Title: Hotels by Independent in Serra Mesa from CA $100 | Expedia.ca [Serra Mesa Travel Guide](https://expedia.ca/San-Diego-Serra-Mesa.dx553248635953501652)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Serra Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Serra-Mesa.d553248635953501652.Car-Rental-Guide)[Serra Mesa Vacations](https://expedia.ca/Serra-Mesa.d553248635953501652.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Independent in Serra Mesa from CA $100 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 12 - Oct 13](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-12&endDate=2025-10-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 13 - Oct 14](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-13&endDate=2025-10-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Serra Mesa Independent Hotels ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/8c022c3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine, pool views ](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/1f20ac82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 7:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/44c79c07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/37cb1415.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bay Club Hotel & Marina Point Loma 9.0/10 Wonderful (3012) "Great location, friendly staff, very clean accommodations and spacious rooms " CA $173 CA $198 total includes taxes & fees Oct 28 - Oct 29 [](https://www.expedia.ca/San-Diego-Hotels-Bay-Club-Hotel-Marina.h2514.Hotel-Information) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/ab6ccd55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor banquet area](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/6257cb78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premier Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/fde0003f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/76794add.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Handlery Hotel Mission Valley 8.2/10 Very good (2126) "Very nice stay" CA $143 CA $164 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/1000000/50000/40600/40531/4d1b251a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 Queen Bed, Non Smoking | View from room](https://images.trvl-media.com/lodging/1000000/50000/40600/40531/e0d53056.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/50000/40600/40531/745163d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/50000/40600/40531/760b1829.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### California Suites Hotel Clairemont 7.6/10 Good (2098) "We enjoyed our stay." CA $100 CA $114 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/San-Diego-Hotels-California-Suites-Hotel.h40531.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/bc1e5add.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; Californian cuisine](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/7c71b256.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; Californian cuisine](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/7fe47de0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![5 outdoor pools, a heated pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/d0f041ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Paradise Point Resort & Spa San Diego 8.6/10 Excellent (2303) "Great spot right on the bay, Been there forever which is part of the charm." CA $217 CA $320 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/San-Diego-Hotels-Paradise-Point-Resort-Spa.h3731.Hotel-Information) ![2 outdoor pools, a heated pool, sun loungers](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Marina](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/444d7583.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/01ecd568.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/2c4c818b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Dana on Mission Bay San Diego 8.8/10 Excellent (3786) "Great stay" CA $189 CA $246 total includes taxes & fees Oct 21 - Oct 22 [](https://www.expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/ba6cea84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/f8b10da9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/75ec9582.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/589f8e80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Sofia Hotel Downtown San Diego 8.4/10 Very good (1618) "I loved the stay here, highly recommended " CA $144 CA $200 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/San-Diego-Hotels-The-Sofia-Hotel.h1573807.Hotel-Information) ![Outdoor pool, open 7:00 AM to 9:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/91a184a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, premium bedding, pillowtop beds, minibar](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/633cc48d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/116e1fe0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/56fafd1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lafayette Hotel & Club University Heights 9.4/10 Exceptional (1206) "Front desk staff was amazing and the property is stunning. We can’t wait to go back!" CA $317 CA $363 total includes taxes & fees Oct 14 - Oct 15 [](https://www.expedia.ca/San-Diego-Hotels-Lafayette-Hotel.h38077738.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/1000000/30000/23900/23816/243b93bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/30000/23900/23816/d154e491.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds (Fab)](https://images.trvl-media.com/lodging/1000000/30000/23900/23816/febc9a76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/23900/23816/8f3ed06e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Bristol Hotel San Diego Downtown San Diego 8.4/10 Very good (1400) "Very nice staff from check in, clean rooms, quiet and comfortable. " CA $187 CA $217 total includes taxes & fees Oct 14 - Oct 15 [](https://www.expedia.ca/San-Diego-Hotels-The-Bristol-Hotel-San-Diego.h23816.Hotel-Information) ![Garden](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/0bbd67f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/7442075b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/43ef19cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/21efa256.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Legacy Resort Hotel & Spa Mission Valley 9.2/10 Wonderful (2895) "Great stay overall" CA $181 CA $208 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/3000000/2210000/2202800/2202716/a98dc1ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast area](https://images.trvl-media.com/lodging/3000000/2210000/2202800/2202716/b67130be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/3000000/2210000/2202800/2202716/0566d122.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/3000000/2210000/2202800/2202716/90271416.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Heritage Inn San Diego Point Loma 7.2/10 Good (1060) "Always a great stay. " CA $87 CA $100 total includes taxes & fees Oct 14 - Oct 15 [](https://www.expedia.ca/San-Diego-Hotels-Heritage-Inn-San-Diego-Near-SeaWorld.h2202716.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-27&endDate=2025-10-28®ionId=553248635953501652&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSerra-Mesa-San-Diego-Hotels-Independent.0-n553248635953501652-0--bIndependent.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSerra-Mesa-San-Diego-Hotels-Independent.0-n553248635953501652-0--bIndependent.Travel-Guide-Filter-Hotels) ## Top Serra Mesa Hotel Reviews ![The DEXTRO Little Italy, BW Premier Collection](//images.trvl-media.com/lodging/1000000/180000/170400/170338/84efd019_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "I really liked this place, it is quiet, clean and is located in a nice place, the only think I didn't like is that I had to pay $35 to use the parking lot." [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Days Inn by Wyndham San Diego Hotel Circle](//images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg) ### Days Inn by Wyndham San Diego Hotel Circle 10/10 Excellent "Location, price amazing! Friendly staff" [](https://expedia.ca/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) ![Hotel del Coronado, Curio Collection by Hilton](//images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg) ### Hotel del Coronado, Curio Collection by Hilton 10/10 Excellent "Amazing property " [](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![DoubleTree by Hilton San Diego - Del Mar](//images.trvl-media.com/lodging/1000000/20000/15300/15236/5afe6cec_y.jpg) ### DoubleTree by Hilton San Diego - Del Mar 10/10 Excellent "Nice staff.! " [](https://expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-San-Diego-Del-Mar.h15236.Hotel-Information) ![Palihotel San Diego Gaslamp Quarter](//images.trvl-media.com/lodging/89000000/88400000/88398500/88398416/4480f6ef_y.jpg) ### Palihotel San Diego Gaslamp Quarter 10/10 Excellent "Staff was great location was great" [](https://expedia.ca/San-Diego-Hotels-Palihotel-San-Diego.h88398416.Hotel-Information) ![Hard Rock Hotel San Diego](//images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Very clean, easy to move a lot things to do and Tourist Really love it" [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![The Sofia Hotel](//images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/ba6cea84_y.jpg) ### The Sofia Hotel 10/10 Excellent "Great location for the gaslamp" [](https://expedia.ca/San-Diego-Hotels-The-Sofia-Hotel.h1573807.Hotel-Information) ![Wyndham San Diego Bayside](//images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Loved the location & ease of access to the city." [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Best Western Plus Marina Gateway Hotel](//images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe_y.jpg) ### Best Western Plus Marina Gateway Hotel 10/10 Excellent "The soap dispenser in the shower was detached from the wall and the AC was blowing a weird smell...like wet clothes." [](https://expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) ## Find out more about Serra Mesa ## Serra Mesa Hotels Guide Expedia.ca offers a selection of 8991 hotels in Serra Mesa. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Serra Mesa. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Serra Mesa neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Serra Mesa, San Diego now! ## Explore a world of travel with Expedia - Lodging - Flights - Packages - More ways to book - [Hilton Hotels in Altadena](https://www.expedia.ca/Altadena-San-Diego-Hotels-Hilton-Hotels.0-n553248635976472078-0--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts in Bay Ho](https://www.expedia.ca/Bay-Ho-San-Diego-Hotels-Marriott-Hotels-Resorts.0-n553248635976471756-0--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Birdland Hotels](https://www.expedia.ca/Birdland-San-Diego-Hotels.0-n553248635976479135-0.Travel-Guide-Filter-Hotels) - [Noble House Hotels in Central San Diego](https://www.expedia.ca/Central-San-Diego-Hotels-Noble-House.0-0-d6056570--bNobleHouse.Travel-Guide-Filter-Hotels) - [Wyndham Hotels in Central San Diego](https://www.expedia.ca/Central-San-Diego-Hotels-Wyndham-Hotels.0-0-d6056570--bWyndhamHotels.Travel-Guide-Filter-Hotels) - [La Quinta Inn & Suites Hotels in Fiesta Island](https://www.expedia.ca/Fiesta-Island-Hotels-La-Quinta-Inn-Suites.0-0-d553248621555611981--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - 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[Oyo Rooms Hotels in San Diego](https://www.expedia.ca/San-Diego-Hotels-OYO-Rooms.0-0-d3073--bOYORooms.Travel-Guide-Filter-Hotels) - [Starwood Capital Hotels in San Diego](https://www.expedia.ca/San-Diego-Hotels-Starwood-Capital.0-0-d3073--bStarwoodCapital.Travel-Guide-Filter-Hotels) - [Wyndham Extra Holidays Hotels in San Diego](https://www.expedia.ca/San-Diego-Hotels-Wyndham-Extra-Holidays.0-0-d3073--bWyndhamExtraHolidays.Travel-Guide-Filter-Hotels) - [Wyndham Hotels in San Diego](https://www.expedia.ca/San-Diego-Hotels-Wyndham-Hotels.0-0-d3073--bWyndhamHotels.Travel-Guide-Filter-Hotels) - [Yotel Hotels in San Diego](https://www.expedia.ca/San-Diego-Hotels-Yotel.0-0-d3073--bYotel.Travel-Guide-Filter-Hotels) - [San Diego Hotels](https://www.expedia.ca/San-Diego-Hotels.d3073.Travel-Guide-Hotels) - [Flights to San Diego](https://www.expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights) - [Flights from Montgomery Field](https://www.expedia.ca/lp/airports/myf/flights-from-montgomery-field-airport) - 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