Title: Book the Best BUSINESS Hotels in Sikeston in 2025 | Expedia.ca [Hotels in Sikeston](https://expedia.ca/Sikeston-Hotels.d6058766.Travel-Guide-Hotels)[Vacation Rentals in Sikeston](https://expedia.ca/Sikeston-Vacation-Rentals.d6058766.Travel-Guide-VacationRentals)[Flights to Sikeston](https://expedia.ca/Cheap-Flights-To-Sikeston.d6058766.Travel-Guide-Flights)[Sikeston Car Rentals](https://expedia.ca/Car-Rentals-In-Sikeston.d6058766.Car-Rental-Guide)[Sikeston Vacation Packages](https://expedia.ca/Sikeston.d6058766.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/798fcf2b70d51325aa2ef18edc87befc.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Ryan Coleman # Find Business Hotels in Sikeston, MO from CA $110 ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Sikeston Business Hotels Tonight [Sep 30 - Oct 1](https://www.expedia.ca/Hotel-Search?regionId=6058766&startDate=2025-09-30&endDate=2025-10-01&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 1 - Oct 2](https://www.expedia.ca/Hotel-Search?regionId=6058766&startDate=2025-10-01&endDate=2025-10-02&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6058766&startDate=2025-10-03&endDate=2025-10-05&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6058766&startDate=2025-10-10&endDate=2025-10-12&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Sikeston Business Hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/fbb12bb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/d0828685.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/132cb18c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Jackson MO Jackson 9.6/10 Exceptional (1020) "Was a clean room, nice staff, good parking " CA $125 CA $132 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/ff050f85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/3c8c0a82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/e3fbcab1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/8fe6deab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pear Tree Inn Sikeston Sikeston 9.4/10 Exceptional (1008) "I love this hotel! Have stayed several times and will definitely stay again. The rooms are always very clean and the staff is so friendly and helpful. I highly recommend this hotel!" CA $107 CA $123 total includes taxes & fees Oct 4 - Oct 5 [](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/16f1820b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/2d914387.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/c279dc08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel Cape Girardeau Conference Center Cape Girardeau 9.6/10 Exceptional (1023) "Clean, friendly staff and business friendly " CA $125 CA $141 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Queen Beds, Accessible, Refrigerator & Microwave (Tub)](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/0941dc05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/f737107e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/ea01e15a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Sikeston, MO Sikeston 9.4/10 Exceptional (1016) "Everything was extremely nice" CA $125 CA $144 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/68f46185.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds | Room amenity](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/d42a6e3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/668f3d2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/1d457549.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Perryville by IHG Perryville 9.4/10 Exceptional (513) "The property was well maintained. Checkin was fast and efficient. Room was clean and comfortable and pillows were great. Breakfast was good. " CA $118 CA $135 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/05fcda41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Single Room, 1 King Bed, Non Smoking (Mobility, Bathtub w/Grab Bars)](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/67f5d6f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/8571b84d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau Jackson 8.8/10 Excellent (629) "Friendly staff, very clean and pleasant environment." CA $117 CA $127 total includes taxes & fees Oct 2 - Oct 3 [](https://www.expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![Business centre](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/c56432e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/05f90b2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/356238c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Cape Girardeau Cape Girardeau 9.4/10 Exceptional (1006) "Excellent place. Really friendly staff" CA $125 CA $141 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 8 AM to 11 PM, sun loungers](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/64fb9857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/479dc559.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/eb2507f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG Cape Girardeau 9.4/10 Exceptional (1008) "It was right off the interstate with lots of restaurant options " CA $132 CA $149 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/347bcd98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/ac6f4af6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/51a3fe78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/266a85bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Cape Girardeau Cape Girardeau 9.4/10 Exceptional (129) "Excellent hotel…" CA $129 CA $146 total includes taxes & fees Oct 9 - Oct 10 [](https://www.expedia.ca/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/540ce58d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/cfaba55a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/acc0b9b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/0578314a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Cape Girardeau I 55 East Cape Girardeau 9.6/10 Exceptional (748) "Would prefer onsite restaurant and bar" CA $153 CA $172 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-14&endDate=2025-10-15®ionId=6058766&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Sikeston Hotel Reviews ![Best Western Plus Sikeston](//images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg) ### Best Western Plus Sikeston 10/10 Excellent "Very convenient and great breakfast " [](https://expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) ![Drury Inn & Suites Sikeston, MO](//images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg) ### Drury Inn & Suites Sikeston, MO 10/10 Excellent "Don’t even bother staying anywhere else. Hands down the best in Sikeston." [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Pear Tree Inn Cape Girardeau West](//images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg) ### Pear Tree Inn Cape Girardeau West 10/10 Excellent "Everything was clean and looked newly renovated. Staff was friendly. Parking was convenient and the area seemed safe. " [](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Drury Plaza Hotel Cape Girardeau Conference Center](//images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg) ### Drury Plaza Hotel Cape Girardeau Conference Center 10/10 Excellent "Very, Very nice. Always, first think I look at is landscaping. It foretells that attitude of the hotel. Drury of the Cape was nicely done, well maintained and fresh. Ok, good start. Start check in and Travelocity computer was not up to speed with Drury's. Desk person got manager, sorted it in just a few short minutes, with a smile the whole time, and up to my room. Room was immaculate, well appointed, nicely decorated, and just plain comfortable. Relaxed a few minutes in the comfortable chair and went down for complimentary dinner. No gigantic spread but, way more than I expected and very tasty. Eveything about my stay was over the top for the price I paid. Everyone working there seemed happy and smiling genuinely.Absolutely one of the nicest hotels I've ever stayed in. This company has the right idea on providing service while not trying to rob you at the same time. Thank You!" [](https://expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Drury Inn & Suites Jackson MO](//images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg) ### Drury Inn & Suites Jackson MO 10/10 Excellent "this place is awesome! evening snacks and drinks (a meal really!) and very nice breakfast comfortable bed and beautiful grounds-quite rural, but Dairy Queen across the road. easy and safe seeming parking " [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![Holiday Inn Express & Suites Sikeston Southwest by IHG](//images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/3aa729da_y.jpg) ### Holiday Inn Express & Suites Sikeston Southwest by IHG 10/10 Excellent "Clean and nice facilities. All the staff we met were friendly and helpful. Breakfast was great." [](https://expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information) ![Pear Tree Inn Sikeston](//images.trvl-media.com/lodging/1000000/20000/19300/19205/ff050f85_y.jpg) ### Pear Tree Inn Sikeston 10/10 Excellent "Very comfortable bed for people with back issues" [](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information) ![Days Inn and Suites by Wyndham Sikeston](//images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg) ### Days Inn and Suites by Wyndham Sikeston 10/10 Excellent "Spacious room " [](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Sikeston cost? > Expect to pay between CA $110 and CA $149 per night for business-friendly hotels in Sikeston. Awesome deals on stays that are suitable for corporate travellers are only a click away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply. ### What are the best business-friendly hotels in Sikeston? > There are multiple business-friendly hotels in Sikeston that have a total average guest review rating of 9.3. [Drury Inn & Suites Sikeston, MO](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) is a favourite with many corporate travellers. This 3-stars property features amenities such as a swimming pool and complimentary breakfast. [Pear Tree Inn Sikeston](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information) is another sought-after option. It has a 2.5-stars rating and conveniences including a swimming pool and a spa tub. ### How many business-friendly hotels are there in Sikeston? > When your job takes you to Sikeston, there are 19 business-friendly hotels to choose from. These properties combine a favourable location with the amenities corporate travellers need. ### What are the best cheap business-friendly hotels in Sikeston? > Cut costs on your next work trip to Sikeston by choosing one of our business-friendly hotels that start from CA $110 per night. One cheap property is [Pear Tree Inn Sikeston](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information), which comes with useful amenities like a swimming pool and a spa tub. [Best Western Plus Sikeston](https://www.expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) is another popular pick for corporate travellers on a tight budget. It has a swimming pool and WiFi. However, your Sikeston visit shouldn't be all work and no play. Find time to explore some fun and free attractions, such as [Sikeston Depot Museum](https://www.expedia.ca/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction) and [Central Park](https://www.expedia.ca/Central-Park-Sikeston.d6305608.Vacation-Attraction). This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply. ### Are there any family-friendly hotels in Sikeston that are also business friendly? > [Drury Inn & Suites Sikeston, MO](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) appeals to leisure and business guests alike. Complimentary breakfast and WiFi are just two of the amenities you'll find at this 3-stars Sikeston stay. Alternatively, vacation with the kids and work on the road at [Pear Tree Inn Sikeston](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information). You'll have use of conveniences such as complimentary breakfast and housekeeping services at this comfortable 2.5-stars option. Once you've gotten work out of the way, there are plenty of family-friendly attractions to explore around Sikeston. [Sikeston Depot Museum](https://www.expedia.ca/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction) and [Central Park](https://www.expedia.ca/Central-Park-Sikeston.d6305608.Vacation-Attraction) are two popular options. ### Why book your business-friendly hotel in Sikeston with Expedia? > With conveniences like conference rooms, room service and free WiFi, our business-friendly properties come with all you'll need to settle your important deal — and then relax! Enter your destination and travel dates and Expedia will help you plan the rest. ### How can I find cheap business-friendly hotels in Sikeston? > When work takes you on the road in Sikeston, our "business friendly" filter will help you find the ideal hotel. From free WiFi and included breakfast to meeting rooms and work desks, they have the amenities you need to get the job done. You can also narrow your search by your preferred star rating and budget to see the cheapest options. ### What is there to do in Sikeston near my business-friendly hotel? > The perfect travel accessory is a well-thought-out travel plan. [Sikeston Depot Museum](https://www.expedia.ca/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction) is a good place to kick-start your exploration of Sikeston. ## Explore a world of travel with Expedia - Lodging - Flights - Cars - More ways to book - [B&B in Advance](https://www.expedia.ca/Advance-Bed-And-Breakfast.d553248634983475122-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Cheap Hotels in Advance](https://www.expedia.ca/Advance-Hotels-Cheap-Hotels.0-0-d553248634983475122-tCheapHotels.Travel-Guide-Filter-Hotels) - [Advance Hotels](https://www.expedia.ca/Advance-Hotels.d553248634983475122.Travel-Guide-Hotels) - [Lodges in Advance](https://www.expedia.ca/Advance-Lodges.d553248634983475122-aaLodges.Travel-Guide-Accommodation) - [Motels in Advance](https://www.expedia.ca/Advance-Motels.d553248634983475122-aaMotels.Travel-Guide-Accommodation) - [Apartments in Baker](https://www.expedia.ca/Baker-Apartments.d553248634983252914-aaApartments.Travel-Guide-Accommodation) - [Apartments in Bell City](https://www.expedia.ca/Bell-City-Apartments.d553248634983588961-aaApartments.Travel-Guide-Accommodation) - 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