Title: Book the Best BOUTIQUE Hotels in Santo Spirito in 2025 | Expedia.ca [Santo Spirito Travel Guide](https://expedia.ca/Florence-Santo-Spirito.dx553248633938935375)[Vacation Rentals in Florence](https://expedia.ca/Florence-Vacation-Rentals.d1222.Travel-Guide-VacationRentals)[Flights to Florence](https://expedia.ca/Cheap-Flights-To-Florence.d1222.Travel-Guide-Flights)[Things to do in Florence](https://expedia.ca/Things-To-Do-In-Florence.d1222.Travel-Guide-Activities)[Santo Spirito Car Rentals](https://expedia.ca/Car-Rentals-In-Santo-Spirito.d553248633938935375.Car-Rental-Guide)[Santo Spirito Vacations](https://expedia.ca/Santo-Spirito.d553248633938935375.Destination-Travel-Guides) ![Province of Florence showing interior views, heritage elements and a church or cathedral](https://images.trvl-media.com/place/179893/dd801080-5529-49c4-b78b-415c9c4a56e9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Boutique Hotels in Santo Spirito from CA $147 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santo Spirito Boutique Hotels Tonight [Nov 28 - Nov 29](https://www.expedia.ca/Hotel-Search?regionId=553248633938935375&startDate=2025-11-28&endDate=2025-11-29&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 29 - Nov 30](https://www.expedia.ca/Hotel-Search?regionId=553248633938935375&startDate=2025-11-29&endDate=2025-11-30&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 28 - Nov 30](https://www.expedia.ca/Hotel-Search?regionId=553248633938935375&startDate=2025-11-28&endDate=2025-11-30&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=553248633938935375&startDate=2025-12-05&endDate=2025-12-07&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Santo Spirito Boutique Hotels ![Premium bedding, pillowtop beds, minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/910000/905700/905634/534e501f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/1000000/910000/905700/905634/00a791c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/1000000/910000/905700/905634/c9d77b08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/910000/905700/905634/ef0ddf53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### UNA Hotels Vittoria Firenze Oltrarno 8.4/10 Very good (1002) "Super nice reception staffs, everyone is so friendly and welcoming. But don’t like the red room decoration. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Tina CA $139 CA $176 total includes taxes & fees Dec 23 - Dec 24 [](https://www.expedia.ca/Florence-Hotels-UNAHOTELS-Vittoria-Firenze.h905634.Hotel-Information) ![City view from property](https://images.trvl-media.com/lodging/1000000/930000/920500/920451/811bce9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/930000/920500/920451/f49db8e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/930000/920500/920451/a3b7ed7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception hall](https://images.trvl-media.com/lodging/1000000/930000/920500/920451/ddef8b4e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Santa Maria Novella Historic Centre of Florence 9.6/10 Exceptional (1009) "Excellent hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Edward CA $218 CA $262 total includes taxes & fees Dec 16 - Dec 17 [](https://www.expedia.ca/Florence-Hotels-Hotel-Santa-Maria-Novella.h920451.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1170000/1167000/1166901/10f2f159.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Double Room, Terrace](https://images.trvl-media.com/lodging/2000000/1170000/1167000/1166901/a067dbe8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/2000000/1170000/1167000/1166901/4fa8fd87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1170000/1167000/1166901/333adee9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Eurostars Florence Boutique Historic Centre of Florence 8.6/10 Excellent (478) "Great little hotel. Everything is within walking distance. The view from the terrace was amazing. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Anna CA $113 CA $147 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Florence-Hotels-Eurostars-Florence-Boutique.h1166901.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/60000/54200/54105/2a00cb08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Elevator](https://images.trvl-media.com/lodging/1000000/60000/54200/54105/1cd6f0bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room](https://images.trvl-media.com/lodging/1000000/60000/54200/54105/b02f6b83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/60000/54200/54105/265dc094.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Pendini Historic Centre of Florence 9.6/10 Exceptional (1011) "Perfect location, great breakfasts, hospitable staff" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Derreck CA $220 CA $262 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Florence-Hotels-Hotel-Pendini.h54105.Hotel-Information) ![Lounge](https://images.trvl-media.com/lodging/1000000/10000/6400/6371/849fb031.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/10000/6400/6371/aa91965a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/10000/6400/6371/84ad3fe0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Classic Double Room Single Use | View from room](https://images.trvl-media.com/lodging/1000000/10000/6400/6371/a1943924.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Grand Hotel Baglioni Historic Centre of Florence 9.0/10 Wonderful (1010) "Fantastic stay!! A wonderful hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jonathan CA $193 CA $235 total includes taxes & fees Dec 1 - Dec 2 [](https://www.expedia.ca/Florence-Hotels-Grand-Hotel-Baglioni.h6371.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/2000000/1450000/1446200/1446101/206e49be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/2000000/1450000/1446200/1446101/443f8444.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Frette Italian sheets, premium bedding, down comforters, in-room safe](https://images.trvl-media.com/lodging/2000000/1450000/1446200/1446101/65e2ccec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/2000000/1450000/1446200/1446101/7cbe4662.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Borghese Palace Art Hotel Historic Centre of Florence 8.6/10 Excellent (987) "Great hotel, nice room, very convenient location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rostislav CA $131 CA $167 total includes taxes & fees Dec 1 - Dec 2 [](https://www.expedia.ca/Florence-Hotels-Borghese-Palace-Art-Hotel.h1446101.Hotel-Information) ![Deluxe Room, 1 Double Bed](https://images.trvl-media.com/lodging/2000000/1570000/1569100/1569085/bd77015a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/2000000/1570000/1569100/1569085/14e26db2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1570000/1569100/1569085/97295b6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite | Bathroom](https://images.trvl-media.com/lodging/2000000/1570000/1569100/1569085/14decad4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Porcellino Gallery Historic Centre of Florence 9.2/10 Wonderful (399) "We loved this property. The location is fabulous. Walking distance to so many attractions we wanted to see. Decor is unique and inviting. Breakfast was especially good. Would definitely recommend this property. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gay [](https://www.expedia.ca/Florence-Hotels-Porcellino-Gallery.h1569085.Hotel-Information) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/5000000/4150000/4148000/4147974/f58b3314.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/5000000/4150000/4148000/4147974/c9e7763e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite](https://images.trvl-media.com/lodging/5000000/4150000/4148000/4147974/2a0f852e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/5000000/4150000/4148000/4147974/ffa9ed09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Riva Lofts Florence Isolotto 9.2/10 Wonderful (78) "I stayed only one night , but I can say that the room was so good and clean, the person at the reception was very nice and available, the hotel position is very close bay to the train station that in the center well served by taxis and buses. Very good international breakfast " ![Italy](https://a.travel-assets.com/egds/marks/flags/it.svg) Gianluca CA $142 CA $180 total includes taxes & fees Dec 16 - Dec 17 [](https://www.expedia.ca/Florence-Hotels-Riva-Lofts-Florence.h4147974.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/520000/517400/517318/3fe4c48d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/520000/517400/517318/5a884190.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily buffet breakfast (EUR 18.95 per person)](https://images.trvl-media.com/lodging/1000000/520000/517400/517318/d7c067d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite](https://images.trvl-media.com/lodging/1000000/520000/517400/517318/1c54c029.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Room Mate Collection Isabella, Florence Historic Centre of Florence 9.2/10 Wonderful (926) "We had a wonderful time and felt the property staff routinely checked with us to ensure our stay met our expectations. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lisa CA $216 CA $260 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Florence-Hotels-Room-Mate-Isabella.h517318.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/6200/6167/45778cb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![6 bars/lounges](https://images.trvl-media.com/lodging/1000000/10000/6200/6167/816408bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/1000000/10000/6200/6167/752fd933.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, minibar, in-room safe, individually decorated](https://images.trvl-media.com/lodging/1000000/10000/6200/6167/9852d1ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cellai Boutique Hotel Historic Centre of Florence 8.2/10 Very good (675) "Great location - good place to stay for price" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cynthia [](https://www.expedia.ca/Florence-Hotels-Cellai-Boutique-Hotel.h6167.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-13®ionId=553248633938935375&adults=2&specialized_stays_group_explore=boutique_property&sort=RECOMMENDED&openPlayBack=true) ## Top Santo Spirito Hotel Reviews ![UNA Hotels Vittoria Firenze](https://images.trvl-media.com/lodging/1000000/910000/905700/905634/534e501f_y.jpg) ### UNA Hotels Vittoria Firenze 10/10 Excellent "Super nice reception staffs, everyone is so friendly and welcoming. But don’t like the red room decoration. " [](https://expedia.ca/Florence-Hotels-UNAHOTELS-Vittoria-Firenze.h905634.Hotel-Information) ![Palazzo Guicciardini](https://images.trvl-media.com/lodging/9000000/8100000/8099100/8099013/77600b23_y.jpg) ### Palazzo Guicciardini 10/10 Excellent "This is a small boutique hotel 5 minutes walk from the ponte Vecchio bridge! The staff were so kind and gave us a map of the city and gave us information on great things to see and restaurants to try! The hotel was beautiful and the room was HUGE and property very clean! Our only issue was when typing in the name of the hotel on Google maps, it had our Uber drop us off at a historical sight a couple blocks away due to the two having the same name- this error is mostly our bad because we didn’t confirm the address before putting it in for the Uber but would have been a nice heads up! " [](https://expedia.ca/Florence-Hotels-Palazzo-Guicciardini.h8099013.Hotel-Information) ## Frequently asked questions ### What's the best boutique hotel in Santo Spirito? > [UNA Hotels Vittoria Firenze](https://www.expedia.ca/Florence-Hotels-UNAHOTELS-Vittoria-Firenze.h905634.Hotel-Information) is a favorite hotel with our travelers looking for a stylish accommodation, and features 83 guestrooms, a garden, and a deli. If you'd prefer to stay at a boutique hotel, you might also want to look at [Palazzo Guicciardini](https://www.expedia.ca/Florence-Hotels-Palazzo-Guicciardini.h8099013.Hotel-Information). ### What's there to see and do in Santo Spirito? > The art and riverfront are just some of the things to enjoy while you're in the area. Experience the cultural highlights around Santo Spirito with a visit to Il Nabucco di Matteo Gabellini, The New Florence Opera House, and Boboli Gardens. You might also like to explore more of the area and take in additional sights like Porta Romana, Piazza Santo Spirito, and Basilica of Santa Maria Novella while you're here. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [Hotels near Boboli Gardens](https://www.expedia.ca/Boboli-Gardens-Hotels.0-l507684-0.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Province of Florence](https://www.expedia.ca/Destinations-In-Province-Of-Florence-Boutique-Hotel.0-0-d179893-tBoutiqueHotel.Hotel-Filter-Destinations) - [Winery Hotels in Province of Florence](https://www.expedia.ca/Destinations-In-Province-Of-Florence-Winery-Hotel.0-0-d179893-tWineryHotel.Hotel-Filter-Destinations) - [Province of Florence Hotels](https://www.expedia.ca/Destinations-In-Province-Of-Florence.d179893.Hotel-Destinations) - [Adults Only Resorts & in Tuscany](https://www.expedia.ca/Destinations-In-Tuscany-Adults-Only-Resorts.0-0-d601686-tAdultsOnlyResorts.Hotel-Filter-Destinations) - 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