Title: Book the Best BUSINESS Hotels in South San Diego in 2025 | Expedia.ca [South San Diego Travel Guide](https://expedia.ca/South-San-Diego.dx553248632063518562)[Hotels in South San Diego](https://expedia.ca/South-San-Diego-Hotels.d553248632063518562.Travel-Guide-Hotels)[Vacation Rentals in South San Diego](https://expedia.ca/South-San-Diego-Vacation-Rentals.d553248632063518562.Travel-Guide-VacationRentals)[Flights to South San Diego](https://expedia.ca/Cheap-Flights-To-South-San-Diego.d553248632063518562.Travel-Guide-Flights)[Things to do in South San Diego](https://expedia.ca/Things-To-Do-In-South-San-Diego.d553248632063518562.Travel-Guide-Activities)[South San Diego Car Rentals](https://expedia.ca/Car-Rentals-In-South-San-Diego.d553248632063518562.Car-Rental-Guide)[South San Diego Vacation Packages](https://expedia.ca/South-San-Diego.d553248632063518562.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/1577a5f9f9b33dbc18377fc367dd66b8.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in South San Diego, CA ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South San Diego Business Hotels Tonight [Sep 26 - Sep 27](https://www.expedia.ca/Hotel-Search?regionId=553248632063518562&startDate=2025-09-26&endDate=2025-09-27&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 27 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=553248632063518562&startDate=2025-09-27&endDate=2025-09-28&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Sep 26 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=553248632063518562&startDate=2025-09-26&endDate=2025-09-28&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=553248632063518562&startDate=2025-10-03&endDate=2025-10-05&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top South San Diego Business Hotels ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/60000/50100/50032/089f0b78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/60000/50100/50032/8aabd9fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/60000/50100/50032/cb94470d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/60000/50100/50032/8fd57751.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ayres Lodge Alpine Alpine 9.2/10 Wonderful (1021) "Our stay was great nice clean place staff are very friendly will definitely stay again " CA $141 CA $152 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Alpine-Hotels-Ayres-Lodge-Alpine.h50032.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/w3836h2556x3y3-467b2b48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/e9cd53ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/w3840h2558x0y3-98d4fb1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/720d452f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Imperial Beach San Diego Imperial Beach 9.4/10 Exceptional (898) "Really nice place to stay!" CA $195 CA $223 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Imperial-Beach-Hotels-Hampton-Inn-Suites-Imperial-Beach-San-Diego.h49284697.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/33000000/32400000/32393800/32393708/3ced364d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/33000000/32400000/32393800/32393708/ff230e8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/33000000/32400000/32393800/32393708/00abc97b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/33000000/32400000/32393800/32393708/3c739431.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ayres Hotel San Diego South - Chula Vista Otay Ranch 9.8/10 Exceptional (1098) "Very nice clean hotel " CA $173 CA $191 total includes taxes & fees Oct 14 - Oct 15 [](https://www.expedia.ca/Chula-Vista-Hotels-Ayres-Hotel-San-Diego-South-Chula-Vista.h32393708.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/36000000/35130000/35129800/35129712/171fb5f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/36000000/35130000/35129800/35129712/971b3017.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/36000000/35130000/35129800/35129712/25ef5399.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/36000000/35130000/35129800/35129712/e155a44a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Chula Vista Eastlake Chula Vista 9.2/10 Wonderful (924) "A good stay with family" CA $140 CA $154 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Chula-Vista-Hotels-Hampton-Inn-Chula-Vista-Eastlake.h35129712.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/102000000/101350000/101340300/101340269/c480e281.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/102000000/101350000/101340300/101340269/99d0930c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/102000000/101350000/101340300/101340269/7991b564.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/102000000/101350000/101340300/101340269/c176e30b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SpringHill Suites by Marriott Chula Vista Eastlake Chula Vista 9.6/10 Exceptional (455) "Nice hotel, nice pool, free breakfast, clean spacious rooms. " CA $191 CA $210 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Chula-Vista-Hotels-SpringHill-Suites-By-Marriott-Chula-Vista-Eastlake.h101340269.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/bfd1ccfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/83180011.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/84883664.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/b3ebadf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn by Wyndham San Diego Chula Vista Chula Vista 8.6/10 Excellent (1423) "Great stay. " CA $141 CA $155 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Chula-Vista-Hotels-La-Quinta-Inn-By-Wyndham-San-Diego-Chula-Vista.h22810.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/c2d82864.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/423e7241.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cafe](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/a3c5905c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/c2540b7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Loews Coronado Bay Resort Silver Strand 8.8/10 Excellent (1051) "Loved this stay, will be back! " CA $277 CA $371 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Coronado-Hotels-Loews-Coronado-Bay-Resort.h25840.Hotel-Information) ![Desk, blackout drapes, soundproofing, free WiFi](https://images.trvl-media.com/lodging/35000000/34910000/34909900/34909853/60b7030b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/35000000/34910000/34909900/34909853/1a9b4d28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, soundproofing, free WiFi](https://images.trvl-media.com/lodging/35000000/34910000/34909900/34909853/06274c72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/35000000/34910000/34909900/34909853/7aa1b6a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Valli Hi Motel San Ysidro 8.2/10 Very good (1013) "Great hotel " CA $107 CA $122 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/San-Ysidro-Hotels-Valli-Hi-Motel.h34909853.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/eda7e8ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Accessible, Non Smoking (Mobility, Transfer Shower)](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/1d234b24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/1779e3cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/c607b0c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG Otay Mesa 8.0/10 Very good (1476) "Very good to stayed " CA $159 CA $181 total includes taxes & fees Oct 2 - Oct 3 [](https://www.expedia.ca/San-Diego-Hotels-Holiday-Inn-Express-Hotel-Suites-San-Diego-Otay-Mesa.h1632358.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/36da2a73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 10:00 AM to 7:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/6211d6de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/2e7509ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/434ca240.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn Chula Vista San Diego South Chula Vista 8.2/10 Very good (1115) "Good Hotel" CA $141 CA $155 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Chula-Vista-Hotels-Comfort-Inn-Chula-Vista-San-Diego-South.h18870.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-10&endDate=2025-10-11®ionId=553248632063518562&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top South San Diego Hotel Reviews ![Bay Club Hotel & Marina](//images.trvl-media.com/lodging/1000000/10000/2600/2514/8c022c3d_y.jpg) ### Bay Club Hotel & Marina 10/10 Excellent "Great calm place" [](https://expedia.ca/San-Diego-Hotels-Bay-Club-Hotel-Marina.h2514.Hotel-Information) ![Wyndham San Diego Bayside](//images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Room was great! Tile in bathroom was dirty. Sink did not function, front desk was notified. Otherwise a great stay, I'll be back" [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Hotel del Coronado, Curio Collection by Hilton](//images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg) ### Hotel del Coronado, Curio Collection by Hilton 10/10 Excellent "Brilliant Atmosphere, all perfect." [](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![Handlery Hotel](//images.trvl-media.com/lodging/1000000/10000/8400/8374/ab6ccd55_y.jpg) ### Handlery Hotel 10/10 Excellent "The hotel was very nice, if a little dated, with a really nice pool area! It felt safe and I slept well here! The air conditioner was quiet which is a bonus in any hotel!" [](https://expedia.ca/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) ![Hard Rock Hotel San Diego](//images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Perfect stay" [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Best Western Plus Marina Gateway Hotel](//images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe_y.jpg) ### Best Western Plus Marina Gateway Hotel 10/10 Excellent "Great " [](https://expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) ![California Suites Hotel](//images.trvl-media.com/lodging/1000000/50000/40600/40531/4d1b251a_y.jpg) ### California Suites Hotel 10/10 Excellent "Location and friendly people " [](https://expedia.ca/San-Diego-Hotels-California-Suites-Hotel.h40531.Hotel-Information) ![Paradise Point Resort & Spa](//images.trvl-media.com/lodging/1000000/10000/3800/3731/bc1e5add_y.jpg) ### Paradise Point Resort & Spa 10/10 Excellent "perfect " [](https://expedia.ca/San-Diego-Hotels-Paradise-Point-Resort-Spa.h3731.Hotel-Information) ![The DEXTRO Little Italy, BW Premier Collection](//images.trvl-media.com/lodging/1000000/180000/170400/170338/84efd019_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "Rooms are clean. Nice staff" [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in South San Diego cost? > Business-friendly hotels in South San Diego range between and per night. This means you can reserve a stay with handy amenities like workspaces and WiFi at a price that fits your budget. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply. ### How many business-friendly hotels are there in South San Diego? > When you need to travel for work in South San Diego, you'll have business-friendly hotels to choose from. ### What are the best cheap business-friendly hotels in South San Diego? > When you need to make and close deals on the go in South San Diego, Expedia will help you find the perfect business-friendly hotel. [Hampton Inn Chula Vista Eastlake](https://www.expedia.ca/Chula-Vista-Hotels-Hampton-Inn-Chula-Vista-Eastlake.h35129712.Hotel-Information) is a favourite budget option in Chula Vista. A barbecue grill and a swimming pool are among its many amenities. Seeking wallet-friendly properties in Imperial Beach? [Holiday Inn Express San Diego South - Chula Vista, an IHG Hotel](https://www.expedia.ca/Chula-Vista-Hotels-Holiday-Inn-Express-San-Diego-South-Chula-Vista.h1664408.Hotel-Information) is preferred by many corporate travellers. It features conveniences that make it easy to both work and play, such as a barbecue grill and a swimming pool. Business-friendly hotels in South San Diego start at just a night. Combine business and leisure by visiting terrific free attractions on your work trip in South San Diego. [Coronado Beach](https://www.expedia.ca/Coronado-Beach-California.d6068513.Vacation-Attraction) in Chula Vista is one for your to-do list. If your travels are taking you to Imperial Beach, you won't have to pull out your wallet when visiting [Coronado Beach](https://www.expedia.ca/Coronado-Beach-California.d6068513.Vacation-Attraction). This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply. ### Are there any family-friendly hotels in South San Diego that are also business friendly? > You'll find some great family-friendly hotels that are also business friendly in South San Diego. If you're planning to stay in Chula Vista, make a booking at [Hampton Inn Chula Vista Eastlake](https://www.expedia.ca/Chula-Vista-Hotels-Hampton-Inn-Chula-Vista-Eastlake.h35129712.Hotel-Information). It comes with conveniences such as an outdoor entertainment area and laundry facilities and has a 2.5-stars rating. Another option worth considering is [The Guild Hotel, San Diego, A Tribute Portfolio Hotel by Marriott](https://www.expedia.ca/San-Diego-Hotels-The-Guild-Hotel.h1117726.Hotel-Information). This 4-stars stay in Chula Vista welcomes business and leisure travellers and features a nearby theme park, a nearby zoo and plenty more. When you've finished work, get out and see Chula Vista with the kids. Popular family-friendly attractions include [San Diego Zoo](https://www.expedia.ca/San-Diego-Zoo-San-Diego.d502547.Vacation-Attraction) and [Coronado Beach](https://www.expedia.ca/Coronado-Beach-California.d6068513.Vacation-Attraction). ### Are there any 5-star business-friendly hotels in South San Diego? > Enjoy luxury and comfort while you work at one of our 5-star business-friendly hotels in South San Diego. [Pendry San Diego](https://www.expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) in Chula Vista is a perfect choice. This 5-star retreat comes with a wide selection of amenities, including Egyptian-cotton sheets and room service. You can also experience the finer things at [THE US GRANT, a Luxury Collection Hotel, San Diego](https://www.expedia.ca/San-Diego-Hotels-THE-US-GRANT.h10802.Hotel-Information). Business-friendly conveniences, designer toiletries and concierge services help make this a superb base for corporate travellers in Chula Vista. ### Why book your business-friendly hotel in South San Diego with Expedia? > Expedia will help you find the ideal business-friendly hotel for your upcoming work trip. From meeting rooms and conference spaces to on-site restaurants and cafés, our properties have the things you'll need to close that big deal. ### How can I find cheap business-friendly hotels in South San Diego? > When work takes you on the road in South San Diego, our "business friendly" filter will help you find the perfect hotel. From dependable WiFi to computer stations and concierge services, they come with the amenities you need to do your job. You can also refine your search by your preferred star rating and budget to view the most affordable properties. ### What is there to do in South San Diego near my business-friendly hotel? > Whatever your interests, there are so many attractions and fun things to do in South San Diego. If you're bound for Chula Vista, drop by [Living Coast Discovery Centre](https://www.expedia.ca/Living-Coast-Discovery-Center-Chula-Vista.d6230025.Vacation-Attraction), [Living Coast Discovery Centre](https://www.expedia.ca/Living-Coast-Discovery-Center-Chula-Vista.d553248621532638599.Vacation-Attraction) and [Atlantis Laser Tag](https://www.expedia.ca/Atlantis-Laser-Tag-Chula-Vista.d553248621532638600.Vacation-Attraction). Organizing a stay in Imperial Beach? [Silver Strand State Beach](https://www.expedia.ca/Silver-Strand-State-Beach-Coronado.d6171344.Vacation-Attraction), [Border Field State Park Beach](https://www.expedia.ca/Border-Field-State-Park-Beach-Imperial-Beach.d628311616783351808.Vacation-Attraction) and [Border Field State Park](https://www.expedia.ca/Border-Field-State-Park-Tijuana-River-Valley.d553248621555611775.Vacation-Attraction) are popular attractions in this city. ## Explore a world of travel with Expedia - Lodging - More ways to book - [Beach Hotel Hotels in Camp Pendleton Marine Corps Base](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Beach-Hotel.0-0-d6068523-tBeachHotel.Travel-Guide-Filter-Hotels) - [Hotels with an Indoor Pool in Camp Pendleton Marine Corps Base](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Hotels-With-Indoor-Pool.0-0-d6068523-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels) - [Oceanfront Hotels in Camp Pendleton Marine Corps Base](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Oceanfront-Hotels.0-0-d6068523-tOceanfrontHotels.Travel-Guide-Filter-Hotels) - 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