Title: Book the Best BUSINESS Hotels in Sister Islands in 2025 | Expedia.ca [Sister Islands Travel Guide](https://expedia.ca/Sister-Islands.dx553248633946460050)[Hotels in Sister Islands](https://expedia.ca/Sister-Islands-Hotels.d553248633946460050.Travel-Guide-Hotels)[Vacation Rentals in Sister Islands](https://expedia.ca/Sister-Islands-Vacation-Rentals.d553248633946460050.Travel-Guide-VacationRentals)[Flights to Sister Islands](https://expedia.ca/Cheap-Flights-To-Sister-Islands.d553248633946460050.Travel-Guide-Flights)[Sister Islands Car Rentals](https://expedia.ca/Car-Rentals-In-Sister-Islands.d553248633946460050.Car-Rental-Guide)[Sister Islands Vacation Packages](https://expedia.ca/Sister-Islands.d553248633946460050.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/ee5503bbfc0fc8ae5ee4ab2cc68e9d52.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Sister Islands ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Sister Islands Business Hotels Tonight [Oct 10 - Oct 11](https://www.expedia.ca/Hotel-Search?regionId=553248633946460050&startDate=2025-10-10&endDate=2025-10-11&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 11 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248633946460050&startDate=2025-10-11&endDate=2025-10-12&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248633946460050&startDate=2025-10-10&endDate=2025-10-12&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248633946460050&startDate=2025-10-17&endDate=2025-10-19&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Sister Islands Business Hotels We don't have any properties that match your exact search [See all properties in Sister Islands](https://expedia.ca/Hotel-Search?startDate=2025-10-24&endDate=2025-10-25®ionId=553248633946460050&adults=2) ## Recommended hotels in Sister Islands ![Exterior](https://images.trvl-media.com/lodging/75000000/74430000/74421900/74421869/72668cc8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/75000000/74430000/74421900/74421869/ed137e46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![The Coast House | Living area](https://images.trvl-media.com/lodging/75000000/74430000/74421900/74421869/864ef166.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/75000000/74430000/74421900/74421869/5c796649.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Le Soleil d'Or CaymanBrac West End 9.4/10 Exceptional (13) "We love this property!! The service is outstanding and the staff is lovely. 100% recommend " CA $496 CA $690 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/George-Town-Hotels-Le-Soleil-DOr-CaymanBrac.h74421869.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/45000000/44420000/44417600/44417537/bc8ab117.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/45000000/44420000/44417600/44417537/63ab8b1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, in-room safe, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/45000000/44420000/44417600/44417537/a5a10bf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/45000000/44420000/44417600/44417537/7b2f278c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Alexander Suites #101 - Queen Suite West End 9.4/10 Exceptional (6) "It is so accessible to the airport and other establishments like shops and grocery store." CA $244 CA $374 total includes taxes & fees Oct 13 - Oct 14 [](https://www.expedia.ca/West-End-Hotels-The-Alexander-Suites-101-Queen-Suite.h44417537.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/50000000/49010000/49000400/49000374/f420876d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/50000000/49010000/49000400/49000374/95893d2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/50000000/49010000/49000400/49000374/ad002b5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/50000000/49010000/49000400/49000374/b6c8f347.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Alexander # 210 - Queen Suite West End 9.4/10 Exceptional (3) "Great restaurant and bar on site. Staff are superb. The best place to stay on Cayman Brac!" CA $244 CA $374 total includes taxes & fees Oct 13 - Oct 14 [](https://www.expedia.ca/West-End-Hotels-The-Alexander-210-Queen-Suite.h49000374.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/46000000/45480000/45473300/45473215/065d18cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/46000000/45480000/45473300/45473215/2e7351ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/46000000/45480000/45473300/45473215/178835fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/46000000/45480000/45473300/45473215/201ded24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Alexander Suites - #103 Queen Suite West End 8.8/10 Excellent (3) "All around great experience with this property. Interior layout of the hotel and grounds was beautiful and well kept. Rooms were upscale, clean and had small kitchenette - really appreciate how they had coffee makers and a fully stocked kitchen with small appliances including dishware, utensils, cups etc... Property was close to airport, ATM (only one on the island) and to town for quick supermarket runs. Couple of restaurants within walking distance and really close to several snorkeling sites... CA $244 CA $374 total includes taxes & fees Oct 13 - Oct 14 [](https://www.expedia.ca/West-End-Hotels-The-Alexander-107-Queen-Suite.h45473215.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/46000000/45530000/45522100/45522008/6a91b423.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/46000000/45530000/45522100/45522008/0767edcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/46000000/45530000/45522100/45522008/20c660a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/46000000/45530000/45522100/45522008/523f8ae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Alexander Suites #102 - Double Queen West End 10/10 Exceptional (1) "This was the perfect place for our short Cayman Brac trip. Next time we will stay longer. Absolutely no negative comments…highly recommend😃" CA $314 CA $459 total includes taxes & fees Oct 13 - Oct 14 [](https://www.expedia.ca/West-End-Hotels-The-Alexander-Suites-102-Double-Queen.h45522008.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/47000000/46110000/46108100/46108028/7ccf8361.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/47000000/46110000/46108100/46108028/3d0e4f0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/47000000/46110000/46108100/46108028/8a928cb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/47000000/46110000/46108100/46108028/f93dae03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Alexander - # 105 Queen Suite West End CA $244 CA $374 total includes taxes & fees Oct 13 - Oct 14 [](https://www.expedia.ca/West-End-Hotels-The-Alexander-105-Queen-Suite.h46108028.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/47000000/46110000/46108700/46108602/05e5b681.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/47000000/46110000/46108700/46108602/1766a27b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/47000000/46110000/46108700/46108602/6b362e8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, in-room safe, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/47000000/46110000/46108700/46108602/5ca749d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Alexander - #201 2 Bedroom Suite West End 10/10 Exceptional (2) "Excellent staff, restaurant was nice." CA $367 CA $557 total includes taxes & fees Oct 13 - Oct 14 [](https://www.expedia.ca/West-End-Hotels-The-Alexander-201-2-Bedroom-Suite.h46108602.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-24&endDate=2025-10-25®ionId=553248633946460050&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Sister Islands Hotel Reviews