Title: Book the Best Southern Illinois LUXURY Hotels - Upscale Hotels in Southern Illinois, IL | Expedia.ca [Southern Illinois Travel Guide](https://expedia.ca/Southern-Illinois.dx6233859)[Hotels in Southern Illinois](https://expedia.ca/Southern-Illinois-Hotels.d6233859.Travel-Guide-Hotels)[Vacation Rentals in Southern Illinois](https://expedia.ca/Southern-Illinois-Vacation-Rentals.d6233859.Travel-Guide-VacationRentals)[Flights to Southern Illinois](https://expedia.ca/Cheap-Flights-To-Southern-Illinois.d6233859.Travel-Guide-Flights)[Southern Illinois Car Rentals](https://expedia.ca/Car-Rentals-In-Southern-Illinois.d6233859.Car-Rental-Guide)[Southern Illinois Vacation Packages](https://expedia.ca/Southern-Illinois.d6233859.Destination-Travel-Guides) ![Southern Illinois featuring a sunset, forests and landscape views](https://images.trvl-media.com/place/553248635944113522/0e29d2f8-2d58-457a-908d-4b89b13776d9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Southernmost Illinois Tourism Bureau # Find luxury hotels in Southern Illinois, IL - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southern Illinois Luxury Hotels Tonight [Dec 15 - Dec 16](https://www.expedia.ca/Hotel-Search?regionId=6233859&startDate=2025-12-15&endDate=2025-12-16&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Dec 16 - Dec 17](https://www.expedia.ca/Hotel-Search?regionId=6233859&startDate=2025-12-16&endDate=2025-12-17&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=6233859&startDate=2025-12-19&endDate=2025-12-21&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6233859&startDate=2025-12-26&endDate=2025-12-28&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Our top choices for Southern Illinois luxury hotels ![Sauna, hot tub, body treatments, hot stone massages](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/8fcd4708.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Casino](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/2902012c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/a0fca68c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/3a123ac6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Walker's Bluff Casino Resort [](https://www.expedia.ca/Carterville-Hotels-Walkers-Bluff-Casino-Resort.h97064786.Hotel-Information) Carterville 9.4/10 Exceptional (386) "Great place!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeff [](https://www.expedia.ca/Carterville-Hotels-Walkers-Bluff-Casino-Resort.h97064786.Hotel-Information) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/5600/5553/5af8e624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/5600/5553/ec25eb2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/5600/5553/86d47a64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5600/5553/25ca1c44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Mt. Vernon [](https://www.expedia.ca/Mount-Vernon-Hotels-DoubleTree-By-Hilton-Mt-Vernon.h5553.Hotel-Information) Mount Vernon 8.4/10 Very good (765) "Everything was great!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rebecca CA $163 CA $183 total includes taxes & fees Dec 25 - Dec 26 [](https://www.expedia.ca/Mount-Vernon-Hotels-DoubleTree-By-Hilton-Mt-Vernon.h5553.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/27100/27006/579b996f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/30000/27100/27006/35f1a1de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/30000/27100/27006/5581a60c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/27100/27006/a497be51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Collinsville - St. Louis [](https://www.expedia.ca/Collinsville-Hotels-DoubleTree-By-Hilton-Collinsville-St-Louis.h27006.Hotel-Information) Eastport 8.2/10 Very good (1000) "Nice restaurant " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shelly CA $146 CA $168 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Collinsville-Hotels-DoubleTree-By-Hilton-Collinsville-St-Louis.h27006.Hotel-Information) ![Classic Single Room](https://images.trvl-media.com/lodging/124000000/123050000/123048300/123048290/53468785.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Classic Suite | Interior](https://images.trvl-media.com/lodging/124000000/123050000/123048300/123048290/c5bd79c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/124000000/123050000/123048300/123048290/a9cf7169.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/124000000/123050000/123048300/123048290/0b27031e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charleston House Bed & Breakfast Inn [](https://www.expedia.ca/Charleston-Hotels-Charleston-House-Bed-Breakfast-Inn.h123048290.Hotel-Information) Charleston CA $226 CA $251 total includes taxes & fees Dec 17 - Dec 18 [](https://www.expedia.ca/Charleston-Hotels-Charleston-House-Bed-Breakfast-Inn.h123048290.Hotel-Information) ![5 restaurants, breakfast, dinner served; American cuisine](https://images.trvl-media.com/lodging/102000000/101750000/101749800/101749750/2fa826c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/102000000/101750000/101749800/101749750/573bb871.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/102000000/101750000/101749800/101749750/650c7224.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![5 restaurants, breakfast, dinner served; American cuisine](https://images.trvl-media.com/lodging/102000000/101750000/101749800/101749750/31f323b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Terre Haute Casino Resort [](https://www.expedia.ca/Terre-Haute-Hotels-Terre-Haute-Casino-Resort.h101749750.Hotel-Information) Terre Haute 9.2/10 Wonderful (716) "Property was very clean and in excellent condition. Was a great stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard CA $185 CA $212 total includes taxes & fees Dec 22 - Dec 23 [](https://www.expedia.ca/Terre-Haute-Hotels-Terre-Haute-Casino-Resort.h101749750.Hotel-Information) ![Oven, stovetop, dishwasher, espresso maker](https://images.trvl-media.com/lodging/104000000/103360000/103357800/103357795/becf52a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/104000000/103360000/103357800/103357795/ab0818b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/104000000/103360000/103357800/103357795/ca731d53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee and/or coffee maker](https://images.trvl-media.com/lodging/104000000/103360000/103357800/103357795/f7d784c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Arbor Rose Boutique Hotel [](https://www.expedia.ca/Arcola-Hotels-Joyful-Life.h103357795.Hotel-Information) Arcola 9.6/10 Exceptional (36) "Great place! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Connie CA $208 CA $231 total includes taxes & fees Dec 17 - Dec 18 [](https://www.expedia.ca/Arcola-Hotels-Joyful-Life.h103357795.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/45000000/44460000/44452500/44452446/bfa9a7c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![36-inch Smart TV with premium channels, TV](https://images.trvl-media.com/lodging/45000000/44460000/44452500/44452446/901ca6ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Elevator](https://images.trvl-media.com/lodging/45000000/44460000/44452500/44452446/46465b3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/45000000/44460000/44452500/44452446/d41f9415.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Respite Bed and Breakfast [](https://www.expedia.ca/Paducah-Hotels-The-Respite-Bed-And-Breakfast.h44452446.Hotel-Information) Paducah 9.8/10 Exceptional (281) "The room was clean and the bed was comfortable. There was everything we needed and the breakfast was amazing " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Korrie [](https://www.expedia.ca/Paducah-Hotels-The-Respite-Bed-And-Breakfast.h44452446.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/53cb7546.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Jackpot Suite | Living area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/e87009c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Grand Riverview Two Queen Room](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/8ba17328.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Riverview [](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) Cape Girardeau 9.4/10 Exceptional (473) "The room was clean and the mattress was extremely comfortable " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stacy CA $126 CA $143 total includes taxes & fees Dec 18 - Dec 19 [](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/ef7a5612.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment rooms, hot tub, body treatments, aromatherapy](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/941b0ba8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment rooms, hot tub, body treatments, aromatherapy](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/56a41562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Suite, 1 King Bed, Non Smoking | Living area](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/3714f01f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Four Seasons Hotel St Louis [](https://www.expedia.ca/St-Louis-Hotels-Four-Seasons-Hotel-St-Louis.h2851438.Hotel-Information) Downtown St. Louis 9.4/10 Exceptional (1002) "Everything exceeded my expectations from the welcoming staff to the luxuriously appointed room, to the 4 feet deep bathtub in which to soak my cares away--it was a total dream come true. I would come back in a heartbeat at this home away from home. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lynne CA $571 CA $668 total includes taxes & fees Jan 5 - Jan 6, 2026 [](https://www.expedia.ca/St-Louis-Hotels-Four-Seasons-Hotel-St-Louis.h2851438.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/a54897ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/3f20ce75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/1817cdae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/37a3040b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Ritz-Carlton, St. Louis [](https://www.expedia.ca/St-Louis-Hotels-The-Ritz-Carlton.h6132.Hotel-Information) Clayton 9.2/10 Wonderful (553) "Service is exceptional!!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jorge CA $687 CA $802 total includes taxes & fees Dec 23 - Dec 24 [](https://www.expedia.ca/St-Louis-Hotels-The-Ritz-Carlton.h6132.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-30&endDate=2025-12-31®ionId=6233859&adults=2&sort=LUXURY&star=50&openPlayBack=true) ## Find out more about Southern Illinois ### Southern Illinoisand its attractions for luxury travelers Southern Illinois offers an intriguing blend of natural beauty and cultural experiences, making it a unique spot for the discerning traveller. Begin your exploration in the Shawnee National Forest, where you can hike the stunning trails, marvel at the towering rock formations of Giant City State Park, or even try your hand at horseback riding through picturesque landscapes. For a more leisurely pace, indulge in wine tasting at the numerous vineyards along the Shawnee Hills Wine Trail, where you can savour exquisite local wines paired with gourmet dining options. Don't miss the captivating Cache River State Natural Area, home to ancient cypress swamps and rich biodiversity, ideal for birdwatching and serene canoeing adventures. For a touch of history and culture, visit the charming town of Carbondale, where you can enjoy fine dining at upscale restaurants and explore local art galleries. For your luxurious stay, consider the exclusive accommodations in the heart of this region, such as the beautiful Stone Creek Lodge, which offers a rustic yet refined atmosphere complete with modern amenities and attentive service that caters to your every need. Here, you can unwind in style after a day of exploration, enjoying the comfort and convenience that make your stay utterly relaxing. ## Top Southern Illinois Hotel Reviews ![Drury Plaza Hotel Mt. Vernon](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/f9296f7b_y.jpg) ### Drury Plaza Hotel Mt. Vernon 10/10 Excellent "Short weekend, clean room, very bright atmosphere, super clean, great staff, no issues will stay again. " [](https://expedia.ca/Mount-Vernon-Hotels-Drury-Inn-Suites-Mt-Vernon.h42021.Hotel-Information) ![Comfort Suites Mount Vernon](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/b34f836a_y.jpg) ### Comfort Suites Mount Vernon 10/10 Excellent "Very clean, good breakfast included. Night staff was very friendly and good. 😊 " [](https://expedia.ca/Mount-Vernon-Hotels-Comfort-Suites-Mount-Vernon.h1387309.Hotel-Information) ![Drury Inn & Suites St. Louis Fairview Heights](https://images.trvl-media.com/lodging/1000000/50000/41900/41802/c56c0460_y.jpg) ### Drury Inn & Suites St. Louis Fairview Heights 10/10 Excellent "I always stay at Drury whenever I can, you can always count on having a great stay! Clean rooms, complimentary cocktails, Hot breakfast, AND complimentary hors d’oeuvres!! " [](https://expedia.ca/Collinsville-Hotels-Drury-Inn-Suites-St-Louis-Fairview-Heights.h41802.Hotel-Information) ![La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis](https://images.trvl-media.com/lodging/1000000/210000/201300/201286/c5041840_y.jpg) ### La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis 8/10 Good "Clean bed and room. Very nice staff" [](https://expedia.ca/Collinsville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-OFallon.h201286.Hotel-Information) ![Red Lion Inn & Suites Pontoon Beach](https://images.trvl-media.com/lodging/1000000/20000/17400/17338/284b6d11_y.jpg) ### Red Lion Inn & Suites Pontoon Beach 10/10 Excellent "Room was clean, staff were really nice & helpful!! We will be back!" [](https://expedia.ca/St-Louis-Hotels-Red-Lion-Inn-Suites-Pontoon-Beach.h17338.Hotel-Information) ![Super 8 by Wyndham O'Fallon](https://images.trvl-media.com/lodging/1000000/20000/11100/11071/055d0e3b_y.jpg) ### Super 8 by Wyndham O'Fallon 10/10 Excellent "Staff were very friendly. It was clean & quiet. I will definitely stop again on my next trip. " [](https://expedia.ca/Collinsville-Hotels-Super-8-By-Wyndham-OFallon.h11071.Hotel-Information) ![DoubleTree by Hilton Mt. Vernon](https://images.trvl-media.com/lodging/1000000/10000/5600/5553/5af8e624_y.jpg) ### DoubleTree by Hilton Mt. Vernon 10/10 Excellent "Everything was great!" [](https://expedia.ca/Mount-Vernon-Hotels-DoubleTree-By-Hilton-Mt-Vernon.h5553.Hotel-Information) ![Quality Inn O'Fallon IL - St. Louis](https://images.trvl-media.com/lodging/1000000/70000/64700/64675/8890354b_y.jpg) ### Quality Inn O'Fallon IL - St. Louis 10/10 Excellent "The room was clean. The room temperature was also perfect upon my arrival. Staff were professional and polite. The bed was pretty comfortable, too. I enjoyed my stay. " [](https://expedia.ca/Collinsville-Hotels-Quality-Inn-OFallon-I-64.h64675.Hotel-Information) ![Baymont by Wyndham O'Fallon St. Louis Area](https://images.trvl-media.com/lodging/1000000/70000/60700/60642/a4ff32db_y.jpg) ### Baymont by Wyndham O'Fallon St. Louis Area 10/10 Excellent "Yes" [](https://expedia.ca/Collinsville-Hotels-Baymont-By-Wyndham-OFallon-St-Louis-Area.h60642.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [Ashley Hotels ](https://www.expedia.ca/Ashley-Hotels.d553248634983445011.Travel-Guide-Hotels) - [Belle Prairie City Hotels ](https://www.expedia.ca/Belle-Prairie-City-Hotels.d553248634983187790.Travel-Guide-Hotels) - [Vacation Homes in Belle Prairie City ](https://www.expedia.ca/Belle-Prairie-City-Private-Vacation-Homes.d553248634983187790-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Belle Rive Hotels ](https://www.expedia.ca/Belle-Rive-Hotels.d78467.Travel-Guide-Hotels) - [Lodges in Belle Rive ](https://www.expedia.ca/Belle-Rive-Lodges.d78467-aaLodges.Travel-Guide-Accommodation) - 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