Title: Book the Best BOUTIQUE Hotels in South San Francisco in 2026 | Expedia.ca

[South San Francisco Travel Guide](https://expedia.ca/South-San-Francisco.dx6773)[Hotels in South San Francisco](https://expedia.ca/South-San-Francisco-Hotels.d6773.Travel-Guide-Hotels)[Vacation Rentals in South San Francisco](https://expedia.ca/South-San-Francisco-Vacation-Rentals.d6773.Travel-Guide-VacationRentals)[Flights to South San Francisco](https://expedia.ca/Cheap-Flights-To-South-San-Francisco.d6773.Travel-Guide-Flights)[Things to do in South San Francisco](https://expedia.ca/Things-To-Do-In-South-San-Francisco.d6773.Travel-Guide-Activities)[South San Francisco Car Rentals](https://expedia.ca/Car-Rentals-In-South-San-Francisco.d6773.Car-Rental-Guide)[South San Francisco Vacation Packages](https://expedia.ca/South-San-Francisco.d6773.Destination-Travel-Guides)

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# Find Boutique Hotels in South San Francisco, CA from CA $202

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## Check availability on South San Francisco Boutique Hotels

Tonight

[Dec 27 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6773&startDate=2025-12-27&endDate=2025-12-28&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Dec 28 - Dec 29](https://www.expedia.ca/Hotel-Search?regionId=6773&startDate=2025-12-28&endDate=2025-12-29&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6773&startDate=2026-01-02&endDate=2026-01-04&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=6773&startDate=2026-01-09&endDate=2026-01-11&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for South San Francisco boutique hotels

![Indoor pool](https://images.trvl-media.com/lodging/2000000/1180000/1175900/1175858/5bd0b8bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lounge](https://images.trvl-media.com/lodging/2000000/1180000/1175900/1175858/cb9fb20d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business centre](https://images.trvl-media.com/lodging/2000000/1180000/1175900/1175858/4da6aa13.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Courtyard](https://images.trvl-media.com/lodging/2000000/1180000/1175900/1175858/7814d514.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Berkeley City Club

[](https://www.expedia.ca/Oakland-Hotels-Berkeley-City-Club.h1175858.Hotel-Information)

Telegraph District

8.8/10

Excellent

(697)

"Wonderful, beautiful, old world hotel, right in the heart of bustling Berkeley. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Peter

[](https://www.expedia.ca/Oakland-Hotels-Berkeley-City-Club.h1175858.Hotel-Information)

![Game room](https://images.trvl-media.com/lodging/10000000/9870000/9868900/9868852/fd976170.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/10000000/9870000/9868900/9868852/d2ac54ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior detail](https://images.trvl-media.com/lodging/10000000/9870000/9868900/9868852/a3393d8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/10000000/9870000/9868900/9868852/fecca267.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Zephyr San Francisco

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Zephyr-San-Francisco.h9868852.Hotel-Information)

Fisherman's Wharf

8.6/10

Excellent

(2334)

"This place is wonderful. Would definitely stay again!!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jenna

CA $171

CA $250 total

includes taxes & fees

Jan 5 - Jan 6, 2026

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Zephyr-San-Francisco.h9868852.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/69c56718.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/03417113.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cafe](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/c3ea453d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Courtyard](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/5023ecf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

###  The Clancy, Autograph Collection by Marriott

[](https://www.expedia.ca/San-Francisco-Hotels-The-Clancy.h693658.Hotel-Information)

Downtown San Francisco

9.2/10

Wonderful

(1000)

"Very professional staff! Central located walking distance to everything!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Edmundo

CA $225

CA $322 total

includes taxes & fees

Jan 2 - Jan 3, 2026

[](https://www.expedia.ca/San-Francisco-Hotels-The-Clancy.h693658.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/920000/915600/915510/39d3931a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, pillowtop beds, minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/920000/915600/915510/2d47f36f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch, dinner served; seafood, alfresco dining ](https://images.trvl-media.com/lodging/1000000/920000/915600/915510/ba1942b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Beach nearby](https://images.trvl-media.com/lodging/1000000/920000/915600/915510/49fa748f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Argonaut Hotel

[](https://www.expedia.ca/San-Francisco-Hotels-Argonaut-Hotel-A-Noble-House-Hotel.h915510.Hotel-Information)

Fisherman's Wharf

9.4/10

Exceptional

(1211)

"Absolutely amazing hotel!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Alicia

CA $220

CA $317 total

includes taxes & fees

Jan 26 - Jan 27, 2026

[](https://www.expedia.ca/San-Francisco-Hotels-Argonaut-Hotel-A-Noble-House-Hotel.h915510.Hotel-Information)

![Room (Private Apartment)](https://images.trvl-media.com/lodging/1000000/30000/21100/21073/7626c0a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cocktail bar](https://images.trvl-media.com/lodging/1000000/30000/21100/21073/7c771a5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room (Private Apartment)](https://images.trvl-media.com/lodging/1000000/30000/21100/21073/174738f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Egyptian cotton sheets, premium bedding, minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/30000/21100/21073/6c69002b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Clift Royal Sonesta San Francisco

[](https://www.expedia.ca/San-Francisco-Hotels-The-Clift-Royal-Sonesta-San-Francisco.h21073.Hotel-Information)

Union Square

9.2/10

Wonderful

(1367)

"Staff was amazing. The rooms felt clean and the hotel was very well maintained."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Misty

CA $206

CA $295 total

includes taxes & fees

Jan 6 - Jan 7, 2026

[](https://www.expedia.ca/San-Francisco-Hotels-The-Clift-Royal-Sonesta-San-Francisco.h21073.Hotel-Information)

![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/20000/15800/15779/05098316.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/15800/15779/e9574f17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15800/15779/e06b2a98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15800/15779/19324471.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Abri - Union Square

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Abri-Union-Square.h15779.Hotel-Information)

Union Square

8.6/10

Excellent

(1002)

"Very nice hotel"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mariam

CA $125

CA $202 total

includes taxes & fees

Jan 9 - Jan 10, 2026

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Abri-Union-Square.h15779.Hotel-Information)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/20000/15800/15769/a6ba3784.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Building design](https://images.trvl-media.com/lodging/1000000/20000/15800/15769/f8220459.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior entrance](https://images.trvl-media.com/lodging/1000000/20000/15800/15769/33ce2394.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/15800/15769/11530a26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Marker Union Square San Francisco

[](https://www.expedia.ca/San-Francisco-Hotels-The-Marker-San-Francisco.h15769.Hotel-Information)

Union Square

9.0/10

Wonderful

(1126)

"The staff was so fabulous, the hotel is gorgeous, and we are already having the best time!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Faith

CA $191

CA $225 total

includes taxes & fees

Jan 3 - Jan 4, 2026

[](https://www.expedia.ca/San-Francisco-Hotels-The-Marker-San-Francisco.h15769.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/10000/700/660/f20db6f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Coffee shop](https://images.trvl-media.com/lodging/1000000/10000/700/660/e5f16b62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/10000/700/660/3ca02425.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/1000000/10000/700/660/c67d692d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Emblem San Francisco

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Emblem-San-Francisco.h660.Hotel-Information)

Union Square

9.4/10

Exceptional

(1001)

"Great place to stay when visiting the City - will return again!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Chris

CA $153

CA $235 total

includes taxes & fees

Jan 2 - Jan 3, 2026

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Emblem-San-Francisco.h660.Hotel-Information)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/5500/5425/bdc280cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/1000000/10000/5500/5425/6e765ef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![55-inch LED TV with cable channels, TV, iPod dock](https://images.trvl-media.com/lodging/1000000/10000/5500/5425/a2ad4847.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Point of interest](https://images.trvl-media.com/lodging/1000000/10000/5500/5425/cb3eeb61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Barnes San Francisco, Tapestry Collection by Hilton

[](https://www.expedia.ca/San-Francisco-Hotels-Villa-Florence-San-Francisco-On-Union-Square.h5425.Hotel-Information)

Union Square

8.2/10

Very good

(774)

"Wonderful Stay, Room was Clean. Close to Union Square. Would Stay Here again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Raquel

CA $178

CA $209 total

includes taxes & fees

Jan 2 - Jan 3, 2026

[](https://www.expedia.ca/San-Francisco-Hotels-Villa-Florence-San-Francisco-On-Union-Square.h5425.Hotel-Information)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/60000/51000/50965/f0d62af8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/1000000/60000/51000/50965/888c52fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Room, 1 Queen Bed](https://images.trvl-media.com/lodging/1000000/60000/51000/50965/f8b3faf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/1000000/60000/51000/50965/711a1d12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### el PRADO

[](https://www.expedia.ca/Palo-Alto-Hotels-El-PRADO.h50965.Hotel-Information)

University South

9.4/10

Exceptional

(615)

"Great stay - big, well appointed rooms in an excellent location "

![Hong Kong SAR China](https://a.travel-assets.com/egds/marks/flags/hk.svg)

David

[](https://www.expedia.ca/Palo-Alto-Hotels-El-PRADO.h50965.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-10&endDate=2026-01-11&regionId=6773&adults=2&specialized_stays_group_explore=boutique_property&sort=RECOMMENDED&openPlayBack=true)

## Top South San Francisco Hotel Reviews

![Fairmont San Francisco](https://images.trvl-media.com/lodging/1000000/20000/18200/18200/6f6889e4_y.jpg)

### Fairmont San Francisco

10/10 Excellent

"YES!"

[](https://expedia.ca/San-Francisco-Hotels-Fairmont-San-Francisco.h18200.Hotel-Information)

![Hotel Riu Plaza Fisherman's Wharf](https://images.trvl-media.com/lodging/1000000/30000/24700/24625/6fb55356_y.jpg)

### Hotel Riu Plaza Fisherman's Wharf

10/10 Excellent

"Good location for travel around the city. Breakfast was great. "

[](https://expedia.ca/San-Francisco-Hotels-Hotel-Riu-Plaza-Fishermans-Wharf.h24625.Hotel-Information)

![Chancellor Hotel on Union Square](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/944f985c_y.jpg)

### Chancellor Hotel on Union Square

10/10 Excellent

"Conveniently located "

[](https://expedia.ca/San-Francisco-Hotels-Chancellor-Hotel-On-Union-Square.h20547.Hotel-Information)

![Hotel Zoe Fisherman's Wharf](https://images.trvl-media.com/lodging/1000000/10000/3600/3552/21cb8d87_y.jpg)

### Hotel Zoe Fisherman's Wharf

10/10 Excellent

"Was hard to tell when I first checked in the power was off, (I Know that was not the hotels' fault) my second impression in the morning was good. Hotel looked to be clean, staff was very accommodating and helpful. "

[](https://expedia.ca/San-Francisco-Hotels-Hotel-Zoe-Fishermans-Wharf.h3552.Hotel-Information)

![Travelodge by Wyndham San Francisco Airport North](https://images.trvl-media.com/lodging/1000000/20000/17000/16955/864c4988_y.jpg)

### Travelodge by Wyndham San Francisco Airport North

10/10 Excellent

"Friendly staff and clean rooms for a low budget motel."

[](https://expedia.ca/San-Francisco-Hotels-Travelodge-By-Wyndham-San-Francisco-Airport-North.h16955.Hotel-Information)

![Club Quarters Hotel in San Francisco](https://images.trvl-media.com/lodging/1000000/920000/913000/912982/5ee1ba27_y.jpg)

### Club Quarters Hotel in San Francisco

10/10 Excellent

"Good ratio of price and quality "

[](https://expedia.ca/San-Francisco-Hotels-Club-Quarters-Hotel-In-San-Francisco.h912982.Hotel-Information)

![Hyatt Centric Fisherman's Wharf San Francisco](https://images.trvl-media.com/lodging/1000000/30000/22500/22500/1d699bf3_y.jpg)

### Hyatt Centric Fisherman's Wharf San Francisco

10/10 Excellent

"Good location "

[](https://expedia.ca/San-Francisco-Hotels-Hyatt-Centric-Fishermans-Wharf-San-Francisco.h22500.Hotel-Information)

![Handlery Union Square Hotel](https://images.trvl-media.com/lodging/1000000/10000/6700/6666/b8dfc462_y.jpg)

### Handlery Union Square Hotel

10/10 Excellent

"Very friendly staff. "

[](https://expedia.ca/San-Francisco-Hotels-Handlery-Union-Square-Hotel.h6666.Hotel-Information)

## Frequently asked questions

### What's there to see and do in South San Francisco?

### What kind of weather should I plan for when I travel to South San Francisco?

### What's the best way to get to my boutique hotel in South San Francisco?

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