Title: Book the Best Southeast Ohio LUXURY Hotels - Upscale Hotels in Southeast Ohio, OH | Expedia.ca [Southeast Ohio Travel Guide](https://expedia.ca/Southeast-Ohio.dx6059285)[Hotels in Southeast Ohio](https://expedia.ca/Southeast-Ohio-Hotels.d6059285.Travel-Guide-Hotels)[Vacation Rentals in Southeast Ohio](https://expedia.ca/Southeast-Ohio-Vacation-Rentals.d6059285.Travel-Guide-VacationRentals)[Flights to Southeast Ohio](https://expedia.ca/Cheap-Flights-To-Southeast-Ohio.d6059285.Travel-Guide-Flights)[Southeast Ohio Car Rentals](https://expedia.ca/Car-Rentals-In-Southeast-Ohio.d6059285.Car-Rental-Guide)[Southeast Ohio Vacation Packages](https://expedia.ca/Southeast-Ohio.d6059285.Destination-Travel-Guides) ![Wheeling featuring a river or creek, a city and a suspension bridge or treetop walkway](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/62000/62340-Wheeling.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Southeast Ohio, OH ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southeast Ohio Luxury Hotels Tonight [Oct 2 - Oct 3](https://www.expedia.ca/Hotel-Search?regionId=6059285&startDate=2025-10-02&endDate=2025-10-03&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 3 - Oct 4](https://www.expedia.ca/Hotel-Search?regionId=6059285&startDate=2025-10-03&endDate=2025-10-04&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6059285&startDate=2025-10-03&endDate=2025-10-05&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6059285&startDate=2025-10-10&endDate=2025-10-12&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Southeast Ohio Luxury Hotels ![Ballroom](https://images.trvl-media.com/lodging/1000000/10000/6100/6032/35b37036.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Library](https://images.trvl-media.com/lodging/1000000/10000/6100/6032/bf347d2c_edited_5de6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/10000/6100/6032/w493h723x8y0-84b46d0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/10000/6100/6032/w489h735x4y0-922fb495.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Blennerhassett Hotel Parkersburg 9.4/10 Exceptional (1000) "We enjoyed our stay and will definitely comeback again." CA $212 CA $247 total includes taxes & fees Oct 16 - Oct 17 [](https://www.expedia.ca/Parkersburg-Hotels-The-Blennerhassett-Hotel.h6032.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/14000000/13480000/13471700/13471606/843aa4a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/14000000/13480000/13471700/13471606/af3d421c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/14000000/13480000/13471700/13471606/bf3decec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/14000000/13480000/13471700/13471606/7aed15ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Garland Hotel New Concord 9.2/10 Wonderful (883) "Right off the HWY. Great price, clean property and friendly staff. " CA $120 CA $138 total includes taxes & fees Oct 23 - Oct 24 [](https://www.expedia.ca/New-Concord-Hotels-Garland-Hotel.h13471606.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/8600/8583/c6b09e9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/8600/8583/60c334e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/10000/8600/8583/8b407aef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/8600/8583/b78b83f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Adena Inn Chillicothe 7.8/10 Good (750) "Nice easy stay. Fast, friendly check in and location was convenient " CA $142 CA $163 total includes taxes & fees Oct 8 - Oct 9 [](https://www.expedia.ca/Chillicothe-Hotels-Best-Western-Adena-Inn.h8583.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/19000000/18720000/18711100/18711017/2d68689d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/19000000/18720000/18711100/18711017/97f39879.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18720000/18711100/18711017/33bcf957.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/19000000/18720000/18711100/18711017/a8872b63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Deluxe Inn Hebron 6.8/10 (268) "Loved my stay" CA $69 CA $78 total includes taxes & fees Oct 7 - Oct 8 [](https://www.expedia.ca/Hebron-Hotels-Deluxe-Inn.h18711017.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/2000000/1870000/1868900/1868803/699e3988.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1870000/1868900/1868803/261d2195.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1870000/1868900/1868803/3780b6ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/2000000/1870000/1868900/1868803/41f3474a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Granville Inn Granville 9.6/10 Exceptional (716) "Best dinner in town" CA $259 CA $286 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Zanesville-Hotels-Granville-Inn.h1868803.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/14000000/13070000/13068200/13068101/752fe927.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/14000000/13070000/13068200/13068101/c13080ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/14000000/13070000/13068200/13068101/09076694.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed](https://images.trvl-media.com/lodging/14000000/13070000/13068200/13068101/8fc7374b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Executive Inn Chillicothe 7.4/10 Good (616) "Nice and clean rooms and helpful staff. " CA $84 CA $97 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Chillicothe-Hotels-Executive-Inn.h13068101.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/40000/40000/39931/4a096f7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine, pool views ](https://images.trvl-media.com/lodging/1000000/40000/40000/39931/bacb3f1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/40000/40000/39931/w5500h3649x0y6-0804e267.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/40000/40000/39931/6420eb92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ohio University Inn & Conference Center Athens 9.2/10 Wonderful (1000) "Great place to stay while in Athens, OH." CA $173 CA $196 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Athens-Hotels-Ohio-University-Inn-Conference-Center.h39931.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1600000/1593300/1593237/fcc2f5e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1600000/1593300/1593237/7f6bfbd9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/2000000/1600000/1593300/1593237/d3f02cae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1600000/1593300/1593237/201b67ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Athens Athens 9.2/10 Wonderful (844) "This was the perfect property for visiting the university and move in weekend. Close to all the shops and many restaurants." CA $177 CA $200 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Athens-Hotels-Hampton-Inn-Athens.h1593237.Hotel-Information) ![Executive Suite, 1 King Bed, Non Smoking, Hot Tub](https://images.trvl-media.com/lodging/1000000/160000/155900/155861/fd9d009f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/160000/155900/155861/3c4f92bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/160000/155900/155861/c44320d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/160000/155900/155861/f1804fc0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Cambridge Cambridge 8.2/10 Very good (1003) "For the least expensive option in the area, I have to say it was a very fine hotel!" CA $82 CA $95 total includes taxes & fees Oct 8 - Oct 9 [](https://www.expedia.ca/Zanesville-Hotels-Baymont-By-Wyndham-Cambridge.h155861.Hotel-Information) ![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/10000/9100/9003/4d0a03ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/9100/9003/c29456d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/9100/9003/36163b70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9100/9003/0412e135.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Zanesville City Center Zanesville 7.6/10 Good (256) "Staying here enabled us to get to The Wilds for early morning tour." CA $118 CA $134 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Zanesville-Hotels-Zane-Inn-And-Suites.h9003.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-16&endDate=2025-10-17®ionId=6059285&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Top Southeast Ohio Hotel Reviews ![Ohio University Inn & Conference Center](//images.trvl-media.com/lodging/1000000/40000/40000/39931/4a096f7d_y.jpg) ### Ohio University Inn & Conference Center 10/10 Excellent "Clean room, great restaurant and bar and most importantly easy walk to campus and Court Street " [](https://expedia.ca/Athens-Hotels-Ohio-University-Inn-Conference-Center.h39931.Hotel-Information) ![Quality Inn](//images.trvl-media.com/lodging/1000000/130000/124400/124351/4aaecbd5_y.jpg) ### Quality Inn 10/10 Excellent "I would stay again. Convenient to where I needed to be. Clean, friendly, Restaurants walking distance" [](https://expedia.ca/Athens-Hotels-Quality-Inn.h124351.Hotel-Information) ![Americas Best Value Inn & Suites St. Clairsville Wheeling](//images.trvl-media.com/lodging/1000000/130000/122900/122815/71c447d0_y.jpg) ### Americas Best Value Inn & Suites St. Clairsville Wheeling 10/10 Excellent "Very clean, friendly staff, quiet comf" [](https://expedia.ca/St-Clairsville-Hotels-Americas-Best-Value-Inn-St-Clairsville-Wheeling.h122815.Hotel-Information) ![Microtel Inn & Suites by Wyndham Marietta](//images.trvl-media.com/lodging/1000000/130000/123900/123877/3aaf17a0_y.jpg) ### Microtel Inn & Suites by Wyndham Marietta 10/10 Excellent "Kind and helpful front desk staff, clean room, lots of towels and washcloths, well maintained room and even the carpeted floors are clean. This is our 2nd visit and we will definitely stay here again. Our room has two queen beds and they are very comfortable. (Cons) Not bad just optional in our eyes: Need a more comfortable desk chair in the room and there's not enough counter space in the restroom for personal items and clothing to lay while trying to shower and get ready. " [](https://expedia.ca/Marietta-Hotels-Microtel-Inn-Suites-By-Wyndham-Marietta.h123877.Hotel-Information) ![Christopher Inn and Suites](//images.trvl-media.com/lodging/2000000/1040000/1039700/1039674/50c4cecb_y.jpg) ### Christopher Inn and Suites 10/10 Excellent "Our room was clean and comfortable. The staff were friendly. The location was convenient for us, and there are plenty of dining options in the area. " [](https://expedia.ca/Chillicothe-Hotels-Christopher-Inn-And-Suites.h1039674.Hotel-Information) ![Days Inn by Wyndham Columbus East Airport](//images.trvl-media.com/lodging/1000000/10000/4600/4541/49a8132f_y.jpg) ### Days Inn by Wyndham Columbus East Airport 10/10 Excellent "House keeping was very attentive and kind! highly recommend coming here <33" [](https://expedia.ca/Columbus-Hotels-Days-Inn-By-Wyndham-Columbus-East-Airport.h4541.Hotel-Information) ![The Lafayette A grand Riverboat Era Hotel](//images.trvl-media.com/lodging/1000000/50000/40200/40137/0b76c640_y.jpg) ### The Lafayette A grand Riverboat Era Hotel 10/10 Excellent "Really cool, o" [](https://expedia.ca/Marietta-Hotels-The-Lafayette-A-Grand-Riverboat-Era-Hotel.h40137.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [Hotels near Ash Cave](https://www.expedia.ca/Ash-Cave-Hotels.0-l6296751-0.Travel-Guide-Filter-Hotels) - [Ski Hotels in Columbus](https://www.expedia.ca/Columbus-Hotels-Ski-Hotel.0-0-d178251-tSkiHotel.Travel-Guide-Filter-Hotels) - 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