Title: Book the Best Southeast Ohio LUXURY Hotels - Upscale Hotels in Southeast Ohio, OH | Expedia.ca [Southeast Ohio Travel Guide](https://expedia.ca/Southeast-Ohio.dx6059285)[Hotels in Southeast Ohio](https://expedia.ca/Southeast-Ohio-Hotels.d6059285.Travel-Guide-Hotels)[Vacation Rentals in Southeast Ohio](https://expedia.ca/Southeast-Ohio-Vacation-Rentals.d6059285.Travel-Guide-VacationRentals)[Flights to Southeast Ohio](https://expedia.ca/Cheap-Flights-To-Southeast-Ohio.d6059285.Travel-Guide-Flights)[Southeast Ohio Car Rentals](https://expedia.ca/Car-Rentals-In-Southeast-Ohio.d6059285.Car-Rental-Guide)[Southeast Ohio Vacation Packages](https://expedia.ca/Southeast-Ohio.d6059285.Destination-Travel-Guides) ![Wheeling featuring a river or creek, a city and a suspension bridge or treetop walkway](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/62000/62340-Wheeling.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Southeast Ohio, OH ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southeast Ohio Luxury Hotels Tonight [Oct 13 - Oct 14](https://www.expedia.ca/Hotel-Search?regionId=6059285&startDate=2025-10-13&endDate=2025-10-14&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 14 - Oct 15](https://www.expedia.ca/Hotel-Search?regionId=6059285&startDate=2025-10-14&endDate=2025-10-15&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6059285&startDate=2025-10-17&endDate=2025-10-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6059285&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Southeast Ohio Luxury Hotels ![Ballroom](https://images.trvl-media.com/lodging/1000000/10000/6100/6032/35b37036.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Library](https://images.trvl-media.com/lodging/1000000/10000/6100/6032/bf347d2c_edited_5de6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/10000/6100/6032/3cfe22fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/10000/6100/6032/w493h723x8y0-84b46d0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Blennerhassett Hotel Parkersburg 9.4/10 Exceptional (1015) "We enjoyed our stay and will definitely comeback again." CA $213 CA $248 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Parkersburg-Hotels-The-Blennerhassett-Hotel.h6032.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/14000000/13480000/13471700/13471606/843aa4a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/14000000/13480000/13471700/13471606/dc8b2454.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/14000000/13480000/13471700/13471606/7aed15ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/14000000/13480000/13471700/13471606/bf3decec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Garland Hotel New Concord 9.2/10 Wonderful (897) "Nice hotel " CA $127 CA $146 total includes taxes & fees Oct 22 - Oct 23 [](https://www.expedia.ca/New-Concord-Hotels-Garland-Hotel.h13471606.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/8600/8583/c6b09e9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/10000/8600/8583/8b407aef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/8600/8583/b78b83f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/8600/8583/60c334e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Adena Inn Chillicothe 7.8/10 Good (754) "Check in was efficient. Staff excellent " CA $143 CA $164 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Chillicothe-Hotels-Best-Western-Adena-Inn.h8583.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/19000000/18720000/18711100/18711017/w1170h878x0y827-f54fdfdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds](https://images.trvl-media.com/lodging/19000000/18720000/18711100/18711017/256821b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds](https://images.trvl-media.com/lodging/19000000/18720000/18711100/18711017/e802ee00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18720000/18711100/18711017/w1170h878x0y827-cd97cadc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Deluxe Inn Hebron 6.8/10 (269) "Loved my stay" CA $63 CA $71 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Hebron-Hotels-Deluxe-Inn.h18711017.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/2000000/1870000/1868900/1868803/699e3988.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1870000/1868900/1868803/fb50516c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/2000000/1870000/1868900/1868803/41f3474a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1870000/1868900/1868803/261d2195.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Granville Inn Granville 9.6/10 Exceptional (716) "Best dinner in town" CA $257 CA $284 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Zanesville-Hotels-Granville-Inn.h1868803.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/14000000/13070000/13068200/13068101/752fe927.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed](https://images.trvl-media.com/lodging/14000000/13070000/13068200/13068101/8fc7374b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/14000000/13070000/13068200/13068101/c13080ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/14000000/13070000/13068200/13068101/09076694.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Executive Inn Chillicothe 7.4/10 Good (621) "Clean and comfortable rooms with friendly staff" CA $85 CA $98 total includes taxes & fees Oct 22 - Oct 23 [](https://www.expedia.ca/Chillicothe-Hotels-Executive-Inn.h13068101.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/40000/40000/39931/4a096f7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/40000/40000/39931/w5500h3649x0y6-0804e267.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/40000/40000/39931/e6baab9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine, pool views ](https://images.trvl-media.com/lodging/1000000/40000/40000/39931/bacb3f1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ohio University Inn & Conference Center Athens 9.2/10 Wonderful (1005) "Great place. " CA $162 CA $184 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Athens-Hotels-Ohio-University-Inn-Conference-Center.h39931.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1600000/1593300/1593237/fcc2f5e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1600000/1593300/1593237/7f6bfbd9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/2000000/1600000/1593300/1593237/dd82e9d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1600000/1593300/1593237/201b67ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Athens Athens 9.2/10 Wonderful (847) "Nice stay, friendly staff, restaurant/bar next door is nice too. " CA $160 CA $181 total includes taxes & fees Nov 10 - Nov 11 [](https://www.expedia.ca/Athens-Hotels-Hampton-Inn-Athens.h1593237.Hotel-Information) ![Executive Suite, 1 King Bed, Non Smoking, Hot Tub](https://images.trvl-media.com/lodging/1000000/160000/155900/155861/fd9d009f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/160000/155900/155861/3c4f92bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/160000/155900/155861/c44320d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/160000/155900/155861/f1804fc0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Cambridge Cambridge 8.2/10 Very good (1011) "Great place" CA $82 CA $96 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Zanesville-Hotels-Baymont-By-Wyndham-Cambridge.h155861.Hotel-Information) ![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/10000/9100/9003/4d0a03ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/9100/9003/c29456d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/10000/9100/9003/b9153f71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/9100/9003/36163b70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Zanesville City Center Zanesville 7.6/10 Good (261) "Restaurants are near" CA $114 CA $130 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Zanesville-Hotels-Zane-Inn-And-Suites.h9003.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-27&endDate=2025-10-28®ionId=6059285&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Top Southeast Ohio Hotel Reviews ![The Lafayette A grand Riverboat Era Hotel](//images.trvl-media.com/lodging/1000000/50000/40200/40137/0b76c640_y.jpg) ### The Lafayette A grand Riverboat Era Hotel 10/10 Excellent "Parking is easy and convenient " [](https://expedia.ca/Marietta-Hotels-The-Lafayette-A-Grand-Riverboat-Era-Hotel.h40137.Hotel-Information) ![Christopher Inn and Suites](//images.trvl-media.com/lodging/2000000/1040000/1039700/1039674/50c4cecb_y.jpg) ### Christopher Inn and Suites 10/10 Excellent "The room was clean and comfortable. The indoor pool was very nice. The staff were very friendly and kind and gave us free coupon for pizza." [](https://expedia.ca/Chillicothe-Hotels-Christopher-Inn-And-Suites.h1039674.Hotel-Information) ![Days Inn by Wyndham Columbus East Airport](//images.trvl-media.com/lodging/1000000/10000/4600/4541/49a8132f_y.jpg) ### Days Inn by Wyndham Columbus East Airport 10/10 Excellent "My check in experience was fast and pleasant. I experienced the most peaceful, quiet, comfortable and restful nights sleep. I will stay here in the future. " [](https://expedia.ca/Columbus-Hotels-Days-Inn-By-Wyndham-Columbus-East-Airport.h4541.Hotel-Information) ![Americas Best Value Inn & Suites St. Clairsville Wheeling](//images.trvl-media.com/lodging/1000000/130000/122900/122815/71c447d0_y.jpg) ### Americas Best Value Inn & Suites St. Clairsville Wheeling 10/10 Excellent "My usual weekend stay for this area. Nothing fancy, but perfectly comfortable & very affordable!" [](https://expedia.ca/St-Clairsville-Hotels-Americas-Best-Value-Inn-St-Clairsville-Wheeling.h122815.Hotel-Information) ![Ohio University Inn & Conference Center](//images.trvl-media.com/lodging/1000000/40000/40000/39931/4a096f7d_y.jpg) ### Ohio University Inn & Conference Center 10/10 Excellent "Beautiful hotel, very clean and staff was very friendly!" [](https://expedia.ca/Athens-Hotels-Ohio-University-Inn-Conference-Center.h39931.Hotel-Information) ![Microtel Inn & Suites by Wyndham Marietta](//images.trvl-media.com/lodging/1000000/130000/123900/123877/3aaf17a0_y.jpg) ### Microtel Inn & Suites by Wyndham Marietta 10/10 Excellent "Liked the roomy shower" [](https://expedia.ca/Marietta-Hotels-Microtel-Inn-Suites-By-Wyndham-Marietta.h123877.Hotel-Information) ![Quality Inn](//images.trvl-media.com/lodging/1000000/130000/124400/124351/4aaecbd5_y.jpg) ### Quality Inn 10/10 Excellent "I would stay again. Convenient to where I needed to be. 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