stay in Syracuse is the downtown district, particularly around Armory Square and Hanover Square.Downtown Syracuse is the heart of the city and offers a blend of historic architecture and modern conveniences. Armory Square, a particularly popular spot, is a pedestrian-friendly area with several blocks of brick-paved streets, historic buildings, and a wide selection of dining options and boutiques. Hanover Square, another historic area, is known for its beautiful architecture and proximity to the Erie Canal Museum.Couples will find downtown Syracuse to be an excellent base. The area's concentration of quality restaurants, cocktail bars, and live music venues, especially around Armory Square, provides plenty of options for evenings out. It's also easy to stroll hand-in-hand through the historic streets or catch a show at the Landmark Theatre.For solo travellers, downtown Syracuse offers convenience and easy access to local attractions. You'll be within walking distance of museums like the Everson Museum of Art and the Museum of Science & Technology, as well as various cafes great for a morning coffee or a casual lunch.

When is the best time to go to Syracuse?

The best time to visit Syracuse, Missouri, is during the spring (April to May) and autumn (September to October) months, when the weather is most agreeable for outdoor activities.Spring in Syracuse brings mild temperatures and blooming flora, making it ideal for exploring the local parks and trails without the intense heat of summer. You'll find comfortable conditions for sightseeing and enjoying the natural beauty of the area.Autumn offers similarly pleasant weather, with cooler temperatures and the vibrant colours of changing leaves. This season is great for those who enjoy hiking, photography, or simply taking scenic drives through the countryside.

Can I cancel my hotel reservation on Expedia?

You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Syracuse.

How much is the nightly rate at a Syracuse hotel?

Prices for hotels in Syracuse often vary, but you can find a great deal from CA $80 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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Missouri Vacation Rentals

Book Hotels in Syracuse on Expedia.com

Find hotels in Syracuse, MO from CA $80

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Syracuse

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Syracuse hotels

1. Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel

2. Quality Inn & Suites Boonville - Columbia

3. Hawthorne Inn

4. Super 8 by Wyndham Boonville

5. Holiday Inn Express Boonville by IHG

6. Comfort Inn Sedalia Station

7. Best Western State Fair Inn

8. Western Hills Motel

9. Econo Lodge Truman Inn

10. Budget Inn

11. American Inn Sedalia

12. Motel 6 Sedalia, MO

13. Super 7 Motel Sedalia

Top Syracuse Hotel Reviews

Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel

Best Western State Fair Inn

Comfort Inn Sedalia Station

Quality Inn & Suites Boonville - Columbia

Super 8 by Wyndham Boonville

Hawthorne Inn

4 Bedroom Comfortable Cottage

Holiday Inn Express Boonville by IHG

Scarlet Suite

More cheap stays in Syracuse

American Inn Sedalia

Motel 6 Sedalia, MO

Econo Lodge Truman Inn

Quality Inn & Suites Boonville - Columbia

Comfort Inn Sedalia Station

Days Inn by Wyndham Boonville

Hotels in Syracuse with star rating

Frequently asked questions

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