Title: Book the Best South Carolina Midlands Adults Only Resorts & Hotels in 2026  | Expedia.ca

[South Carolina Midlands Travel Guide](https://expedia.ca/South-Carolina-Midlands.dx6057938)[Hotels in South Carolina Midlands](https://expedia.ca/South-Carolina-Midlands-Hotels.d6057938.Travel-Guide-Hotels)[Vacation Rentals in South Carolina Midlands](https://expedia.ca/South-Carolina-Midlands-Vacation-Rentals.d6057938.Travel-Guide-VacationRentals)[Flights to South Carolina Midlands](https://expedia.ca/Cheap-Flights-To-South-Carolina-Midlands.d6057938.Travel-Guide-Flights)[Things to do in South Carolina Midlands](https://expedia.ca/Things-To-Do-In-South-Carolina-Midlands.d6057938.Travel-Guide-Activities)[South Carolina Midlands Car Rentals](https://expedia.ca/Car-Rentals-In-South-Carolina-Midlands.d6057938.Car-Rental-Guide)[South Carolina Midlands Vacation Packages](https://expedia.ca/South-Carolina-Midlands.d6057938.Destination-Travel-Guides)

![South Carolina State House](https://images.trvl-media.com/place/6082681/1934af6a-1aa9-4e01-8cd3-8eb8fe4af18f.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

# Find Adults Only Resorts & Hotels in South Carolina Midlands, SC 

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## Check availability on South Carolina Midlands Adults Only Resorts & Hotels

Tonight

[Dec 17 - Dec 18](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-12-17&endDate=2025-12-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only)

Tomorrow

[Dec 18 - Dec 19](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-12-18&endDate=2025-12-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only)

This weekend

[Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only)

Next weekend

[Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only)

## Our top choices for South Carolina Midlands adults-only hotels

![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/30000/20500/20500/b15e751d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Check-in/check-out kiosk](https://images.trvl-media.com/lodging/1000000/30000/20500/20500/3e8501ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/1000000/30000/20500/20500/cfcbf535.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/20500/20500/3ea4aa47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Baymont by Wyndham Orangeburg North

[](https://www.expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Orangeburg-North.h20500.Hotel-Information)

Orangeburg

6.0/10

(1003)

"The room was clean, it just need updating. The tv was small"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lyquita

CA $76

CA $84 total

includes taxes & fees

Dec 24 - Dec 25

[](https://www.expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Orangeburg-North.h20500.Hotel-Information)

![Junior Suite, Non Smoking | Private kitchen](https://images.trvl-media.com/lodging/120000000/119990000/119989000/119988964/2f80b07d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 Queen Bed, Non Smoking | Private kitchen](https://images.trvl-media.com/lodging/120000000/119990000/119989000/119988964/d3ff6b72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/120000000/119990000/119989000/119988964/aa365e5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Junior Suite, Non Smoking | Living area](https://images.trvl-media.com/lodging/120000000/119990000/119989000/119988964/0394b80f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Inkwell

[](https://www.expedia.ca/Charlotte-Hotels-Inkwell.h119988964.Hotel-Information)

NoDa

CA $129

CA $314 total

includes taxes & fees

Jan 5 - Jan 6, 2026

[](https://www.expedia.ca/Charlotte-Hotels-Inkwell.h119988964.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-31&endDate=2026-01-01&regionId=6057938&adults=2&travelerType=adults_only&sort=RECOMMENDED&openPlayBack=true)

## Top South Carolina Midlands Hotel Reviews

## Frequently asked questions

### How much do adults-only hotels in South Carolina Midlands cost?

### Are there any adult-only all-inclusive resorts in South Carolina Midlands?

### What is there to do in South Carolina Midlands near my adults-only hotel?

### How can I find cheap adults-only hotels in South Carolina Midlands?

### From what age can you stay in an adult-only hotel in South Carolina Midlands?

### Are all adult-only resorts all-inclusive in South Carolina Midlands?

### Why book your adults-only hotel in South Carolina Midlands with Expedia?

### When is the best time to stay at an adult-only all-inclusive resort in South Carolina Midlands?

### Can I cancel or change my adult-only resort booking?

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