Title: Book the Best Santo Spirito LUXURY Hotels - Upscale Hotels in Santo Spirito, Florence | Expedia.ca [Santo Spirito Travel Guide](https://expedia.ca/Florence-Santo-Spirito.dx553248633938935375)[Vacation Rentals in Florence](https://expedia.ca/Florence-Vacation-Rentals.d1222.Travel-Guide-VacationRentals)[Flights to Florence](https://expedia.ca/Cheap-Flights-To-Florence.d1222.Travel-Guide-Flights)[Things to do in Florence](https://expedia.ca/Things-To-Do-In-Florence.d1222.Travel-Guide-Activities)[Santo Spirito Car Rentals](https://expedia.ca/Car-Rentals-In-Santo-Spirito.d553248633938935375.Car-Rental-Guide)[Santo Spirito Vacations](https://expedia.ca/Santo-Spirito.d553248633938935375.Destination-Travel-Guides) ![Province of Florence showing interior views, heritage elements and a church or cathedral](https://images.trvl-media.com/place/179893/dd801080-5529-49c4-b78b-415c9c4a56e9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/179893/dd801080-5529-49c4-b78b-415c9c4a56e9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santo Spirito Luxury Hotels Tonight [Jan 28 - Jan 29](https://www.expedia.ca/Hotel-Search?regionId=553248633938935375&startDate=2026-01-28&endDate=2026-01-29&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Jan 29 - Jan 30](https://www.expedia.ca/Hotel-Search?regionId=553248633938935375&startDate=2026-01-29&endDate=2026-01-30&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=553248633938935375&startDate=2026-01-30&endDate=2026-02-01&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=553248633938935375&startDate=2026-02-06&endDate=2026-02-08&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Our top choices for Santo Spirito luxury hotels ![Suite | Room amenity](https://images.trvl-media.com/lodging/2000000/1570000/1563900/1563886/213d0291.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/2000000/1570000/1563900/1563886/fa37c9fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1570000/1563900/1563886/577c5eba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1570000/1563900/1563886/ae1768f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Torre di Bellosguardo [](https://www.expedia.ca/Florence-Hotels-Torre-Di-Bellosguardo.h1563886.Hotel-Information) Oltrarno 9.0/10 Wonderful (103 reviews) "Beautiful property and wonderful staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brad CA $524 CA $599 total includes taxes & fees Feb 17 - Feb 18 [](https://www.expedia.ca/Florence-Hotels-Torre-Di-Bellosguardo.h1563886.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/18000000/17940000/17933900/17933824/9c90a529.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/18000000/17940000/17933900/17933824/99ad8e32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/18000000/17940000/17933900/17933824/410051d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/18000000/17940000/17933900/17933824/c93d1e27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Horto Convento [](https://www.expedia.ca/Florence-Hotels-Hotel-Horto-Convento.h17933824.Hotel-Information) Historic Centre of Florence 9.8/10 Exceptional (613 reviews) "Lovely clean, quiet and safe hotel. really good breakfast and staff. Good location within walking distance to everything. " ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) Shaunna CA $153 CA $192 total includes taxes & fees Feb 5 - Feb 6 [](https://www.expedia.ca/Florence-Hotels-Hotel-Horto-Convento.h17933824.Hotel-Information) ![Suite](https://images.trvl-media.com/lodging/3000000/2530000/2524400/2524373/494dead9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, 1 Bedroom | Living area](https://images.trvl-media.com/lodging/3000000/2530000/2524400/2524373/dc605e9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/3000000/2530000/2524400/2524373/807f1dbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2530000/2524400/2524373/1a3abf8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Palazzo Mannaioni Suites [](https://www.expedia.ca/Florence-Hotels-Palazzo-Mannaioni-Suites.h2524373.Hotel-Information) Historic Centre of Florence 9.2/10 Wonderful (1,080 reviews) "Everything great. A+ Looking forward to stay again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rafael CA $141 CA $201 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Florence-Hotels-Palazzo-Mannaioni-Suites.h2524373.Hotel-Information) ![Daily continental breakfast (EUR 14 per person)](https://images.trvl-media.com/lodging/1000000/910000/905700/905634/25bb1a41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/1000000/910000/905700/905634/00a791c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/910000/905700/905634/534e501f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/910000/905700/905634/6e8292d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### UNA Hotels Vittoria Firenze [](https://www.expedia.ca/Florence-Hotels-UNAHOTELS-Vittoria-Firenze.h905634.Hotel-Information) Oltrarno 8.4/10 Very good (1,000 reviews) "Perfect stay! Not only was the check-in smooth, but everything else was also satisfying. The breakfast was delicious, the staff were friendly, and the location was ideal. There wasn't a single thing I didn't like. I’ll definitely be back!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) JINHEE CA $118 CA $153 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Florence-Hotels-UNAHOTELS-Vittoria-Firenze.h905634.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/1000000/30000/22600/22579/bc8037ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/30000/22600/22579/01d144a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/22600/22579/41ce8798.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22600/22579/8de77b8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Villa Cora [](https://www.expedia.ca/Florence-Hotels-Villa-Cora.h22579.Hotel-Information) Oltrarno 9.8/10 Exceptional (470 reviews) "Nice property and staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Hugo CA $615 CA $703 total includes taxes & fees Feb 12 - Feb 13 [](https://www.expedia.ca/Florence-Hotels-Villa-Cora.h22579.Hotel-Information) ![Seasonal outdoor pool, open 9:00 AM to 7:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/1000000/590000/582300/582298/8956a807.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/590000/582300/582298/13407108.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/590000/582300/582298/cc68f053.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite (Open Space 103) | View from room](https://images.trvl-media.com/lodging/1000000/590000/582300/582298/8fd7b9fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Grand Hotel Minerva [](https://www.expedia.ca/Florence-Hotels-Grand-Hotel-Minerva.h582298.Hotel-Information) Historic Centre of Florence 9.6/10 Exceptional (1,002 reviews) "room is clean and well maintained, really great breakfast options, staffs are friendly. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ye CA $450 CA $518 total includes taxes & fees Feb 28 - Mar 1 [](https://www.expedia.ca/Florence-Hotels-Grand-Hotel-Minerva.h582298.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/3000/2947/81b4e9b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/3000/2947/27bb6e9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/3000/2947/0d8c9b03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/10000/3000/2947/6c034cb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Brunelleschi Hotel [](https://www.expedia.ca/Florence-Hotels-Brunelleschi-Hotel.h2947.Hotel-Information) Historic Centre of Florence 9.4/10 Exceptional (675 reviews) "Great location service breakfast" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Aileen CA $390 CA $452 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Florence-Hotels-Brunelleschi-Hotel.h2947.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/2000000/1220000/1216500/1216478/18221048.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; local cuisine, garden views ](https://images.trvl-media.com/lodging/2000000/1220000/1216500/1216478/cf05a6fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/2000000/1220000/1216500/1216478/54415207.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1220000/1216500/1216478/56435536.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Borgo di Cortefreda Relais [](https://www.expedia.ca/Barberino-Tavarnelle-Hotels-Hotel-Borgo-Di-Cortefreda-Relais.h1216478.Hotel-Information) Barberino Tavarnelle 9.4/10 Exceptional (483 reviews) "The views were spectacular and the grounds were so peaceful" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michelle CA $122 CA $144 total includes taxes & fees Jan 30 - Jan 31 [](https://www.expedia.ca/Barberino-Tavarnelle-Hotels-Hotel-Borgo-Di-Cortefreda-Relais.h1216478.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/1000000/570000/561900/561844/w1022h680x2y3-6d439196.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/570000/561900/561844/w1020h679x4y2-f4aaef99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/570000/561900/561844/w1020h678x4y3-bfb8ddd7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Minibar, in-room safe, individually decorated, desk](https://images.trvl-media.com/lodging/1000000/570000/561900/561844/67dab52c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### NH Collection Firenze Porta Rossa [](https://www.expedia.ca/Florence-Hotels-NH-Collection-Firenze-Porta-Rossa.h561844.Hotel-Information) Historic Centre of Florence 9.4/10 Exceptional (1,003 reviews) "Very courteous staff and spacious room!! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Milana CA $371 CA $435 total includes taxes & fees Feb 2 - Feb 3 [](https://www.expedia.ca/Florence-Hotels-NH-Collection-Firenze-Porta-Rossa.h561844.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/910000/905800/905768/c6f46203.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/1000000/910000/905800/905768/4a64413d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/910000/905800/905768/0ff8c174.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Room, River View (Prestige) | Bathroom](https://images.trvl-media.com/lodging/1000000/910000/905800/905768/08257311.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Continentale - Lungarno Collection [](https://www.expedia.ca/Florence-Hotels-Continentale-Lungarno-Collection.h905768.Hotel-Information) Historic Centre of Florence 9.4/10 Exceptional (732 reviews) "Excellent location, service and room! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lindsay [](https://www.expedia.ca/Florence-Hotels-Continentale-Lungarno-Collection.h905768.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-11&endDate=2026-02-12®ionId=553248633938935375&adults=2&sort=LUXURY&star=40,50&openPlayBack=true) ## Find out more about Santo Spirito ### Santo Spiritoand its attractions for luxury travelers Santo Spirito, nestled in the heart of Florence, is a paradise for luxury travellers seeking an authentic Italian experience. Begin your journey at the stunning Basilica di Santo Spirito, where you can admire exquisite Renaissance art by masters like Michelangelo and enjoy the peaceful cloister gardens. Just a short stroll away lies the lively Piazza Santo Spirito, adorned with a vibrant local market on Sundays, perfect for picking up unique artisanal goods and enjoying gourmet street food from local vendors. For a touch of elegance, indulge in a wine tasting at Enoteca Pitti Gola e Cantina, where you can sip on exquisite Tuscan wines while soaking in the rustic charm of the surroundings. Don't miss the chance to explore the stunning Boboli Gardens, a short walk away, offering sprawling landscapes and breathtaking views of Florence, ideal for a leisurely afternoon. Finally, unwind at one of the luxury hotels in the area, where impeccable service meets charming Florentine decor, ensuring that your stay is as comfortable as it is memorable. Picture settling into a suite with panoramic views of the Arno River, enjoying a bespoke dining experience that celebrates local cuisine, and being pampered at a tranquil spa—all while being steps away from the rich cultural heritage of this enchanting neighbourhood. ## Top Santo Spirito Hotel Reviews ![UNA Hotels Vittoria Firenze](https://images.trvl-media.com/lodging/1000000/910000/905700/905634/534e501f_y.jpg) ### UNA Hotels Vittoria Firenze 10/10 Excellent "Perfect stay! Not only was the check-in smooth, but everything else was also satisfying. The breakfast was delicious, the staff were friendly, and the location was ideal. There wasn't a single thing I didn't like. I’ll definitely be back!" [](https://expedia.ca/Florence-Hotels-UNAHOTELS-Vittoria-Firenze.h905634.Hotel-Information) ![Palazzo Guicciardini](https://images.trvl-media.com/lodging/9000000/8100000/8099100/8099013/77600b23_y.jpg) ### Palazzo Guicciardini 10/10 Excellent "This is a small boutique hotel 5 minutes walk from the ponte Vecchio bridge! The staff were so kind and gave us a map of the city and gave us information on great things to see and restaurants to try! The hotel was beautiful and the room was HUGE and property very clean! Our only issue was when typing in the name of the hotel on Google maps, it had our Uber drop us off at a historical sight a couple blocks away due to the two having the same name- this error is mostly our bad because we didn’t confirm the address before putting it in for the Uber but would have been a nice heads up! " [](https://expedia.ca/Florence-Hotels-Palazzo-Guicciardini.h8099013.Hotel-Information) ## Frequently asked questions ### Are you searching for a great accommodation for your luxury getaway to Santo Spirito? ### What's the best high-end hotel in Santo Spirito? ### What's there to see and do in Santo Spirito? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [Hotels near Boboli Gardens ](https://www.expedia.ca/Boboli-Gardens-Hotels.0-l507684-0.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Province of Florence ](https://www.expedia.ca/Destinations-In-Province-Of-Florence-Boutique-Hotel.0-0-d179893-tBoutiqueHotel.Hotel-Filter-Destinations) - [Winery Hotels in Province of Florence ](https://www.expedia.ca/Destinations-In-Province-Of-Florence-Winery-Hotel.0-0-d179893-tWineryHotel.Hotel-Filter-Destinations) - [Province of Florence Hotels ](https://www.expedia.ca/Destinations-In-Province-Of-Florence.d179893.Hotel-Destinations) - 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