Title: Book the Best Seacoast Region LUXURY Hotels - Upscale Hotels in Seacoast Region, NH | Expedia.ca [Seacoast Region Travel Guide](https://expedia.ca/Seacoast-Region.dx553248635975749568)[Hotels in Seacoast Region](https://expedia.ca/Seacoast-Region-Hotels.d553248635975749568.Travel-Guide-Hotels)[Vacation Rentals in Seacoast Region](https://expedia.ca/Seacoast-Region-Vacation-Rentals.d553248635975749568.Travel-Guide-VacationRentals)[Flights to Seacoast Region](https://expedia.ca/Cheap-Flights-To-Seacoast-Region.d553248635975749568.Travel-Guide-Flights)[Seacoast Region Car Rentals](https://expedia.ca/Car-Rentals-In-Seacoast-Region.d553248635975749568.Car-Rental-Guide)[Seacoast Region Vacation Packages](https://expedia.ca/Seacoast-Region.d553248635975749568.Destination-Travel-Guides) ![Portsmouth](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/105000/105138-Portsmouth.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Seacoast Region, NH ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Seacoast Region Luxury Hotels Tonight [Oct 7 - Oct 8](https://www.expedia.ca/Hotel-Search?regionId=553248635975749568&startDate=2025-10-07&endDate=2025-10-08&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 8 - Oct 9](https://www.expedia.ca/Hotel-Search?regionId=553248635975749568&startDate=2025-10-08&endDate=2025-10-09&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248635975749568&startDate=2025-10-10&endDate=2025-10-12&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635975749568&startDate=2025-10-17&endDate=2025-10-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Seacoast Region Luxury Hotels ## Top Seacoast Region Hotel Reviews ![Hampton House Hotel](//images.trvl-media.com/lodging/10000000/9750000/9743400/9743358/f3d16a83_y.jpg) ### Hampton House Hotel 10/10 Excellent "Great room right across from beach. Very nice stay." [](https://expedia.ca/Portsmouth-Hotels-Hampton-House-Hotel.h9743358.Hotel-Information) ![Howard Johnson by Wyndham Portsmouth](//images.trvl-media.com/lodging/1000000/520000/517500/517424/e05bdc89_y.jpg) ### Howard Johnson by Wyndham Portsmouth 10/10 Excellent "Very interesting "Howard Johnson" theme with retro paint and accessories." [](https://expedia.ca/Portsmouth-Hotels-Howard-Johnson-By-Wyndham-Portsmouth.h517424.Hotel-Information) ![Motel 6 Portsmouth, NH](//images.trvl-media.com/lodging/1000000/1000000/996300/996239/10ee4974_y.jpg) ### Motel 6 Portsmouth, NH 10/10 Excellent "No apparent area for pets. Parking lot has a road running through it so cars may be coming through fast. Room clean, staff efficient. " [](https://expedia.ca/Portsmouth-Hotels-Motel-6-Portsmouth.h996239.Hotel-Information) ![Port Inn and Suites Portsmouth, an Ascend Collection Hotel](//images.trvl-media.com/lodging/1000000/900000/894200/894133/c1712c91_y.jpg) ### Port Inn and Suites Portsmouth, an Ascend Collection Hotel 10/10 Excellent "Excellent one-night stay. Spacious room, clean, and comfortable bed. Lots of dining options close by. Opted to buy food at the local grocery store." [](https://expedia.ca/Portsmouth-Hotels-Port-Inn-And-Suites-Portsmouth.h894133.Hotel-Information) ![Hampton Inn & Suites Portsmouth Downtown](//images.trvl-media.com/lodging/9000000/8270000/8268900/8268861/b0df55fb_y.jpg) ### Hampton Inn & Suites Portsmouth Downtown 10/10 Excellent "Unfortunately, did not stay long enough to explore the area, but there were several interesting shops nearby." [](https://expedia.ca/Portsmouth-Hotels-Hampton-Inn-Suites-Portsmouth-Downtown.h8268861.Hotel-Information) ![Holiday Inn Express Hotel & Suites Seabrook by IHG](//images.trvl-media.com/lodging/2000000/1700000/1696000/1695935/d4b7d85f_y.jpg) ### Holiday Inn Express Hotel & Suites Seabrook by IHG 10/10 Excellent "Room was clean and facility was convenient to I-95. Staff was friendly." [](https://expedia.ca/Portsmouth-Hotels-Holiday-Inn-Express-Hotel-Suites-Seabrook.h1695935.Hotel-Information) ![Exeter Inn](//images.trvl-media.com/lodging/1000000/40000/37600/37517/e7318ed7_y.jpg) ### Exeter Inn 10/10 Excellent "This is an older hotel but is kept up very well. The room was nice and comfortable. Everyone we encountered at the property was nice. Will stay again when in the area!" [](https://expedia.ca/Portsmouth-Hotels-Exeter-Inn.h37517.Hotel-Information) ![Best Western Hampshire Inn](//images.trvl-media.com/lodging/3000000/2480000/2475600/2475562/ec99ca0c_y.jpg) ### Best Western Hampshire Inn 10/10 Excellent "Yes" [](https://expedia.ca/Portsmouth-Hotels-Best-Western-Hampshire-Inn.h2475562.Hotel-Information) ![Hilton Garden Inn Portsmouth Downtown](//images.trvl-media.com/lodging/2000000/1470000/1464400/1464340/7de77d01_y.jpg) ### Hilton Garden Inn Portsmouth Downtown 10/10 Excellent "We loved the location..it was convenient and very walkable to anywhere in town..The room was spotless and comfortable " [](https://expedia.ca/Portsmouth-Hotels-Hilton-Garden-Inn-Portsmouth-Downtown.h1464340.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [4 Star Hotels in Exeter](https://www.expedia.ca/4Star-Exeter-Hotels.s40-0-d8057.Travel-Guide-Filter-Hotels) - [Adults Only Resorts & in New Hampshire](https://www.expedia.ca/Destinations-In-New-Hampshire-Adults-Only-Resorts.0-0-d231-tAdultsOnlyResorts.Hotel-Filter-Destinations) - 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