Title: Book the Best BUSINESS Hotels in Second Mesa in 2025 | Expedia.ca [Second Mesa Travel Guide](https://expedia.ca/Second-Mesa.dx553248624339242280)[Hotels in Second Mesa](https://expedia.ca/Second-Mesa-Hotels.d553248624339242280.Travel-Guide-Hotels)[Vacation Rentals in Second Mesa](https://expedia.ca/Second-Mesa-Vacation-Rentals.d553248624339242280.Travel-Guide-VacationRentals)[Things to do in Second Mesa](https://expedia.ca/Things-To-Do-In-Second-Mesa.d553248624339242280.Travel-Guide-Activities)[Second Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Second-Mesa.d553248624339242280.Car-Rental-Guide)[Second Mesa Vacation Packages](https://expedia.ca/Second-Mesa.d553248624339242280.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/197d2580a91a6b51818947d18e1a7a81.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Yasser Hamid Syed # Find Business Hotels in Second Mesa, AZ ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Second Mesa Business Hotels Tonight [Oct 18 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248624339242280&startDate=2025-10-18&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Oct 19 - Oct 20](https://www.expedia.ca/Hotel-Search?regionId=553248624339242280&startDate=2025-10-19&endDate=2025-10-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248624339242280&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) In two weeks [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248624339242280&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Top Second Mesa Business Hotels We don't have any properties that match your exact search [See all properties in Second Mesa](https://expedia.ca/Hotel-Search?startDate=2025-11-02&endDate=2025-11-03®ionId=553248624339242280&adults=2) ## Recommended hotels in Second Mesa ![Restaurant](https://images.trvl-media.com/lodging/18000000/17070000/17067800/17067718/3974928f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/18000000/17070000/17067800/17067718/f66ebcfd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, blackout drapes, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/18000000/17070000/17067800/17067718/05f397bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom, Kitchenette, Courtyard View | Private kitchen](https://images.trvl-media.com/lodging/18000000/17070000/17067800/17067718/c5665f0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hopi Cultural Center Second Mesa 8.2/10 Very good (336) "grateful this hotel is available in this remote area" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Denver [](https://www.expedia.ca/Second-Mesa-Hotels-Hopi-Cultural-Center.h17067718.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-02&endDate=2025-11-03®ionId=553248624339242280&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Second Mesa Hotel Reviews ![Hopi Cultural Center](//images.trvl-media.com/lodging/18000000/17070000/17067800/17067718/3974928f_y.jpg) ### Hopi Cultural Center 10/10 Excellent "A unique olace to stay on our way to the Grand Canyon. lean, quiet, and a nice restaurant with a selection of Hopi food." [](https://expedia.ca/Second-Mesa-Hotels-Hopi-Cultural-Center.h17067718.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Second Mesa cost? > Prices for business hotels in Second Mesa range between and per night. Whatever your budget, Expedia will help you find the right space for a smooth work trip. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply. ### Why book your business-friendly hotel in Second Mesa with Expedia? > Expedia will help you find the ideal business-friendly hotel for your upcoming work trip. From free WiFi and parking to on-site cafés and restaurants, our stays come with the conveniences you'll need to settle that big contract. ### How can I find cheap business-friendly hotels in Second Mesa? > Expedia can help you easily locate cheap business-friendly hotels in Second Mesa. Simply go to our "traveller experience" filter and click on "business friendly." This will show you accommodations with amenities designed to help you work effectively and comfortably, like free WiFi and included breakfast. 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