Title: Book the Best Southeast Ohio LUXURY Hotels - Upscale Hotels in Southeast Ohio, OH | Expedia.ca [Southeast Ohio Travel Guide](https://expedia.ca/Southeast-Ohio.dx6059285)[Hotels in Southeast Ohio](https://expedia.ca/Southeast-Ohio-Hotels.d6059285.Travel-Guide-Hotels)[Vacation Rentals in Southeast Ohio](https://expedia.ca/Southeast-Ohio-Vacation-Rentals.d6059285.Travel-Guide-VacationRentals)[Flights to Southeast Ohio](https://expedia.ca/Cheap-Flights-To-Southeast-Ohio.d6059285.Travel-Guide-Flights)[Southeast Ohio Car Rentals](https://expedia.ca/Car-Rentals-In-Southeast-Ohio.d6059285.Car-Rental-Guide)[Southeast Ohio Vacation Packages](https://expedia.ca/Southeast-Ohio.d6059285.Destination-Travel-Guides) ![Wheeling featuring a river or creek, a city and a suspension bridge or treetop walkway](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/62000/62340-Wheeling.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Southeast Ohio, OH ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southeast Ohio Luxury Hotels Tonight [Oct 28 - Oct 29](https://www.expedia.ca/Hotel-Search?regionId=6059285&startDate=2025-10-28&endDate=2025-10-29&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Oct 29 - Oct 30](https://www.expedia.ca/Hotel-Search?regionId=6059285&startDate=2025-10-29&endDate=2025-10-30&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6059285&startDate=2025-10-31&endDate=2025-11-02&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6059285&startDate=2025-11-07&endDate=2025-11-09&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Southeast Ohio Luxury Hotels ## Top Southeast Ohio Hotel Reviews ## Explore a world of travel with Expedia - 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