Title: Book the Best Santo Spirito LUXURY Hotels - Upscale Hotels in Santo Spirito, Florence | Expedia.ca [Santo Spirito Travel Guide](https://expedia.ca/Florence-Santo-Spirito.dx553248633938935375)[Vacation Rentals in Florence](https://expedia.ca/Florence-Vacation-Rentals.d1222.Travel-Guide-VacationRentals)[Flights to Florence](https://expedia.ca/Cheap-Flights-To-Florence.d1222.Travel-Guide-Flights)[Things to do in Florence](https://expedia.ca/Things-To-Do-In-Florence.d1222.Travel-Guide-Activities)[Santo Spirito Car Rentals](https://expedia.ca/Car-Rentals-In-Santo-Spirito.d553248633938935375.Car-Rental-Guide)[Santo Spirito Vacations](https://expedia.ca/Santo-Spirito.d553248633938935375.Destination-Travel-Guides) ![Province of Florence showing interior views, heritage elements and a church or cathedral](https://images.trvl-media.com/place/179893/dd801080-5529-49c4-b78b-415c9c4a56e9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Luxury Hotels in Santo Spirito, Florence - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santo Spirito Luxury Hotels Tonight [Dec 5 - Dec 6](https://www.expedia.ca/Hotel-Search?regionId=553248633938935375&startDate=2025-12-05&endDate=2025-12-06&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Dec 6 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=553248633938935375&startDate=2025-12-06&endDate=2025-12-07&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=553248633938935375&startDate=2025-12-05&endDate=2025-12-07&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=553248633938935375&startDate=2025-12-12&endDate=2025-12-14&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Santo Spirito Luxury Hotels ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/2000000/1570000/1563900/1563886/12c83c84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1570000/1563900/1563886/577c5eba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1570000/1563900/1563886/ae1768f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room](https://images.trvl-media.com/lodging/2000000/1570000/1563900/1563886/cc30c683.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Torre di Bellosguardo Oltrarno 9.0/10 Wonderful (103) "Beautiful property and wonderful staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brad CA $523 CA $598 total includes taxes & fees Dec 6 - Dec 7 [](https://www.expedia.ca/Florence-Hotels-Torre-Di-Bellosguardo.h1563886.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/18000000/17940000/17933900/17933824/9c90a529.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/18000000/17940000/17933900/17933824/c93d1e27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/18000000/17940000/17933900/17933824/410051d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/18000000/17940000/17933900/17933824/2fcd3ee1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Horto Convento Historic Centre of Florence 9.8/10 Exceptional (594) "Excellent staff, so friendly and helpful. Lovely hotel in a great location. " ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) Emma CA $154 CA $193 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Florence-Hotels-Hotel-Horto-Convento.h17933824.Hotel-Information) ![Interior detail](https://images.trvl-media.com/lodging/3000000/2530000/2524400/2524373/5017fcc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, 1 Bedroom](https://images.trvl-media.com/lodging/3000000/2530000/2524400/2524373/db68a5eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/3000000/2530000/2524400/2524373/b5e20b89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, 1 Bedroom](https://images.trvl-media.com/lodging/3000000/2530000/2524400/2524373/5d36466d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Palazzo Mannaioni Suites Historic Centre of Florence 9.2/10 Wonderful (1070) "Perfect stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Juan P CA $207 CA $251 total includes taxes & fees Dec 7 - Dec 8 [](https://www.expedia.ca/Florence-Hotels-Palazzo-Mannaioni-Suites.h2524373.Hotel-Information) ![Premium bedding, pillowtop beds, minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/910000/905700/905634/534e501f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily continental breakfast (EUR 14 per person)](https://images.trvl-media.com/lodging/1000000/910000/905700/905634/25bb1a41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/1000000/910000/905700/905634/c9d77b08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/910000/905700/905634/ef0ddf53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### UNA Hotels Vittoria Firenze Oltrarno 8.4/10 Very good (1000) "Super nice reception staffs, everyone is so friendly and welcoming. But don’t like the red room decoration. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Tina [](https://www.expedia.ca/Florence-Hotels-UNAHOTELS-Vittoria-Firenze.h905634.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/14600/14583/9c1dd8be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/20000/14600/14583/aec9cff4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Design Suite, River View | View from room](https://images.trvl-media.com/lodging/1000000/20000/14600/14583/74e11d88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, River View | View from room](https://images.trvl-media.com/lodging/1000000/20000/14600/14583/20017c13.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Lungarno - Lungarno Collection Historic Centre of Florence 9.6/10 Exceptional (597) "Excellent location! Truly a 5 star hotel ! Great service, breakfast, and service . Bedrooms were clean! Bathrooms were excellent!" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Pam CA $968 CA $1,091 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Florence-Hotels-Hotel-Lungarno-Lungarno-Collection.h14583.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/1000000/30000/22600/22579/bc8037ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22600/22579/8de77b8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/22600/22579/3979fa4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/30000/22600/22579/1b8b315e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Villa Cora Oltrarno 9.8/10 Exceptional (468) "Nice property and staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Hugo [](https://www.expedia.ca/Florence-Hotels-Villa-Cora.h22579.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/6000000/5320000/5316500/5316421/0971031a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, minibar, in-room safe, individually furnished](https://images.trvl-media.com/lodging/6000000/5320000/5316500/5316421/79ed03a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/6000000/5320000/5316500/5316421/f3566b22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/6000000/5320000/5316500/5316421/a01bdbf1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Number Nine Historic Centre of Florence 9.6/10 Exceptional (1000) "Excellent staff, beautiful rooms, location was perfect! The breakfast staff were exceptional! Lovely every morning and they were so sweet and kind! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer CA $400 CA $466 total includes taxes & fees Dec 9 - Dec 10 [](https://www.expedia.ca/Florence-Hotels-Hotel-Firenze-Number-Nine.h5316421.Hotel-Information) ![Seasonal outdoor pool, open 9:00 AM to 7:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/2000000/1220000/1216500/1216478/288cff0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; local cuisine, garden views ](https://images.trvl-media.com/lodging/2000000/1220000/1216500/1216478/346cd924.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Studio Suite | View from room](https://images.trvl-media.com/lodging/2000000/1220000/1216500/1216478/07f20b30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; local cuisine, garden views ](https://images.trvl-media.com/lodging/2000000/1220000/1216500/1216478/ac1776a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Borgo di Cortefreda Relais Barberino Tavarnelle 9.4/10 Exceptional (477) "The views were spectacular and the grounds were so peaceful" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michelle CA $126 CA $149 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/Barberino-Tavarnelle-Hotels-Hotel-Borgo-Di-Cortefreda-Relais.h1216478.Hotel-Information) ![Dinner served, Regional cuisine, alfresco dining ](https://images.trvl-media.com/lodging/1000000/40000/34800/34764/d1fde459.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite Bristol](https://images.trvl-media.com/lodging/1000000/40000/34800/34764/eb28c244.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/40000/34800/34764/9e68aeac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/40000/34800/34764/a4a0df4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Helvetia & Bristol Firenze – Starhotels Collezione Historic Centre of Florence 9.2/10 Wonderful (546) "The nightly turndown service, front desk attentiveness, clean rooms, and wonderful doormen were all just wonderful. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kevin CA $710 CA $807 total includes taxes & fees Jan 5 - Jan 6, 2026 [](https://www.expedia.ca/Florence-Hotels-Helvetia-Bristol-Firenze-Starhotels-Collezione.h34764.Hotel-Information) ![Seasonal outdoor pool, open 9:00 AM to 7:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/1000000/590000/582300/582298/e755ba4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily buffet breakfast for a fee](https://images.trvl-media.com/lodging/1000000/590000/582300/582298/9789acb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/1000000/590000/582300/582298/308ed609.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Romantic Suite (428)](https://images.trvl-media.com/lodging/1000000/590000/582300/582298/0a5079d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Grand Hotel Minerva Historic Centre of Florence 9.6/10 Exceptional (1001) "Beautiful Hotel, Great Central Location, Kind Staff and Excellent Food" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Preeti CA $421 CA $486 total includes taxes & fees Dec 7 - Dec 8 [](https://www.expedia.ca/Florence-Hotels-Grand-Hotel-Minerva.h582298.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-19&endDate=2025-12-20®ionId=553248633938935375&adults=2&sort=LUXURY&star=50&openPlayBack=true) ## Find out more about Santo Spirito ### Santo Spiritoand its attractions for luxury travelers Santo Spirito, nestled in the heart of Florence, is a paradise for luxury travellers seeking an authentic Italian experience. Begin your journey at the stunning Basilica di Santo Spirito, where you can admire exquisite Renaissance art by masters like Michelangelo and enjoy the peaceful cloister gardens. Just a short stroll away lies the lively Piazza Santo Spirito, adorned with a vibrant local market on Sundays, perfect for picking up unique artisanal goods and enjoying gourmet street food from local vendors. For a touch of elegance, indulge in a wine tasting at Enoteca Pitti Gola e Cantina, where you can sip on exquisite Tuscan wines while soaking in the rustic charm of the surroundings. Don't miss the chance to explore the stunning Boboli Gardens, a short walk away, offering sprawling landscapes and breathtaking views of Florence, ideal for a leisurely afternoon. Finally, unwind at one of the luxury hotels in the area, where impeccable service meets charming Florentine decor, ensuring that your stay is as comfortable as it is memorable. Picture settling into a suite with panoramic views of the Arno River, enjoying a bespoke dining experience that celebrates local cuisine, and being pampered at a tranquil spa—all while being steps away from the rich cultural heritage of this enchanting neighbourhood. ## Top Santo Spirito Hotel Reviews ![UNA Hotels Vittoria Firenze](https://images.trvl-media.com/lodging/1000000/910000/905700/905634/534e501f_y.jpg) ### UNA Hotels Vittoria Firenze 10/10 Excellent "Super nice reception staffs, everyone is so friendly and welcoming. But don’t like the red room decoration. " [](https://expedia.ca/Florence-Hotels-UNAHOTELS-Vittoria-Firenze.h905634.Hotel-Information) ![Hotel Palazzo Guadagni](https://images.trvl-media.com/lodging/4000000/3200000/3196400/3196305/12e1df84_y.jpg) ### Hotel Palazzo Guadagni 10/10 Excellent "Hotel Palazzo was stunning. I would definitely stay here again and I already can't wait to! The staff were so friendly and made you feel right at home. Everything was walking distance and the area was incredible!" [](https://expedia.ca/Florence-Hotels-Hotel-Palazzo-Guadagni.h3196305.Hotel-Information) ![Palazzo Guicciardini](https://images.trvl-media.com/lodging/9000000/8100000/8099100/8099013/77600b23_y.jpg) ### Palazzo Guicciardini 10/10 Excellent "This is a small boutique hotel 5 minutes walk from the ponte Vecchio bridge! The staff were so kind and gave us a map of the city and gave us information on great things to see and restaurants to try! The hotel was beautiful and the room was HUGE and property very clean! Our only issue was when typing in the name of the hotel on Google maps, it had our Uber drop us off at a historical sight a couple blocks away due to the two having the same name- this error is mostly our bad because we didn’t confirm the address before putting it in for the Uber but would have been a nice heads up! " [](https://expedia.ca/Florence-Hotels-Palazzo-Guicciardini.h8099013.Hotel-Information) ## Frequently asked questions ### Are you searching for a great accommodation for your luxury getaway to Santo Spirito? ### What's the best high-end hotel in Santo Spirito? ### What's there to see and do in Santo Spirito? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [Hotels near Boboli Gardens ](https://www.expedia.ca/Boboli-Gardens-Hotels.0-l507684-0.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Province of Florence ](https://www.expedia.ca/Destinations-In-Province-Of-Florence-Boutique-Hotel.0-0-d179893-tBoutiqueHotel.Hotel-Filter-Destinations) - [Winery Hotels in Province of Florence ](https://www.expedia.ca/Destinations-In-Province-Of-Florence-Winery-Hotel.0-0-d179893-tWineryHotel.Hotel-Filter-Destinations) - [Province of Florence Hotels ](https://www.expedia.ca/Destinations-In-Province-Of-Florence.d179893.Hotel-Destinations) - 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