Title: Hotels by Best Western in Serra Mesa from CA $108 | Expedia.ca [Serra Mesa Travel Guide](https://expedia.ca/San-Diego-Serra-Mesa.dx553248635953501652)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Serra Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Serra-Mesa.d553248635953501652.Car-Rental-Guide)[Serra Mesa Vacations](https://expedia.ca/Serra-Mesa.d553248635953501652.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Best Western in Serra Mesa from CA $108 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Dec 12 - Dec 13](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-12-12&endDate=2025-12-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 13 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-12-13&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-12-12&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Serra Mesa Best Western ![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/50000/40800/40745/297b9804.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/50000/40800/40745/50e4f8af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40800/40745/6bd68dda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 10 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/50000/40800/40745/0303dbfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Inn & Suites San Diego – Zoo/SeaWorld Area [](https://www.expedia.ca/San-Diego-Hotels-Comfort-Inn-Suites-San-Diego-Zoo-SeaWorld-Area.h40745.Hotel-Information) Mission Valley 8.0/10 Very good (2311) "It was a good family hotel. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jurida CA $164 CA $188 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/San-Diego-Hotels-Comfort-Inn-Suites-San-Diego-Zoo-SeaWorld-Area.h40745.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2556x3y3-8b148daf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2557x3y3-6971afdd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2557x3y3-2f0f89f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3840h2556x0y3-1f0ee309.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Seven Seas [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Seven-Seas.h1734.Hotel-Information) Mission Valley 7.8/10 Good (3045) "Very clean hotel and the people that cleans are really nice. Perfect to visit San Diego, great location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ernesto Alonso CA $102 CA $117 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Seven-Seas.h1734.Hotel-Information) ![Free continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/bc7617fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/ddddbc6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/5a519562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/6ad23cf3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Chula Vista/Otay Valley Hotel [](https://www.expedia.ca/Chula-Vista-Hotels-Best-Western-Chula-VistaOtay-Valley-Hotel.h12645.Hotel-Information) Otay 7.8/10 Good (1538) "The breakfast was good there were healthy options. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Selene CA $139 CA $153 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Chula-Vista-Hotels-Best-Western-Chula-VistaOtay-Valley-Hotel.h12645.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/025fd645.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/e40d2481.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/2ba90811.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 Queen Bed, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/44f8822a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Americana Inn [](https://www.expedia.ca/San-Ysidro-Hotels-Best-Western-Americana-Inn.h806327.Hotel-Information) San Ysidro 9.0/10 Wonderful (1192) "Amazing time at this place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maria de Los Angeles CA $139 CA $159 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Ysidro-Hotels-Best-Western-Americana-Inn.h806327.Hotel-Information) ![Standard Room, 2 Queen Beds, Non Smoking, Microwave](https://images.trvl-media.com/lodging/1000000/30000/21600/21527/08f46b14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/21600/21527/6a4d216d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/21600/21527/3a81799d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21527/02dbf386.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Yacht Harbor Hotel [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Yacht-Harbor-Hotel.h21527.Hotel-Information) Point Loma 8.6/10 Excellent (1629) "The breakfast options were good and the staff were very helpful." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Gail or Rob CA $135 CA $155 total includes taxes & fees Dec 17 - Dec 18 [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Yacht-Harbor-Hotel.h21527.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/17400/17302/w3833h2560x4y0-33c373fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/17400/17302/76ab713b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/20000/17400/17302/w3840h2554x0y6-4b5b551a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/1000000/20000/17400/17302/w3837h2556x3y4-cf706a1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western San Diego/Miramar Hotel [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-San-DiegoMiramar-Hotel.h17302.Hotel-Information) Miramar 7.8/10 Good (1148) "Comfy bed, huge tv, great breakfast!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Grace CA $117 CA $135 total includes taxes & fees Dec 17 - Dec 18 [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-San-DiegoMiramar-Hotel.h17302.Hotel-Information) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/20000/18200/18147/w3840h2877x0y3-498f6208.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/1000000/20000/18200/18147/a137d768.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/18200/18147/w3840h2877x0y3-a0181fa6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18200/18147/1a78c634.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western San Diego Pacific Beach/Mission Bay [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-San-Diego-Pacific-BeachMission-Bay.h18147.Hotel-Information) Bay Park 8.2/10 Very good (190) "Great stay, the staff was very friendly! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) frances CA $94 CA $108 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-San-Diego-Pacific-BeachMission-Bay.h18147.Hotel-Information) ![Free continental breakfast](https://images.trvl-media.com/lodging/1000000/60000/50600/50594/9cdc0885.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/60000/50600/50594/803bd000.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/50600/50594/bca5eea9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/60000/50600/50594/594daf9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Poway/San Diego Hotel [](https://www.expedia.ca/Poway-Hotels-Best-Western-PowaySan-Diego-Hotel.h50594.Hotel-Information) Poway 7.2/10 Good (1000) "Spotless room, courteous staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bill CA $123 CA $135 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Poway-Hotels-Best-Western-PowaySan-Diego-Hotel.h50594.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/27100/27004/1954ac96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/27100/27004/3bd865c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/1000000/30000/27100/27004/w3840h2560x0y1-a53682c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/1000000/30000/27100/27004/bb0bbb71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Santee Lodge [](https://www.expedia.ca/Santee-Hotels-Best-Western-Santee-Lodge.h27004.Hotel-Information) Santee 7.8/10 Good (588) " Room was clean and the staff was friendly" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Daniel CA $143 CA $157 total includes taxes & fees Dec 16 - Dec 17 [](https://www.expedia.ca/Santee-Hotels-Best-Western-Santee-Lodge.h27004.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/980000/973700/973615/8edd50b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast area](https://images.trvl-media.com/lodging/1000000/980000/973700/973615/c3b7953f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/980000/973700/973615/3ce0d724.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/980000/973700/973615/5fc043be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Downtown San Diego [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Cabrillo-Garden-Inn.h973615.Hotel-Information) Downtown San Diego 8.4/10 Very good (922) "Staff was exceptionally helpful and the room was very clean. Will definitely stay here again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Blanca CA $169 CA $192 total includes taxes & fees Dec 30 - Dec 31 [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Cabrillo-Garden-Inn.h973615.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-26&endDate=2025-12-27®ionId=553248635953501652&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSerra-Mesa-San-Diego-Hotels-Best-Western.0-n553248635953501652-0--bBestWestern.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSerra-Mesa-San-Diego-Hotels-Best-Western.0-n553248635953501652-0--bBestWestern.Travel-Guide-Filter-Hotels) ## Top Serra Mesa Hotel Reviews ![Best Western Plus Marina Gateway Hotel](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe_y.jpg) ### Best Western Plus Marina Gateway Hotel 10/10 Excellent "Room was spotless. Staff were really nice." [](https://expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) ![Wyndham San Diego Bayside](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "yes " [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "Good staff" [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Sheraton San Diego Resort](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg) ### Sheraton San Diego Resort 10/10 Excellent "Clean room great staff and amenities " [](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Hotel-And-Marina.h11109.Hotel-Information) ![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Breakfast was great " [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![San Diego Marriott La Jolla](https://images.trvl-media.com/lodging/1000000/10000/2100/2097/05285107_y.jpg) ### San Diego Marriott La Jolla 10/10 Excellent "Quiet and clean room! Comfortable bed! Friendly staff at check-in! It was wonderful!" [](https://expedia.ca/La-Jolla-Hotels-San-Diego-Marriott-La-Jolla.h2097.Hotel-Information) ![Hotel del Coronado, Curio Collection by Hilton](https://images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg) ### Hotel del Coronado, Curio Collection by Hilton 10/10 Excellent "Magical" [](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![Lafayette Hotel & Club](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/91a184a3_y.jpg) ### Lafayette Hotel & Club 10/10 Excellent "These guy do a terrific job always love coming here. The staff is so friendly and accommodating. We will be back " [](https://expedia.ca/San-Diego-Hotels-Lafayette-Hotel.h38077738.Hotel-Information) ![Kings Inn San Diego](https://images.trvl-media.com/lodging/1000000/20000/17000/16910/a5f26080_y.jpg) ### Kings Inn San Diego 10/10 Excellent "good" [](https://expedia.ca/San-Diego-Hotels-Kings-Inn-San-Diego-Seaworld-Zoo.h16910.Hotel-Information) ## Find out more about Serra Mesa ## Serra Mesa Hotels Guide Expedia.ca offers a selection of 9077 hotels in Serra Mesa. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Serra Mesa. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Serra Mesa neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Serra Mesa, San Diego now! ## Explore a world of travel with Expedia - Lodging - Flights - Packages - More ways to book - [Hilton Hotels in Altadena ](https://www.expedia.ca/Altadena-San-Diego-Hotels-Hilton-Hotels.0-n553248635976472078-0--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts in Bay Ho ](https://www.expedia.ca/Bay-Ho-San-Diego-Hotels-Marriott-Hotels-Resorts.0-n553248635976471756-0--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Birdland Hotels ](https://www.expedia.ca/Birdland-San-Diego-Hotels.0-n553248635976479135-0.Travel-Guide-Filter-Hotels) - [Noble House Hotels in Central San Diego ](https://www.expedia.ca/Central-San-Diego-Hotels-Noble-House.0-0-d6056570--bNobleHouse.Travel-Guide-Filter-Hotels) - [Wyndham Hotels in Central San Diego ](https://www.expedia.ca/Central-San-Diego-Hotels-Wyndham-Hotels.0-0-d6056570--bWyndhamHotels.Travel-Guide-Filter-Hotels) - [La Quinta Inn & Suites Hotels in Fiesta Island ](https://www.expedia.ca/Fiesta-Island-Hotels-La-Quinta-Inn-Suites.0-0-d553248621555611981--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - 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