Title: Book the Best BUSINESS Hotels in South Carolina Midlands in 2025 | Expedia.ca [South Carolina Midlands Travel Guide](https://expedia.ca/South-Carolina-Midlands.dx6057938)[Hotels in South Carolina Midlands](https://expedia.ca/South-Carolina-Midlands-Hotels.d6057938.Travel-Guide-Hotels)[Vacation Rentals in South Carolina Midlands](https://expedia.ca/South-Carolina-Midlands-Vacation-Rentals.d6057938.Travel-Guide-VacationRentals)[Flights to South Carolina Midlands](https://expedia.ca/Cheap-Flights-To-South-Carolina-Midlands.d6057938.Travel-Guide-Flights)[Things to do in South Carolina Midlands](https://expedia.ca/Things-To-Do-In-South-Carolina-Midlands.d6057938.Travel-Guide-Activities)[South Carolina Midlands Car Rentals](https://expedia.ca/Car-Rentals-In-South-Carolina-Midlands.d6057938.Car-Rental-Guide)[South Carolina Midlands Vacation Packages](https://expedia.ca/South-Carolina-Midlands.d6057938.Destination-Travel-Guides) ![South Carolina State House](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/184000/184006-State-House.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in South Carolina Midlands, SC ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South Carolina Midlands Business Hotels Tonight [Oct 15 - Oct 16](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-10-15&endDate=2025-10-16&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 16 - Oct 17](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-10-16&endDate=2025-10-17&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-10-17&endDate=2025-10-19&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-10-24&endDate=2025-10-26&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top South Carolina Midlands Business Hotels ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1380000/1374000/1373944/98250f43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1380000/1374000/1373944/3ac9b49e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/2000000/1380000/1374000/1373944/9691c8d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1380000/1374000/1373944/b776e301.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Camden-I20 (Hwy 521) by IHG Camden 8.4/10 Very good (667) "Every thing was very clean and the staff was very efficient and polite. Check in was very quick and easy as well as check out. " CA $156 CA $175 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/Columbia-Hotels-Holiday-Inn-Express-Hotel-Suites-Camden-I20.h1373944.Hotel-Information) ![Interior entrance](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418684/54902f8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418684/f127cd7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Two queen beds non smoking](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418684/e1b5940b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418684/8a3bfd5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Manning Manning 8.4/10 Very good (981) "Clean Easy room access, spacious couch and comfortable king bed combination room " CA $149 CA $166 total includes taxes & fees Nov 5 - Nov 6 [](https://www.expedia.ca/Sumter-Hotels-Hampton-Inn-Manning.h1418684.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/25ebdfeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/c5237c95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/756b4cd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Santee Santee 8.0/10 Very good (1361) "Good overall stay." CA $105 CA $117 total includes taxes & fees Oct 16 - Oct 17 [](https://www.expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a0861bce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/0ea8f0b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/83187168.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/c7afe694.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Florence 9.2/10 Wonderful (1107) "Friendly staff. Comfortable bed and a well lit parking area. " CA $150 CA $168 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c29c3321.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c8bc9166.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/bee831df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/cbc9a37d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Florence Downtown Florence 8.8/10 Excellent (1009) "Bar well stocked, friendly staff, and clean accommodations" CA $156 CA $175 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/96d5feb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/00586c85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/51d8f371.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/e4f3361f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Park Inn by Radisson Florence, SC Florence 9.0/10 Wonderful (2154) "We only stayed one night, but honestly our stay as very comfortable, and staff very nice, and welcoming. " CA $133 CA $149 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/36a85f8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/16ca8b57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/22eb9cd7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/59604fe9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Florence-North-I-95 Florence 9.0/10 Wonderful (750) "Enjoyed our stay" CA $149 CA $166 total includes taxes & fees Oct 21 - Oct 22 [](https://www.expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-North-I-95.h2392993.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/ebea43b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/7b1066c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/b5687a1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Howard Johnson by Wyndham Florence Florence 8.8/10 Excellent (2393) "Great stay" CA $96 CA $107 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/aa173c27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/c7fdb599.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/ae964a26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/f8fbcf77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn by Marriott Orangeburg Orangeburg 8.4/10 Very good (655) "Enjoyed my stay for homecoming go Bulldogs ! " CA $118 CA $131 total includes taxes & fees Oct 16 - Oct 17 [](https://www.expedia.ca/Orangeburg-Hotels-Fairfield-Inn-By-Marriott-Orangeburg.h563976.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1510000/1509700/1509674/17df73d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/1510000/1509700/1509674/4c689938.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1510000/1509700/1509674/9c0353ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1510000/1509700/1509674/6c72c859.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG Florence 9.2/10 Wonderful (1005) "Easy drive right off the interstate. Good dining options nearby." CA $156 CA $175 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Florence-Hotels-Holiday-Inn-Ex-Hotel-Suites-Florence-I-95-I-20-Civic-Ctr.h1509674.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-29&endDate=2025-10-30®ionId=6057938&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top South Carolina Midlands Hotel Reviews ![La Quinta Inn by Wyndham Columbia SE / Fort Jackson](//images.trvl-media.com/lodging/1000000/10000/5100/5038/e9b1ea9e_y.jpg) ### La Quinta Inn by Wyndham Columbia SE / Fort Jackson 10/10 Excellent "All" [](https://expedia.ca/Columbia-Hotels-La-Quinta-Inn-By-Wyndham-Columbia-SE-Fort-Jackson.h5038.Hotel-Information) ![Hilton Garden Inn Columbia/Harbison](//images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/f8933df9_y.jpg) ### Hilton Garden Inn Columbia/Harbison 10/10 Excellent "Every went smooth and was very nice!" [](https://expedia.ca/Columbia-Hotels-Hilton-Garden-Inn-ColumbiaHarbison.h1513707.Hotel-Information) ![Graduate by Hilton Columbia SC](//images.trvl-media.com/lodging/3000000/2520000/2515100/2515057/22f12a1f_y.jpg) ### Graduate by Hilton Columbia SC 10/10 Excellent "Good breakfast Easy parking" [](https://expedia.ca/Columbia-Hotels-Graduate-Columbia.h2515057.Hotel-Information) ![Marriott Columbia](//images.trvl-media.com/lodging/1000000/20000/17400/17353/4bcf0c43_y.jpg) ### Marriott Columbia 10/10 Excellent "We stayed here for our wedding anniversary trip. Cleanliness is very important to me and the room and common areas of this property were very clean. Our bed was very comfortable. We were pleased with the value- we try to prioritize Marriott because they rarely disappoint us and we were so happy this was under budget for us. It was a treat to have the Soda City market right on site on Saturday morning. Transmission Arcade is a few blocks down. The art museum is right across the street and we enjoyed the Keith Haring exhibit. It is about 30 mins away from Congaree National Park, which was an affordable rideshare drive. If you’re visiting to see any of these attractions, this is the hotel for you. :) " [](https://expedia.ca/Columbia-Hotels-Marriott-Columbia.h17353.Hotel-Information) ![Super 8 by Wyndham Harbison/Parkridge Hospital](//images.trvl-media.com/lodging/1000000/530000/523100/523046/42de4f92_y.jpg) ### Super 8 by Wyndham Harbison/Parkridge Hospital 10/10 Excellent " management was great" [](https://expedia.ca/Columbia-Hotels-Super-8-By-Wyndham-HarbisonParkridge-Hospital.h523046.Hotel-Information) ![Hampton Inn Columbia-I-26 Airport](//images.trvl-media.com/lodging/1000000/10000/7600/7503/e8ace719_y.jpg) ### Hampton Inn Columbia-I-26 Airport 10/10 Excellent "5 stars " [](https://expedia.ca/Columbia-Hotels-Hampton-Inn-Columbia-I-26-Airport.h7503.Hotel-Information) ![ La Quinta Inn by Wyndham Columbia NE/Fort Jackson](//images.trvl-media.com/lodging/1000000/50000/43600/43541/ebebcc50_y.jpg) ### La Quinta Inn by Wyndham Columbia NE/Fort Jackson 10/10 Excellent "It was solid." [](https://expedia.ca/Columbia-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Columbia-NE-Fort-Jackson.h43541.Hotel-Information) ![Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG](//images.trvl-media.com/lodging/1000000/690000/688700/688607/805d082b_y.jpg) ### Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG 10/10 Excellent "Clean excelentt" [](https://expedia.ca/Columbia-Hotels-Holiday-Inn-Express-Suites-Columbia-I-26-Harbison-Blvd.h688607.Hotel-Information) ![Howard Johnson by Wyndham Florence](//images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg) ### Howard Johnson by Wyndham Florence 10/10 Excellent "Clean room" [](https://expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in South Carolina Midlands cost? > You can expect to pay between and per night for business-friendly hotels in South Carolina Midlands. Epic deals on stays that cater to work-related guests are a few clicks away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply. ### What are the best business-friendly hotels in South Carolina Midlands? > There are multiple business-friendly hotels in South Carolina Midlands with a total average guest review rating of , so you're sure to discover a place that suits your needs. Basing yourself in Columbia? [Staybridge Suites Columbia, an IHG Hotel](https://www.expedia.ca/Columbia-Hotels-Staybridge-Suites-Columbia.h2246543.Hotel-Information) is popular with corporate travellers. This 3-stars option offers conveniences like a barbecue grill and a swimming pool. [Hampton Inn Columbia I-26/Harbison Blvd.](https://www.expedia.ca/Columbia-Hotels-Hampton-Inn-Columbia-I-26Harbison-Blvd.h42875.Hotel-Information) also scores top marks from business guests. Take advantage of complimentary use of a nearby fitness centre and a swimming pool at this 2.5-stars property in Columbia. ### How many business-friendly hotels are there in South Carolina Midlands? > When your next meeting or networking event takes you someplace in South Carolina Midlands, you'll have business-friendly hotels to choose from. ### What are the best cheap business-friendly hotels in South Carolina Midlands? > That depends on where in South Carolina Midlands your journey is taking you. If your destination is Columbia, [Hampton Inn Columbia I-26/Harbison Blvd.](https://www.expedia.ca/Columbia-Hotels-Hampton-Inn-Columbia-I-26Harbison-Blvd.h42875.Hotel-Information) meets the needs of business travellers at an affordable price. A terrace and pool sun loungers are among its many conveniences. On your way to Florence? Consider staying at [Hampton Inn & Suites Florence Centre](https://www.expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-Center.h42876.Hotel-Information). A swimming pool and WiFi help make this cheaper property a top choice for corporate guests. Business-friendly hotels start from a night, so your next work trip doesn't have to cost a lot. Want to see the sights of South Carolina Midlands without the high admission prices? Take time out from your business commitments to visit free attractions like [Trinity Episcopal Cathedral](https://www.expedia.ca/Trinity-Episcopal-Cathedral-Downtown-Columbia.d553248621532657318.Vacation-Attraction) in Columbia. Florence also has plenty of things to do that don't cost anything, including [Florence Museum](https://www.expedia.ca/Florence-Museum-Florence.d6162137.Vacation-Attraction). This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply. ### What are the top business-friendly motels in South Carolina Midlands? > If your South Carolina Midlands business visit includes Columbia, check in to [Days Inn by Wyndham Columbia](https://www.expedia.ca/Columbia-Hotels-Days-Inn-By-Wyndham-Columbia.h532027.Hotel-Information). Around 6 kilometres northwest of the downtown area and offering a swimming pool and a terrace, it's popular with corporate guests. Alternatively, work comfortably from [America's Best Inn Columbia](https://www.expedia.ca/Columbia-Hotels-Americas-Best-Inn-Columbia.h18676.Hotel-Information). A balcony and front desk services are among the conveniences at this property, located around 6 kilometres northwest of the centre of Columbia.There's no shortage of things to keep you entertained during your downtime in Columbia. [Riverbanks Zoo and Garden](https://www.expedia.ca/Riverbanks-Zoo-And-Garden-Columbia.d6082673.Vacation-Attraction) and [Township Auditorium](https://www.expedia.ca/Township-Auditorium-Downtown-Columbia.d553248621532657321.Vacation-Attraction) should be on your travel itinerary. ### Are there any family-friendly hotels in South Carolina Midlands that are also business friendly? > If you're travelling for business in South Carolina Midlands and bringing family along with you, Expedia will help you find a cozy and convenient stay. [Hampton Inn Columbia I-26/Harbison Blvd.](https://www.expedia.ca/Columbia-Hotels-Hampton-Inn-Columbia-I-26Harbison-Blvd.h42875.Hotel-Information) in Columbia is the perfect option for those juggling work and pleasure. This 2.5-stars hotel offers all the amenities you need, like a playground and complimentary breakfast. [Holiday Inn Columbia - Downtown, an IHG Hotel](https://www.expedia.ca/Columbia-Hotels-Holiday-Inn-Columbia-Downtown.h36264221.Hotel-Information) is another good choice in Columbia. You'll be able to combine corporate travel and quality time with your family at this 3-stars property. Laundry facilities and housekeeping services are among the numerous conveniences here. There are plenty of exciting things to do with your little travellers in Columbia. [Riverbanks Zoo and Garden](https://www.expedia.ca/Riverbanks-Zoo-And-Garden-Columbia.d6082673.Vacation-Attraction) and [South Carolina State Museum](https://www.expedia.ca/South-Carolina-State-Museum-Downtown-Columbia.d6082675.Vacation-Attraction) offer a memorable day out. ### Why book your business-friendly hotel in South Carolina Midlands with Expedia? > Expedia is here to help you find a fabulous business-friendly hotel when work takes you out of town. From free WiFi and parking to on-site cafés and restaurants, our stays have the things you need to get the job done. ### How can I find cheap business-friendly hotels in South Carolina Midlands? > Expedia can help you narrow down your search for cheap business-friendly hotels in South Carolina Midlands. Simply go to the "traveller experience" filter and click on "business friendly." This will show you stays with amenities designed to help you work effectively and comfortably, like free WiFi and included breakfast. You can also choose your preferred star rating and budget to keep costs to a minimum. ### What is there to do in South Carolina Midlands near my business-friendly hotel? > You'll discover plenty of things to keep you entertained in South Carolina Midlands. If you're making your way to Columbia, drop by [Riverbanks Zoo and Garden](https://www.expedia.ca/Riverbanks-Zoo-And-Garden-Columbia.d6082673.Vacation-Attraction), [Township Auditorium](https://www.expedia.ca/Township-Auditorium-Downtown-Columbia.d553248621532657321.Vacation-Attraction) and [South Carolina State Museum](https://www.expedia.ca/South-Carolina-State-Museum-Downtown-Columbia.d6082675.Vacation-Attraction). Packing your suitcases for Florence? [Florence Museum](https://www.expedia.ca/Florence-Museum-Florence.d6162137.Vacation-Attraction), [Mcleod Regional Medical Centre](https://www.expedia.ca/Mcleod-Regional-Medical-Center-Florence.d6162127.Vacation-Attraction) and [Florence National Cemetery](https://www.expedia.ca/Florence-National-Cemetery-Florence.d553248621532657341.Vacation-Attraction) are top attractions here. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [Hotels near Allen University](https://www.expedia.ca/Allen-University-Hotels.0-l6245638-0.Travel-Guide-Filter-Hotels) - [B&B in Arcadia Lakes](https://www.expedia.ca/Arcadia-Lakes-Bed-And-Breakfast.d553248634998974994-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Guest Houses in Arcadia Lakes](https://www.expedia.ca/Arcadia-Lakes-Guest-Houses.d553248634998974994-aaGuestHouses.Travel-Guide-Accommodation) - [Arcadia Lakes Hotels](https://www.expedia.ca/Arcadia-Lakes-Hotels.d553248634998974994.Travel-Guide-Hotels) - 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[Book Business Hotels in South Carolina Midlands on Expedia.com](https://www.expedia.com/South-Carolina-Midlands-Hotels-Business-Hotel.0-0-d6057938-tBusinessHotel.Travel-Guide-Filter-Hotels)