Title: Book the Best Santo Spirito LUXURY Hotels - Upscale Hotels in Santo Spirito, Florence | Expedia.ca [Santo Spirito Travel Guide](https://expedia.ca/Florence-Santo-Spirito.dx553248633938935375)[Vacation Rentals in Florence](https://expedia.ca/Florence-Vacation-Rentals.d1222.Travel-Guide-VacationRentals)[Flights to Florence](https://expedia.ca/Cheap-Flights-To-Florence.d1222.Travel-Guide-Flights)[Things to do in Florence](https://expedia.ca/Things-To-Do-In-Florence.d1222.Travel-Guide-Activities)[Santo Spirito Car Rentals](https://expedia.ca/Car-Rentals-In-Santo-Spirito.d553248633938935375.Car-Rental-Guide)[Santo Spirito Vacations](https://expedia.ca/Santo-Spirito.d553248633938935375.Destination-Travel-Guides) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/409000/409791-Brancacci-Chapel.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Luxury Hotels in Santo Spirito, Florence ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santo Spirito Luxury Hotels Tonight [Oct 2 - Oct 3](https://www.expedia.ca/Hotel-Search?regionId=553248633938935375&startDate=2025-10-02&endDate=2025-10-03&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 3 - Oct 4](https://www.expedia.ca/Hotel-Search?regionId=553248633938935375&startDate=2025-10-03&endDate=2025-10-04&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=553248633938935375&startDate=2025-10-03&endDate=2025-10-05&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248633938935375&startDate=2025-10-10&endDate=2025-10-12&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Santo Spirito Luxury Hotels ![Junior Suite (4 pax)](https://images.trvl-media.com/lodging/9000000/8100000/8099100/8099013/77600b23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/9000000/8100000/8099100/8099013/207eb9ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/9000000/8100000/8099100/8099013/905a3719.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Concierge desk](https://images.trvl-media.com/lodging/9000000/8100000/8099100/8099013/51036047.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Palazzo Guicciardini Historic Centre of Florence 9.2/10 Wonderful (150) "Beautiful palazzo residence with a very easy check-in and departure. Our room was of generous proportions with beautiful windows and curtains framed by the alfresco ceiling. " [](https://www.expedia.ca/Florence-Hotels-Palazzo-Guicciardini.h8099013.Hotel-Information) ![Food and drink](https://images.trvl-media.com/lodging/9000000/8110000/8108100/8108094/bedaf6bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, minibar, desk, soundproofing](https://images.trvl-media.com/lodging/9000000/8110000/8108100/8108094/21e13295.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast area](https://images.trvl-media.com/lodging/9000000/8110000/8108100/8108094/a699159c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/9000000/8110000/8108100/8108094/fc3ef310.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Terrazza su Boboli Oltrarno 9.6/10 Exceptional (32) "Un bel B&B con gestione molto professionale e cortese. Anche se non in centro, comodo al centro. La terrazza e' stupenda." [](https://www.expedia.ca/Florence-Hotels-La-Terrazza-Su-Boboli.h8108094.Hotel-Information) ![Premium bedding, pillowtop beds, minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/910000/905700/905634/534e501f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/910000/905700/905634/ef0ddf53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily continental breakfast (EUR 14 per person)](https://images.trvl-media.com/lodging/1000000/910000/905700/905634/25bb1a41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/1000000/910000/905700/905634/c9d77b08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### UNA Hotels Vittoria Firenze Oltrarno 8.4/10 Very good (1003) "Excellent location 5 min walk to downtown " CA $230 CA $276 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/Florence-Hotels-UNAHOTELS-Vittoria-Firenze.h905634.Hotel-Information) ![Lounge](https://images.trvl-media.com/lodging/4000000/3200000/3196400/3196305/12e1df84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Double Room | Bathroom](https://images.trvl-media.com/lodging/4000000/3200000/3196400/3196305/86f90239.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Double Room, Balcony](https://images.trvl-media.com/lodging/4000000/3200000/3196400/3196305/05eb4ba3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/4000000/3200000/3196400/3196305/c79fc6eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Palazzo Guadagni Historic Centre of Florence 9.0/10 Wonderful (200) "Hotel Palazzo was stunning. I would definitely stay here again and I already can't wait to! The staff were so friendly and made you feel right at home. Everything was walking distance and the area was incredible!" CA $498 CA $567 total includes taxes & fees Oct 6 - Oct 7 [](https://www.expedia.ca/Florence-Hotels-Hotel-Palazzo-Guadagni.h3196305.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-16&endDate=2025-10-17®ionId=553248633938935375&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Santo Spirito ### Santo Spiritoand its attractions for luxury travelers Santo Spirito, nestled in the heart of Florence, is a paradise for luxury travellers seeking an authentic Italian experience. Begin your journey at the stunning Basilica di Santo Spirito, where you can admire exquisite Renaissance art by masters like Michelangelo and enjoy the peaceful cloister gardens. Just a short stroll away lies the lively Piazza Santo Spirito, adorned with a vibrant local market on Sundays, perfect for picking up unique artisanal goods and enjoying gourmet street food from local vendors. For a touch of elegance, indulge in a wine tasting at Enoteca Pitti Gola e Cantina, where you can sip on exquisite Tuscan wines while soaking in the rustic charm of the surroundings. Don't miss the chance to explore the stunning Boboli Gardens, a short walk away, offering sprawling landscapes and breathtaking views of Florence, ideal for a leisurely afternoon. Finally, unwind at one of the luxury hotels in the area, where impeccable service meets charming Florentine decor, ensuring that your stay is as comfortable as it is memorable. Picture settling into a suite with panoramic views of the Arno River, enjoying a bespoke dining experience that celebrates local cuisine, and being pampered at a tranquil spa—all while being steps away from the rich cultural heritage of this enchanting neighbourhood. ## Top Santo Spirito Hotel Reviews ![Hotel Palazzo Guadagni](//images.trvl-media.com/lodging/4000000/3200000/3196400/3196305/12e1df84_y.jpg) ### Hotel Palazzo Guadagni 10/10 Excellent "Hotel Palazzo was stunning. I would definitely stay here again and I already can't wait to! The staff were so friendly and made you feel right at home. Everything was walking distance and the area was incredible!" [](https://expedia.ca/Florence-Hotels-Hotel-Palazzo-Guadagni.h3196305.Hotel-Information) ![UNA Hotels Vittoria Firenze](//images.trvl-media.com/lodging/1000000/910000/905700/905634/534e501f_y.jpg) ### UNA Hotels Vittoria Firenze 10/10 Excellent "Amazing place, love the decor!" [](https://expedia.ca/Florence-Hotels-UNAHOTELS-Vittoria-Firenze.h905634.Hotel-Information) ![Palazzo Guicciardini](//images.trvl-media.com/lodging/9000000/8100000/8099100/8099013/77600b23_y.jpg) ### Palazzo Guicciardini 10/10 Excellent "This is a small boutique hotel 5 minutes walk from the ponte Vecchio bridge! The staff were so kind and gave us a map of the city and gave us information on great things to see and restaurants to try! The hotel was beautiful and the room was HUGE and property very clean! Our only issue was when typing in the name of the hotel on Google maps, it had our Uber drop us off at a historical sight a couple blocks away due to the two having the same name- this error is mostly our bad because we didn’t confirm the address before putting it in for the Uber but would have been a nice heads up! " [](https://expedia.ca/Florence-Hotels-Palazzo-Guicciardini.h8099013.Hotel-Information) ## Frequently asked questions ### Are you searching for a great accommodation for your luxury getaway to Santo Spirito? > During your visit, you might want to enjoy the riverfront which Santo Spirito is known for. ### What's the best high-end hotel in Santo Spirito? > [Palazzo Guicciardini](https://www.expedia.ca/Florence-Hotels-Palazzo-Guicciardini.h8099013.Hotel-Information) is a luxury guesthouse with in-room massages and a bar, and it's a popular choice for Expedia travelers looking for an elegant place to stay. ### What's there to see and do in Santo Spirito? > Enjoy all that Santo Spirito has to offer when you visit Porta Romana, Piazza Santo Spirito, and Santo Spirito Basilica. 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