Title: Book the Best Serenity Bay SPA Resorts from CA $115 - Spa Hotels in Serenity Bay, Seneca | Expedia.ca [Serenity Bay Travel Guide](https://expedia.ca/Seneca-Serenity-Bay.dx553248635976468572)[Vacation Rentals in Seneca](https://expedia.ca/Seneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals)[Flights to Seneca](https://expedia.ca/Cheap-Flights-To-Seneca.d6548.Travel-Guide-Flights)[Things to do in Seneca](https://expedia.ca/Things-To-Do-In-Seneca.d6548.Travel-Guide-Activities)[Serenity Bay Car Rentals](https://expedia.ca/Car-Rentals-In-Serenity-Bay.d553248635976468572.Car-Rental-Guide)[Serenity Bay Vacations](https://expedia.ca/Serenity-Bay.d553248635976468572.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/pool.jpeg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Serenity Bay, Seneca from CA $115 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Serenity Bay Spa Hotels Tonight [Oct 14 - Oct 15](https://www.expedia.ca/Hotel-Search?regionId=553248635976468572&startDate=2025-10-14&endDate=2025-10-15&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 15 - Oct 16](https://www.expedia.ca/Hotel-Search?regionId=553248635976468572&startDate=2025-10-15&endDate=2025-10-16&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635976468572&startDate=2025-10-17&endDate=2025-10-19&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635976468572&startDate=2025-10-24&endDate=2025-10-26&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Serenity Bay Spa Hotels We don't have any properties that match your exact search [See all properties in Serenity Bay](https://expedia.ca/Hotel-Search?startDate=2025-10-28&endDate=2025-10-29®ionId=553248635976468572&adults=2) ## Recommended hotels in Serenity Bay ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/ce0e5825.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/a1808626.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, video games, stereo](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/10afe7c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/644a4539.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger Serenity Bay 9.8/10 Exceptional (126) "A wonderful stay! The house offered many different spaces and the lake access/dock was perfect!!" CA $490 CA $952 total includes taxes & fees Oct 15 - Oct 16 [](https://www.expedia.ca/Seneca-Hotels-Deepwater-Cove-On-Lake-Keowee-Complete-With-Dock-And-Kayaks-EV-Charger.h24155990.Hotel-Information) ![Aerial view](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/9732d3ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/ad742419.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Resort Studio with Kitchen and Two Queen | Private kitchen](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/70e13494.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/d191b963.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lakeside Lodge Clemson Seneca 9.0/10 Wonderful (1015) "Very beautiful place to stay" CA $153 CA $190 total includes taxes & fees Oct 15 - Oct 16 [](https://www.expedia.ca/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/286fc023.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/a75f160d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/a42189bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Single Room](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/8c83b96e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Liberty Hall Bed and Breakfast Pendleton 10/10 Exceptional (74) "Beautiful home, very clean, easy self check in. I unfortunately was not able to join breakfast during my stay, but the host gave me a goodie bag to go, which was much appreciated! " CA $161 CA $249 total includes taxes & fees Oct 21 - Oct 22 [](https://www.expedia.ca/Pendleton-Hotels-Liberty-Hall-Bed-And-Breakfast.h83025265.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3840h2557x0y4-16ef7416.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/aa533fe0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free breakfast](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3837h2558x3y3-4efd29d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Down comforters, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3837h2557x3y4-050d425f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Clemson Hotel & Conference Center Clemson 8.2/10 Very good (1013) "Great value and great hotel. We would stay there again. " CA $118 CA $131 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information) ![Reception hall](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/959a330b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/4d00561c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/06863ceb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/241a5cc6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Inn at Patrick Square Clemson 9.8/10 Exceptional (765) "Beautiful hotel and close to restaurants and bars. " CA $209 CA $232 total includes taxes & fees Oct 15 - Oct 16 [](https://www.expedia.ca/Anderson-Hotels-The-Inn-At-Patrick-Square.h19511329.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/56d69457.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/e408dd97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Custom King Full](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/179daec9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/e914f3bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Abernathy of Clemson Clemson 9.6/10 Exceptional (546) "Great place for visiting the university " CA $201 CA $223 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Anderson-Hotels-The-Abernathy-Of-Clemson.h17229377.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/78008f7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room, 2 Queen Beds](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/3e16f761.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/10c576cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/d257793d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn @ Clemson Clemson 8.0/10 Very good (1007) "Very nice staff and great place to stay" CA $103 CA $115 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Anderson-Hotels-Inn-Clemson.h84636.Hotel-Information) ![Signature Cottage, 2 Bedrooms | Living room](https://images.trvl-media.com/lodging/90000000/89510000/89502700/89502605/7ab0b44b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature Cottage, 2 Bedrooms | Living room](https://images.trvl-media.com/lodging/90000000/89510000/89502700/89502605/e60c998d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature Cottage, 2 Bedrooms | Living room](https://images.trvl-media.com/lodging/90000000/89510000/89502700/89502605/2033b27c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature Cottage, 2 Bedrooms | Private kitchen](https://images.trvl-media.com/lodging/90000000/89510000/89502700/89502605/2af03635.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Clemson Memorabilia House Clemson 9.8/10 Exceptional (8) "Cute cottage and perfect location for visiting Clemson University. " CA $117 CA $324 total includes taxes & fees Oct 15 - Oct 16 [](https://www.expedia.ca/Clemson-Hotels-Clemson-Memorabilia-House.h89502605.Hotel-Information) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Accessible, Non Smoking](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/347fe1fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/eab53b27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/270-2efd6ebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Seneca Clemson Area US-123 Downtown 8.0/10 Very good (646) "Staff was friendly very clean " CA $106 CA $130 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/19100/19019/e51fff20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/19100/19019/76bc86a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/19100/19019/f179f4b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/20000/19100/19019/7f8f2b8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Clemson - University Area Clemson 8.2/10 Very good (1004) "Awesome place to stay" CA $136 CA $151 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/Anderson-Hotels-Comfort-Inn-Suites-Clemson-University-Area.h19019.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-28&endDate=2025-10-29®ionId=553248635976468572&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top Serenity Bay Hotel Reviews ![Hampton Inn & Suites Seneca-Clemson Area](//images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9_y.jpg) ### Hampton Inn & Suites Seneca-Clemson Area 10/10 Excellent "Great place to stay" [](https://expedia.ca/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information) ![Courtyard Marriott Clemson](//images.trvl-media.com/lodging/3000000/2990000/2983200/2983181/w3996h2667x0y0-e59088f3_y.jpg) ### Courtyard Marriott Clemson 10/10 Excellent "Excellent!!! We loved everything about it!!! " [](https://expedia.ca/Anderson-Hotels-Courtyard-Marriott-Clemson.h2983181.Hotel-Information) ## Frequently asked questions ### Looking to vacation at a spa hotel in Serenity Bay? > Book one of our lush spa hotels and pamper yourself from the moment you arrive. Spa hotels are the perfect way to break out of your daily routine and add a layer of luxury to your weekend away. ### What's there to see and do in Serenity Bay? > Take in the sights and attractions that Serenity Bay offers with a visit to Lake Keowee, Keowee Key Golf Course, and Stumphouse Mountain Tunnel. If you have a bit of extra time while you're in the area, you might want to check out Whitewater Lake and Littlejohn Coliseum. ### What is a Serenity Bay spa hotel? > Spa hotels in Serenity Bay feature on-site spas which offer services including therapies and a range of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. 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