Title: Book the Best South Carolina Midlands LUXURY Hotels - Upscale Hotels in South Carolina Midlands, SC | Expedia.ca [South Carolina Midlands Travel Guide](https://expedia.ca/South-Carolina-Midlands.dx6057938)[Hotels in South Carolina Midlands](https://expedia.ca/South-Carolina-Midlands-Hotels.d6057938.Travel-Guide-Hotels)[Vacation Rentals in South Carolina Midlands](https://expedia.ca/South-Carolina-Midlands-Vacation-Rentals.d6057938.Travel-Guide-VacationRentals)[Flights to South Carolina Midlands](https://expedia.ca/Cheap-Flights-To-South-Carolina-Midlands.d6057938.Travel-Guide-Flights)[Things to do in South Carolina Midlands](https://expedia.ca/Things-To-Do-In-South-Carolina-Midlands.d6057938.Travel-Guide-Activities)[South Carolina Midlands Car Rentals](https://expedia.ca/Car-Rentals-In-South-Carolina-Midlands.d6057938.Car-Rental-Guide)[South Carolina Midlands Vacation Packages](https://expedia.ca/South-Carolina-Midlands.d6057938.Destination-Travel-Guides) ![South Carolina State House](https://images.trvl-media.com/place/6082681/71cf3b5c-9d86-43bb-9d0c-9410d9116af7.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in South Carolina Midlands, SC - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South Carolina Midlands Luxury Hotels Tonight [Dec 3 - Dec 4](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-12-03&endDate=2025-12-04&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Dec 4 - Dec 5](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-12-04&endDate=2025-12-05&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-12-05&endDate=2025-12-07&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-12-12&endDate=2025-12-14&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top South Carolina Midlands Luxury Hotels ![View from property](https://images.trvl-media.com/lodging/1000000/800000/798500/798446/317b0952.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, lobby lounge](https://images.trvl-media.com/lodging/1000000/800000/798500/798446/a2869f0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, lobby lounge](https://images.trvl-media.com/lodging/1000000/800000/798500/798446/24906fad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 indoor pools, seasonal outdoor pool, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/800000/798500/798446/96f40d74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Ballantyne, A Luxury Collection Hotel, Charlotte Ballantyne 9.4/10 Exceptional (1003) "This hotel is always amazing I find it so welcoming and relaxing. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $391 CA $450 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/Charlotte-Hotels-The-Ballantyne.h798446.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/1000000/30000/20100/20030/f4cdc91c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20100/20030/64598b80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/30000/20100/20030/6b0c9b69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/30000/20100/20030/4c3cb9cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Willcox Aiken 9.6/10 Exceptional (142) "Wonderful stay all around." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anastasija CA $400 CA $448 total includes taxes & fees Dec 17 - Dec 18 [](https://www.expedia.ca/Aiken-Hotels-The-Willcox.h20030.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/16000000/15720000/15719100/15719033/39339da9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/16000000/15720000/15719100/15719033/acb68e54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Queen Suite | Private kitchen](https://images.trvl-media.com/lodging/16000000/15720000/15719100/15719033/83bdb053.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/16000000/15720000/15719100/15719033/5a87853c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Mantissa Hotel Hartsville 9.2/10 Wonderful (269) "Very nice spacious rooms friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Duane CA $208 CA $234 total includes taxes & fees Dec 11 - Dec 12 [](https://www.expedia.ca/Florence-Hotels-The-Mantissa-Hotel.h15719033.Hotel-Information) ![Breakfast area](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/bfdc100f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Smoking](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/77c6db86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/c4ff1065.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/5f1ffd39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelodge by Wyndham Orangeburg Orangeburg 8.2/10 Very good (1000) "Enjoyed our stay " ![Australia](https://a.travel-assets.com/egds/marks/flags/au.svg) Marie CA $94 CA $104 total includes taxes & fees Dec 4 - Dec 5 [](https://www.expedia.ca/Orangeburg-Hotels-Travelodge-By-Wyndham-Orangeburg.h17380261.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/11000000/10940000/10931100/10931075/fed76e51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/11000000/10940000/10931100/10931075/7dcea9ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, individually decorated, individually furnished, desk](https://images.trvl-media.com/lodging/11000000/10940000/10931100/10931075/d579010a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City view from property](https://images.trvl-media.com/lodging/11000000/10940000/10931100/10931075/4f102d5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Carriage House Inn Aiken 9.4/10 Exceptional (460) "Friendly and helpful staff that truly make you feel like a priority. Beautiful historic/boutique hotel in the heart of downtown Aiken. 10/10 will stay here again! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Evan CA $278 CA $311 total includes taxes & fees Dec 4 - Dec 5 [](https://www.expedia.ca/Aiken-Hotels-Carriage-House-Inn.h10931075.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/160000/151400/151368/e887cc1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/160000/151400/151368/d5754d94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/160000/151400/151368/706048fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/160000/151400/151368/5d33828f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area Rock Hill 7.0/10 Good (1000) "Quiet and affordable " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tyler CA $80 CA $89 total includes taxes & fees Dec 7 - Dec 8 [](https://www.expedia.ca/Rock-Hill-Hotels-Microtel-Inn-Suites-By-Wyndham-Rock-HillCharlotte-Area.h151368.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/42f27498.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/02445a7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/a1af3ca9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/c321176c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn on the Square, an Ascend Collection Hotel Uptown Greenwood 9.2/10 Wonderful (707) "It was a very clean and beautiful lace to stay. We were there for our honeymoon " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tracy CA $172 CA $191 total includes taxes & fees Jan 2 - Jan 3, 2026 [](https://www.expedia.ca/Greenwood-Hotels-Inn-On-The-Square.h1212931.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/ba61cb6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/f767549c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/24bdaf71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/5e830f88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton Columbia Downtown Hotel Downtown Columbia 8.4/10 Very good (1001) "Clean rooms and hospitable staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James CA $144 CA $161 total includes taxes & fees Dec 29 - Dec 30 [](https://www.expedia.ca/Columbia-Hotels-Sheraton-Columbia-Downtown-Hotel.h1805074.Hotel-Information) ![Seasonal outdoor pool, open 10 AM to 9:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/50000/43600/43558/107411e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/50000/43600/43558/9b60048e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/43600/43558/1f2d2d2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/43600/43558/d2dce3b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Greenwood Greenwood 7.6/10 Good (764) "Was perfect for one stay, and located close to my Buinness meeting " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Raymond C CA $98 CA $109 total includes taxes & fees Dec 25 - Dec 26 [](https://www.expedia.ca/Greenwood-Hotels-Baymont-By-Wyndham-Greenwood.h43558.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/4686cd8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/b105c391.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/8136c59d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/e9087580.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Santee Santee 6.6/10 (637) "It's a good stop for the price " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Martin CA $98 CA $109 total includes taxes & fees Dec 4 - Dec 5 [](https://www.expedia.ca/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-17&endDate=2025-12-18®ionId=6057938&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Find out more about South Carolina Midlands ### South Carolina Midlandsand its attractions for luxury travelers For luxury travellers seeking a memorable getaway in the South Carolina Midlands, the region offers a delightful blend of culture, nature, and indulgence. Begin your adventure at the historic city of Columbia, where you can explore the magnificent South Carolina State House, an architectural gem surrounded by lush gardens, perfect for a leisurely stroll. Next, immerse yourself in art and history at the Columbia Museum of Art, showcasing an impressive collection from the Renaissance to the modern era. For those who appreciate the great outdoors, the Congaree National Park offers a unique opportunity to experience stunning old-growth forests, with guided canoe tours available for an intimate encounter with nature. Don't miss the elegant Riverbanks Zoo & Garden, where you can enjoy a VIP experience, including behind-the-scenes tours and animal encounters. Finally, for golf enthusiasts, the prestigious Palmetto Club in Columbia provides an exclusive golfing experience amidst beautifully manicured landscapes. When it comes to accommodations, the luxurious 5-star hotel, The Graduate Columbia, provides a sophisticated stay, complete with plush amenities and a rooftop bar that offers stunning views of the city skyline. This area combines rich history with upscale amenities, ensuring that every moment of your stay is both relaxing and enriching. ## Top South Carolina Midlands Hotel Reviews ![Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG](https://images.trvl-media.com/lodging/1000000/690000/688700/688607/805d082b_y.jpg) ### Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG 10/10 Excellent "Clean room, comfortable bed and pillows, new big screen tv, friendly staff, and above average breakfast." [](https://expedia.ca/Columbia-Hotels-Holiday-Inn-Express-Suites-Columbia-I-26-Harbison-Blvd.h688607.Hotel-Information) ![Sleep Inn Columbia](https://images.trvl-media.com/lodging/1000000/130000/127000/126908/de238acf_y.jpg) ### Sleep Inn Columbia 10/10 Excellent "Fast Check In" [](https://expedia.ca/Columbia-Hotels-Sleep-Inn-At-Bush-River-Road.h126908.Hotel-Information) ![Baymont by Wyndham Columbia Fort Jackson](https://images.trvl-media.com/lodging/1000000/580000/574500/574461/c68af965_y.jpg) ### Baymont by Wyndham Columbia Fort Jackson 10/10 Excellent "Yes" [](https://expedia.ca/Columbia-Hotels-Baymont-By-Wyndham-Columbia-Fort-Jackson.h574461.Hotel-Information) ![Courtyard by Marriott Columbia Downtown at USC](https://images.trvl-media.com/lodging/1000000/10000/2300/2289/w3996h2667x0y0-8dd1e3e0_y.jpg) ### Courtyard by Marriott Columbia Downtown at USC 10/10 Excellent "Fast service and great perks!" [](https://expedia.ca/Columbia-Hotels-Courtyard-By-Marriott-Columbia-Downtown-At-USC.h2289.Hotel-Information) ![Graduate by Hilton Columbia SC](https://images.trvl-media.com/lodging/3000000/2520000/2515100/2515057/22f12a1f_y.jpg) ### Graduate by Hilton Columbia SC 10/10 Excellent "Awesome location!" [](https://expedia.ca/Columbia-Hotels-Graduate-Columbia.h2515057.Hotel-Information) ![Country Inn & Suites by Radisson, Columbia, SC](https://images.trvl-media.com/lodging/1000000/210000/202900/202867/04e820c9_y.jpg) ### Country Inn & Suites by Radisson, Columbia, SC 10/10 Excellent "Will stay again" [](https://expedia.ca/Columbia-Hotels-Country-Inn-Suites-By-Radisson.h202867.Hotel-Information) ![Hyatt Place Columbia/Harbison](https://images.trvl-media.com/lodging/1000000/330000/327100/327027/68fe8568_y.jpg) ### Hyatt Place Columbia/Harbison 10/10 Excellent "The breakfast was fresh made. The biscuits were like pillows in the mouth " [](https://expedia.ca/Columbia-Hotels-Hyatt-Place-ColumbiaHarbison.h327027.Hotel-Information) ![La Quinta Inn by Wyndham Columbia SE / Fort Jackson](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/e9b1ea9e_y.jpg) ### La Quinta Inn by Wyndham Columbia SE / Fort Jackson 10/10 Excellent "This was the best experience I’ve had in a while, staying in a hotel. 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