Title: Book the Best South Carolina Midlands LUXURY Hotels - Upscale Hotels in South Carolina Midlands, SC | Expedia.ca [South Carolina Midlands Travel Guide](https://expedia.ca/South-Carolina-Midlands.dx6057938)[Hotels in South Carolina Midlands](https://expedia.ca/South-Carolina-Midlands-Hotels.d6057938.Travel-Guide-Hotels)[Vacation Rentals in South Carolina Midlands](https://expedia.ca/South-Carolina-Midlands-Vacation-Rentals.d6057938.Travel-Guide-VacationRentals)[Flights to South Carolina Midlands](https://expedia.ca/Cheap-Flights-To-South-Carolina-Midlands.d6057938.Travel-Guide-Flights)[Things to do in South Carolina Midlands](https://expedia.ca/Things-To-Do-In-South-Carolina-Midlands.d6057938.Travel-Guide-Activities)[South Carolina Midlands Car Rentals](https://expedia.ca/Car-Rentals-In-South-Carolina-Midlands.d6057938.Car-Rental-Guide)[South Carolina Midlands Vacation Packages](https://expedia.ca/South-Carolina-Midlands.d6057938.Destination-Travel-Guides) ![South Carolina State House](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/184000/184006-State-House.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in South Carolina Midlands, SC ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South Carolina Midlands Luxury Hotels Tonight [Oct 17 - Oct 18](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-10-17&endDate=2025-10-18&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Oct 18 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-10-18&endDate=2025-10-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-10-17&endDate=2025-10-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top South Carolina Midlands Luxury Hotels ![View from property](https://images.trvl-media.com/lodging/1000000/800000/798500/798446/317b0952.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage, 4 Bedrooms, Balcony](https://images.trvl-media.com/lodging/1000000/800000/798500/798446/9a165410.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, lobby lounge](https://images.trvl-media.com/lodging/1000000/800000/798500/798446/24906fad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, lobby lounge](https://images.trvl-media.com/lodging/1000000/800000/798500/798446/a2869f0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Ballantyne, A Luxury Collection Hotel, Charlotte Ballantyne 9.4/10 Exceptional (999) "Room was very clean and the outdoor pool was amazing! " ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Terri CA $365 CA $420 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Charlotte-Hotels-The-Ballantyne.h798446.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/1000000/30000/20100/20030/f4cdc91c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/30000/20100/20030/6b0c9b69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/20100/20030/926d1d42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/30000/20100/20030/4c3cb9cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Willcox Aiken 9.6/10 Exceptional (140) "Wonderful stay all around." ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Anastasija CA $401 CA $450 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Aiken-Hotels-The-Willcox.h20030.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/16000000/15720000/15719100/15719033/39339da9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Queen Suite | Private kitchen](https://images.trvl-media.com/lodging/16000000/15720000/15719100/15719033/83bdb053.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/16000000/15720000/15719100/15719033/5a87853c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Regal mid-King Suite | Private kitchen](https://images.trvl-media.com/lodging/16000000/15720000/15719100/15719033/ff7460f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Mantissa Hotel Hartsville 9.2/10 Wonderful (265) "Very nice spacious rooms friendly staff" ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Duane CA $192 CA $216 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Florence-Hotels-The-Mantissa-Hotel.h15719033.Hotel-Information) ![Breakfast area](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/bfdc100f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Smoking](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/77c6db86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Smoking | Bathroom sink](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/13cfcb42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/5f1ffd39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelodge by Wyndham Orangeburg Orangeburg 8.2/10 Very good (1005) "Enjoyed our stay " ![](https://a.travel-assets.com/egds/marks/flags/au.svg) Marie CA $100 CA $111 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Orangeburg-Hotels-Travelodge-By-Wyndham-Orangeburg.h17380261.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/11000000/10940000/10931100/10931075/fed76e51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City view from property](https://images.trvl-media.com/lodging/11000000/10940000/10931100/10931075/4f102d5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, individually decorated, individually furnished, desk](https://images.trvl-media.com/lodging/11000000/10940000/10931100/10931075/d579010a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/11000000/10940000/10931100/10931075/df26a103.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Carriage House Inn Aiken 9.4/10 Exceptional (453) "The beautiful property was in a great location within walking distance to great shops and restaurants." ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Traci CA $279 CA $312 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Aiken-Hotels-Carriage-House-Inn.h10931075.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/160000/151400/151368/e887cc1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/160000/151400/151368/5d33828f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/160000/151400/151368/d5754d94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/160000/151400/151368/67187d7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area Rock Hill 7.0/10 Good (1005) "Nice stay. Nice price range. Clean rooms" ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Timothy CA $84 CA $93 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/Rock-Hill-Hotels-Microtel-Inn-Suites-By-Wyndham-Rock-HillCharlotte-Area.h151368.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/e60a54aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/a1af3ca9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/d45644f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/42f27498.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn on the Square, an Ascend Collection Hotel Uptown Greenwood 9.2/10 Wonderful (698) "It was a very clean and beautiful lace to stay. We were there for our honeymoon " ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Tracy CA $166 CA $184 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Greenwood-Hotels-Inn-On-The-Square.h1212931.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/ba61cb6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/5e830f88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/647c5c2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/24bdaf71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton Columbia Downtown Hotel Downtown Columbia 8.4/10 Very good (1006) "Wonderful stay" ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Laura CA $185 CA $207 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/Columbia-Hotels-Sheraton-Columbia-Downtown-Hotel.h1805074.Hotel-Information) ![Seasonal outdoor pool, open 10 AM to 9:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/50000/43600/43558/107411e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/50000/43600/43558/9b60048e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/43600/43558/1f2d2d2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/43600/43558/d2dce3b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Greenwood Greenwood 7.6/10 Good (744) "I had my small dog with me and the staff were friendly and the grounds were clean. Its very well located to Abbeville and Greenwood " ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Carol CA $104 CA $116 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Greenwood-Hotels-Baymont-By-Wyndham-Greenwood.h43558.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/4686cd8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/e9087580.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/a90b57ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/b105c391.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Santee Santee 6.6/10 (630) "Despite offering breakfast, it was lackluster " ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Seth CA $98 CA $109 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-01&endDate=2025-11-02®ionId=6057938&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Find out more about South Carolina Midlands ### South Carolina Midlandsand its attractions for luxury travelers For luxury travellers seeking a memorable getaway in the South Carolina Midlands, the region offers a delightful blend of culture, nature, and indulgence. Begin your adventure at the historic city of Columbia, where you can explore the magnificent South Carolina State House, an architectural gem surrounded by lush gardens, perfect for a leisurely stroll. Next, immerse yourself in art and history at the Columbia Museum of Art, showcasing an impressive collection from the Renaissance to the modern era. For those who appreciate the great outdoors, the Congaree National Park offers a unique opportunity to experience stunning old-growth forests, with guided canoe tours available for an intimate encounter with nature. Don't miss the elegant Riverbanks Zoo & Garden, where you can enjoy a VIP experience, including behind-the-scenes tours and animal encounters. Finally, for golf enthusiasts, the prestigious Palmetto Club in Columbia provides an exclusive golfing experience amidst beautifully manicured landscapes. When it comes to accommodations, the luxurious 5-star hotel, The Graduate Columbia, provides a sophisticated stay, complete with plush amenities and a rooftop bar that offers stunning views of the city skyline. This area combines rich history with upscale amenities, ensuring that every moment of your stay is both relaxing and enriching. ## Top South Carolina Midlands Hotel Reviews ![Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG](//images.trvl-media.com/lodging/1000000/690000/688700/688607/805d082b_y.jpg) ### Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG 10/10 Excellent "The check in staff were awesome and she was a joy to meet. The bathroom has water damage on tje door and it is in need of replacement. Would be nice to have a spare roll of toilet paper in the bathroom. The room was clean and tidy. The bed was too firm for me. " [](https://expedia.ca/Columbia-Hotels-Holiday-Inn-Express-Suites-Columbia-I-26-Harbison-Blvd.h688607.Hotel-Information) ![Country Inn & Suites by Radisson, Columbia, SC](//images.trvl-media.com/lodging/1000000/210000/202900/202867/04e820c9_y.jpg) ### Country Inn & Suites by Radisson, Columbia, SC 10/10 Excellent "very easy!" [](https://expedia.ca/Columbia-Hotels-Country-Inn-Suites-By-Radisson.h202867.Hotel-Information) ![Sleep Inn Columbia](//images.trvl-media.com/lodging/1000000/130000/127000/126908/de238acf_y.jpg) ### Sleep Inn Columbia 10/10 Excellent "Beth at the front desk went out of her way to help us she was very friendly, courteous and professional would very much recomend to others" [](https://expedia.ca/Columbia-Hotels-Sleep-Inn-At-Bush-River-Road.h126908.Hotel-Information) ![La Quinta Inn by Wyndham Columbia SE / Fort Jackson](//images.trvl-media.com/lodging/1000000/10000/5100/5038/e9b1ea9e_y.jpg) ### La Quinta Inn by Wyndham Columbia SE / Fort Jackson 10/10 Excellent "All" [](https://expedia.ca/Columbia-Hotels-La-Quinta-Inn-By-Wyndham-Columbia-SE-Fort-Jackson.h5038.Hotel-Information) ![Graduate by Hilton Columbia SC](//images.trvl-media.com/lodging/3000000/2520000/2515100/2515057/22f12a1f_y.jpg) ### Graduate by Hilton Columbia SC 10/10 Excellent "Good breakfast Easy parking" [](https://expedia.ca/Columbia-Hotels-Graduate-Columbia.h2515057.Hotel-Information) ![Super 8 by Wyndham Harbison/Parkridge Hospital](//images.trvl-media.com/lodging/1000000/530000/523100/523046/42de4f92_y.jpg) ### Super 8 by Wyndham Harbison/Parkridge Hospital 10/10 Excellent " management was great" [](https://expedia.ca/Columbia-Hotels-Super-8-By-Wyndham-HarbisonParkridge-Hospital.h523046.Hotel-Information) ![Hyatt Place Columbia/Harbison](//images.trvl-media.com/lodging/1000000/330000/327100/327027/68fe8568_y.jpg) ### Hyatt Place Columbia/Harbison 10/10 Excellent "This place was good the units felt like a mini suite. Beds were not too comfortable, felt like we were sinking in. Woke up with some back pain. The breakfast was great and free so that's a huge plus. However not so accommodating if you have any food allergies. They have adjoining rooms so if you have a family it's great. Ample parking. Right next to a cracker barrel and short drives to plenty of restaurants. Also a short drive to the city for some exploring. Some reviews have mentioned that the rooms felt dated. I completely disagree." [](https://expedia.ca/Columbia-Hotels-Hyatt-Place-ColumbiaHarbison.h327027.Hotel-Information) ![Baymont by Wyndham Columbia Fort Jackson](//images.trvl-media.com/lodging/1000000/580000/574500/574461/c68af965_y.jpg) ### Baymont by Wyndham Columbia Fort Jackson 10/10 Excellent "The bed was comfortable and firm" [](https://expedia.ca/Columbia-Hotels-Baymont-By-Wyndham-Columbia-Fort-Jackson.h574461.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [Hotels near Allen University](https://www.expedia.ca/Allen-University-Hotels.0-l6245638-0.Travel-Guide-Filter-Hotels) - [B&B in Arcadia Lakes](https://www.expedia.ca/Arcadia-Lakes-Bed-And-Breakfast.d553248634998974994-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Guest Houses in Arcadia Lakes](https://www.expedia.ca/Arcadia-Lakes-Guest-Houses.d553248634998974994-aaGuestHouses.Travel-Guide-Accommodation) - [Arcadia Lakes Hotels](https://www.expedia.ca/Arcadia-Lakes-Hotels.d553248634998974994.Travel-Guide-Hotels) - 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