Title: Book the Best BUSINESS Hotels in South San Francisco in 2026 | Expedia.ca

[South San Francisco Travel Guide](https://expedia.ca/South-San-Francisco.dx6773)[Hotels in South San Francisco](https://expedia.ca/South-San-Francisco-Hotels.d6773.Travel-Guide-Hotels)[Vacation Rentals in South San Francisco](https://expedia.ca/South-San-Francisco-Vacation-Rentals.d6773.Travel-Guide-VacationRentals)[Flights to South San Francisco](https://expedia.ca/Cheap-Flights-To-South-San-Francisco.d6773.Travel-Guide-Flights)[Things to do in South San Francisco](https://expedia.ca/Things-To-Do-In-South-San-Francisco.d6773.Travel-Guide-Activities)[South San Francisco Car Rentals](https://expedia.ca/Car-Rentals-In-South-San-Francisco.d6773.Car-Rental-Guide)[South San Francisco Vacation Packages](https://expedia.ca/South-San-Francisco.d6773.Destination-Travel-Guides)

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# Find Business Hotels in South San Francisco, CA from CA $147

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## Check availability on South San Francisco Business Hotels

Tonight

[Dec 5 - Dec 6](https://www.expedia.ca/Hotel-Search?regionId=6773&startDate=2025-12-05&endDate=2025-12-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

Tomorrow

[Dec 6 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=6773&startDate=2025-12-06&endDate=2025-12-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

This weekend

[Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=6773&startDate=2025-12-05&endDate=2025-12-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

Next weekend

[Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=6773&startDate=2025-12-12&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

## Top South San Francisco Business Hotels

![Terrace/patio](https://images.trvl-media.com/lodging/32000000/31900000/31891900/31891814/197051b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/32000000/31900000/31891900/31891814/27d2834d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Full-size fridge, microwave, dishwasher, coffee/tea maker](https://images.trvl-media.com/lodging/32000000/31900000/31891900/31891814/0bb5eeac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/32000000/31900000/31891900/31891814/cd3ddee1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Home2 Suites by Hilton San Francisco Airport North

The East Side

8.8/10

Excellent

(1155)

"Breakfast very good and clean, quiet and relaxing "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mark

CA $144

CA $169 total

includes taxes & fees

Jan 3 - Jan 4, 2026

[](https://www.expedia.ca/San-Francisco-Hotels-Home2-Suites-By-Hilton-San-Francisco-Airport-North.h31891814.Hotel-Information)

![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/3000/2981/de8c7326.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/10000/3000/2981/6b43e156.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/10000/3000/2981/50e65829.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/10000/3000/2981/5e906d0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Embassy Suites by Hilton San Francisco Airport Oyster Point

The East Side

8.6/10

Excellent

(1228)

"Everything was just great the amenities the staff the cleanliness the breakfast I had a very relaxing and great time "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lily

CA $200

CA $235 total

includes taxes & fees

Dec 23 - Dec 24

[](https://www.expedia.ca/San-Francisco-Hotels-Embassy-Suites-San-Francisco-Airport-South-San-Francisco.h2981.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/300000/296800/296720/2a2b3f43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/300000/296800/296720/e5ddacdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Courtyard](https://images.trvl-media.com/lodging/1000000/300000/296800/296720/2786f2ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/300000/296800/296720/4de8a98f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hilton Garden Inn San Francisco Arpt North

The East Side

8.4/10

Very good

(1003)

"Staff, amenities, clean rooms "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

ROMEO JR

CA $127

CA $150 total

includes taxes & fees

Dec 23 - Dec 24

[](https://www.expedia.ca/San-Francisco-Hotels-Hilton-Garden-Inn-San-Francisco-Airport-North.h296720.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/10000/7700/7635/062e9dfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/7700/7635/76976cda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, individually decorated, individually furnished, desk](https://images.trvl-media.com/lodging/1000000/10000/7700/7635/2ef696cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/10000/7700/7635/6553e455.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus Grosvenor Airport Hotel

South San Francisco

8.4/10

Very good

(1690)

"Great place to stay "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Florence

CA $128

CA $151 total

includes taxes & fees

Dec 19 - Dec 20

[](https://www.expedia.ca/San-Francisco-Hotels-Best-Western-Plus-Grosvenor-Airport-Hotel.h7635.Hotel-Information)

![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/500/487/fda694f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/1000000/10000/500/487/ffe8e817.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/500/487/950e2043.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/10000/500/487/111baa3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### DoubleTree by Hilton San Francisco South Airport Blvd

South San Francisco

8.4/10

Very good

(2027)

"Room was very clean and front desk ladies were very friendly and helpful. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Carolyn

CA $160

CA $189 total

includes taxes & fees

Jan 1 - Jan 2, 2026

[](https://www.expedia.ca/San-Francisco-Hotels-DoubleTree-By-Hilton-San-Francisco-South-Airport-Blvd.h487.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/1000000/860000/856900/856888/c6d8f6a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/860000/856900/856888/abda588b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/860000/856900/856888/50bb7e1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pillowtop beds, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/860000/856900/856888/2e84837a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express San Francisco-Airport North by IHG

South San Francisco

8.2/10

Very good

(1002)

"Overall stay is excellent ✨"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Chloe Nicole Badajos

CA $124

CA $147 total

includes taxes & fees

Dec 7 - Dec 8

[](https://www.expedia.ca/San-Francisco-Hotels-Holiday-Inn-Express-San-Francisco-Airport-North.h856888.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/59000000/58950000/58946000/58945916/cd25a913.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/59000000/58950000/58946000/58945916/fc0dbc9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 1 King Bed](https://images.trvl-media.com/lodging/59000000/58950000/58946000/58945916/77088351.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/59000000/58950000/58946000/58945916/118701c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area

The East Side

9.0/10

Wonderful

(436)

"Clean room, helpful staff, complimentary breakfast. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Veronica

CA $162

CA $190 total

includes taxes & fees

Jan 3 - Jan 4, 2026

[](https://www.expedia.ca/San-Francisco-Hotels-Fairfield-Inn-Suites-By-Marriott-San-Francisco-Airport-North.h58945916.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/550000/548400/548380/0a287fc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/550000/548400/548380/6a2adbcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/550000/548400/548380/772b55bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/550000/548400/548380/1cf5958e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Sonesta Select San Francisco Airport Oyster Point Waterfront

Oyster Point

8.6/10

Excellent

(1868)

"always a great stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Marco

CA $130

CA $156 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/San-Francisco-Hotels-Sonesta-Select-San-Francisco-Airport.h548380.Hotel-Information)

![View from property](https://images.trvl-media.com/lodging/19000000/18790000/18787400/18787381/11167df3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/19000000/18790000/18787400/18787381/d13b3a84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Banquet hall](https://images.trvl-media.com/lodging/19000000/18790000/18787400/18787381/9dc844cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/19000000/18790000/18787400/18787381/98ea62c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

Oyster Point

9.2/10

Wonderful

(1002)

"Very convenient stay for San Francisco. Clean hotel and very comfortable bed. Excellent gym. Will stay again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Andy

CA $172

CA $205 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/San-Francisco-Hotels-AC-Hotel-By-Marriott-San-Francisco-Airport-Oyster-PointWaterfront.h18787381.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/10000/9400/9329/5d196618.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Suite, Multiple Beds, Accessible, Non Smoking (Mobility/Hearing Impaired Accessible)](https://images.trvl-media.com/lodging/1000000/10000/9400/9329/6c7a44bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/10000/9400/9329/4becccdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9400/9329/f426e9e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Quinta Inn & Suites by Wyndham San Francisco Airport N

Downtown South San Francisco

8.0/10

Very good

(2004)

"Breakfast is great. Staff is great."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Trina

CA $159

CA $186 total

includes taxes & fees

Dec 6 - Dec 7

[](https://www.expedia.ca/San-Francisco-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Francisco-Airport-N.h9329.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-19&endDate=2025-12-20&regionId=6773&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true)

## Top South San Francisco Hotel Reviews

![DoubleTree by Hilton Hotel Berkeley Marina](https://images.trvl-media.com/lodging/1000000/30000/23800/23800/ba0da8d5_y.jpg)

### DoubleTree by Hilton Hotel Berkeley Marina

10/10 Excellent

"Hotel was reasonably priced, room was clean and staff was helpful. The view was nice and a big park with great views was right next to the hotel. Great breakfast "

[](https://expedia.ca/Oakland-Hotels-DoubleTree-By-Hilton-Hotel-Berkeley-Marina.h23800.Hotel-Information)

![Best Western Plus Grosvenor Airport Hotel](https://images.trvl-media.com/lodging/1000000/10000/7700/7635/062e9dfe_y.jpg)

### Best Western Plus Grosvenor Airport Hotel

10/10 Excellent

"Great experience"

[](https://expedia.ca/San-Francisco-Hotels-Best-Western-Plus-Grosvenor-Airport-Hotel.h7635.Hotel-Information)

![Bay Landing San Francisco Airport Hotel](https://images.trvl-media.com/lodging/2000000/1120000/1110800/1110785/0c231d9b_y.jpg)

### Bay Landing San Francisco Airport Hotel

10/10 Excellent

"Excellent stay with a great staff! Love staying here - close to the airport and walkable to restaurants."

[](https://expedia.ca/San-Francisco-Hotels-Bay-Landing-San-Francisco-Airport-Hotel.h1110785.Hotel-Information)

![Holiday Inn Golden Gateway by IHG](https://images.trvl-media.com/lodging/1000000/20000/10600/10538/9ba9bb1f_y.jpg)

### Holiday Inn Golden Gateway by IHG

10/10 Excellent

"Awesome hotel, clean room, nice staff and all around a fantastic view. Walkable to many places"

[](https://expedia.ca/San-Francisco-Hotels-Holiday-Inn-Golden-Gateway.h10538.Hotel-Information)

![Hilton San Francisco Financial District](https://images.trvl-media.com/lodging/1000000/10000/4400/4302/77af977e_y.jpg)

### Hilton San Francisco Financial District

10/10 Excellent

"All was nice"

[](https://expedia.ca/San-Francisco-Hotels-Hilton-San-Francisco-Financial-District.h4302.Hotel-Information)

![DoubleTree by Hilton San Francisco South Airport Blvd](https://images.trvl-media.com/lodging/1000000/10000/500/487/fda694f4_y.jpg)

### DoubleTree by Hilton San Francisco South Airport Blvd

10/10 Excellent

"Room was very clean and front desk ladies were very friendly and helpful. "

[](https://expedia.ca/San-Francisco-Hotels-DoubleTree-By-Hilton-San-Francisco-South-Airport-Blvd.h487.Hotel-Information)

![Travelodge by Wyndham San Francisco Airport North](https://images.trvl-media.com/lodging/1000000/20000/17000/16955/864c4988_y.jpg)

### Travelodge by Wyndham San Francisco Airport North

10/10 Excellent

" yes, clean and warm"

[](https://expedia.ca/San-Francisco-Hotels-Travelodge-By-Wyndham-San-Francisco-Airport-North.h16955.Hotel-Information)

![Sonesta Select San Francisco Airport Oyster Point Waterfront](https://images.trvl-media.com/lodging/1000000/550000/548400/548380/0a287fc7_y.jpg)

### Sonesta Select San Francisco Airport Oyster Point Waterfront

10/10 Excellent

"Nice staff, clean room, clean overall, convenient shuttle to the airport"

[](https://expedia.ca/San-Francisco-Hotels-Sonesta-Select-San-Francisco-Airport.h548380.Hotel-Information)

![Hotel Riu Plaza Fisherman's Wharf](https://images.trvl-media.com/lodging/1000000/30000/24700/24625/6fb55356_y.jpg)

### Hotel Riu Plaza Fisherman's Wharf

10/10 Excellent

"Room was good, breakfast buffet was outstanding! "

[](https://expedia.ca/San-Francisco-Hotels-Hotel-Riu-Plaza-Fishermans-Wharf.h24625.Hotel-Information)

## Frequently asked questions

### How much do business-friendly hotels in South San Francisco cost?

### What are the best business-friendly hotels in South San Francisco?

### How many business-friendly hotels are there in South San Francisco?

### What are the best cheap business-friendly hotels in South San Francisco?

### What are the top business-friendly motels in South San Francisco?

### Are there any family-friendly hotels in South San Francisco that are also business friendly?

### Are there any 5-star business-friendly hotels in South San Francisco?

### Why book your business-friendly hotel in South San Francisco with Expedia?

### How can I find cheap business-friendly hotels in South San Francisco?

### What is there to do in South San Francisco near my business-friendly hotel?

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