Title: Hotels by Omni in South Main from CA $285 | Expedia.ca [South Main Travel Guide](https://expedia.ca/Houston-South-Main.dx553248635976386992)[Vacation Rentals in Houston](https://expedia.ca/Houston-Vacation-Rentals.d178265.Travel-Guide-VacationRentals)[Flights to Houston](https://expedia.ca/Cheap-Flights-To-Houston.d178265.Travel-Guide-Flights)[Things to do in Houston](https://expedia.ca/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities)[South Main Car Rentals](https://expedia.ca/Car-Rentals-In-South-Main.d553248635976386992.Car-Rental-Guide)[South Main Vacations](https://expedia.ca/South-Main.d553248635976386992.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/7fff8623dc31b090fdc6a6747a27a07c.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Hazem Abdul # Find Hotels by Omni in South Main from CA $285 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 13 - Oct 14](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-10-13&endDate=2025-10-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 14 - Oct 15](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-10-14&endDate=2025-10-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top South Main Omni Hotels ![Interior](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/37423ee4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/516b3f9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/79071c33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Nightclub](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/w6992h4673x0y8-ea923e10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omni Houston Hotel Greater Uptown 9.0/10 Wonderful (1014) "Really enjoyed my stay. " CA $240 CA $285 total includes taxes & fees Nov 8 - Nov 9 [](https://www.expedia.ca/Houston-Hotels-Omni-Houston-Hotel.h17746.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-27&endDate=2025-10-28®ionId=553248635976386992&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSouth-Main-Houston-Hotels-Omni.0-n553248635976386992-0--bOmni.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSouth-Main-Houston-Hotels-Omni.0-n553248635976386992-0--bOmni.Travel-Guide-Filter-Hotels) ## Top South Main Hotel Reviews ![SpringHill Suites by Marriott Houston Intercontinental Arprt](//images.trvl-media.com/lodging/3000000/2970000/2964300/2964240/69d373fc_y.jpg) ### SpringHill Suites by Marriott Houston Intercontinental Arprt 10/10 Excellent "None" [](https://expedia.ca/Houston-Hotels-SpringHill-Suites-By-Marriott-Houston-Intercontinental-Arprt.h2964240.Hotel-Information) ![Crowne Plaza Houston Med Ctr-Galleria Area by IHG](//images.trvl-media.com/lodging/1000000/30000/28100/28060/38218191_y.jpg) ### Crowne Plaza Houston Med Ctr-Galleria Area by IHG 10/10 Excellent "Breakfast was so so" [](https://expedia.ca/Houston-Hotels-Crowne-Plaza-Houston-River-Oaks.h28060.Hotel-Information) ![Marriott Marquis Houston](//images.trvl-media.com/lodging/15000000/14990000/14986100/14986044/4666f7f4_y.jpg) ### Marriott Marquis Houston 10/10 Excellent "We love this hotel! This is our fourth time staying at this hotel and every time we thoroughly enjoy it. The rooms are nice. The hotel is clean. The staff is super friendly and very helpful and the pool is great." [](https://expedia.ca/Houston-Hotels-Marriott-Marquis-Houston.h14986044.Hotel-Information) ![Hyatt Place Houston Downtown](//images.trvl-media.com/lodging/45000000/44400000/44399600/44399547/0c065c18_y.jpg) ### Hyatt Place Houston Downtown 10/10 Excellent "The staff were amazing, the building was c" [](https://expedia.ca/Houston-Hotels-Hyatt-Place-Houston-Downtown.h44399547.Hotel-Information) ![The Whitehall Houston](//images.trvl-media.com/lodging/1000000/700000/693700/693655/f1d85056_y.jpg) ### The Whitehall Houston 10/10 Excellent "Only part I have something to say about is the valet workers they were rude " [](https://expedia.ca/Houston-Hotels-The-Whitehall-Houston.h693655.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Houston Bush IAH South](//images.trvl-media.com/lodging/1000000/170000/165600/165562/0afb5a51_y.jpg) ### La Quinta Inn & Suites by Wyndham Houston Bush IAH South 10/10 Excellent "The room was clean, and the staff was friendly." [](https://expedia.ca/Houston-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Houston-Bush-IAH-South.h165562.Hotel-Information) ![DoubleTree by Hilton Hotel Houston - Greenway Plaza](//images.trvl-media.com/lodging/1000000/30000/20200/20177/682ca680_y.jpg) ### DoubleTree by Hilton Hotel Houston - Greenway Plaza 10/10 Excellent "Every staff member was friendly and helpful, answering any and all our questions. We had a pleasant room that was quiet. " [](https://expedia.ca/Houston-Hotels-DoubleTree-By-Hilton-Hotel-Houston-Greenway-Plaza.h20177.Hotel-Information) ![Club Quarters Hotel Downtown, Houston](//images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/44a9a3fd_y.jpg) ### Club Quarters Hotel Downtown, Houston 10/10 Excellent "Loved my stay 5 stars" [](https://expedia.ca/Houston-Hotels-Club-Quarters-Hotel-In-Houston.h1156923.Hotel-Information) ![Hilton Americas-Houston](//images.trvl-media.com/lodging/1000000/980000/976200/976144/09dd0b59_y.jpg) ### Hilton Americas-Houston 10/10 Excellent "Clean room, friendly staff, walkable to GRB, Discovery Green and Toyota Center " [](https://expedia.ca/Houston-Hotels-Hilton-Americas-Houston.h976144.Hotel-Information) ## Find out more about South Main ## South Main Hotels Guide Expedia.ca offers a selection of 6562 hotels in South Main. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in South Main. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the South Main neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in South Main, Houston now! ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [Casino Hotels in Astrodome](https://www.expedia.ca/Astrodome-Houston-Hotels-Casino-Hotel.0-n553248635976007975-0-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Astrodome](https://www.expedia.ca/Astrodome-Houston-Hotels-Cheap-Hotels.0-n553248635976007975-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Astrodome](https://www.expedia.ca/Astrodome-Houston-Hotels-Luxury-Hotel.0-n553248635976007975-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Astrodome](https://www.expedia.ca/Astrodome-Houston-Hotels-Spa-Hotel.0-n553248635976007975-0-tSpaHotel.Travel-Guide-Filter-Hotels) - [Astrodome Hotels](https://www.expedia.ca/Astrodome-Houston-Hotels.0-n553248635976007975-0.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Braeswood Place](https://www.expedia.ca/Braeswood-Place-Houston-Hotels-Cheap-Hotels.0-n553248635976387047-0-tCheapHotels.Travel-Guide-Filter-Hotels) - 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[Hertz Rental Cars in Southwest Houston](https://www.expedia.ca/Hertz-Car-Rentals-In-Southwest-Houston.d6189441-c40.Car-Rental-Guide-Suppliers) - [Localiza Rental Cars in Southwest Houston](https://www.expedia.ca/Localiza-Car-Rentals-In-Southwest-Houston.d6189441-c1063.Car-Rental-Guide-Suppliers) - [Locauto Rental Cars in Southwest Houston](https://www.expedia.ca/Locauto-Car-Rentals-In-Southwest-Houston.d6189441-c1140.Car-Rental-Guide-Suppliers) - [Book Hotels in South Main on Expedia.com](https://www.expedia.com/South-Main-Houston-Hotels-Omni.0-n553248635976386992-0--bOmni.Travel-Guide-Filter-Hotels)