Title: Book the Best Seneca LUXURY Hotels - Upscale Hotels in Seneca, MO | Expedia.ca [Hotels in Seneca](https://expedia.ca/Seneca-Hotels.d553248634998773096.Travel-Guide-Hotels)[Vacation Rentals in Seneca](https://expedia.ca/Seneca-Vacation-Rentals.d553248634998773096.Travel-Guide-VacationRentals)[Seneca Car Rentals](https://expedia.ca/Car-Rentals-In-Seneca.d553248634998773096.Car-Rental-Guide)[Seneca Vacation Packages](https://expedia.ca/Seneca.d553248634998773096.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Seneca, MO ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Seneca Luxury Hotels Tonight [Oct 14 - Oct 15](https://www.expedia.ca/Hotel-Search?regionId=553248634998773096&startDate=2025-10-14&endDate=2025-10-15&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 15 - Oct 16](https://www.expedia.ca/Hotel-Search?regionId=553248634998773096&startDate=2025-10-15&endDate=2025-10-16&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248634998773096&startDate=2025-10-17&endDate=2025-10-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248634998773096&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Seneca Luxury Hotels ## Top Seneca Hotel Reviews ![La Quinta Inn & Suites by Wyndham Joplin](//images.trvl-media.com/lodging/1000000/30000/23200/23115/afcfaeed_y.jpg) ### La Quinta Inn & Suites by Wyndham Joplin 10/10 Excellent "I checked in online the day before so when I arrived at the hotel the check in process took less than 30 seconds!" [](https://expedia.ca/Joplin-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Joplin.h23115.Hotel-Information) ![Best Western The Oasis at Joplin](//images.trvl-media.com/lodging/1000000/910000/900200/900127/f77a3a9d_y.jpg) ### Best Western The Oasis at Joplin 10/10 Excellent "Clean room. Great breakfast. Easy to walk to at least 5 or more eating places" [](https://expedia.ca/Joplin-Hotels-Best-Western-The-Oasis-At-Joplin.h900127.Hotel-Information) ![Days Inn by Wyndham Joplin](//images.trvl-media.com/lodging/1000000/20000/13500/13457/74418677_y.jpg) ### Days Inn by Wyndham Joplin 10/10 Excellent "Great place to stay. I always stay here when I travel to Joplin. " [](https://expedia.ca/Joplin-Hotels-Days-Inn-By-Wyndham-Joplin.h13457.Hotel-Information) ![Econo Lodge Inn & Suites Joplin](//images.trvl-media.com/lodging/1000000/10000/7400/7376/62fc0a14_y.jpg) ### Econo Lodge Inn & Suites Joplin 10/10 Excellent "The gal at the front desk was great; very friendly and helpful! The pool area was nice to sit in and unwind from a long drive. All other aspects of our stay weren't so great - but we got what we paid for as we arrived late and needed to leave early in the morning. Allergies were running rampant in our room, the doors closed so loudly and our shower curtain seemed to have some dried blood on it....ick. There are plenty of other places to stay in Joplin." [](https://expedia.ca/Joplin-Hotels-Econo-Lodge-Inn-Suites-Joplin.h7376.Hotel-Information) ![Residence Inn Marriott Joplin](//images.trvl-media.com/lodging/2000000/1430000/1427900/1427814/44e9ea9b_y.jpg) ### Residence Inn Marriott Joplin 10/10 Excellent "The Staff was polite, courteous, and very friendly. When I had a few concerning issues. They were quick to respond and resolved it in a timely matter. The room overall was nice and clean. It had everything I needed to make my time comfortable. The free breakfast was good. It had different options for you to choose from. I would stay here again when I plan to revisit Joplin, MO. in the near future. " [](https://expedia.ca/Joplin-Hotels-Residence-Inn-Marriott-Joplin.h1427814.Hotel-Information) ## Frequently asked questions ### Are you searching for a great accommodation for your luxury trip to Seneca? > Expedia can help you arrange a flight to Joplin, MO (JLN-Joplin Regional) airport, and then you can select from various places to stay that will deliver the luxury you'd like to find. Amenities are an important consideration when you plan a trip, so we make it easy to find what you need to make your stay relaxing and comfortable. If you want a posh hotel with a spa, an indoor pool, or luxury bedding, Expedia can help you find the best luxury hotel experience that Seneca offers. ### When can I expect good weather in Seneca? > Planning for the weather is an important factor for making your trip to Seneca a success, especially when you're splurging. The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Seneca is 52 inches. ### What's there to see and do in Seneca? > Experience Seneca with a stop at Indigo Sky Casino, Downstream Casino Resort, and Buffalo Run Casino. 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