Title: Book the Best Southeast Ohio LUXURY Hotels - Upscale Hotels in Southeast Ohio, OH | Expedia.ca

[Southeast Ohio Travel Guide](https://expedia.ca/Southeast-Ohio.dx6059285)[Hotels in Southeast Ohio](https://expedia.ca/Southeast-Ohio-Hotels.d6059285.Travel-Guide-Hotels)[Vacation Rentals in Southeast Ohio](https://expedia.ca/Southeast-Ohio-Vacation-Rentals.d6059285.Travel-Guide-VacationRentals)[Flights to Southeast Ohio](https://expedia.ca/Cheap-Flights-To-Southeast-Ohio.d6059285.Travel-Guide-Flights)[Southeast Ohio Car Rentals](https://expedia.ca/Car-Rentals-In-Southeast-Ohio.d6059285.Car-Rental-Guide)[Southeast Ohio Vacation Packages](https://expedia.ca/Southeast-Ohio.d6059285.Destination-Travel-Guides)

![The Upper Falls](https://images.trvl-media.com/place/6140554/71ed754c-3170-47db-be5e-3b5d1faa9c16.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Jake Blucker

# Find luxury hotels in Southeast Ohio, OH

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## Check availability on Southeast Ohio Luxury Hotels

Tonight

[Dec 14 - Dec 15](https://www.expedia.ca/Hotel-Search?regionId=6059285&startDate=2025-12-14&endDate=2025-12-15&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

Tomorrow

[Dec 15 - Dec 16](https://www.expedia.ca/Hotel-Search?regionId=6059285&startDate=2025-12-15&endDate=2025-12-16&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

Next weekend

[Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=6059285&startDate=2025-12-19&endDate=2025-12-21&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

In two weeks

[Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6059285&startDate=2025-12-26&endDate=2025-12-28&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

## Our top choices for Southeast Ohio luxury hotels

![Exterior](https://images.trvl-media.com/lodging/1000000/10000/6100/6032/29cf6016.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Ballroom](https://images.trvl-media.com/lodging/1000000/10000/6100/6032/35b37036.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lounge](https://images.trvl-media.com/lodging/1000000/10000/6100/6032/w493h723x8y0-84b46d0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Library](https://images.trvl-media.com/lodging/1000000/10000/6100/6032/bf347d2c_edited_5de6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Blennerhassett Hotel

[](https://www.expedia.ca/Parkersburg-Hotels-The-Blennerhassett-Hotel.h6032.Hotel-Information)

Parkersburg

9.4/10

Exceptional

(1002)

"Staff are phenomenal; hotel is pet friendly and made me and my dog feel perfectly at home. The thanksgiving buffet is fantastic!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Stephen

CA $174

CA $203 total

includes taxes & fees

Dec 31 - Jan 1, 2026

[](https://www.expedia.ca/Parkersburg-Hotels-The-Blennerhassett-Hotel.h6032.Hotel-Information)

![Lobby sitting area](https://images.trvl-media.com/lodging/14000000/13480000/13471700/13471606/843aa4a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/14000000/13480000/13471700/13471606/dc8b2454.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, iron/ironing board, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/14000000/13480000/13471700/13471606/7aed15ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, iron/ironing board, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/14000000/13480000/13471700/13471606/af3d421c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Garland Hotel

[](https://www.expedia.ca/New-Concord-Hotels-Garland-Hotel.h13471606.Hotel-Information)

New Concord

9.2/10

Wonderful

(948)

"Good breakfast, quiet, clean modern room"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Julie

CA $104

CA $119 total

includes taxes & fees

Dec 15 - Dec 16

[](https://www.expedia.ca/New-Concord-Hotels-Garland-Hotel.h13471606.Hotel-Information)

![Desk, laptop workspace, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/1000000/10000/8600/8583/77e26219.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/10000/8600/8583/60c334e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/10000/8600/8583/8b407aef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/10000/8600/8583/11afaa81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Adena Inn

[](https://www.expedia.ca/Chillicothe-Hotels-Best-Western-Adena-Inn.h8583.Hotel-Information)

Chillicothe

7.8/10

Good

(775)

"The room was very clean and the staff was great. The continental breakfast was very good with a lot of variety. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Virginia

CA $141

CA $162 total

includes taxes & fees

Dec 16 - Dec 17

[](https://www.expedia.ca/Chillicothe-Hotels-Best-Western-Adena-Inn.h8583.Hotel-Information)

![Standard Room, 2 Queen Beds](https://images.trvl-media.com/lodging/19000000/18720000/18711100/18711017/6a6cb63e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 2 Queen Beds | Bathroom](https://images.trvl-media.com/lodging/19000000/18720000/18711100/18711017/949f2c90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/19000000/18720000/18711100/18711017/7d3649c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/19000000/18720000/18711100/18711017/33bcf957.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Deluxe Inn

[](https://www.expedia.ca/Hebron-Hotels-Deluxe-Inn.h18711017.Hotel-Information)

Hebron

6.8/10

(272)

"Loved my stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Robert

CA $68

CA $77 total

includes taxes & fees

Jan 6 - Jan 7, 2026

[](https://www.expedia.ca/Hebron-Hotels-Deluxe-Inn.h18711017.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/2000000/1870000/1868900/1868803/699e3988.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1870000/1868900/1868803/fb50516c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/2000000/1870000/1868900/1868803/aca18406.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1870000/1868900/1868803/3780b6ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Granville Inn

[](https://www.expedia.ca/Zanesville-Hotels-Granville-Inn.h1868803.Hotel-Information)

Granville

9.6/10

Exceptional

(728)

"It was great!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Theresa M.

CA $291

CA $321 total

includes taxes & fees

Jan 7 - Jan 8, 2026

[](https://www.expedia.ca/Zanesville-Hotels-Granville-Inn.h1868803.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/14000000/13070000/13068200/13068101/752fe927.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 King Bed](https://images.trvl-media.com/lodging/14000000/13070000/13068200/13068101/8fc7374b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/14000000/13070000/13068200/13068101/c13080ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/14000000/13070000/13068200/13068101/5b64035e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Executive Inn

[](https://www.expedia.ca/Chillicothe-Hotels-Executive-Inn.h13068101.Hotel-Information)

Chillicothe

7.6/10

Good

(648)

"Great room, clean and beds and pillows super comfy! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jason

CA $84

CA $97 total

includes taxes & fees

Dec 16 - Dec 17

[](https://www.expedia.ca/Chillicothe-Hotels-Executive-Inn.h13068101.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/40000/40000/39931/4a096f7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room amenity](https://images.trvl-media.com/lodging/1000000/40000/40000/39931/53c6f001.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/40000/40000/39931/w5500h3649x0y6-0804e267.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch, dinner served; American cuisine, pool views ](https://images.trvl-media.com/lodging/1000000/40000/40000/39931/862c0e90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Ohio University Inn & Conference Center

[](https://www.expedia.ca/Athens-Hotels-Ohio-University-Inn-Conference-Center.h39931.Hotel-Information)

Athens

9.2/10

Wonderful

(1003)

"My favorite hotel in Athens"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Laurie

CA $149

CA $169 total

includes taxes & fees

Dec 18 - Dec 19

[](https://www.expedia.ca/Athens-Hotels-Ohio-University-Inn-Conference-Center.h39931.Hotel-Information)

![Restaurant](https://images.trvl-media.com/lodging/2000000/1600000/1593300/1593237/fcc2f5e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/2000000/1600000/1593300/1593237/d767c45b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/2000000/1600000/1593300/1593237/0b055336.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pool](https://images.trvl-media.com/lodging/2000000/1600000/1593300/1593237/0bee4e7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Athens

[](https://www.expedia.ca/Athens-Hotels-Hampton-Inn-Athens.h1593237.Hotel-Information)

Athens

9.2/10

Wonderful

(871)

"The room was spotless and the beds were extremely comfortable."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Nancy

CA $134

CA $152 total

includes taxes & fees

Dec 25 - Dec 26

[](https://www.expedia.ca/Athens-Hotels-Hampton-Inn-Athens.h1593237.Hotel-Information)

![Executive Suite, 1 King Bed, Non Smoking, Hot Tub](https://images.trvl-media.com/lodging/1000000/160000/155900/155861/fd9d009f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/1000000/160000/155900/155861/c44320d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/160000/155900/155861/e7449803.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/160000/155900/155861/3c4f92bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Baymont by Wyndham Cambridge

[](https://www.expedia.ca/Zanesville-Hotels-Baymont-By-Wyndham-Cambridge.h155861.Hotel-Information)

Cambridge

8.2/10

Very good

(1000)

"Clean and nicely kept building. Pool area was also very nice as well as breakfast area and options. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Nathan

CA $81

CA $94 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/Zanesville-Hotels-Baymont-By-Wyndham-Cambridge.h155861.Hotel-Information)

![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/10000/9100/9003/4d0a03ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/9100/9003/6457a0a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9100/9003/ca83c7fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9100/9003/0412e135.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Inn & Suites Zanesville City Center

[](https://www.expedia.ca/Zanesville-Hotels-Zane-Inn-And-Suites.h9003.Hotel-Information)

Zanesville

7.8/10

Good

(275)

"We had a nice stay! The staff was friendly , the room was clean! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

James

CA $120

CA $137 total

includes taxes & fees

Jan 11 - Jan 12, 2026

[](https://www.expedia.ca/Zanesville-Hotels-Zane-Inn-And-Suites.h9003.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-28&endDate=2025-12-29&regionId=6059285&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true)

## Top Southeast Ohio Hotel Reviews

![Ohio University Inn & Conference Center](https://images.trvl-media.com/lodging/1000000/40000/40000/39931/4a096f7d_y.jpg)

### Ohio University Inn & Conference Center

10/10 Excellent

"My favorite hotel in Athens"

[](https://expedia.ca/Athens-Hotels-Ohio-University-Inn-Conference-Center.h39931.Hotel-Information)

![Microtel Inn & Suites by Wyndham Marietta](https://images.trvl-media.com/lodging/1000000/130000/123900/123877/3aaf17a0_y.jpg)

### Microtel Inn & Suites by Wyndham Marietta

10/10 Excellent

"People"

[](https://expedia.ca/Marietta-Hotels-Microtel-Inn-Suites-By-Wyndham-Marietta.h123877.Hotel-Information)

![Quality Inn](https://images.trvl-media.com/lodging/1000000/130000/124400/124351/4aaecbd5_y.jpg)

### Quality Inn

10/10 Excellent

"Always easy check in "

[](https://expedia.ca/Athens-Hotels-Quality-Inn.h124351.Hotel-Information)

![Garland Hotel](https://images.trvl-media.com/lodging/14000000/13480000/13471700/13471606/843aa4a9_y.jpg)

### Garland Hotel

10/10 Excellent

"Good"

[](https://expedia.ca/New-Concord-Hotels-Garland-Hotel.h13471606.Hotel-Information)

![Americas Best Value Inn & Suites St. Clairsville Wheeling](https://images.trvl-media.com/lodging/1000000/130000/122900/122815/71c447d0_y.jpg)

### Americas Best Value Inn & Suites St. Clairsville Wheeling

10/10 Excellent

"It was a great place to stay for the price. I will return when I’m in the area again. "

[](https://expedia.ca/St-Clairsville-Hotels-Americas-Best-Value-Inn-St-Clairsville-Wheeling.h122815.Hotel-Information)

![Days Inn by Wyndham Columbus East Airport](https://images.trvl-media.com/lodging/1000000/10000/4600/4541/49a8132f_y.jpg)

### Days Inn by Wyndham Columbus East Airport

10/10 Excellent

"Quick ,easy, clean!!"

[](https://expedia.ca/Columbus-Hotels-Days-Inn-By-Wyndham-Columbus-East-Airport.h4541.Hotel-Information)

![Christopher Inn and Suites](https://images.trvl-media.com/lodging/2000000/1040000/1039700/1039674/50c4cecb_y.jpg)

### Christopher Inn and Suites

10/10 Excellent

"Great"

[](https://expedia.ca/Chillicothe-Hotels-Christopher-Inn-And-Suites.h1039674.Hotel-Information)

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