Title: Book the Best BUSINESS Hotels in São Tomé Island in 2026 | Expedia.ca [São Tomé Island Travel Guide](https://expedia.ca/Sao-Tome-Island.dx3486)[Hotels in São Tomé Island](https://expedia.ca/Sao-Tome-Island-Hotels.d3486.Travel-Guide-Hotels)[Vacation Rentals in São Tomé Island](https://expedia.ca/Sao-Tome-Island-Vacation-Rentals.d3486.Travel-Guide-VacationRentals)[Flights to São Tomé Island](https://expedia.ca/Cheap-Flights-To-Sao-Tome-Island.d3486.Travel-Guide-Flights)[Things to do in São Tomé Island](https://expedia.ca/Things-To-Do-In-Sao-Tome-Island.d3486.Travel-Guide-Activities)[São Tomé Island Car Rentals](https://expedia.ca/Car-Rentals-In-Sao-Tome-Island.d3486.Car-Rental-Guide)[São Tomé Island Vacation Packages](https://expedia.ca/Sao-Tome-Island.d3486.Destination-Travel-Guides) ![Nice place, good food... Quite difficult to reach, you need a good car...](https://images.trvl-media.com/place/553248621565299214/edf5448a-52b1-44ed-852d-bc5327dd1c36.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Fabrice Récalt # Find Business Hotels in São Tomé Island from CA $322 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on São Tomé Island Business Hotels Tonight [Dec 9 - Dec 10](https://www.expedia.ca/Hotel-Search?regionId=3486&startDate=2025-12-09&endDate=2025-12-10&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Dec 10 - Dec 11](https://www.expedia.ca/Hotel-Search?regionId=3486&startDate=2025-12-10&endDate=2025-12-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=3486&startDate=2025-12-12&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=3486&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for São Tomé Island business-friendly hotels ![Lobby sitting area](https://images.trvl-media.com/lodging/23000000/22450000/22443300/22443247/bab20d17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/23000000/22450000/22443300/22443247/68d94f7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Buffet](https://images.trvl-media.com/lodging/23000000/22450000/22443300/22443247/e6d4a2d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/23000000/22450000/22443300/22443247/c4101405.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SH Boutique Hotel São Tomé 8.6/10 Excellent (10) "Staff were very accommodating " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Simon Peter [](https://www.expedia.ca/Sao-Tome-Island-Hotels-SH-Boutique-Hotel.h22443247.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/107000000/106990000/106989500/106989405/10340e2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/107000000/106990000/106989500/106989405/a0b55f38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/107000000/106990000/106989500/106989405/1ba9ed4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Double Room, Partial Sea View](https://images.trvl-media.com/lodging/107000000/106990000/106989500/106989405/2db5e3ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Kriola São Tomé 9.0/10 Wonderful (4) "Loved the mermaids in the pool" ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) Eduardo Jorge Bettencourt da [](https://www.expedia.ca/Sao-Tome-Hotels-Hotel-Kriola.h106989405.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/7000000/6770000/6762300/6762264/d1688203.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/7000000/6770000/6762300/6762264/741e11cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor wedding area](https://images.trvl-media.com/lodging/7000000/6770000/6762300/6762264/7d8ab7b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/7000000/6770000/6762300/6762264/1d47642d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omali São Tomé – Principe Collection São Tomé 9.4/10 Exceptional (62) "The employees really make the property a superstar. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mona CA $271 CA $322 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/Sao-Tome-Island-Hotels-Omali-Sao-Tome.h6762264.Hotel-Information) ![Coffee shop](https://images.trvl-media.com/lodging/38000000/37700000/37697100/37697027/5e2988d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/38000000/37700000/37697100/37697027/5c6a7fa0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room, City View](https://images.trvl-media.com/lodging/38000000/37700000/37697100/37697027/03eea49c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/38000000/37700000/37697100/37697027/fc496aaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Central São Tomé 8.2/10 Very good (24) "Great value. Great location. Ok breakfast. Overall good value for money" ![Norway](https://a.travel-assets.com/egds/marks/flags/no.svg) Elisabeth [](https://www.expedia.ca/Sao-Tome-Island-Hotels-Hotel-Central.h37697027.Hotel-Information) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/19000000/18910000/18900300/18900207/3031ec18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/19000000/18910000/18900300/18900207/5242c321.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Beach](https://images.trvl-media.com/lodging/19000000/18910000/18900300/18900207/74d1540a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18910000/18900300/18900207/29be8553.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Praia São Tomé 7.6/10 Good (17) "Solid, basic hotel. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jonathan [](https://www.expedia.ca/Sao-Tome-Island-Hotels-Hotel-Praia.h18900207.Hotel-Information) ![Poolside bar](https://images.trvl-media.com/lodging/27000000/26600000/26593200/26593135/0767273b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Twin Room, 2 Single Beds](https://images.trvl-media.com/lodging/27000000/26600000/26593200/26593135/ed868ec8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch plasma TV with cable channels, TV](https://images.trvl-media.com/lodging/27000000/26600000/26593200/26593135/46f82fa2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/27000000/26600000/26593200/26593135/54c71534.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Praia Accommodation São Tomé 7.2/10 Good (17) "Great place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Daniel [](https://www.expedia.ca/Sao-Tome-Island-Hotels-Praia-Accommodation.h26593135.Hotel-Information) ![Bungalow](https://images.trvl-media.com/lodging/40000000/39490000/39486200/39486195/e4d8c6e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bungalow](https://images.trvl-media.com/lodging/40000000/39490000/39486200/39486195/b8ac8133.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Classic House | In-room dining](https://images.trvl-media.com/lodging/40000000/39490000/39486200/39486195/4670fd80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/40000000/39490000/39486200/39486195/2d9f01d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Guest House Quinta Natural Trindade 10/10 Exceptional (1) [](https://www.expedia.ca/Sao-Tome-Island-Hotels-Guest-House-Quinta-Natural.h39486195.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-23&endDate=2025-12-24®ionId=3486&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top São Tomé Island Hotel Reviews ![Pestana São Tomé](https://images.trvl-media.com/lodging/3000000/2160000/2150500/2150447/ea6ea619_y.jpg) ### Pestana São Tomé 10/10 Excellent "Had a great time had a very nice view and great people working here." [](https://expedia.ca/Sao-Tome-Island-Hotels-Pestana-Sao-Tome.h2150447.Hotel-Information) ![Omali São Tomé – Principe Collection](https://images.trvl-media.com/lodging/7000000/6770000/6762300/6762264/d1688203_y.jpg) ### Omali São Tomé – Principe Collection 10/10 Excellent "Room was very clean. I didn't get to get the full experience as i was only there overnight. But the pizza i had was delicious as well. Staff was friendly." [](https://expedia.ca/Sao-Tome-Island-Hotels-Omali-Sao-Tome.h6762264.Hotel-Information) ## Frequently asked questions ### Why book your business-friendly hotel in São Tomé Island with Expedia? ### How can I find cheap business-friendly hotels in São Tomé Island? ### What is there to do in São Tomé Island near my business-friendly hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - [All Inclusive Resorts and in São Tomé and Príncipe ](https://www.expedia.ca/Destinations-In-Sao-Tome-And-Principe-All-Inclusive-Hotel.0-0-d156-tAllInclusiveHotel.Hotel-Filter-Destinations) - [Beach Hotel Hotels in São Tomé and Príncipe ](https://www.expedia.ca/Destinations-In-Sao-Tome-And-Principe-Beach-Hotel.0-0-d156-tBeachHotel.Hotel-Filter-Destinations) - [Boutique Hotels in São Tomé and Príncipe ](https://www.expedia.ca/Destinations-In-Sao-Tome-And-Principe-Boutique-Hotel.0-0-d156-tBoutiqueHotel.Hotel-Filter-Destinations) - [Business Hotels in São Tomé and Príncipe ](https://www.expedia.ca/Destinations-In-Sao-Tome-And-Principe-Business-Hotel.0-0-d156-tBusinessHotel.Hotel-Filter-Destinations) - 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