Title: Book the Best BUSINESS Hotels in Southeast Illinois in 2026 | Expedia.ca [Southeast Illinois Travel Guide](https://expedia.ca/Southeast-Illinois.dx6058934)[Hotels in Southeast Illinois](https://expedia.ca/Southeast-Illinois-Hotels.d6058934.Travel-Guide-Hotels)[Vacation Rentals in Southeast Illinois](https://expedia.ca/Southeast-Illinois-Vacation-Rentals.d6058934.Travel-Guide-VacationRentals)[Flights to Southeast Illinois](https://expedia.ca/Cheap-Flights-To-Southeast-Illinois.d6058934.Travel-Guide-Flights)[Southeast Illinois Car Rentals](https://expedia.ca/Car-Rentals-In-Southeast-Illinois.d6058934.Car-Rental-Guide)[Southeast Illinois Vacation Packages](https://expedia.ca/Southeast-Illinois.d6058934.Destination-Travel-Guides) ![Southern Illinois which includes rocky coastline and a lake or waterhole](https://images.trvl-media.com/place/87494/1b8c6b56-b76a-4a6c-a179-ef7dda71d358.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Southernmost Illinois Tourism Bureau # Find Business Hotels in Southeast Illinois, IL from CA $87 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southeast Illinois Business Hotels Tonight [Dec 26 - Dec 27](https://www.expedia.ca/Hotel-Search?regionId=6058934&startDate=2025-12-26&endDate=2025-12-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Dec 27 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6058934&startDate=2025-12-27&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6058934&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6058934&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Southeast Illinois business-friendly hotels ![Exterior](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/ee5a3a7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/d519a6dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, desk, blackout drapes](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/ba1b9560.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/16f1378e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Effingham by IHG [](https://www.expedia.ca/Effingham-Hotels-Holiday-Inn-Express-And-Suites-Effingham.h11474428.Hotel-Information) Effingham 9.4/10 Exceptional (1001) "Clean room, excellent staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nancy CA $142 CA $159 total includes taxes & fees Jan 10 - Jan 11, 2026 [](https://www.expedia.ca/Effingham-Hotels-Holiday-Inn-Express-And-Suites-Effingham.h11474428.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/be582add.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/5f2b59be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/82da38ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/w3840h2556x0y4-dd5ad558.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Delta Inn [](https://www.expedia.ca/Effingham-Hotels-Best-Western-Delta-Inn.h3382.Hotel-Information) Effingham 9.2/10 Wonderful (1002) "Great breakfast!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michele CA $115 CA $129 total includes taxes & fees Jan 6 - Jan 7, 2026 [](https://www.expedia.ca/Effingham-Hotels-Best-Western-Delta-Inn.h3382.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/f2163f3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/cb0960c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/4c50f376.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/0c22f262.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, Effingham, IL [](https://www.expedia.ca/Effingham-Hotels-Country-Inn-Suites-By-Radisson.h914400.Hotel-Information) Effingham 8.8/10 Excellent (1000) "Clean rooms and kind staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linda CA $122 CA $135 total includes taxes & fees Jan 15 - Jan 16, 2026 [](https://www.expedia.ca/Effingham-Hotels-Country-Inn-Suites-By-Radisson.h914400.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/6cba26b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 6:00 AM to 11:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/453e2ca5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/8e4b3d15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking, Jetted Tub](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/140c98cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Effingham [](https://www.expedia.ca/Effingham-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Effingham.h50093.Hotel-Information) Effingham 9.2/10 Wonderful (1000) "Clean, pleasant, fast check in, and warm pool! I have stayed here 2 times before and have already booked a room for my return trip here. Great place to stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Barbara CA $127 CA $142 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Effingham-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Effingham.h50093.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/9200/9151/13aae8b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/10000/9200/9151/3340f2af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/9200/9151/8b3db0ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/9200/9151/2e6379a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ramada by Wyndham Effingham [](https://www.expedia.ca/Effingham-Hotels-Ramada-By-Wyndham-Effingham.h9151.Hotel-Information) Effingham 7.6/10 Good (1000) "Nice place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Saifullah CA $78 CA $87 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Effingham-Hotels-Ramada-By-Wyndham-Effingham.h9151.Hotel-Information) ![Studio Suite, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/6000000/5690000/5685800/5685735/5e25407f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/6000000/5690000/5685800/5685735/a3a4b14b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/6000000/5690000/5685800/5685735/0be3bf86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/6000000/5690000/5685800/5685735/bba4b648.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn & Suites by Wyndham Casey [](https://www.expedia.ca/Effingham-Hotels-Days-Inn-Suites-By-Wyndham-Casey.h5685735.Hotel-Information) Casey 7.4/10 Good (830) "Nice place, quiet, clean, and I would stay there again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kym CA $96 CA $106 total includes taxes & fees Jan 2 - Jan 3, 2026 [](https://www.expedia.ca/Effingham-Hotels-Days-Inn-Suites-By-Wyndham-Casey.h5685735.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/15000000/14830000/14820400/14820315/ec495250.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/15000000/14830000/14820400/14820315/e9350d80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/15000000/14830000/14820400/14820315/7407fe6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/15000000/14830000/14820400/14820315/w1024h676x0y0-c83e1009.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cobblestone Inn & Suites - Altamont [](https://www.expedia.ca/Effingham-Hotels-Cobblestone-Inn-Suites-Altamont.h14820315.Hotel-Information) Altamont 9.6/10 Exceptional (804) "Just beautiful. I love staying here. Very cozy and clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lisa [](https://www.expedia.ca/Effingham-Hotels-Cobblestone-Inn-Suites-Altamont.h14820315.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113164/2fb633cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113164/9bfd4c57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113164/b86d8b28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113164/416a4136.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Effingham by IHG [](https://www.expedia.ca/Effingham-Hotels-Holiday-Inn-Effingham.h1113164.Hotel-Information) Effingham 9.0/10 Wonderful (656) "Nice place with bar and restaurant on site." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steve CA $144 CA $161 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Effingham-Hotels-Holiday-Inn-Effingham.h1113164.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/36000000/35030000/35020800/35020703/727bbbb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/36000000/35030000/35020800/35020703/w3840h2550x0y4-a875172e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/36000000/35030000/35020800/35020703/w3837h2551x3y3-84f618ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/36000000/35030000/35020800/35020703/w3837h2550x3y4-ddda9070.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Parkside Inn & Suites [](https://www.expedia.ca/Olney-Hotels-Best-Western-Plus-Parkside-Inn-Suites.h35020703.Hotel-Information) Olney 9.8/10 Exceptional (319) "A great hotel-- best in Olney! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nathan CA $150 CA $166 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/Olney-Hotels-Best-Western-Plus-Parkside-Inn-Suites.h35020703.Hotel-Information) ![Gastropub](https://images.trvl-media.com/lodging/1000000/10000/1600/1591/7a3778a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/1000000/10000/1600/1591/22942804.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Multiple Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/10000/1600/1591/53516431.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/1600/1591/ba0a6ccd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Effingham [](https://www.expedia.ca/Effingham-Hotels-Baymont-By-Wyndham-Effingham.h1591.Hotel-Information) Effingham 8.0/10 Very good (1000) "Clean rooms, toiletries available, great breakfast and friendly staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Angela CA $87 CA $97 total includes taxes & fees Jan 26 - Jan 27, 2026 [](https://www.expedia.ca/Effingham-Hotels-Baymont-By-Wyndham-Effingham.h1591.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-09&endDate=2026-01-10®ionId=6058934&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Southeast Illinois Hotel Reviews ![Baymont by Wyndham Effingham](https://images.trvl-media.com/lodging/1000000/10000/1600/1591/7a3778a0_y.jpg) ### Baymont by Wyndham Effingham 10/10 Excellent "Good value, clean room. Close to the interstate so you do get some road noise. " [](https://expedia.ca/Effingham-Hotels-Baymont-By-Wyndham-Effingham.h1591.Hotel-Information) ![Best Western Delta Inn](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/be582add_y.jpg) ### Best Western Delta Inn 10/10 Excellent "Our room was clean and comfortable. It was quiet and they took care to make sure we had a pet free room. The breakfast was delicious. Many choices and constantly being replenished. The only thing is the quality of plastic ware needs to be upgraded. Staff are all very friendly and welcoming. We always stay here on our FL trips. Great job." [](https://expedia.ca/Effingham-Hotels-Best-Western-Delta-Inn.h3382.Hotel-Information) ![Drury Inn & Suites Terre Haute](https://images.trvl-media.com/lodging/1000000/20000/15000/14944/69cc0b6a_y.jpg) ### Drury Inn & Suites Terre Haute 10/10 Excellent "Friendly and helpful staff. Fresh, hot and very tasty breakfast. Our room was nice and it was cleaned well. The bed was as comfortable as home. The next time we travel to Terre Haute, Indiana to vist relatives we will definitely stay at Drury Inn & Suites. I would highly recommend this hotel. This was our first time staying at Drury Inn we usually stay at Holiday Inn, Hampton Inn or Hilton Gardens, but next time we travel I'll look for a Drury Inn. Thank you for a great stay." [](https://expedia.ca/Terre-Haute-Hotels-Drury-Inn-Suites-Terre-Haute.h14944.Hotel-Information) ![Hampton Inn & Suites Effingham](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321975/11916b3a_y.jpg) ### Hampton Inn & Suites Effingham 10/10 Excellent "Cleanliness. Professional. Excellent flatscreens! Awesome rooms! Showers perfect!" [](https://expedia.ca/Effingham-Hotels-Hampton-Inn-Suites-Effingham.h1321975.Hotel-Information) ![Drury Plaza Hotel Mt. Vernon](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/f9296f7b_y.jpg) ### Drury Plaza Hotel Mt. Vernon 10/10 Excellent "Nice and clean place. Friendly staff." [](https://expedia.ca/Mount-Vernon-Hotels-Drury-Inn-Suites-Mt-Vernon.h42021.Hotel-Information) ![Holiday Inn Express & Suites Effingham by IHG](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/ee5a3a7f_y.jpg) ### Holiday Inn Express & Suites Effingham by IHG 10/10 Excellent "Great location and service " [](https://expedia.ca/Effingham-Hotels-Holiday-Inn-Express-And-Suites-Effingham.h11474428.Hotel-Information) ![Comfort Suites Mount Vernon](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/b34f836a_y.jpg) ### Comfort Suites Mount Vernon 10/10 Excellent "Check in was quick, staff was friendly and helpful, room was very nice and clean." [](https://expedia.ca/Mount-Vernon-Hotels-Comfort-Suites-Mount-Vernon.h1387309.Hotel-Information) ![Quality Inn & Suites Metropolis I-24](https://images.trvl-media.com/lodging/1000000/20000/17100/17025/cdfedf28_y.jpg) ### Quality Inn & Suites Metropolis I-24 10/10 Excellent "Everything was great" [](https://expedia.ca/Metropolis-Hotels-Quality-Inn-Suites-Metropolis-I-24.h17025.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Effingham](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/6cba26b8_y.jpg) ### La Quinta Inn & Suites by Wyndham Effingham 10/10 Excellent "Clean, pleasant, fast check in, and warm pool! I have stayed here 2 times before and have already booked a room for my return trip here. Great place to stay!" [](https://expedia.ca/Effingham-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Effingham.h50093.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Southeast Illinois cost? ### What are the best business-friendly hotels in Southeast Illinois? ### How many business-friendly hotels are there in Southeast Illinois? ### What are the best cheap business-friendly hotels in Southeast Illinois? ### Are there any family-friendly hotels in Southeast Illinois that are also business friendly? ### Why book your business-friendly hotel in Southeast Illinois with Expedia? ### How can I find cheap business-friendly hotels in Southeast Illinois? ### What is there to do in Southeast Illinois near my business-friendly hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [3 Star Hotels in Olney ](https://www.expedia.ca/3Star-Olney-Hotels.s30-0-d6139852.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Albion ](https://www.expedia.ca/Albion-Hotels-Luxury-Hotel.0-0-d553248626387841190-tLuxuryHotel.Travel-Guide-Filter-Hotels) - 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