Title: Book the Best South End LUXURY Hotels - Upscale Hotels in South End, Portsmouth | Expedia.ca [South End Travel Guide](https://expedia.ca/Portsmouth-South-End.dx905208930211381248)[Vacation Rentals in Portsmouth](https://expedia.ca/Portsmouth-Vacation-Rentals.d6057414.Travel-Guide-VacationRentals)[Flights to Portsmouth](https://expedia.ca/Cheap-Flights-To-Portsmouth.d6057414.Travel-Guide-Flights)[Things to do in Portsmouth](https://expedia.ca/Things-To-Do-In-Portsmouth.d6057414.Travel-Guide-Activities)[South End Car Rentals](https://expedia.ca/Car-Rentals-In-South-End.d905208930211381248.Car-Rental-Guide)[South End Vacations](https://expedia.ca/South-End.d905208930211381248.Destination-Travel-Guides) ![South end waterfront skyline with white cloud sky](https://images.trvl-media.com/place/905208930211381248/c2b3b12b-64df-4e41-b9d5-dc8ded8a994c.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Luxury Hotels in South End, Portsmouth - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South End Luxury Hotels Tonight [Nov 23 - Nov 24](https://www.expedia.ca/Hotel-Search?regionId=905208930211381248&startDate=2025-11-23&endDate=2025-11-24&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Nov 24 - Nov 25](https://www.expedia.ca/Hotel-Search?regionId=905208930211381248&startDate=2025-11-24&endDate=2025-11-25&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Nov 28 - Nov 30](https://www.expedia.ca/Hotel-Search?regionId=905208930211381248&startDate=2025-11-28&endDate=2025-11-30&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) In two weeks [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=905208930211381248&startDate=2025-12-05&endDate=2025-12-07&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top South End Luxury Hotels ## Top South End Hotel Reviews ![Howard Johnson by Wyndham Portsmouth](https://images.trvl-media.com/lodging/1000000/520000/517500/517424/e05bdc89_y.jpg) ### Howard Johnson by Wyndham Portsmouth 10/10 Excellent "Nice and reasonable prices" [](https://expedia.ca/Portsmouth-Hotels-Howard-Johnson-By-Wyndham-Portsmouth.h517424.Hotel-Information) ![Hampton Inn & Suites Portsmouth Downtown](https://images.trvl-media.com/lodging/9000000/8270000/8268900/8268861/b0df55fb_y.jpg) ### Hampton Inn & Suites Portsmouth Downtown 10/10 Excellent "Room was huge and super clean. Very quiet as well. Check in and out was super quick and efficient! " [](https://expedia.ca/Portsmouth-Hotels-Hampton-Inn-Suites-Portsmouth-Downtown.h8268861.Hotel-Information) ![Cliff House Maine](https://images.trvl-media.com/lodging/4000000/3990000/3981200/3981160/eb122fc0_y.jpg) ### Cliff House Maine 10/10 Excellent "What an amazing experience! Definitely heading back there" [](https://expedia.ca/Cape-Neddick-Hotels-Cliff-House-Maine.h3981160.Hotel-Information) ![Hilton Garden Inn Portsmouth Downtown](https://images.trvl-media.com/lodging/2000000/1470000/1464400/1464340/7de77d01_y.jpg) ### Hilton Garden Inn Portsmouth Downtown 10/10 Excellent "Wonderfully friendly staff. Clean rooms, beautiful lobby and PERFECT location!" [](https://expedia.ca/Portsmouth-Hotels-Hilton-Garden-Inn-Portsmouth-Downtown.h1464340.Hotel-Information) ![Sheraton Portsmouth Harborside Hotel](https://images.trvl-media.com/lodging/1000000/10000/6000/5911/92cc7e79_y.jpg) ### Sheraton Portsmouth Harborside Hotel 10/10 Excellent "Spotless and new room. Staff was super nice!" [](https://expedia.ca/Portsmouth-Hotels-Sheraton-Portsmouth-Harborside-Hotel.h5911.Hotel-Information) ![Quality Inn](https://images.trvl-media.com/lodging/1000000/10000/1600/1553/3ef38fa1_y.jpg) ### Quality Inn 10/10 Excellent "We were very happy with this hotel. The room was clean, the bed was comfortable and the hotel was quiet. Breakfast was excellent, better than average. " [](https://expedia.ca/Portsmouth-Hotels-Quality-Inn.h1553.Hotel-Information) ## Frequently asked questions ### Are you searching for a great accommodation for your luxury holiday in South End? > Let Expedia help you arrange your flight to Portsmouth, NH (PSM-Portsmouth Intl.) airport or Sanford, ME (SFM-Sanford Seacoast Regional) airport, and then choose from some places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to find what you want to make your stay special. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can help you find the best luxury hotel experience that South End offers. South End has some interesting things to see and do including Wentworth Gardner and Tobias Lear Houses and Children's Museum of Portsmouth, so you might want to take in the local sights during your visit. ### What's there to see and do in South End? > Experience South End and visit Wentworth Gardner and Tobias Lear Houses, Strawbery Banke Museum, and Market Square. If you have a little extra time during your trip, you might want to check out Seacoast Repertory Theatre and The Music Hall. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Other - More ways to book - [4 Star Hotels in Portsmouth](https://www.expedia.ca/4Star-Portsmouth-Hotels.s40-0-d6057414.Travel-Guide-Filter-Hotels) - [Adults Only Resorts & in New Hampshire](https://www.expedia.ca/Destinations-In-New-Hampshire-Adults-Only-Resorts.0-0-d231-tAdultsOnlyResorts.Hotel-Filter-Destinations) - [Green Hotels in New Hampshire](https://www.expedia.ca/Destinations-In-New-Hampshire-Green-Sustainable.0-0-d231-tGreenSustainable.Hotel-Filter-Destinations) - [Hotels with Early Check-in in New Hampshire](https://www.expedia.ca/Destinations-In-New-Hampshire-Hotel-With-Early-Check-In.0-0-d231-thotelwithearlycheckin.Hotel-Filter-Destinations) - [Hotels with a Pool in New Hampshire](https://www.expedia.ca/Destinations-In-New-Hampshire-Hotel-With-Pool.0-0-d231-tHotelwithPool.Hotel-Filter-Destinations) - 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