Title: Hotels by Hyatt Hotels in Serra Mesa | Expedia.ca [Serra Mesa Travel Guide](https://expedia.ca/San-Diego-Serra-Mesa.dx553248635953501652)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Serra Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Serra-Mesa.d553248635953501652.Car-Rental-Guide)[Serra Mesa Vacations](https://expedia.ca/Serra-Mesa.d553248635953501652.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Hyatt Hotels in Serra Mesa ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 2 - Oct 3](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-02&endDate=2025-10-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 3 - Oct 4](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-03&endDate=2025-10-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-03&endDate=2025-10-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-10&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Serra Mesa Hyatt Hotels Hotels ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSerra-Mesa-San-Diego-Hotels-Hyatt-Hotels.0-n553248635953501652-0--bHyattHotels.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSerra-Mesa-San-Diego-Hotels-Hyatt-Hotels.0-n553248635953501652-0--bHyattHotels.Travel-Guide-Filter-Hotels) ## Top Serra Mesa Hotel Reviews ![Pendry San Diego](//images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05d0e601_y.jpg) ### Pendry San Diego 10/10 Excellent "Hotel is pretty and is in a great location to be able to walk to shops, restaurants and bars " [](https://expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) ![The DEXTRO Little Italy, BW Premier Collection](//images.trvl-media.com/lodging/1000000/180000/170400/170338/84efd019_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "It was centrally located,. I had private car and they had parking in. It was perfect for me, the rooms were comfortable and clean. Pretty view." [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Hard Rock Hotel San Diego](//images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Clean room" [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Best Western Plus Marina Gateway Hotel](//images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe_y.jpg) ### Best Western Plus Marina Gateway Hotel 10/10 Excellent "Thanks " [](https://expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) ![Wyndham San Diego Bayside](//images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Hotel is in a great location right near airport and trolley. Has an airport shuttle, pool, 3 restaurants on site and a few access the street. Best of all the staff and management are really friendly and professional. " [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![The Sofia Hotel](//images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/ba6cea84_y.jpg) ### The Sofia Hotel 10/10 Excellent "Clean room, friendly staff " [](https://expedia.ca/San-Diego-Hotels-The-Sofia-Hotel.h1573807.Hotel-Information) ![The Dana on Mission Bay](//images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg) ### The Dana on Mission Bay 10/10 Excellent "We stayed for 9 nights and had an awesome time! Staff was friendly and accommodating. " [](https://expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![Hotel del Coronado, Curio Collection by Hilton](//images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg) ### Hotel del Coronado, Curio Collection by Hilton 10/10 Excellent "Great ocean view located right on wide beach. Hotel is awesome." [](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![Manchester Grand Hyatt San Diego](//images.trvl-media.com/lodging/1000000/20000/12100/12073/w3840h2092x0y3-447c77a4_y.jpg) ### Manchester Grand Hyatt San Diego 10/10 Excellent "The Manchester Grand Hyatt is our go to hotel in San Diego due to its convenient location by the Seaport Village and many restaurants and shops. We have stayed there several times and always enjoy the scenic views from our room and the hospitality of the hotel staff. The breakfast buffet has a large variety of offerings including an omelette station. The MarketOne Cafe downstairs has many items including delicious pastries and other food and drink items. It is always a great experience to stay at the Manchester Grand Hyatt in San Diego." [](https://expedia.ca/San-Diego-Hotels-Manchester-Grand-Hyatt-San-Diego.h12073.Hotel-Information) ## Find out more about Serra Mesa ## Serra Mesa Hotels Guide Expedia.ca offers a selection of 8927 hotels in Serra Mesa. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Serra Mesa. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Serra Mesa neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Serra Mesa, San Diego now! ## Explore a world of travel with Expedia - Lodging - Flights - Packages - More ways to book - [Hilton Hotels in Altadena](https://www.expedia.ca/Altadena-San-Diego-Hotels-Hilton-Hotels.0-n553248635976472078-0--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts in Bay Ho](https://www.expedia.ca/Bay-Ho-San-Diego-Hotels-Marriott-Hotels-Resorts.0-n553248635976471756-0--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Birdland Hotels](https://www.expedia.ca/Birdland-San-Diego-Hotels.0-n553248635976479135-0.Travel-Guide-Filter-Hotels) - [Noble House Hotels in Central San Diego](https://www.expedia.ca/Central-San-Diego-Hotels-Noble-House.0-0-d6056570--bNobleHouse.Travel-Guide-Filter-Hotels) - [Wyndham Hotels in Central San Diego](https://www.expedia.ca/Central-San-Diego-Hotels-Wyndham-Hotels.0-0-d6056570--bWyndhamHotels.Travel-Guide-Filter-Hotels) - [La Quinta Inn & Suites Hotels in Fiesta Island](https://www.expedia.ca/Fiesta-Island-Hotels-La-Quinta-Inn-Suites.0-0-d553248621555611981--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - 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(OAX) to San Diego (MYF)](https://www.expedia.ca/lp/flights/oax/myf/oaxaca-intl-to-san-diego) - [Flights from Oceanside (OCN) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ocn/myf/oceanside-to-san-diego) - [Flights from Nogales (OLS) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ols/myf/nogales-to-san-diego) - [Flights from Omaha (OMA) to San Diego (MYF)](https://www.expedia.ca/lp/flights/oma/myf/omaha-to-san-diego) - [Flights from Phoenix (PHX) to San Diego (MYF)](https://www.expedia.ca/lp/flights/phx/myf/phoenix-to-san-diego) - [Flights from Pompano Beach (PPM) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ppm/myf/pompano-beach-to-san-diego) - [Flights from Murrieta (RBK) to San Diego (MYF)](https://www.expedia.ca/lp/flights/rbk/myf/murrieta-to-san-diego) - [Flights from Redding (RDD) to San Diego (MYF)](https://www.expedia.ca/lp/flights/rdd/myf/redding-to-san-diego) - [Flights from Rifle (RIL) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ril/myf/rifle-to-san-diego) - [Flights from Mariposa (RMY) to San Diego (MYF)](https://www.expedia.ca/lp/flights/rmy/myf/mariposa-to-san-diego) - [Flights from Reno (RNO) to San Diego (MYF)](https://www.expedia.ca/lp/flights/rno/myf/reno-to-san-diego) - [Flights from Seattle (SEA) to San Diego (MYF)](https://www.expedia.ca/lp/flights/sea/myf/seattle-to-san-diego) - [Flights from San Francisco (SFO) to San Diego (MYF)](https://www.expedia.ca/lp/flights/sfo/myf/san-francisco-to-san-diego) - [Flights from Spearfish (SPF) to San Diego (MYF)](https://www.expedia.ca/lp/flights/spf/myf/spearfish-to-san-diego) - [Flights from San Carlos (SQL) to San Diego (MYF)](https://www.expedia.ca/lp/flights/sql/myf/san-carlos-to-san-diego) - [Flights from Santa Paula (SZP) to San Diego (MYF)](https://www.expedia.ca/lp/flights/szp/myf/santa-paula-to-san-diego) - [Flights from Tacoma (TIW) to San Diego (MYF)](https://www.expedia.ca/lp/flights/tiw/myf/tacoma-to-san-diego) - [Flights from Temple (TPL) to San Diego (MYF)](https://www.expedia.ca/lp/flights/tpl/myf/temple-to-san-diego) - [Flights from Watsonville (WVI) to San Diego (MYF)](https://www.expedia.ca/lp/flights/wvi/myf/watsonville-to-san-diego) - [Flights from Ottawa (YOW) to San Diego (MYF)](https://www.expedia.ca/lp/flights/yow/myf/ottawa-to-san-diego) - [Flights from Montreal (YUL) to San Diego (MYF)](https://www.expedia.ca/lp/flights/yul/myf/montreal-to-san-diego) - [Flights from Yuma (YUM) to San Diego (MYF)](https://www.expedia.ca/lp/flights/yum/myf/yuma-to-san-diego) - [Flights from Vancouver (YVR) to San Diego (MYF)](https://www.expedia.ca/lp/flights/yvr/myf/vancouver-to-san-diego) - [Flights from Vancouver (YVR) to San Diego (SAN)](https://www.expedia.ca/lp/flights/yvr/san/vancouver-to-san-diego) - [Flights from Winnipeg (YWG) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ywg/myf/winnipeg-to-san-diego) - [Flights from Calgary (YYC) to San Diego (MYF)](https://www.expedia.ca/lp/flights/yyc/myf/calgary-to-san-diego) - [Flights from Toronto (YYZ) to San Diego (MYF)](https://www.expedia.ca/lp/flights/yyz/myf/toronto-to-san-diego) - [Flights from Toronto (YYZ) to San Diego (SAN)](https://www.expedia.ca/lp/flights/yyz/san/toronto-to-san-diego) - [Visit Birdland](https://www.expedia.ca/San-Diego-Birdland.dx553248635976479135) - [Book Hotels in Serra Mesa on Expedia.com](https://www.expedia.com/Serra-Mesa-San-Diego-Hotels-Hyatt-Hotels.0-n553248635953501652-0--bHyattHotels.Travel-Guide-Filter-Hotels)