Title: Hotels by Hilton Hotels in Serra Mesa from CA $201 | Expedia.ca [Serra Mesa Travel Guide](https://expedia.ca/San-Diego-Serra-Mesa.dx553248635953501652)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Serra Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Serra-Mesa.d553248635953501652.Car-Rental-Guide)[Serra Mesa Vacations](https://expedia.ca/Serra-Mesa.d553248635953501652.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Hilton Hotels in Serra Mesa from CA $201 ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 4 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-04&endDate=2025-10-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 5 - Oct 6](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-05&endDate=2025-10-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-10&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Serra Mesa Hilton Hotels Hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/w3839h2160x1y0-98566ca3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/bd692b4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/df29ea56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/9101297c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton San Diego Mission Valley Mission Valley 8.0/10 Very good (2029) "Clean rooms, easy access, friendly and helpful staff. Very good stay!" CA $175 CA $201 total includes taxes & fees Oct 13 - Oct 14 [](https://www.expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![Suite, 1 King Bed (The Champion Suite) | View from room](https://images.trvl-media.com/lodging/1000000/10000/4700/4698/w3839h2553x0y3-858b98fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4700/4698/56d7876e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4700/4698/w3840h2875x0y0-28e322e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed (The Champion Suite) | Living area](https://images.trvl-media.com/lodging/1000000/10000/4700/4698/b792367e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton La Jolla Torrey Pines Torrey Pines 7.8/10 Good (1003) "great views from locations around the hotel" CA $300 CA $401 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/La-Jolla-Hotels-Hilton-La-Jolla-Torrey-Pines.h4698.Hotel-Information) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/9fc82331.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; Californian cuisine, ocean views ](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/06f19e3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/2df2def5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, lobby lounge](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/ed2e1ba0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton San Diego Bayfront Downtown San Diego 8.6/10 Excellent (1769) "Check-in was easy and the reception staff was very welcoming, he even accommodated having our room next to my family." CA $251 CA $359 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Bayfront.h1871645.Hotel-Information) ![60-inch flat-screen TV with cable channels, TV, pay movies](https://images.trvl-media.com/lodging/1000000/480000/477000/476989/915cb89b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed | Living area](https://images.trvl-media.com/lodging/1000000/480000/477000/476989/651eee83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/480000/477000/476989/w3837h2557x3y3-fb76a9e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/480000/477000/476989/6612b3ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton San Diego Gaslamp Quarter Downtown San Diego 8.8/10 Excellent (208) "Hotel is super clean and the staff are very attentive and friendly." CA $279 CA $383 total includes taxes & fees Oct 23 - Oct 24 [](https://www.expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Gaslamp-Quarter.h476989.Hotel-Information) ![View from room](https://images.trvl-media.com/lodging/1000000/30000/24900/24895/918edbf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/24900/24895/06ebc015.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Bathtub (Mobility)](https://images.trvl-media.com/lodging/1000000/30000/24900/24895/26c5ea6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool views, open daily](https://images.trvl-media.com/lodging/1000000/30000/24900/24895/da068331.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton San Diego/Del Mar Del Mar Heights 8.6/10 Excellent (1000) "Simple staying for travelers." CA $212 CA $241 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Del-Mar-Hotels-Hilton-San-Diego-Del-Mar.h24895.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/3600/3563/f402b5f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/3600/3563/9916bae6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, dinner served; American cuisine, ocean views ](https://images.trvl-media.com/lodging/1000000/10000/3600/3563/8e82ae91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/10000/3600/3563/7229585c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton San Diego Airport/Harbor Island Harbor Island 8.8/10 Excellent (1180) "Liked that it had great views of the harbor .. and the park. " CA $248 CA $285 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/San-Diego-Hotels-Hilton-San-Diego-AirportHarbor-Island.h3563.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-18&endDate=2025-10-19®ionId=553248635953501652&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSerra-Mesa-San-Diego-Hotels-Hilton-Hotels.0-n553248635953501652-0--bHiltonHotels.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSerra-Mesa-San-Diego-Hotels-Hilton-Hotels.0-n553248635953501652-0--bHiltonHotels.Travel-Guide-Filter-Hotels) ## Top Serra Mesa Hotel Reviews ![Wyndham San Diego Bayside](//images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Stay was excellent room always cleaned and beds made promptly. Room was very spacious and view of the bay with balcony amazing. Location is excellent." [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Pendry San Diego](//images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05d0e601_y.jpg) ### Pendry San Diego 10/10 Excellent "Hotel is pretty and is in a great location to be able to walk to shops, restaurants and bars " [](https://expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) ![The DEXTRO Little Italy, BW Premier Collection](//images.trvl-media.com/lodging/1000000/180000/170400/170338/84efd019_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "It was centrally located,. I had private car and they had parking in. It was perfect for me, the rooms were comfortable and clean. Pretty view." [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Hard Rock Hotel San Diego](//images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Clean room" [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Best Western Plus Marina Gateway Hotel](//images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe_y.jpg) ### Best Western Plus Marina Gateway Hotel 10/10 Excellent "Thanks " [](https://expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) ![The Sofia Hotel](//images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/ba6cea84_y.jpg) ### The Sofia Hotel 10/10 Excellent "Clean room, friendly staff " [](https://expedia.ca/San-Diego-Hotels-The-Sofia-Hotel.h1573807.Hotel-Information) ![San Diego Marriott La Jolla](//images.trvl-media.com/lodging/1000000/10000/2100/2097/05285107_y.jpg) ### San Diego Marriott La Jolla 10/10 Excellent "We appreciate the check-in procedure with one of your great staff named Aronze. She made the check-in procedure convenient. We did not avail ourselves of having our rooms cleaned for the three days we stayed. However, we did ask for additional towels and paper cups which a maintenance person cleaning other rooms graciously gave us. Regarding the safe box in the room - it doesnt work (it kept indicating/flashing CLOSED). I know I could have asked for it to be fixed but we are busy/on a schedule and dont have the time to wait for a repair person. We like the convenient location of the hotel to nearby restaurants, bakeries, and shops. This is why I chose this particular Marriott. Thank you for asking our opinion regarding our Marriott stay. " [](https://expedia.ca/La-Jolla-Hotels-San-Diego-Marriott-La-Jolla.h2097.Hotel-Information) ![The Dana on Mission Bay](//images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg) ### The Dana on Mission Bay 10/10 Excellent "We stayed for 9 nights and had an awesome time! Staff was friendly and accommodating. " [](https://expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![Hotel del Coronado, Curio Collection by Hilton](//images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg) ### Hotel del Coronado, Curio Collection by Hilton 10/10 Excellent "Great ocean view located right on wide beach. Hotel is awesome." [](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ## Find out more about Serra Mesa ## Serra Mesa Hotels Guide Expedia.ca offers a selection of 8927 hotels in Serra Mesa. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Serra Mesa. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Serra Mesa neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Serra Mesa, San Diego now! ## Explore a world of travel with Expedia - Lodging - Flights - Packages - More ways to book - [Hilton Hotels in Altadena](https://www.expedia.ca/Altadena-San-Diego-Hotels-Hilton-Hotels.0-n553248635976472078-0--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts in Bay Ho](https://www.expedia.ca/Bay-Ho-San-Diego-Hotels-Marriott-Hotels-Resorts.0-n553248635976471756-0--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Birdland Hotels](https://www.expedia.ca/Birdland-San-Diego-Hotels.0-n553248635976479135-0.Travel-Guide-Filter-Hotels) - [Noble House Hotels in Central San Diego](https://www.expedia.ca/Central-San-Diego-Hotels-Noble-House.0-0-d6056570--bNobleHouse.Travel-Guide-Filter-Hotels) - [Wyndham Hotels in Central San Diego](https://www.expedia.ca/Central-San-Diego-Hotels-Wyndham-Hotels.0-0-d6056570--bWyndhamHotels.Travel-Guide-Filter-Hotels) - [La Quinta Inn & Suites Hotels in Fiesta Island](https://www.expedia.ca/Fiesta-Island-Hotels-La-Quinta-Inn-Suites.0-0-d553248621555611981--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - 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[Flights from Newark Liberty Intl. Airport (EWR) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ewr/myf/newark-liberty-intl-airport-to-san-diego) - [Flights from Fallon (FLX) to San Diego (MYF)](https://www.expedia.ca/lp/flights/flx/myf/fallon-to-san-diego) - [Flights from Sioux Falls (FSD) to San Diego (MYF)](https://www.expedia.ca/lp/flights/fsd/myf/sioux-falls-to-san-diego) - [Flights from Gallup (GUP) to San Diego (MYF)](https://www.expedia.ca/lp/flights/gup/myf/gallup-to-san-diego) - [Flights from Hawthorne (HHR) to San Diego (MYF)](https://www.expedia.ca/lp/flights/hhr/myf/hawthorne-to-san-diego) - [Flights from Hot Springs (HOT) to San Diego (MYF)](https://www.expedia.ca/lp/flights/hot/myf/hot-springs-to-san-diego) - [Flights from Henderson (HSH) to San Diego (MYF)](https://www.expedia.ca/lp/flights/hsh/myf/henderson-to-san-diego) - [Flights from Hayward (HWD) to San Diego (MYF)](https://www.expedia.ca/lp/flights/hwd/myf/hayward-to-san-diego) - [Flights from Indianapolis (IND) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ind/myf/indianapolis-to-san-diego) - [Flights from International Falls (INL) to San Diego (MYF)](https://www.expedia.ca/lp/flights/inl/myf/international-falls-to-san-diego) - [Flights from El Centro (IPL) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ipl/myf/el-centro-to-san-diego) - [Flights from New York (JFK) to San Diego (MYF)](https://www.expedia.ca/lp/flights/jfk/myf/new-york-to-san-diego) - [Flights from Los Angeles (LAX) to San Diego (MYF)](https://www.expedia.ca/lp/flights/lax/myf/los-angeles-to-san-diego) - [Flights from Harrisburg (MDT) to San Diego (MYF)](https://www.expedia.ca/lp/flights/mdt/myf/harrisburg-to-san-diego) - [Flights from Mexico City (MEX) to San Diego (MYF)](https://www.expedia.ca/lp/flights/mex/myf/mexico-city-to-san-diego) - [Flights from Milan (MIL) to San Diego (MYF)](https://www.expedia.ca/lp/flights/mil/myf/milan-to-san-diego) - [Flights from Mammoth Lakes (MMH) to San Diego (MYF)](https://www.expedia.ca/lp/flights/mmh/myf/mammoth-lakes-to-san-diego) - [Flights from Modesto (MOD) to San Diego (MYF)](https://www.expedia.ca/lp/flights/mod/myf/modesto-to-san-diego) - [Flights from Oaxaca Intl. (OAX) to San Diego (MYF)](https://www.expedia.ca/lp/flights/oax/myf/oaxaca-intl-to-san-diego) - [Flights from Oceanside (OCN) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ocn/myf/oceanside-to-san-diego) - [Flights from Nogales (OLS) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ols/myf/nogales-to-san-diego) - [Flights from Omaha (OMA) to San Diego (MYF)](https://www.expedia.ca/lp/flights/oma/myf/omaha-to-san-diego) - [Flights from Phoenix (PHX) to San Diego (MYF)](https://www.expedia.ca/lp/flights/phx/myf/phoenix-to-san-diego) - [Flights from Pompano Beach (PPM) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ppm/myf/pompano-beach-to-san-diego) - [Flights from Murrieta (RBK) to San Diego (MYF)](https://www.expedia.ca/lp/flights/rbk/myf/murrieta-to-san-diego) - [Flights from Redding (RDD) to San Diego (MYF)](https://www.expedia.ca/lp/flights/rdd/myf/redding-to-san-diego) - [Flights from Rifle (RIL) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ril/myf/rifle-to-san-diego) - [Flights from Mariposa (RMY) to San Diego (MYF)](https://www.expedia.ca/lp/flights/rmy/myf/mariposa-to-san-diego) - [Flights from Reno (RNO) to San Diego (MYF)](https://www.expedia.ca/lp/flights/rno/myf/reno-to-san-diego) - [Flights from Seattle (SEA) to San Diego (MYF)](https://www.expedia.ca/lp/flights/sea/myf/seattle-to-san-diego) - [Flights from San Francisco (SFO) to San Diego (MYF)](https://www.expedia.ca/lp/flights/sfo/myf/san-francisco-to-san-diego) - [Flights from Spearfish (SPF) to San Diego (MYF)](https://www.expedia.ca/lp/flights/spf/myf/spearfish-to-san-diego) - [Flights from San Carlos (SQL) to San Diego (MYF)](https://www.expedia.ca/lp/flights/sql/myf/san-carlos-to-san-diego) - [Flights from Santa Paula (SZP) to San Diego (MYF)](https://www.expedia.ca/lp/flights/szp/myf/santa-paula-to-san-diego) - [Flights from Tacoma (TIW) to San Diego (MYF)](https://www.expedia.ca/lp/flights/tiw/myf/tacoma-to-san-diego) - [Flights from Temple (TPL) to San Diego (MYF)](https://www.expedia.ca/lp/flights/tpl/myf/temple-to-san-diego) - [Flights from Watsonville (WVI) to San Diego (MYF)](https://www.expedia.ca/lp/flights/wvi/myf/watsonville-to-san-diego) - [Flights from Ottawa (YOW) to San Diego (MYF)](https://www.expedia.ca/lp/flights/yow/myf/ottawa-to-san-diego) - [Flights from Montreal (YUL) to San Diego (MYF)](https://www.expedia.ca/lp/flights/yul/myf/montreal-to-san-diego) - [Flights from Yuma (YUM) to San Diego (MYF)](https://www.expedia.ca/lp/flights/yum/myf/yuma-to-san-diego) - [Flights from Vancouver (YVR) to San Diego (MYF)](https://www.expedia.ca/lp/flights/yvr/myf/vancouver-to-san-diego) - [Flights from Vancouver (YVR) to San Diego (SAN)](https://www.expedia.ca/lp/flights/yvr/san/vancouver-to-san-diego) - [Flights from Winnipeg (YWG) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ywg/myf/winnipeg-to-san-diego) - [Flights from Calgary (YYC) to San Diego (MYF)](https://www.expedia.ca/lp/flights/yyc/myf/calgary-to-san-diego) - [Flights from Toronto (YYZ) to San Diego (MYF)](https://www.expedia.ca/lp/flights/yyz/myf/toronto-to-san-diego) - [Flights from Toronto (YYZ) to San Diego (SAN)](https://www.expedia.ca/lp/flights/yyz/san/toronto-to-san-diego) - [Visit Birdland](https://www.expedia.ca/San-Diego-Birdland.dx553248635976479135) - [Book Hotels in Serra Mesa on Expedia.com](https://www.expedia.com/Serra-Mesa-San-Diego-Hotels-Hilton-Hotels.0-n553248635953501652-0--bHiltonHotels.Travel-Guide-Filter-Hotels)