Title: The 10 Best Hotels Near Sioux Empire Medical Museum, Sioux Falls from CA $79 | Expedia.ca

[University Heights Travel Guide](https://expedia.ca/Sioux-Falls-University-Heights.dx978416295039057920)[Sioux Empire Medical Museum Car Rentals](https://expedia.ca/Car-Rentals-In-Sioux-Empire-Medical-Museum.d553248621532648850.Car-Rental-Guide)[Sioux Empire Medical Museum Vacations](https://expedia.ca/Sioux-Empire-Medical-Museum-University-Heights.d553248621532648850.Vacation-Attraction)

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# Find hotels near Sioux Empire Medical Museum, Sioux Falls from CA $79

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## Check prices for these dates

Tonight

[Dec 15 - Dec 16](https://www.expedia.ca/Hotel-Search?regionId=553248621532648850&startDate=2025-12-15&endDate=2025-12-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Dec 16 - Dec 17](https://www.expedia.ca/Hotel-Search?regionId=553248621532648850&startDate=2025-12-16&endDate=2025-12-17&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248621532648850&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248621532648850&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Recommended

Price (low to high)

Distance

Star rating

## Our top choices for Sioux Empire Medical Museum hotels

![Terrace/patio](https://images.trvl-media.com/lodging/10000000/9020000/9011900/9011875/10270e0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/10000000/9020000/9011900/9011875/7ff68e14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 Bedroom, Non Smoking](https://images.trvl-media.com/lodging/10000000/9020000/9011900/9011875/w3840h2557x0y3-db64646b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Studio Suite, 1 King Bed, Non Smoking | Living area](https://images.trvl-media.com/lodging/10000000/9020000/9011900/9011875/w3837h2557x3y3-a3ae36e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

[](https://www.expedia.ca/Sioux-Falls-Hotels-Home2-Suites-By-Hilton-Sioux-FallsSanford-Medical-Center.h9011875.Hotel-Information)

University Heights, 0.2 km from Sioux Empire Medical Museum

9.4/10

Exceptional

(585)

"This is a great hotel - centrally located and very clean and quiet. Will definitely be staying there again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tracey

CA $142

CA $159 total

includes taxes & fees

Dec 22 - Dec 23

[](https://www.expedia.ca/Sioux-Falls-Hotels-Home2-Suites-By-Hilton-Sioux-FallsSanford-Medical-Center.h9011875.Hotel-Information)

![Interior detail](https://images.trvl-media.com/lodging/37000000/36450000/36447800/36447711/edd573eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Room, 1 King Bed, River View (Blarney Stone King)](https://images.trvl-media.com/lodging/37000000/36450000/36447800/36447711/19a1b775.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/37000000/36450000/36447800/36447711/93b8eb51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/37000000/36450000/36447800/36447711/31b10812.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel On Phillips

[](https://www.expedia.ca/Sioux-Falls-Hotels-Hotel-On-Phillips.h36447711.Hotel-Information)

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

9.6/10

Exceptional

(1297)

"Great staff and location!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gerald

[](https://www.expedia.ca/Sioux-Falls-Hotels-Hotel-On-Phillips.h36447711.Hotel-Information)

![Exterior detail](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/4f6166ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/4e8d1af3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/3e8532be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/e6f72405.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Clubhouse Hotel Suites Sioux Falls

[](https://www.expedia.ca/Sioux-Falls-Hotels-Clubhouse-Hotel-Suites-Sioux-Falls.h1100190.Hotel-Information)

Mall District, 2.8 km from Sioux Empire Medical Museum

9.4/10

Exceptional

(1003)

"Absolutely beautiful places to stay with family excellent service staff great food service great hospitality great "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rosario

[](https://www.expedia.ca/Sioux-Falls-Hotels-Clubhouse-Hotel-Suites-Sioux-Falls.h1100190.Hotel-Information)

![Meeting facility](https://images.trvl-media.com/lodging/105000000/104100000/104094900/104094801/282817a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/105000000/104100000/104094900/104094801/a83b67b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/105000000/104100000/104094900/104094801/2f8dce6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Presidential Suite, 1 Bedroom | Private kitchen](https://images.trvl-media.com/lodging/105000000/104100000/104094900/104094801/cf8c60fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Canopy By Hilton Sioux Falls Downtown

[](https://www.expedia.ca/Sioux-Falls-Hotels-Canopy-By-Hilton-Sioux-Falls-Downtown.h104094801.Hotel-Information)

Downtown Sioux Falls, 2.5 km from Sioux Empire Medical Museum

9.4/10

Exceptional

(156)

"Room was very clean, great overall stay."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Destiny

CA $180

CA $205 total

includes taxes & fees

Jan 1 - Jan 2, 2026

[](https://www.expedia.ca/Sioux-Falls-Hotels-Canopy-By-Hilton-Sioux-Falls-Downtown.h104094801.Hotel-Information)

![Meeting facility](https://images.trvl-media.com/lodging/7000000/6410000/6404700/6404700/w3837h2557x3y3-da1cbf43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lunch and dinner served, American cuisine](https://images.trvl-media.com/lodging/7000000/6410000/6404700/6404700/f7df70ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free cribs/infant beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/7000000/6410000/6404700/6404700/8fd379c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/7000000/6410000/6404700/6404700/w3836h2560x4y0-5db521c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hilton Garden Inn Sioux Falls Downtown

[](https://www.expedia.ca/Sioux-Falls-Hotels-Hilton-Garden-Inn-Sioux-Falls-Downtown.h6404700.Hotel-Information)

Downtown Sioux Falls, 2.1 km from Sioux Empire Medical Museum

9.0/10

Wonderful

(883)

"Friendly front desk staff, clean room, great location, safe "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Hannah

CA $140

CA $162 total

includes taxes & fees

Jan 4 - Jan 5, 2026

[](https://www.expedia.ca/Sioux-Falls-Hotels-Hilton-Garden-Inn-Sioux-Falls-Downtown.h6404700.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/80000/74500/74429/5eaeb99e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/80000/74500/74429/9beb2ccd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/80000/74500/74429/1421b1c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Two Queens Study Sofabed Nonsmoking](https://images.trvl-media.com/lodging/1000000/80000/74500/74429/ff09a66b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Sioux Falls

[](https://www.expedia.ca/Sioux-Falls-Hotels-Hampton-Inn-Sioux-Falls.h74429.Hotel-Information)

Mall District, 3.1 km from Sioux Empire Medical Museum

9.2/10

Wonderful

(1000)

"Great location and a friendly staff "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Dan

CA $134

CA $150 total

includes taxes & fees

Dec 26 - Dec 27

[](https://www.expedia.ca/Sioux-Falls-Hotels-Hampton-Inn-Sioux-Falls.h74429.Hotel-Information)

![Porch](https://images.trvl-media.com/lodging/46000000/45040000/45035200/45035119/e471ae53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/46000000/45040000/45035200/45035119/2fcb2d1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Garden](https://images.trvl-media.com/lodging/46000000/45040000/45035200/45035119/566cc0a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/46000000/45040000/45035200/45035119/07efade6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Historic Victorian Inn

[](https://www.expedia.ca/Sioux-Falls-Hotels-Historic-Victorian-Inn.h45035119.Hotel-Information)

Cathedral, 1.5 km from Sioux Empire Medical Museum

8.8/10

Excellent

(56)

"It was a great place to stay and super interesting."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kathy

CA $149

CA $186 total

includes taxes & fees

Dec 18 - Dec 19

[](https://www.expedia.ca/Sioux-Falls-Hotels-Historic-Victorian-Inn.h45035119.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4800/4722/c76521c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Presidential Suite, 1 King Bed](https://images.trvl-media.com/lodging/1000000/10000/4800/4722/6ecf1dd3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 King Bed with Sofa bed, City View](https://images.trvl-media.com/lodging/1000000/10000/4800/4722/815973f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/4800/4722/a50b7486.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Sioux Falls-City Centre by IHG

[](https://www.expedia.ca/Sioux-Falls-Hotels-Holiday-Inn-Sioux-Falls-City-Centre.h4722.Hotel-Information)

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

8.6/10

Excellent

(1002)

"Always a great stay. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Shawn

CA $125

CA $140 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/Sioux-Falls-Hotels-Holiday-Inn-Sioux-Falls-City-Centre.h4722.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/130000/127000/126929/835a882c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/130000/127000/126929/c4b07f10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed, Accessible Bathtub, Non Smoking (Communications, Mobility)](https://images.trvl-media.com/lodging/1000000/130000/127000/126929/edd7efef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/130000/127000/126929/93743ca6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

[](https://www.expedia.ca/Sioux-Falls-Hotels-Holiday-Inn-Express-Suites-Sioux-Falls-At-Empire-Mall.h126929.Hotel-Information)

Mall District, 3.1 km from Sioux Empire Medical Museum

8.8/10

Excellent

(1001)

"Breakfast good, staff very accommodating and friendly. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Geraldine

CA $176

CA $196 total

includes taxes & fees

Jan 4 - Jan 5, 2026

[](https://www.expedia.ca/Sioux-Falls-Hotels-Holiday-Inn-Express-Suites-Sioux-Falls-At-Empire-Mall.h126929.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34300/34225/9ba9d9dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hypo-allergenic bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/40000/34300/34225/59d8aa71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/40000/34300/34225/96cc4a2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/1000000/40000/34300/34225/46626862.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Country Inn & Suites by Radisson, Sioux Falls, SD

[](https://www.expedia.ca/Sioux-Falls-Hotels-Country-Inn-Suites-By-Radisson.h34225.Hotel-Information)

Downtown Sioux Falls, 2 km from Sioux Empire Medical Museum

8.4/10

Very good

(1153)

"It was a great place to stay!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Trinity

CA $133

CA $149 total

includes taxes & fees

Jan 4 - Jan 5, 2026

[](https://www.expedia.ca/Sioux-Falls-Hotels-Country-Inn-Suites-By-Radisson.h34225.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/120000/119000/118966/c06c9122.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/120000/119000/118966/247f7239.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, down comforters, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/120000/119000/118966/bd8a3927.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/120000/119000/118966/880f9dee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Sheraton Sioux Falls Hotel & Convention Center

[](https://www.expedia.ca/Sioux-Falls-Hotels-Sheraton-Sioux-Falls-Convention-Center.h118966.Hotel-Information)

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

8.6/10

Excellent

(1000)

"Great hotel. Staff was excellent "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kristina

CA $133

CA $149 total

includes taxes & fees

Jan 4 - Jan 5, 2026

[](https://www.expedia.ca/Sioux-Falls-Hotels-Sheraton-Sioux-Falls-Convention-Center.h118966.Hotel-Information)

![Suite 2 Queens, Recliner, Pullout Sofa](https://images.trvl-media.com/lodging/60000000/59830000/59829700/59829643/ea709935.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Handi 1 queen, MF, Recliner](https://images.trvl-media.com/lodging/60000000/59830000/59829700/59829643/3c5850aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/60000000/59830000/59829700/59829643/2e93ca6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/60000000/59830000/59829700/59829643/2f94c1d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Center Inn

[](https://www.expedia.ca/Sioux-Falls-Hotels-The-Center-Inn.h59829643.Hotel-Information)

All Saints, 2.4 km from Sioux Empire Medical Museum

8.4/10

Very good

(701)

"Clean room and friendly staff."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Betty

[](https://www.expedia.ca/Sioux-Falls-Hotels-The-Center-Inn.h59829643.Hotel-Information)

![Basic Studio, 1 King Bed](https://images.trvl-media.com/lodging/4000000/3890000/3886300/3886239/38fc7edf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/4000000/3890000/3886300/3886239/05067e34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/4000000/3890000/3886300/3886239/24e9ff66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![32-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/4000000/3890000/3886300/3886239/92752fe2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Valley Inn

[](https://www.expedia.ca/Sioux-Falls-Hotels-Valley-Inn.h3886239.Hotel-Information)

University Heights, 0.2 km from Sioux Empire Medical Museum

7.6/10

Good

(1001)

"Room was clean, staff was friendly, very convenient location "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Theresa

[](https://www.expedia.ca/Sioux-Falls-Hotels-Valley-Inn.h3886239.Hotel-Information)

![3 indoor pools, open 9:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/14200/14107/fe163ebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 2 Bedrooms, Non Smoking (1 King Bed and 2 Queen Beds) | Living room](https://images.trvl-media.com/lodging/1000000/20000/14200/14107/6f285d9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/1000000/20000/14200/14107/7248bace.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/14200/14107/8735dc1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

[](https://www.expedia.ca/Sioux-Falls-Hotels-Ramada-By-Wyndham-Sioux-Falls-Airport-Waterpark-Event-Ctr.h14107.Hotel-Information)

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

7.8/10

Good

(1461)

"staff was friendly "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rob

CA $82

CA $93 total

includes taxes & fees

Dec 18 - Dec 19

[](https://www.expedia.ca/Sioux-Falls-Hotels-Ramada-By-Wyndham-Sioux-Falls-Airport-Waterpark-Event-Ctr.h14107.Hotel-Information)

![50-inch flat-screen TV with cable channels, fireplace, Netflix](https://images.trvl-media.com/lodging/101000000/100460000/100456000/100455928/cc5b60f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining room](https://images.trvl-media.com/lodging/101000000/100460000/100456000/100455928/5fb9fa52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/101000000/100460000/100456000/100455928/c8a90a6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/101000000/100460000/100456000/100455928/77757565.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Historic Twin Tudors Inn

[](https://www.expedia.ca/Sioux-Falls-Hotels-Historic-Twin-Tudors-Inn-Mc-Kennan-Park.h100455928.Hotel-Information)

1.4 km from Sioux Empire Medical Museum

8.8/10

Excellent

(3)

"Lovely place! Wish we could have stayed longer. Steve was attentive and helpful. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Anonymous traveller

CA $371

CA $420 total

includes taxes & fees

Dec 16 - Dec 17

[](https://www.expedia.ca/Sioux-Falls-Hotels-Historic-Twin-Tudors-Inn-Mc-Kennan-Park.h100455928.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/58000000/57890000/57889400/57889349/f71c8bcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, iron/ironing board, alarm clocks](https://images.trvl-media.com/lodging/58000000/57890000/57889400/57889349/bfd7245a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/58000000/57890000/57889400/57889349/a1c640d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/58000000/57890000/57889400/57889349/51fb710c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Ramada by Wyndham Sioux Falls Arpt & Suites

[](https://www.expedia.ca/Sioux-Falls-Hotels-Ramada-By-Sioux-Falls-Airport-Hotel-Suites.h57889349.Hotel-Information)

Northwest Sioux Falls, 3 km from Sioux Empire Medical Museum

7.0/10

Good

(51)

"Great "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jorge

[](https://www.expedia.ca/Sioux-Falls-Hotels-Ramada-By-Sioux-Falls-Airport-Hotel-Suites.h57889349.Hotel-Information)

![Double Room, 2 Queen Beds](https://images.trvl-media.com/lodging/121000000/120710000/120706800/120706759/24bd8fd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/121000000/120710000/120706800/120706759/8b0ea35c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/121000000/120710000/120706800/120706759/bf2b57f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Single Room, 1 King Bed | Reception](https://images.trvl-media.com/lodging/121000000/120710000/120706800/120706759/576b00bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Highpoint Hotel

[](https://www.expedia.ca/Sioux-Falls-Hotels-Highpoint-Hotel.h120706759.Hotel-Information)

University Heights, 0.2 km from Sioux Empire Medical Museum

CA $232

CA $257 total

includes taxes & fees

Dec 22 - Dec 23

[](https://www.expedia.ca/Sioux-Falls-Hotels-Highpoint-Hotel.h120706759.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40700/40621/f8bdcdf0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/40700/40621/a1ad628e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40700/40621/76cea52f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/50000/40700/40621/4ba92d6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Ramada by Wyndham Sioux Falls

[](https://www.expedia.ca/Sioux-Falls-Hotels-Ramada-By-Wyndham-Sioux-Falls.h40621.Hotel-Information)

2.6 km from Sioux Empire Medical Museum

5.6/10

(1001)

"Good room for the price."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Michael

CA $69

CA $79 total

includes taxes & fees

Dec 23 - Dec 24

[](https://www.expedia.ca/Sioux-Falls-Hotels-Ramada-By-Wyndham-Sioux-Falls.h40621.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/21000000/20160000/20154600/20154580/c0f8d747.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/21000000/20160000/20154600/20154580/1c571094.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/21000000/20160000/20154600/20154580/25e69854.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/21000000/20160000/20154600/20154580/43b129df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn & Suites Sioux Falls - Airport by IHG

[](https://www.expedia.ca/Sioux-Falls-Hotels-Holiday-Inn-Hotel-Suites-Sioux-Falls-Airport.h20154580.Hotel-Information)

Northwest Sioux Falls, 3.4 km from Sioux Empire Medical Museum

9.2/10

Wonderful

(838)

"I wish they a continental breakfast. I believe its because there's a restaurant next door. Otherwise, our stay was wonderful."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Julie

CA $136

CA $152 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/Sioux-Falls-Hotels-Holiday-Inn-Hotel-Suites-Sioux-Falls-Airport.h20154580.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/54000000/54000000/53992100/53992029/4accd249.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/54000000/54000000/53992100/53992029/7e85057e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/54000000/54000000/53992100/53992029/03970b6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/54000000/54000000/53992100/53992029/89ab6f8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt Place Sioux Falls South

[](https://www.expedia.ca/Sioux-Falls-Hotels-Hyatt-Place-Sioux-Falls-South.h53992029.Hotel-Information)

Mall District, 3.7 km from Sioux Empire Medical Museum

9.4/10

Exceptional

(1003)

"Great location for travel. Various dining options close by."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Russell

CA $161

CA $180 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/Sioux-Falls-Hotels-Hyatt-Place-Sioux-Falls-South.h53992029.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-29&endDate=2025-12-30&regionId=553248621532648850&adults=2&sort=RECOMMENDED&openPlayBack=true)

## Top Sioux Empire Medical Museum Hotel Reviews

![La Quinta Inn & Suites by Wyndham Sioux Falls](https://images.trvl-media.com/lodging/8000000/7730000/7726800/7726793/b4415201_y.jpg)

### La Quinta Inn & Suites by Wyndham Sioux Falls

10/10 Excellent

"Spotless, friendly staff, even a happy hour..nice touch. Friendly to our dog as well. Perkins across the parking lot for nice inexpensive meals! Small enough that no one parks that far from a door.,plots of carts available to bring things to your room.."

[](https://expedia.ca/Sioux-Falls-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Sioux-Falls.h7726793.Hotel-Information)

![AeroStay Hotel](https://images.trvl-media.com/lodging/12000000/11270000/11268300/11268258/32d35456_y.jpg)

### AeroStay Hotel

10/10 Excellent

"Yes"

[](https://expedia.ca/Sioux-Falls-Hotels-AeroStay-Hotel.h11268258.Hotel-Information)

![Hilton Garden Inn Sioux Falls Downtown](https://images.trvl-media.com/lodging/7000000/6410000/6404700/6404700/31e53656_y.jpg)

### Hilton Garden Inn Sioux Falls Downtown

10/10 Excellent

"Friendly front desk staff, clean room, great location, safe "

[](https://expedia.ca/Sioux-Falls-Hotels-Hilton-Garden-Inn-Sioux-Falls-Downtown.h6404700.Hotel-Information)

![Country Inn & Suites by Radisson, Sioux Falls, SD](https://images.trvl-media.com/lodging/1000000/40000/34300/34225/9ba9d9dd_y.jpg)

### Country Inn & Suites by Radisson, Sioux Falls, SD

10/10 Excellent

"Good"

[](https://expedia.ca/Sioux-Falls-Hotels-Country-Inn-Suites-By-Radisson.h34225.Hotel-Information)

![Cozy, 2-bedroom vacation home. 1 mile to DT: Hot Tub, 86" TV, Golf & Fenced Yard](https://images.trvl-media.com/lodging/72000000/71760000/71755400/71755342/97026395_y.jpg)

### Cozy, 2-bedroom vacation home. 1 mile to DT: Hot Tub, 86" TV, Golf & Fenced Yard

10/10 Excellent

"Nice, clean, cozy home. Quiet neighborhood and best stocked kitchen I’ve seen yet!"

[](https://expedia.ca/Sioux-Falls-Hotels-The-Lounge.h71755342.Hotel-Information)

![Hampton Inn Sioux Falls](https://images.trvl-media.com/lodging/1000000/80000/74500/74429/ceab3d5c_y.jpg)

### Hampton Inn Sioux Falls

10/10 Excellent

"YES"

[](https://expedia.ca/Sioux-Falls-Hotels-Hampton-Inn-Sioux-Falls.h74429.Hotel-Information)

![Clubhouse Hotel Suites Sioux Falls](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/4e13e753_y.jpg)

### Clubhouse Hotel Suites Sioux Falls

10/10 Excellent

"Absolutely beautiful places to stay with family excellent service staff great food service great hospitality great "

[](https://expedia.ca/Sioux-Falls-Hotels-Clubhouse-Hotel-Suites-Sioux-Falls.h1100190.Hotel-Information)

![Hotel On Phillips](https://images.trvl-media.com/lodging/37000000/36450000/36447800/36447711/edd573eb_y.jpg)

### Hotel On Phillips

10/10 Excellent

"Clean, beautiful room. Great bar inside hotel. "

[](https://expedia.ca/Sioux-Falls-Hotels-Hotel-On-Phillips.h36447711.Hotel-Information)

![Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr](https://images.trvl-media.com/lodging/1000000/20000/14200/14107/d8a57168_y.jpg)

### Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

10/10 Excellent

"We had a great stay in our poolside room! Everyone enjoyed the pool!"

[](https://expedia.ca/Sioux-Falls-Hotels-Ramada-By-Wyndham-Sioux-Falls-Airport-Waterpark-Event-Ctr.h14107.Hotel-Information)

## Hotels near other Sioux Empire Medical Museum attractions

### Great Plains Zoo

4.3/5 (74 reviews)

Why not visit the native and exotic animals who live at Great Plains Zoo during your travels in Sioux Falls? Attend a sporting event or discover the area's beautiful waterfalls. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6091003)

### University of Sioux Falls

4.1/5 (170 reviews)

Take a campus tour or just explore the area of University of Sioux Falls, during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6090979)

### Augustana College

4.0/5 (188 reviews)

Take a campus tour or just explore the area of Augustana College, during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6150272)

### Center for Western Studies

You can spend time browsing the exhibits at Center for Western Studies in Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648851)

### Delbridge Museum of Natural History

You can spend time exploring the galleries in Delbridge Museum of Natural History during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6090987)

### Washington Pavilion of Arts and Science

4.7/5 (63 reviews)

You can enjoy a show at Washington Pavilion of Arts and Science on your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6090975)

### Pettigrew Home and Museum

You can spend time browsing the exhibits at Pettigrew Home and Museum during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648852)

### USS South Dakota Battleship Memorial

Find out about the history of Sioux Falls with a stop at USS South Dakota Battleship Memorial. Attend a sporting event or discover the area's beautiful waterfalls. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6091005)

## Frequently asked questions

### What's the area like around Sioux Empire Medical Museum?

### What's the best place to stay close to Sioux Empire Medical Museum?

### How many hotels will I be able to find close to Sioux Empire Medical Museum?

### If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund?

### What can I see and do near Sioux Empire Medical Museum?

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- [Hotels with Waterslides in Sioux Falls ](https://www.expedia.ca/Sioux-Falls-Hotels-Hotels-With-Waterslides.0-0-d6059512-tHotelswithWaterslides.Travel-Guide-Filter-Hotels)
- [Lake Hotels in Sioux Falls ](https://www.expedia.ca/Sioux-Falls-Hotels-Lake-Hotels.0-0-d6059512-tLakeHotels.Travel-Guide-Filter-Hotels)
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- [Sioux Falls Hotels ](https://www.expedia.ca/Sioux-Falls-Hotels.d6059512.Travel-Guide-Hotels)
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- [Tea Hotels ](https://www.expedia.ca/Tea-Hotels.d6346936.Travel-Guide-Hotels)
- [Hotels near University of Sioux Falls ](https://www.expedia.ca/University-Of-Sioux-Falls-Hotels.0-l6090979-0.Travel-Guide-Filter-Hotels)
- [Pet-Friendly Hotels in West 10th Street ](https://www.expedia.ca/West-10th-Street-Sioux-Falls-Hotels-Pet-Friendly-Hotel.0-n897425306103865344-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
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- [Flights to Sioux Falls ](https://www.expedia.ca/Cheap-Flights-To-Sioux-Falls.d6059512.Travel-Guide-Flights)
- [Flights from Minnehaha County ](https://www.expedia.ca/lp/flights/553248635976433608/flights-from-minnehaha-county)
- [Flights from Sioux Falls ](https://www.expedia.ca/lp/flights/6059512/flights-from-sioux-falls)

- [Delbridge Museum of Natural History ](https://www.expedia.ca/Delbridge-Museum-Of-Natural-History-Sioux-Falls.d6090987.Vacation-Attraction)
- [Visit Folsom's Addition ](https://www.expedia.ca/Sioux-Falls-Folsoms-Addition.dx553248635976473553)
- [Visit McKennan Park ](https://www.expedia.ca/Sioux-Falls-McKennan-Park.dx897425214072446976)
- [Visit Pettigrew Heights ](https://www.expedia.ca/Sioux-Falls-Pettigrew-Heights.dx897423859844915200)
- [Sioux Falls Vacations ](https://www.expedia.ca/Sioux-Falls.d6059512.Destination-Travel-Guides)
- [Visit Sioux Falls ](https://www.expedia.ca/Sioux-Falls.dx6059512)

- [Car rental Sioux Falls ](https://www.expedia.ca/Car-Rentals-In-Sioux-Falls.d6059512.Car-Rental-Guide)