Title: Book the Best Serra Mesa LUXURY Hotels - Upscale Hotels in Serra Mesa, San Diego | Expedia.ca [Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Serra Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Serra-Mesa.d553248635953501652.Car-Rental-Guide)[Serra Mesa Vacations](https://expedia.ca/Serra-Mesa.d553248635953501652.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/luxury.jpeg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Luxury Hotels in Serra Mesa, San Diego - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Serra Mesa Luxury Hotels Tonight [Nov 12 - Nov 13](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-11-12&endDate=2025-11-13&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Nov 13 - Nov 14](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-11-13&endDate=2025-11-14&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-11-14&endDate=2025-11-16&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Nov 21 - Nov 23](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-11-21&endDate=2025-11-23&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Serra Mesa Luxury Hotels ## Top Serra Mesa Hotel Reviews ![Pendry San Diego](//images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05d0e601_y.jpg) ### Pendry San Diego 10/10 Excellent "I had a really good time staying at the Pendry. The rooms were nice and clean. Service was great. We had a little issue with a clogged sink, but we called the front desk. Took care of it immediately. I would say if you touch anything in the." [](https://expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) ![The Dana on Mission Bay](//images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg) ### The Dana on Mission Bay 10/10 Excellent "Quiet, clean, amazing location, friendly staff" [](https://expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![Loews Coronado Bay Resort](//images.trvl-media.com/lodging/1000000/30000/25900/25840/c2d82864_y.jpg) ### Loews Coronado Bay Resort 10/10 Excellent "I love this hotel so much. " [](https://expedia.ca/Coronado-Hotels-Loews-Coronado-Bay-Resort.h25840.Hotel-Information) ![Comfort Inn Sea World Area](//images.trvl-media.com/lodging/1000000/550000/544700/544662/44f458a2_y.jpg) ### Comfort Inn Sea World Area 10/10 Excellent "This is a great Motel. Spacious rooms. Very clean, comfy beds. Great showers. Off street parking with a security guard at night. Close to shops, takeaways, even a couple of good restaurants, Target, Ralphs etc all within walking distance. Includes breakfast with your stay. It has a gym, reverse osmosis water machine and laundry onsite. Wonderful, helpful and very courteous staff. Even a grassy area out back for the kids to sit in the sun. The price is right, and plus it's about 10 or 15 minutes from the Airport. What's not to like? For the last 2 years this has been my number 1 choice to stay in San Diego." [](https://expedia.ca/San-Diego-Hotels-Comfort-Inn-Sea-World-Area.h544662.Hotel-Information) ![Hard Rock Hotel San Diego](//images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "The room was extremely clean, and they came by daily and refreshed it completely. Very nice !! " [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Sheraton San Diego Resort](//images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg) ### Sheraton San Diego Resort 10/10 Excellent "Clean. Bed was comfy. Check great" [](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Hotel-And-Marina.h11109.Hotel-Information) ![Hotel del Coronado, Curio Collection by Hilton](//images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg) ### Hotel del Coronado, Curio Collection by Hilton 10/10 Excellent "Gorgeous facility and wonderful staff! " [](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![Handlery Hotel](//images.trvl-media.com/lodging/1000000/10000/8400/8374/ab6ccd55_y.jpg) ### Handlery Hotel 10/10 Excellent "Found this hotel a couple years back when an event I attended was scheduled there, and have stayed there a handful of times since then. You really can't beat the room price, nothing fancy but clean and quiet with a pleasant atmosphere. Nice for a staycation.The only negative is that they started charging $24 per night for parking, which seems like lot. " [](https://expedia.ca/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) ![The Sofia Hotel](//images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/ba6cea84_y.jpg) ### The Sofia Hotel 10/10 Excellent "Good " [](https://expedia.ca/San-Diego-Hotels-The-Sofia-Hotel.h1573807.Hotel-Information) ## Frequently asked questions ### Are you looking for a luxury hotel for your Serra Mesa vacation? > Use Expedia to arrange your flight to San Diego, CA (MYF-Montgomery Field) airport or San Diego Intl. Airport (SAN) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to get what you'd like to make your stay special. If you want an upscale hotel with fine dining, a spa, or several swimming pools, Expedia can assist you in finding the best luxury hotel experience that Serra Mesa has to offer. Serra Mesa has some interesting things to see and do including Stadium Golf Center & Batting Cages, so you might want to take in the local sights during your visit. ### What's there to see and do in Serra Mesa? > Take in the sights and attractions that Serra Mesa offers with a visit to San Diego Zoo, Mission Bay, and Marine Corps Recruit Depot. 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