Title: Hotels by La Quinta Inn & Suites in Serra Mesa from CA $125 | Expedia.ca

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# Find Hotels by La Quinta Inn & Suites in Serra Mesa from CA $125

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## Check prices for these dates

Tonight

[Dec 14 - Dec 15](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-12-14&endDate=2025-12-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Dec 15 - Dec 16](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-12-15&endDate=2025-12-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Serra Mesa La Quinta Inn & Suites

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/20000/11400/11366/b2f86861.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business centre](https://images.trvl-media.com/lodging/1000000/20000/11400/11366/e912e2a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/20000/11400/11366/3e11c449.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11400/11366/87139cb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Quinta Inn & Suites by Wyndham San Diego Mission Bay

[](https://www.expedia.ca/San-Diego-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Diego-Mission-Bay.h11366.Hotel-Information)

Pacific Beach

8.0/10

Very good

(1430)

"Friendly staff, clean room"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Janice

CA $124

CA $142 total

includes taxes & fees

Dec 16 - Dec 17

[](https://www.expedia.ca/San-Diego-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Diego-Mission-Bay.h11366.Hotel-Information)

![Reception](https://images.trvl-media.com/lodging/1000000/10000/5700/5684/49f2cd82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/10000/5700/5684/bc2ee3cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/5700/5684/0d512cb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5700/5684/4b32319c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Quinta Inn by Wyndham San Diego - Miramar

[](https://www.expedia.ca/San-Diego-Hotels-La-Quinta-Inn-By-Wyndham-San-Diego-Miramar.h5684.Hotel-Information)

Rancho Peñasquitos

7.8/10

Good

(1094)

"Very nice roomsGreat staff breakfast was decent."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Stephen

CA $109

CA $125 total

includes taxes & fees

Jan 4 - Jan 5, 2026

[](https://www.expedia.ca/San-Diego-Hotels-La-Quinta-Inn-By-Wyndham-San-Diego-Miramar.h5684.Hotel-Information)

![Free continental breakfast](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/079ae4ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/83180011.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/bfd1ccfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/4e7175aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Quinta Inn by Wyndham San Diego Chula Vista

[](https://www.expedia.ca/Chula-Vista-Hotels-La-Quinta-Inn-By-Wyndham-San-Diego-Chula-Vista.h22810.Hotel-Information)

Chula Vista

8.6/10

Excellent

(1496)

"Everything was great, staff , Room , clean , great place to stay "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Luis

CA $137

CA $151 total

includes taxes & fees

Jan 4 - Jan 5, 2026

[](https://www.expedia.ca/Chula-Vista-Hotels-La-Quinta-Inn-By-Wyndham-San-Diego-Chula-Vista.h22810.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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## Top Serra Mesa Hotel Reviews

![Bay Club Hotel & Marina](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/8c022c3d_y.jpg)

### Bay Club Hotel & Marina

10/10 Excellent

"Nice hotel, very clean. "

[](https://expedia.ca/San-Diego-Hotels-Bay-Club-Hotel-Marina.h2514.Hotel-Information)

![Hampton Inn & Suites by Hilton San Diego SeaWorld](https://images.trvl-media.com/lodging/13000000/12970000/12963400/12963301/cc52443d_y.jpg)

### Hampton Inn & Suites by Hilton San Diego SeaWorld

10/10 Excellent

"Excellent "

[](https://expedia.ca/San-Diego-Hotels-Hampton-Inn-Suites-San-Diego-Point-Loma.h12963301.Hotel-Information)

![Legacy Resort Hotel & Spa](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/0bbd67f4_y.jpg)

### Legacy Resort Hotel & Spa

10/10 Excellent

"Very well and clean "

[](https://expedia.ca/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information)

![The Dana on Mission Bay](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg)

### The Dana on Mission Bay

10/10 Excellent

"Always love staying here. Staff was very courteous and the rooms very clean. "

[](https://expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information)

![Best Western Plus Marina Gateway Hotel](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe_y.jpg)

### Best Western Plus Marina Gateway Hotel

10/10 Excellent

"Room was spotless. Staff were really nice."

[](https://expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information)

![Wyndham San Diego Bayside](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg)

### Wyndham San Diego Bayside

10/10 Excellent

"yes "

[](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information)

![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg)

### The DEXTRO Little Italy, BW Premier Collection

10/10 Excellent

"Good staff"

[](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information)

![Sheraton San Diego Resort](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg)

### Sheraton San Diego Resort

10/10 Excellent

"Clean room great staff and amenities "

[](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Hotel-And-Marina.h11109.Hotel-Information)

![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg)

### Hard Rock Hotel San Diego

10/10 Excellent

"Breakfast was great "

[](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information)

## Find out more about Serra Mesa

## Serra Mesa Hotels Guide

Expedia.ca offers a selection of 9077 hotels in Serra Mesa. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. 

Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Serra Mesa. Making reservations so you can stay within your budget is easy with us. 

Expedia.ca even provides you with a map so you may find hotels in the Serra Mesa neighborhood you prefer. 

Go ahead. Enter your travel dates to view the best offers on hotel rooms in Serra Mesa, San Diego now! 

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- [Flights from Pompano Beach (PPM) to San Diego (MYF) ](https://www.expedia.ca/lp/flights/ppm/myf/pompano-beach-to-san-diego)
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- [Flights from Ottawa (YOW) to San Diego (MYF) ](https://www.expedia.ca/lp/flights/yow/myf/ottawa-to-san-diego)
- [Flights from Montreal (YUL) to San Diego (MYF) ](https://www.expedia.ca/lp/flights/yul/myf/montreal-to-san-diego)
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- [Flights from Vancouver (YVR) to San Diego (SAN) ](https://www.expedia.ca/lp/flights/yvr/san/vancouver-to-san-diego)
- [Flights from Winnipeg (YWG) to San Diego (MYF) ](https://www.expedia.ca/lp/flights/ywg/myf/winnipeg-to-san-diego)
- [Flights from Calgary (YYC) to San Diego (MYF) ](https://www.expedia.ca/lp/flights/yyc/myf/calgary-to-san-diego)
- [Flights from Toronto (YYZ) to San Diego (MYF) ](https://www.expedia.ca/lp/flights/yyz/myf/toronto-to-san-diego)
- [Flights from Toronto (YYZ) to San Diego (SAN) ](https://www.expedia.ca/lp/flights/yyz/san/toronto-to-san-diego)

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