Title: Hotels by Independent in South Main from CA $85 | Expedia.ca [South Main Travel Guide](https://expedia.ca/Houston-South-Main.dx553248635976386992)[Vacation Rentals in Houston](https://expedia.ca/Houston-Vacation-Rentals.d178265.Travel-Guide-VacationRentals)[Flights to Houston](https://expedia.ca/Cheap-Flights-To-Houston.d178265.Travel-Guide-Flights)[Things to do in Houston](https://expedia.ca/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities)[South Main Car Rentals](https://expedia.ca/Car-Rentals-In-South-Main.d553248635976386992.Car-Rental-Guide)[South Main Vacations](https://expedia.ca/South-Main.d553248635976386992.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/7fff8623dc31b090fdc6a6747a27a07c.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Hazem Abdul # Find Hotels by Independent in South Main from CA $85 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 19 - Oct 20](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-10-19&endDate=2025-10-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 20 - Oct 21](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-10-20&endDate=2025-10-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top South Main Independent Hotels ![1 bedroom, premium bedding, pillowtop beds, minibar](https://images.trvl-media.com/lodging/1000000/10000/3400/3306/47c5ade4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, pillowtop beds, minibar](https://images.trvl-media.com/lodging/1000000/10000/3400/3306/53ee2707.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hydromassage showerhead, designer toiletries, hair dryer, bathrobes](https://images.trvl-media.com/lodging/1000000/10000/3400/3306/4c4b17d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, pillowtop beds, minibar](https://images.trvl-media.com/lodging/1000000/10000/3400/3306/0f950f88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Zaza Houston Museum District South Central Houston 9.0/10 Wonderful (1800) "Best place I have stayed in decades." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Preston CA $380 CA $505 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/Houston-Hotels-Hotel-Zaza-Houston-Museum-District.h3306.Hotel-Information) ![City view from property](https://images.trvl-media.com/lodging/1000000/700000/693700/693655/f1d85056.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/700000/693700/693655/ebaa4874.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cocktail bar](https://images.trvl-media.com/lodging/1000000/700000/693700/693655/0c8e0486.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/700000/693700/693655/31209257.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Whitehall Houston Downtown Houston 8.6/10 Excellent (1813) "Great staff nice rooms" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Matthew CA $200 CA $235 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Houston-Hotels-The-Whitehall-Houston.h693655.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2310000/2302900/2302841/e3524014.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop bar, garden views, open daily](https://images.trvl-media.com/lodging/3000000/2310000/2302900/2302841/w6106h4075x5y0-36a0348c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, pillowtop beds, minibar](https://images.trvl-media.com/lodging/3000000/2310000/2302900/2302841/15b65951.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/3000000/2310000/2302900/2302841/1f1ee4a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Moran CITYCENTRE Memorial 9.0/10 Wonderful (1017) "Great place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anthony CA $224 CA $303 total includes taxes & fees Nov 1 - Nov 2 [](https://www.expedia.ca/Houston-Hotels-The-Moran-CITYCENTRE.h2302841.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/2000000/1060000/1050300/1050240/8e6fcf6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/2000000/1060000/1050300/1050240/99b0388b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1060000/1050300/1050240/2da54771.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/2000000/1060000/1050300/1050240/1409f299.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Ylem Braeswood Place 8.4/10 Very good (2380) "Friendly place, great location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shelia CA $87 CA $109 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Houston-Hotels-Hotel-Ylem.h1050240.Hotel-Information) ![Sauna](https://images.trvl-media.com/lodging/20000000/19640000/19635300/19635222/e3d02312.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Ballroom](https://images.trvl-media.com/lodging/20000000/19640000/19635300/19635222/38df7384.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature Suite](https://images.trvl-media.com/lodging/20000000/19640000/19635300/19635222/ff3c32dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/20000000/19640000/19635300/19635222/9dd55fb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel ZaZa Houston Memorial City Memorial 9.4/10 Exceptional (1000) "Wonderful place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gervase CA $334 CA $450 total includes taxes & fees Oct 23 - Oct 24 [](https://www.expedia.ca/Houston-Hotels-Hotel-ZaZa-Houston-Memorial-City.h19635222.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/6300/6298/90f3bec7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast area](https://images.trvl-media.com/lodging/1000000/10000/6300/6298/0c1ec1a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 7:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/6300/6298/897c7071.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/10000/6300/6298/9b1acb52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Heritage Place Houston Brookhollow Lazybrook/Timbergrove 8.4/10 Very good (466) "Staff was exceptional, great place to lay your head, hidden gem!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alana CA $94 CA $111 total includes taxes & fees Oct 28 - Oct 29 [](https://www.expedia.ca/Houston-Hotels-Heritage-Place-Houston-Brookhollow.h6298.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/c40a6103.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, free minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/a617bbb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/dd9a3669.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite (Composer) | Dining room](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/f9f8ae11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Lancaster Hotel Downtown Houston 9.8/10 Exceptional (1011) "Great place... lots of nice people and nice rooms." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kenneth CA $278 CA $325 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Houston-Hotels-The-Lancaster-Hotel.h13295.Hotel-Information) ![Couples treatment rooms, hot tub, steam room, body treatments](https://images.trvl-media.com/lodging/1000000/30000/22100/22016/9913c8c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22100/22016/6c751cf0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/30000/22100/22016/6f98ef84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor banquet area](https://images.trvl-media.com/lodging/1000000/30000/22100/22016/f0e0846f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Houstonian Hotel, Club & Spa Greater Uptown 9.4/10 Exceptional (1005) "Great property, great staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $502 CA $592 total includes taxes & fees Nov 15 - Nov 16 [](https://www.expedia.ca/Houston-Hotels-The-Houstonian-Hotel.h22016.Hotel-Information) ![Exclusive Room, Multiple Beds, Non Smoking](https://images.trvl-media.com/lodging/2000000/1250000/1240800/1240788/dcc5346d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1250000/1240800/1240788/557d86e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/2000000/1250000/1240800/1240788/6c2cf751.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1250000/1240800/1240788/w800h584x0y0-b8e2ff5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Platinum Inn & Suites Webster Webster 7.8/10 Good (1020) "Clean room easy check in and nice staff,and they a bunch of restaurant in the area " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Raynand CA $72 CA $85 total includes taxes & fees Oct 28 - Oct 29 [](https://www.expedia.ca/Houston-Hotels-Platinum-Inn-Suites-Webster.h1240788.Hotel-Information) ![Premium bedding, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/19000000/18130000/18122200/18122141/e02c73c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/19000000/18130000/18122200/18122141/be7d736f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/19000000/18130000/18122200/18122141/18c0750c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/19000000/18130000/18122200/18122141/a514112d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Haven Inn & Suites Downtown Houston Northside 9.4/10 Exceptional (1021) "Very clean and safe, would stay again" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Krimson CA $91 CA $106 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/Houston-Hotels-Haven-Inn-Suites-Downtown-Houston.h18122141.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-02&endDate=2025-11-03®ionId=553248635976386992&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSouth-Main-Houston-Hotels-Independent.0-n553248635976386992-0--bIndependent.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSouth-Main-Houston-Hotels-Independent.0-n553248635976386992-0--bIndependent.Travel-Guide-Filter-Hotels) ## Top South Main Hotel Reviews ![Club Quarters Hotel Downtown, Houston](//images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/44a9a3fd_y.jpg) ### Club Quarters Hotel Downtown, Houston 10/10 Excellent "Stay was great, check in was very easy and it was in a great location " [](https://expedia.ca/Houston-Hotels-Club-Quarters-Hotel-In-Houston.h1156923.Hotel-Information) ![Crowne Plaza Houston Med Ctr-Galleria Area by IHG](//images.trvl-media.com/lodging/1000000/30000/28100/28060/38218191_y.jpg) ### Crowne Plaza Houston Med Ctr-Galleria Area by IHG 10/10 Excellent "I didn’t eat breakfast." [](https://expedia.ca/Houston-Hotels-Crowne-Plaza-Houston-River-Oaks.h28060.Hotel-Information) ![Hilton Houston Plaza/Medical Center](//images.trvl-media.com/lodging/1000000/30000/25200/25188/294f3d50_y.jpg) ### Hilton Houston Plaza/Medical Center 10/10 Excellent "This hotel was comfortable and reasonably priced for the area. I’d stay here again. " [](https://expedia.ca/Houston-Hotels-Hilton-Houston-Plaza-Medical-Center.h25188.Hotel-Information) ![Magnolia Hotel Houston, A Tribute Portfolio Hotel](//images.trvl-media.com/lodging/1000000/910000/907500/907459/0b2adb37_y.jpg) ### Magnolia Hotel Houston, A Tribute Portfolio Hotel 10/10 Excellent "We had a perfect time for our parents weekend visiting our son at college! " [](https://expedia.ca/Houston-Hotels-Magnolia-Hotel-Houston.h907459.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Houston Bush IAH South](//images.trvl-media.com/lodging/1000000/170000/165600/165562/0afb5a51_y.jpg) ### La Quinta Inn & Suites by Wyndham Houston Bush IAH South 10/10 Excellent "i tried numerous times to arrange a shuttle from IAH to the hotel... but no one ever answered the front desk number that was provided. In frustration i booked a cab. As i checked in i made sure that i would be on the 8am shuttle rhe following morning. The following morning i went to wait for the airport shuttle and was told my name wasn't on the list. Thankfully an uber was available to take me to mt flight. Not happy!!" [](https://expedia.ca/Houston-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Houston-Bush-IAH-South.h165562.Hotel-Information) ![Hotel Zaza Houston Museum District](//images.trvl-media.com/lodging/1000000/10000/3400/3306/47c5ade4_y.jpg) ### Hotel Zaza Houston Museum District 10/10 Excellent "Nice room- thought it would be fancier. The bathrooms were really nice! When we got back from out event there was a charcuterie board waiting for us. Loved that suprise!!" [](https://expedia.ca/Houston-Hotels-Hotel-Zaza-Houston-Museum-District.h3306.Hotel-Information) ![DoubleTree by Hilton Hotel Houston - Greenway Plaza](//images.trvl-media.com/lodging/1000000/30000/20200/20177/682ca680_y.jpg) ### DoubleTree by Hilton Hotel Houston - Greenway Plaza 10/10 Excellent "VERY GOOD PLACE TO STAY." [](https://expedia.ca/Houston-Hotels-DoubleTree-By-Hilton-Hotel-Houston-Greenway-Plaza.h20177.Hotel-Information) ![DoubleTree by Hilton Hotel & Suites Houston by the Galleria](//images.trvl-media.com/lodging/1000000/30000/20200/20116/555244ce_y.jpg) ### DoubleTree by Hilton Hotel & Suites Houston by the Galleria 10/10 Excellent "Nice stay" [](https://expedia.ca/Houston-Hotels-DoubleTree-By-Hilton-Hotel-Suites-Houston-By-The-Galleria.h20116.Hotel-Information) ![The Whitehall Houston](//images.trvl-media.com/lodging/1000000/700000/693700/693655/f1d85056_y.jpg) ### The Whitehall Houston 10/10 Excellent "Good" [](https://expedia.ca/Houston-Hotels-The-Whitehall-Houston.h693655.Hotel-Information) ## Find out more about South Main ## South Main Hotels Guide Expedia.ca offers a selection of 6554 hotels in South Main. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in South Main. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the South Main neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in South Main, Houston now! ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [Casino Hotels in Astrodome](https://www.expedia.ca/Astrodome-Houston-Hotels-Casino-Hotel.0-n553248635976007975-0-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Astrodome](https://www.expedia.ca/Astrodome-Houston-Hotels-Cheap-Hotels.0-n553248635976007975-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Astrodome](https://www.expedia.ca/Astrodome-Houston-Hotels-Luxury-Hotel.0-n553248635976007975-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Astrodome](https://www.expedia.ca/Astrodome-Houston-Hotels-Spa-Hotel.0-n553248635976007975-0-tSpaHotel.Travel-Guide-Filter-Hotels) - [Astrodome Hotels](https://www.expedia.ca/Astrodome-Houston-Hotels.0-n553248635976007975-0.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Braeswood Place](https://www.expedia.ca/Braeswood-Place-Houston-Hotels-Cheap-Hotels.0-n553248635976387047-0-tCheapHotels.Travel-Guide-Filter-Hotels) - 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[La Quinta Inn & Suites Hotels in Houston](https://www.expedia.ca/Houston-Hotels-La-Quinta-Inn-Suites.0-0-d178265--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts in Houston](https://www.expedia.ca/Houston-Hotels-Marriott-Hotels-Resorts.0-0-d178265--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Prince Hotels in Houston](https://www.expedia.ca/Houston-Hotels-Prince-Hotels.0-0-d178265--bPrinceHotels.Travel-Guide-Filter-Hotels) - [Red Lion Hotels in Houston](https://www.expedia.ca/Houston-Hotels-Red-Lion.0-0-d178265--bRedLion.Travel-Guide-Filter-Hotels) - [Scottish Inn Hotels in Houston](https://www.expedia.ca/Houston-Hotels-Scottish-Inn.0-0-d178265--bScottishInn.Travel-Guide-Filter-Hotels) - [Houston Hotels](https://www.expedia.ca/Houston-Hotels.d178265.Travel-Guide-Hotels) - [Hotels near Houston Methodist Hospital](https://www.expedia.ca/Houston-Methodist-Hospital-Hotels.0-l553248635389802729-0.Travel-Guide-Filter-Hotels) - [Hotels near MD Anderson Cancer Center](https://www.expedia.ca/MD-Anderson-Cancer-Center-Hotels.0-l6248539-0.Travel-Guide-Filter-Hotels) - 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[Southside Place Hotels](https://www.expedia.ca/Southside-Place-Houston-Hotels.0-n160529-0.Travel-Guide-Filter-Hotels) - [Apartments in Southwest Houston](https://www.expedia.ca/Southwest-Houston-Apartments.d6189441-aaApartments.Travel-Guide-Accommodation) - [Beach Hotel Hotels in Southwest Houston](https://www.expedia.ca/Southwest-Houston-Hotels-Beach-Hotel.0-0-d6189441-tBeachHotel.Travel-Guide-Filter-Hotels) - [Casino Hotels in Southwest Houston](https://www.expedia.ca/Southwest-Houston-Hotels-Casino-Hotel.0-0-d6189441-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Hilton Hotels in Southwest Houston](https://www.expedia.ca/Southwest-Houston-Hotels-Hilton-Hotels.0-0-d6189441--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Southwest Houston Hotels](https://www.expedia.ca/Southwest-Houston-Hotels.d6189441.Travel-Guide-Hotels) - [Aparthotels in Stadium Park/Astrodome Station](https://www.expedia.ca/Stadium-ParkAstrodome-Station-Apart-Hotels.d6211680-aaApartHotels.Travel-Guide-Accommodation) - 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[Visit Astrodome](https://www.expedia.ca/Houston-Astrodome.dx553248635976007975) - [Visit Southside Place](https://www.expedia.ca/Houston-Southside-Place.dx160529) - [Visit Texas Medical Center](https://www.expedia.ca/Houston-Texas-Medical-Center.dx6143504) - [Md Anderson Cancer Center](https://www.expedia.ca/MD-Anderson-Cancer-Center-Texas-Medical-Center.d6248539.Vacation-Attraction) - [Nrg Stadium](https://www.expedia.ca/NRG-Stadium-Astrodome.d553248635929331916.Vacation-Attraction) - [Alamo Rent A Car Rental Cars in Southwest Houston](https://www.expedia.ca/Alamo-Rent-A-Car-Car-Rentals-In-Southwest-Houston.d6189441-c6.Car-Rental-Guide-Suppliers) - [Global Rent a Car Rental Cars in Southwest Houston](https://www.expedia.ca/Global-Rent-A-Car-Car-Rentals-In-Southwest-Houston.d6189441-c1062.Car-Rental-Guide-Suppliers) - [Goldcar Key’n Go Rental Cars in Southwest Houston](https://www.expedia.ca/Goldcar-Keyn-Go-Car-Rentals-In-Southwest-Houston.d6189441-c1044.Car-Rental-Guide-Suppliers) - [Hertz Rental Cars in Southwest Houston](https://www.expedia.ca/Hertz-Car-Rentals-In-Southwest-Houston.d6189441-c40.Car-Rental-Guide-Suppliers) - [Localiza Rental Cars in Southwest Houston](https://www.expedia.ca/Localiza-Car-Rentals-In-Southwest-Houston.d6189441-c1063.Car-Rental-Guide-Suppliers) - [Locauto Rental Cars in Southwest Houston](https://www.expedia.ca/Locauto-Car-Rentals-In-Southwest-Houston.d6189441-c1140.Car-Rental-Guide-Suppliers) - [Book Hotels in South Main on Expedia.com](https://www.expedia.com/South-Main-Houston-Hotels-Independent.0-n553248635976386992-0--bIndependent.Travel-Guide-Filter-Hotels)