Title: Book the Best BOUTIQUE Hotels in South San Francisco in 2025 | Expedia.ca [South San Francisco Travel Guide](https://expedia.ca/South-San-Francisco.dx6773)[Hotels in South San Francisco](https://expedia.ca/South-San-Francisco-Hotels.d6773.Travel-Guide-Hotels)[Vacation Rentals in South San Francisco](https://expedia.ca/South-San-Francisco-Vacation-Rentals.d6773.Travel-Guide-VacationRentals)[Flights to South San Francisco](https://expedia.ca/Cheap-Flights-To-South-San-Francisco.d6773.Travel-Guide-Flights)[Things to do in South San Francisco](https://expedia.ca/Things-To-Do-In-South-San-Francisco.d6773.Travel-Guide-Activities)[South San Francisco Car Rentals](https://expedia.ca/Car-Rentals-In-South-San-Francisco.d6773.Car-Rental-Guide)[South San Francisco Vacation Packages](https://expedia.ca/South-San-Francisco.d6773.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/9/edf3b75ded644f2805fb6e835771cc8f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Boutique Hotels in South San Francisco, CA from CA $103 ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South San Francisco Boutique Hotels Tonight [Oct 1 - Oct 2](https://www.expedia.ca/Hotel-Search?regionId=6773&startDate=2025-10-01&endDate=2025-10-02&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 2 - Oct 3](https://www.expedia.ca/Hotel-Search?regionId=6773&startDate=2025-10-02&endDate=2025-10-03&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6773&startDate=2025-10-03&endDate=2025-10-05&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6773&startDate=2025-10-10&endDate=2025-10-12&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top South San Francisco Boutique Hotels ![Property entrance](https://images.trvl-media.com/lodging/1000000/290000/287700/287665/cd5db6b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/290000/287700/287665/6a958fd0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-size fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/1000000/290000/287700/287665/092e6332.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily self-serve breakfast](https://images.trvl-media.com/lodging/1000000/290000/287700/287665/4ca9d27e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Larkspur Landing Extended Stay Suites South San Francisco The East Side 7.8/10 Good (1000) "Will stay again highly recommended " CA $174 CA $205 total includes taxes & fees Oct 3 - Oct 4 [](https://www.expedia.ca/San-Francisco-Hotels-Larkspur-Landing-South-San-Francisco-An-All-Suite-Hotel.h287665.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/17000/16955/864c4988.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/20000/17000/16955/ef26db43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9 AM to 10 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/17000/16955/ccc198f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/17000/16955/ea6e792d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelodge by Wyndham San Francisco Airport North South San Francisco 5.8/10 (2604) "Budget hotel" CA $86 CA $103 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/San-Francisco-Hotels-Travelodge-By-Wyndham-San-Francisco-Airport-North.h16955.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-15&endDate=2025-10-16®ionId=6773&adults=2&specialized_stays_group_explore=boutique_property&sort=RECOMMENDED&openPlayBack=true) ## Top South San Francisco Hotel Reviews ![Hotel Riu Plaza Fisherman's Wharf](//images.trvl-media.com/lodging/1000000/30000/24700/24625/6fb55356_y.jpg) ### Hotel Riu Plaza Fisherman's Wharf 10/10 Excellent "Nice breakfast, easy parking (freely go out and back)" [](https://expedia.ca/San-Francisco-Hotels-Hotel-Riu-Plaza-Fishermans-Wharf.h24625.Hotel-Information) ![Handlery Union Square Hotel](//images.trvl-media.com/lodging/1000000/10000/6700/6666/b8dfc462_y.jpg) ### Handlery Union Square Hotel 10/10 Excellent "Convenient location and Friendly staffs " [](https://expedia.ca/San-Francisco-Hotels-Handlery-Union-Square-Hotel.h6666.Hotel-Information) ![King George Hotel](//images.trvl-media.com/lodging/1000000/20000/14500/14451/42c7dbc6_y.jpg) ### King George Hotel 10/10 Excellent "Staff is always welcoming, and I enjoy the breakfast bar in the lobby." [](https://expedia.ca/San-Francisco-Hotels-King-George-Hotel.h14451.Hotel-Information) ![Travelodge by Wyndham San Francisco Airport North](//images.trvl-media.com/lodging/1000000/20000/17000/16955/864c4988_y.jpg) ### Travelodge by Wyndham San Francisco Airport North 10/10 Excellent "It was cool everybody minds there own business " [](https://expedia.ca/San-Francisco-Hotels-Travelodge-By-Wyndham-San-Francisco-Airport-North.h16955.Hotel-Information) ![Club Quarters Hotel in San Francisco](//images.trvl-media.com/lodging/1000000/920000/913000/912982/5ee1ba27_y.jpg) ### Club Quarters Hotel in San Francisco 10/10 Excellent "The hotel has reasonable prices at most times of the year. The rooms are clean and the beds are comfortable. It's quiet if you have an interior-facing room; if you have a room facing the street, it's quiet unless you open a window. There isn't much hotel staff in the lobby, but check-in is generally quick and easy. The Embaracadero parking garage are nearby that you can park at for $37 overnight if you want more peace of mind about your car's safety, but I parked on the street a block over and was fine. " [](https://expedia.ca/San-Francisco-Hotels-Club-Quarters-Hotel-In-San-Francisco.h912982.Hotel-Information) ![Chancellor Hotel on Union Square](//images.trvl-media.com/lodging/1000000/30000/20600/20547/944f985c_y.jpg) ### Chancellor Hotel on Union Square 10/10 Excellent "Without hesitation the front desk let us check in early. The hotel were great and very welcoming during our entire stay. Right down the street from union square it was close to everything and super convenient. Definitely staying here on our next trip! " [](https://expedia.ca/San-Francisco-Hotels-Chancellor-Hotel-On-Union-Square.h20547.Hotel-Information) ## Frequently asked questions ### What's there to see and do in South San Francisco? > The shopping, restaurants, and cafes are just some of the things to enjoy while you're in the area. While you're out and about in South San Francisco, popular attractions like Pier 39, San Francisco Bay, and Chase Center are worth a visit. You might also want to see spots like Oracle Park, Santa Cruz Mountains, and See's Candies during your trip. ### What kind of weather should I plan for when I travel to South San Francisco? > Having a good idea of the weather in South San Francisco is important when you plan your trip. The hottest months are usually September and August with an average temp of 62°F, while the coldest months are February and January with an average of 53°F. Average annual precipitation for South San Francisco is 23 inches. ### What's the best way to get to my boutique hotel in South San Francisco? > You have a few options for traveling to and around South San Francisco. The closest major airport is San Francisco Intl. Airport (SFO), which is located 2.9 mi (4.6 km) from the heart of the city, but Oakland Intl. Airport (OAK) may also be an option. Make your way to South San Francisco Metro Station for metro transit. 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[Hotels & Resorts for Couples in San Francisco](https://www.expedia.ca/San-Francisco-Hotels-Couples-Resorts-Hotels.0-0-d178305-tCouplesResortsHotels.Travel-Guide-Filter-Hotels) - [Green Hotels in San Francisco](https://www.expedia.ca/San-Francisco-Hotels-Green-Sustainable.0-0-d178305-tGreenSustainable.Travel-Guide-Filter-Hotels) - [Hotels with Wifi in San Francisco](https://www.expedia.ca/San-Francisco-Hotels-Hotel-With-Wifi.0-0-d178305-tHotelwithwifi.Travel-Guide-Filter-Hotels) - [Hotels with a Lazy River in San Francisco](https://www.expedia.ca/San-Francisco-Hotels-Hotels-With-A-Lazy-River.0-0-d178305-tHotelswithaLazyRiver.Travel-Guide-Filter-Hotels) - [Hotels with Childcare in San Francisco](https://www.expedia.ca/San-Francisco-Hotels-Hotels-With-Childcare.0-0-d178305-tHotelswithChildcare.Travel-Guide-Filter-Hotels) - [Hotels with Waterslides in San Francisco](https://www.expedia.ca/San-Francisco-Hotels-Hotels-With-Waterslides.0-0-d178305-tHotelswithWaterslides.Travel-Guide-Filter-Hotels) - [Lake Hotels in San Francisco](https://www.expedia.ca/San-Francisco-Hotels-Lake-Hotels.0-0-d178305-tLakeHotels.Travel-Guide-Filter-Hotels) - [Scuba Diving Hotels in San Francisco](https://www.expedia.ca/San-Francisco-Hotels-Scuba-Diving-Vacations.0-0-d178305-tscubadivingvacations.Travel-Guide-Filter-Hotels) - [Ski Hotels in San Francisco](https://www.expedia.ca/San-Francisco-Hotels-Ski-Hotel.0-0-d178305-tSkiHotel.Travel-Guide-Filter-Hotels) - [Waterpark Hotels in San Francisco](https://www.expedia.ca/San-Francisco-Hotels-Waterpark-Hotels.0-0-d178305-tWaterparkHotels.Travel-Guide-Filter-Hotels) - [Hotel Wedding Venues Hotels in San Francisco](https://www.expedia.ca/San-Francisco-Hotels-Wedding-Hotels.0-0-d178305-tWeddingHotels.Travel-Guide-Filter-Hotels) - [Hotels with Free Airport Shuttle in The East Side](https://www.expedia.ca/The-East-Side-San-Francisco-Hotels-Hotels-With-Free-Airport-Shuttle.0-n553248635976472836-0-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels) - [Hotels with Free Breakfast in The East Side](https://www.expedia.ca/The-East-Side-San-Francisco-Hotels-Hotels-With-Free-Breakfast.0-n553248635976472836-0-tHotelswithFreeBreakfast.Travel-Guide-Filter-Hotels) - [Romantic Hotels in The East Side](https://www.expedia.ca/The-East-Side-San-Francisco-Hotels-Romantic-Hotel.0-n553248635976472836-0-tRomanticHotel.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Treasure Island](https://www.expedia.ca/Treasure-Island-Hotels-Beach-Hotel.0-0-d506142-tBeachHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Treasure Island](https://www.expedia.ca/Treasure-Island-Hotels-Cheap-Hotels.0-0-d506142-tCheapHotels.Travel-Guide-Filter-Hotels) - [Hotels & Resorts for Couples in Treasure Island](https://www.expedia.ca/Treasure-Island-Hotels-Couples-Resorts-Hotels.0-0-d506142-tCouplesResortsHotels.Travel-Guide-Filter-Hotels) - [Family Hotels in Treasure Island](https://www.expedia.ca/Treasure-Island-Hotels-Family-Hotel.0-0-d506142-tFamilyHotel.Travel-Guide-Filter-Hotels) - [Historic Hotels in Treasure Island](https://www.expedia.ca/Treasure-Island-Hotels-Historic-Hotel.0-0-d506142-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Hotels with a Pool in Treasure Island](https://www.expedia.ca/Treasure-Island-Hotels-Hotel-With-Pool.0-0-d506142-tHotelwithPool.Travel-Guide-Filter-Hotels) - [Lgbt Friendly Hotels in Treasure Island](https://www.expedia.ca/Treasure-Island-Hotels-LGBT-Friendly-Hotel.0-0-d506142-tLGBTFriendlyHotel.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Treasure Island](https://www.expedia.ca/Treasure-Island-Hotels-Luxury-Hotel.0-0-d506142-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Treasure Island](https://www.expedia.ca/Treasure-Island-Hotels-Pet-Friendly-Hotel.0-0-d506142-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Ski Hotels in Treasure Island](https://www.expedia.ca/Treasure-Island-Hotels-Ski-Hotel.0-0-d506142-tSkiHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Treasure Island](https://www.expedia.ca/Treasure-Island-Hotels-Spa-Hotel.0-0-d506142-tSpaHotel.Travel-Guide-Filter-Hotels) - [Hotels with Childcare in Union Square](https://www.expedia.ca/Union-Square-San-Francisco-Hotels-Hotels-With-Childcare.0-n800129-0-tHotelswithChildcare.Travel-Guide-Filter-Hotels) - [Book Boutique Hotels in South San Francisco on Expedia.com](https://www.expedia.com/South-San-Francisco-Hotels-Boutique-Hotel.0-0-d6773-tBoutiqueHotel.Travel-Guide-Filter-Hotels)