Title: The 10 Best Hotels Near Sioux Empire Medical Museum, Sioux Falls  | Expedia.ca

 

[University Heights Travel Guide](https://expedia.ca/Sioux-Falls-University-Heights.dx978416295039057920)[Sioux Empire Medical Museum Car Rentals](https://expedia.ca/Car-Rentals-In-Sioux-Empire-Medical-Museum.d553248621532648850.Car-Rental-Guide)[Sioux Empire Medical Museum Vacations](https://expedia.ca/Sioux-Empire-Medical-Museum-University-Heights.d553248621532648850.Vacation-Attraction)

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# Find hotels near Sioux Empire Medical Museum, Sioux Falls

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## Check prices for these dates

Tonight

[Oct 30 - Oct 31](https://www.expedia.ca/Hotel-Search?regionId=553248621532648850&startDate=2025-10-30&endDate=2025-10-31&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Oct 31 - Nov 1](https://www.expedia.ca/Hotel-Search?regionId=553248621532648850&startDate=2025-10-31&endDate=2025-11-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248621532648850&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=553248621532648850&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Recommended

Price (low to high)

Distance

Star rating

## Top Hotels Close to Sioux Empire Medical Museum

![Terrace/patio](https://images.trvl-media.com/lodging/10000000/9020000/9011900/9011875/10270e0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/10000000/9020000/9011900/9011875/7ff68e14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/10000000/9020000/9011900/9011875/4fdf14cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![LCD TV](https://images.trvl-media.com/lodging/10000000/9020000/9011900/9011875/0da5ea75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

University Heights, 0.2 km from Sioux Empire Medical Museum

9.4/10

Exceptional

(566)

"The cleanest hotel I’ve been to. Very quiet and nice. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Katherine

CA $182

CA $203 total

includes taxes & fees

Nov 27 - Nov 28

[](https://www.expedia.ca/Sioux-Falls-Hotels-Home2-Suites-By-Hilton-Sioux-FallsSanford-Medical-Center.h9011875.Hotel-Information)

![Interior detail](https://images.trvl-media.com/lodging/37000000/36450000/36447800/36447711/edd573eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/37000000/36450000/36447800/36447711/31b10812.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Superior Suite, 1 King Bed, City View (Phillips Mural Suites) | View from room](https://images.trvl-media.com/lodging/37000000/36450000/36447800/36447711/d5305b8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/37000000/36450000/36447800/36447711/93b8eb51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel On Phillips

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

9.6/10

Exceptional

(1255)

"Beautiful hotel."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Amy

[](https://www.expedia.ca/Sioux-Falls-Hotels-Hotel-On-Phillips.h36447711.Hotel-Information)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/4e13e753.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/d22edaaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/4e8d1af3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/dfaa8fa2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Clubhouse Hotel Suites Sioux Falls

Mall District, 2.8 km from Sioux Empire Medical Museum

9.6/10

Exceptional

(1004)

"Clean, friendly staff, great breakfast"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jennifer

[](https://www.expedia.ca/Sioux-Falls-Hotels-Clubhouse-Hotel-Suites-Sioux-Falls.h1100190.Hotel-Information)

![Meeting facility](https://images.trvl-media.com/lodging/105000000/104100000/104094900/104094801/4a36c889.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Presidential Suite, 1 Bedroom | Private kitchen](https://images.trvl-media.com/lodging/105000000/104100000/104094900/104094801/cf8c60fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/105000000/104100000/104094900/104094801/05f2adce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, individually decorated, individually furnished, desk](https://images.trvl-media.com/lodging/105000000/104100000/104094900/104094801/bbd4aa0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Canopy By Hilton Sioux Falls Downtown

Downtown Sioux Falls, 2.5 km from Sioux Empire Medical Museum

9.4/10

Exceptional

(137)

"Great hotel"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

BRIAN

CA $200

CA $228 total

includes taxes & fees

Nov 25 - Nov 26

[](https://www.expedia.ca/Sioux-Falls-Hotels-Canopy-By-Hilton-Sioux-Falls-Downtown.h104094801.Hotel-Information)

![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/80000/74500/74429/ceab3d5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Sports facility](https://images.trvl-media.com/lodging/1000000/80000/74500/74429/730e5238.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Two queen bed non smoking](https://images.trvl-media.com/lodging/1000000/80000/74500/74429/1589a090.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/80000/74500/74429/9beb2ccd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Sioux Falls

Mall District, 3.1 km from Sioux Empire Medical Museum

9.2/10

Wonderful

(1014)

"Great location, updated bathroom, friendly staff and convenient hot breakfast."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Susan

CA $136

CA $152 total

includes taxes & fees

Nov 29 - Nov 30

[](https://www.expedia.ca/Sioux-Falls-Hotels-Hampton-Inn-Sioux-Falls.h74429.Hotel-Information)

![Presidential Suite, 1 King Bed, Jetted Tub (Balcony) | Living area](https://images.trvl-media.com/lodging/7000000/6410000/6404700/6404700/31e53656.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lunch and dinner served, American cuisine](https://images.trvl-media.com/lodging/7000000/6410000/6404700/6404700/515d74f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free cribs/infant beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/7000000/6410000/6404700/6404700/8fd379c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lunch and dinner served, American cuisine](https://images.trvl-media.com/lodging/7000000/6410000/6404700/6404700/43a47820.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hilton Garden Inn Sioux Falls Downtown

Downtown Sioux Falls, 2.1 km from Sioux Empire Medical Museum

9.0/10

Wonderful

(875)

"Under construction but staff adapted and accommodated very well. Room was clean and quiet. Perfect location "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Joseph

CA $174

CA $200 total

includes taxes & fees

Nov 23 - Nov 24

[](https://www.expedia.ca/Sioux-Falls-Hotels-Hilton-Garden-Inn-Sioux-Falls-Downtown.h6404700.Hotel-Information)

![Porch](https://images.trvl-media.com/lodging/46000000/45040000/45035200/45035119/e471ae53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Garden](https://images.trvl-media.com/lodging/46000000/45040000/45035200/45035119/566cc0a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shared fridge, microwave, oven, coffee/tea maker](https://images.trvl-media.com/lodging/46000000/45040000/45035200/45035119/c2b6d037.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/46000000/45040000/45035200/45035119/07efade6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Historic Victorian Inn

Cathedral, 1.5 km from Sioux Empire Medical Museum

8.8/10

Excellent

(56)

"It was a great place to stay and super interesting."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kathy

CA $193

CA $234 total

includes taxes & fees

Nov 4 - Nov 5

[](https://www.expedia.ca/Sioux-Falls-Hotels-Historic-Victorian-Inn.h45035119.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34300/34225/9ba9d9dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/40000/34300/34225/f9a72157.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/40000/34300/34225/96cc4a2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, hypo-allergenic bedding, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/40000/34300/34225/3f5c4ef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Country Inn & Suites by Radisson, Sioux Falls, SD

Downtown Sioux Falls, 2 km from Sioux Empire Medical Museum

8.4/10

Very good

(1126)

"Mostly Clean.. Great views of River.. Pretty decent restaurant on site. Would stay there again for sure."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Todd

CA $133

CA $148 total

includes taxes & fees

Nov 24 - Nov 25

[](https://www.expedia.ca/Sioux-Falls-Hotels-Country-Inn-Suites-By-Radisson.h34225.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4800/4722/34cad0f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium Room, 1 King Bed with Sofa bed](https://images.trvl-media.com/lodging/1000000/10000/4800/4722/1471fa86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4800/4722/2df9adda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/10000/4800/4722/1920c746.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Sioux Falls-City Centre by IHG

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

8.4/10

Very good

(1005)

"Always a great stay. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Shawn

CA $132

CA $148 total

includes taxes & fees

Nov 2 - Nov 3

[](https://www.expedia.ca/Sioux-Falls-Hotels-Holiday-Inn-Sioux-Falls-City-Centre.h4722.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/130000/127000/126929/835a882c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/130000/127000/126929/90015fdb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/130000/127000/126929/c4b07f10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/130000/127000/126929/acf1c582.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Mall District, 3.1 km from Sioux Empire Medical Museum

8.8/10

Excellent

(1000)

"Really enjoyed the stay and nice staff "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

jenny

CA $135

CA $151 total

includes taxes & fees

Nov 29 - Nov 30

[](https://www.expedia.ca/Sioux-Falls-Hotels-Holiday-Inn-Express-Suites-Sioux-Falls-At-Empire-Mall.h126929.Hotel-Information)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/60000000/59830000/59829700/59829643/cce804ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/60000000/59830000/59829700/59829643/03926f8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/60000000/59830000/59829700/59829643/e6d45314.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/60000000/59830000/59829700/59829643/2f94c1d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Center Inn

All Saints, 2.4 km from Sioux Empire Medical Museum

8.4/10

Very good

(681)

"Quite place to stay staff was very friendly beds comfortable and rooms were clean. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tina

[](https://www.expedia.ca/Sioux-Falls-Hotels-The-Center-Inn.h59829643.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/120000/119000/118966/c06c9122.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, down comforters, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/120000/119000/118966/bd8a3927.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/120000/119000/118966/247f7239.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/120000/119000/118966/749ebeb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Sheraton Sioux Falls Hotel & Convention Center

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

8.6/10

Excellent

(1001)

"Clean room - comfy beds!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rhonda

CA $153

CA $171 total

includes taxes & fees

Nov 23 - Nov 24

[](https://www.expedia.ca/Sioux-Falls-Hotels-Sheraton-Sioux-Falls-Convention-Center.h118966.Hotel-Information)

![Room, 2 Queen Beds](https://images.trvl-media.com/lodging/4000000/3890000/3886300/3886239/1be1ec75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/4000000/3890000/3886300/3886239/05067e34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/4000000/3890000/3886300/3886239/1c1d99e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![32-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/4000000/3890000/3886300/3886239/92752fe2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Valley Inn

University Heights, 0.2 km from Sioux Empire Medical Museum

7.6/10

Good

(1006)

"Friendly staff and clean room."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

DeLaine

[](https://www.expedia.ca/Sioux-Falls-Hotels-Valley-Inn.h3886239.Hotel-Information)

![3 indoor pools, open 9:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/14200/14107/d8a57168.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/14200/14107/08b6bbb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Arcade](https://images.trvl-media.com/lodging/1000000/20000/14200/14107/1c831ee9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Food and drink](https://images.trvl-media.com/lodging/1000000/20000/14200/14107/b9c3f403.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

7.8/10

Good

(1412)

"Everything was great! Would stay there again next time i make it to Sioux Falls!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Judy

CA $83

CA $94 total

includes taxes & fees

Nov 16 - Nov 17

[](https://www.expedia.ca/Sioux-Falls-Hotels-Ramada-By-Wyndham-Sioux-Falls-Airport-Waterpark-Event-Ctr.h14107.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/58000000/57890000/57889400/57889349/a24c12e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, iron/ironing board, alarm clocks](https://images.trvl-media.com/lodging/58000000/57890000/57889400/57889349/f3e9512a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, iron/ironing board, alarm clocks](https://images.trvl-media.com/lodging/58000000/57890000/57889400/57889349/f6f21d78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, iron/ironing board, alarm clocks](https://images.trvl-media.com/lodging/58000000/57890000/57889400/57889349/9eb8ac3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Ramada by Wyndham Sioux Falls Arpt & Suites

Northwest Sioux Falls, 3 km from Sioux Empire Medical Museum

7.0/10

Good

(49)

"Great "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jorge

[](https://www.expedia.ca/Sioux-Falls-Hotels-Ramada-By-Sioux-Falls-Airport-Hotel-Suites.h57889349.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40700/40621/f8bdcdf0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40700/40621/76cea52f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/50000/40700/40621/4ba92d6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/40700/40621/a1ad628e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Ramada by Wyndham Sioux Falls

2.6 km from Sioux Empire Medical Museum

5.4/10

(1002)

"Close to I 29"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

David

CA $71

CA $81 total

includes taxes & fees

Nov 5 - Nov 6

[](https://www.expedia.ca/Sioux-Falls-Hotels-Ramada-By-Wyndham-Sioux-Falls.h40621.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/54000000/54000000/53992100/53992029/4accd249.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/54000000/54000000/53992100/53992029/fdb6b2e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/54000000/54000000/53992100/53992029/89ab6f8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, Lake View (2 Queen Beds)](https://images.trvl-media.com/lodging/54000000/54000000/53992100/53992029/ac0ce7ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt Place Sioux Falls South

Mall District, 3.7 km from Sioux Empire Medical Museum

9.4/10

Exceptional

(1025)

"Comfortable bed after a long trip, breakfast is good, I like the location"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Dulce ann

CA $163

CA $182 total

includes taxes & fees

Nov 9 - Nov 10

[](https://www.expedia.ca/Sioux-Falls-Hotels-Hyatt-Place-Sioux-Falls-South.h53992029.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/8000000/7730000/7726800/7726793/b4415201.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/8000000/7730000/7726800/7726793/4f3ca8ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/8000000/7730000/7726800/7726793/02f5a164.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/8000000/7730000/7726800/7726793/feb85953.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Quinta Inn & Suites by Wyndham Sioux Falls

Mall District, 4 km from Sioux Empire Medical Museum

9.2/10

Wonderful

(1548)

"Great place, clean , good food,"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Joanne

CA $114

CA $127 total

includes taxes & fees

Nov 30 - Dec 1

[](https://www.expedia.ca/Sioux-Falls-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Sioux-Falls.h7726793.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/21000000/20160000/20154600/20154580/c0f8d747.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/21000000/20160000/20154600/20154580/366c0a17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/21000000/20160000/20154600/20154580/dc7d28d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/21000000/20160000/20154600/20154580/1c571094.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn & Suites Sioux Falls - Airport by IHG

Northwest Sioux Falls, 3.4 km from Sioux Empire Medical Museum

9.2/10

Wonderful

(825)

"Loved that we got a free breakfast meal voucher for the restaurant attached!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Makella

CA $144

CA $160 total

includes taxes & fees

Nov 23 - Nov 24

[](https://www.expedia.ca/Sioux-Falls-Hotels-Holiday-Inn-Hotel-Suites-Sioux-Falls-Airport.h20154580.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1260000/1252800/1252731/546d8b44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/2000000/1260000/1252800/1252731/49f47bbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1260000/1252800/1252731/21132c7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/2000000/1260000/1252800/1252731/31e1681f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Staybridge Suites Sioux Falls by IHG

Mall District, 3.2 km from Sioux Empire Medical Museum

9.2/10

Wonderful

(1001)

"This is a very nice place to stay. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Margy

CA $149

CA $166 total

includes taxes & fees

Nov 28 - Nov 29

[](https://www.expedia.ca/Sioux-Falls-Hotels-Staybridge-Suites-Sioux-Falls.h1252731.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-13&endDate=2025-11-14&regionId=553248621532648850&adults=2&sort=RECOMMENDED&openPlayBack=true)

## Top Sioux Empire Medical Museum Hotel Reviews

![Comfort Inn & Suites at Sanford Sports Complex](//images.trvl-media.com/lodging/101000000/100320000/100310800/100310778/d6d757bd_y.jpg)

### Comfort Inn & Suites at Sanford Sports Complex

10/10 Excellent

"Easy peasy! Loved the check in!"

[](https://expedia.ca/Sioux-Falls-Hotels-Comfort-Inn-Suites-At-Sanford-Sports-Complex.h100310778.Hotel-Information)

![AmericInn by Wyndham Sioux Falls North](//images.trvl-media.com/lodging/33000000/32590000/32581500/32581411/09113cdb_y.jpg)

### AmericInn by Wyndham Sioux Falls North

10/10 Excellent

"First room smelled heavily of deodorizer. Dustin, the clerk, offered us another room which was completely acceptible. The next morning I asked another clerk if I could work out in the fitness room an hour early. He didn't have to, but was more than happy to help."

[](https://expedia.ca/Sioux-Falls-Hotels-AmericInn-By-Wyndham-Sioux-Falls-North.h32581411.Hotel-Information)

![Holiday Inn & Suites Sioux Falls - Airport by IHG](//images.trvl-media.com/lodging/21000000/20160000/20154600/20154580/c0f8d747_y.jpg)

### Holiday Inn & Suites Sioux Falls - Airport by IHG

10/10 Excellent

"I always stay here when I'm in Sioux Falls. I've never had a bad experience!"

[](https://expedia.ca/Sioux-Falls-Hotels-Holiday-Inn-Hotel-Suites-Sioux-Falls-Airport.h20154580.Hotel-Information)

![Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr](//images.trvl-media.com/lodging/1000000/20000/14200/14107/d8a57168_y.jpg)

### Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

10/10 Excellent

"Everything was great! Would stay there again next time i make it to Sioux Falls!"

[](https://expedia.ca/Sioux-Falls-Hotels-Ramada-By-Wyndham-Sioux-Falls-Airport-Waterpark-Event-Ctr.h14107.Hotel-Information)

![Days Inn by Wyndham Sioux Falls Empire](//images.trvl-media.com/lodging/1000000/10000/8300/8283/f89bacde_y.jpg)

### Days Inn by Wyndham Sioux Falls Empire

10/10 Excellent

"Thanks for my very comfortable stay. "

[](https://expedia.ca/Sioux-Falls-Hotels-Days-Inn-By-Wyndham-Sioux-Falls-Empire.h8283.Hotel-Information)

![Holiday Inn Sioux Falls-City Centre by IHG](//images.trvl-media.com/lodging/1000000/10000/4800/4722/34cad0f4_y.jpg)

### Holiday Inn Sioux Falls-City Centre by IHG

10/10 Excellent

"I really liked the bar and restaurant in the hotel. "

[](https://expedia.ca/Sioux-Falls-Hotels-Holiday-Inn-Sioux-Falls-City-Centre.h4722.Hotel-Information)

![Valley Inn](//images.trvl-media.com/lodging/4000000/3890000/3886300/3886239/1be1ec75_y.jpg)

### Valley Inn

10/10 Excellent

"My"

[](https://expedia.ca/Sioux-Falls-Hotels-Valley-Inn.h3886239.Hotel-Information)

![Clubhouse Hotel Suites Sioux Falls](//images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/4e13e753_y.jpg)

### Clubhouse Hotel Suites Sioux Falls

10/10 Excellent

"Only green apple for fresh fruit. Would loved to havè seen 1 or 2 more options. "

[](https://expedia.ca/Sioux-Falls-Hotels-Clubhouse-Hotel-Suites-Sioux-Falls.h1100190.Hotel-Information)

![Country Inn & Suites by Radisson, Sioux Falls, SD](//images.trvl-media.com/lodging/1000000/40000/34300/34225/9ba9d9dd_y.jpg)

### Country Inn & Suites by Radisson, Sioux Falls, SD

10/10 Excellent

"We would stay again, it was nice."

[](https://expedia.ca/Sioux-Falls-Hotels-Country-Inn-Suites-By-Radisson.h34225.Hotel-Information)

## Hotels near other Sioux Empire Medical Museum attractions

[](https://www.expedia.ca/Great-Plains-Zoo-Hotels.0-l6091003-0.Travel-Guide-Filter-Hotels)

### Great Plains Zoo

4.3/5 (74 reviews)

Why not visit the native and exotic animals who live at Great Plains Zoo during your travels in Sioux Falls? Attend a sporting event or discover the area's beautiful waterfalls.

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6091003)

[](https://www.expedia.ca/University-Of-Sioux-Falls-Hotels.0-l6090979-0.Travel-Guide-Filter-Hotels)

### University of Sioux Falls

4.1/5 (170 reviews)

Take a campus tour or just explore the area of University of Sioux Falls, during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6090979)

[](https://www.expedia.ca/Augustana-College-Hotels.0-l6150272-0.Travel-Guide-Filter-Hotels)

### Augustana College

4.0/5 (188 reviews)

Take a campus tour or just explore the area of Augustana College, during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6150272)

[](https://www.expedia.ca/Center-For-Western-Studies-Hotels.0-l553248621532648851-0.Travel-Guide-Filter-Hotels)

### Center for Western Studies

You can spend time browsing the exhibits at Center for Western Studies in Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648851)

[](https://www.expedia.ca/Delbridge-Museum-Of-Natural-History-Hotels.0-l6090987-0.Travel-Guide-Filter-Hotels)

### Delbridge Museum of Natural History

You can spend time exploring the galleries in Delbridge Museum of Natural History during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6090987)

[](https://www.expedia.ca/Washington-Pavilion-Of-Arts-And-Science-Hotels.0-l6090975-0.Travel-Guide-Filter-Hotels)

### Washington Pavilion of Arts and Science

4.7/5 (63 reviews)

You can enjoy a show at Washington Pavilion of Arts and Science on your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6090975)

[](https://www.expedia.ca/Pettigrew-Home-And-Museum-Hotels.0-l553248621532648852-0.Travel-Guide-Filter-Hotels)

### Pettigrew Home and Museum

You can spend time browsing the exhibits at Pettigrew Home and Museum during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648852)

[](https://www.expedia.ca/USS-South-Dakota-Battleship-Memorial-Hotels.0-l6091005-0.Travel-Guide-Filter-Hotels)

### USS South Dakota Battleship Memorial

Find out about the history of Sioux Falls with a stop at USS South Dakota Battleship Memorial. Attend a sporting event or discover the area's beautiful waterfalls.

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6091005)

## Frequently asked questions

### What's the area like around Sioux Empire Medical Museum?

> Sioux Empire Medical Museum is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, check out the 106 hotels and other accommodations you'll find within a mile.

### What's the best place to stay close to Sioux Empire Medical Museum?

> Adjacent to Sioux Empire Medical Museum, [Valley Inn](https://www.expedia.ca/Sioux-Falls-Hotels-Valley-Inn.h3886239.Hotel-Information) is one of the top choices for your stay based on our traveler data, and this hotel offers free parking and free WiFi. Another good choice is [Home2 Suites By Hilton Sioux Falls/Sanford Medical Center](https://www.expedia.ca/Sioux-Falls-Hotels-Home2-Suites-By-Hilton-Sioux-FallsSanford-Medical-Center.h9011875.Hotel-Information), located just 0.1 mi (0.2 km) away.

### How many hotels will I be able to find close to Sioux Empire Medical Museum?

> Expedia has 106 hotels and other accommodations within a mile from Sioux Empire Medical Museum.

### If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund?

> Yes, most hotel room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to review the best options available near Sioux Empire Medical Museum.

### What can I see and do near Sioux Empire Medical Museum?

> Washington Pavilion of Arts and Science, Center for Western Studies, and The Outdoor Campus feature a variety of fascinating exhibits to see while you're in town. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. You can wander around Sherman Park, Falls Park, or Veterans' Memorial Park if you want a dose of fresh air.

## Explore a world of travel with Expedia

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-   [Hotels with an Indoor Pool in Sioux Falls](https://www.expedia.ca/Sioux-Falls-Hotels-Hotels-With-Indoor-Pool.0-0-d6059512-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels)
-   [Hotels with Kitchenettes in Sioux Falls](https://www.expedia.ca/Sioux-Falls-Hotels-Hotels-With-Kitchenettes.0-0-d6059512-tHotelswithKitchenettes.Travel-Guide-Filter-Hotels)
-   [Hotels with Waterslides in Sioux Falls](https://www.expedia.ca/Sioux-Falls-Hotels-Hotels-With-Waterslides.0-0-d6059512-tHotelswithWaterslides.Travel-Guide-Filter-Hotels)
-   [Lake Hotels in Sioux Falls](https://www.expedia.ca/Sioux-Falls-Hotels-Lake-Hotels.0-0-d6059512-tLakeHotels.Travel-Guide-Filter-Hotels)
-   [Luxury Hotels in Sioux Falls](https://www.expedia.ca/Sioux-Falls-Hotels-Luxury-Hotel.0-0-d6059512-tLuxuryHotel.Travel-Guide-Filter-Hotels)
-   [Mountain Hotels in Sioux Falls](https://www.expedia.ca/Sioux-Falls-Hotels-Mountain-Hotels.0-0-d6059512-tMountainHotels.Travel-Guide-Filter-Hotels)
-   [Pet-Friendly Hotels in Sioux Falls](https://www.expedia.ca/Sioux-Falls-Hotels-Pet-Friendly-Hotel.0-0-d6059512-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
-   [Red Roof Inn Hotels in Sioux Falls](https://www.expedia.ca/Sioux-Falls-Hotels-Red-Roof-Inn.0-0-d6059512--bRedRoofInn.Travel-Guide-Filter-Hotels)
-   [Romantic Hotels in Sioux Falls](https://www.expedia.ca/Sioux-Falls-Hotels-Romantic-Hotel.0-0-d6059512-tRomanticHotel.Travel-Guide-Filter-Hotels)
-   [Spa Hotels in Sioux Falls](https://www.expedia.ca/Sioux-Falls-Hotels-Spa-Hotel.0-0-d6059512-tSpaHotel.Travel-Guide-Filter-Hotels)
-   [Waterpark Hotels in Sioux Falls](https://www.expedia.ca/Sioux-Falls-Hotels-Waterpark-Hotels.0-0-d6059512-tWaterparkHotels.Travel-Guide-Filter-Hotels)
-   [Hotel Wedding Venues Hotels in Sioux Falls](https://www.expedia.ca/Sioux-Falls-Hotels-Wedding-Hotels.0-0-d6059512-tWeddingHotels.Travel-Guide-Filter-Hotels)
-   [Wyndham Hotels in Sioux Falls](https://www.expedia.ca/Sioux-Falls-Hotels-Wyndham-Hotels.0-0-d6059512--bWyndhamHotels.Travel-Guide-Filter-Hotels)
-   [Sioux Falls Hotels](https://www.expedia.ca/Sioux-Falls-Hotels.d6059512.Travel-Guide-Hotels)
-   [Inns in Sioux Falls](https://www.expedia.ca/Sioux-Falls-Inns.d6059512-aaInns.Travel-Guide-Accommodation)
-   [Lodges in Sioux Falls](https://www.expedia.ca/Sioux-Falls-Lodges.d6059512-aaLodges.Travel-Guide-Accommodation)
-   [Motels in Sioux Falls](https://www.expedia.ca/Sioux-Falls-Motels.d6059512-aaMotels.Travel-Guide-Accommodation)
-   [Ranches in Sioux Falls](https://www.expedia.ca/Sioux-Falls-Ranches.d6059512-aaRanches.Travel-Guide-Accommodation)
-   [Hotels near Sioux Falls Regional](https://www.expedia.ca/Sioux-Falls-Regional-Airport-Hotels.0-aFSD-0.Travel-Guide-Filter-Hotels)
-   [Resorts in Sioux Falls](https://www.expedia.ca/Sioux-Falls-Resort-Hotels.d6059512-aaResortHotels.Travel-Guide-Accommodation)
-   [Treehouses in Sioux Falls](https://www.expedia.ca/Sioux-Falls-Treehouses.d6059512-aaTreehouses.Travel-Guide-Accommodation)
-   [South Sioux Falls Hotels](https://www.expedia.ca/South-Sioux-Falls-Hotels.d6059535.Travel-Guide-Hotels)
-   [Tea Hotels](https://www.expedia.ca/Tea-Hotels.d6346936.Travel-Guide-Hotels)
-   [Hotels near University of Sioux Falls](https://www.expedia.ca/University-Of-Sioux-Falls-Hotels.0-l6090979-0.Travel-Guide-Filter-Hotels)
-   [Pet-Friendly Hotels in West 10th Street](https://www.expedia.ca/West-10th-Street-Sioux-Falls-Hotels-Pet-Friendly-Hotel.0-n897425306103865344-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
-   [Hotels near Wild Water West](https://www.expedia.ca/Wild-Water-West-Hotels.0-l553248621532648845-0.Travel-Guide-Filter-Hotels)
-   [Worthing Hotels](https://www.expedia.ca/Worthing-Hotels.d553248634983094834.Travel-Guide-Hotels)

-   [Flights to Sioux Falls](https://www.expedia.ca/Cheap-Flights-To-Sioux-Falls.d6059512.Travel-Guide-Flights)
-   [Flights from Minnehaha County](https://www.expedia.ca/lp/flights/553248635976433608/flights-from-minnehaha-county)
-   [Flights from Sioux Falls](https://www.expedia.ca/lp/flights/6059512/flights-from-sioux-falls)

-   [Delbridge Museum of Natural History](https://www.expedia.ca/Delbridge-Museum-Of-Natural-History-Sioux-Falls.d6090987.Vacation-Attraction)
-   [Visit Folsom's Addition](https://www.expedia.ca/Sioux-Falls-Folsoms-Addition.dx553248635976473553)
-   [Visit McKennan Park](https://www.expedia.ca/Sioux-Falls-McKennan-Park.dx897425214072446976)
-   [Visit Pettigrew Heights](https://www.expedia.ca/Sioux-Falls-Pettigrew-Heights.dx897423859844915200)
-   [Sioux Falls Vacations](https://www.expedia.ca/Sioux-Falls.d6059512.Destination-Travel-Guides)
-   [Visit Sioux Falls](https://www.expedia.ca/Sioux-Falls.dx6059512)

-   [Car rental Sioux Falls](https://www.expedia.ca/Car-Rentals-In-Sioux-Falls.d6059512.Car-Rental-Guide)