Title: Book the Best BUSINESS Hotels in Santo Domingo in 2026 | Expedia.ca [Vacation Rentals in Lady Lake](https://expedia.ca/Lady-Lake-Vacation-Rentals.d602301.Travel-Guide-VacationRentals)[Flights to Lady Lake](https://expedia.ca/Cheap-Flights-To-Lady-Lake.d602301.Travel-Guide-Flights)[Santo Domingo Car Rentals](https://expedia.ca/Car-Rentals-In-Santo-Domingo.d553248635976471427.Car-Rental-Guide)[Santo Domingo Vacations](https://expedia.ca/Santo-Domingo.d553248635976471427.Destination-Travel-Guides) ![Dramatic skies over Mount Dora's Lighthouse, located at the Port of Mount Dora in Grantham Point Park, Florida, USA.](https://images.trvl-media.com/place/553248635976471427/4d8083eb-0a0b-4527-99b6-73a1d35324a2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Santo Domingo, FL from CA $102 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santo Domingo Business Hotels Tonight [Dec 23 - Dec 24](https://www.expedia.ca/Hotel-Search?regionId=553248635976471427&startDate=2025-12-23&endDate=2025-12-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Dec 24 - Dec 25](https://www.expedia.ca/Hotel-Search?regionId=553248635976471427&startDate=2025-12-24&endDate=2025-12-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248635976471427&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=553248635976471427&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Santo Domingo business-friendly hotels ![Exterior](https://images.trvl-media.com/lodging/2000000/1190000/1184000/1183971/0bba19b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds](https://images.trvl-media.com/lodging/2000000/1190000/1184000/1183971/f72ebe07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1190000/1184000/1183971/aa82a8e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast](https://images.trvl-media.com/lodging/2000000/1190000/1184000/1183971/42e74358.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Tavares North [](https://www.expedia.ca/Leesburg-Hotels-Comfort-Inn-Suites-Tavares-North.h1183971.Hotel-Information) Tavares 8.2/10 Very good (1000) "Very clean and the lady at the front desk was very friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Adolfo CA $124 CA $138 total includes taxes & fees Dec 30 - Dec 31 [](https://www.expedia.ca/Leesburg-Hotels-Comfort-Inn-Suites-Tavares-North.h1183971.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/430000/429400/429339/fbb41ad1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/430000/429400/429339/c030ccfc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/430000/429400/429339/c8aec93f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/430000/429400/429339/e5855067.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Ocala Park Centre [](https://www.expedia.ca/Ocala-Hotels-Best-Western-Ocala-Park-Centre.h429339.Hotel-Information) Ocala 8.4/10 Very good (1229) "The property was clean and the beds were comfortable" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) sharon CA $92 CA $102 total includes taxes & fees Dec 29 - Dec 30 [](https://www.expedia.ca/Ocala-Hotels-Best-Western-Ocala-Park-Centre.h429339.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/3000000/2060000/2057700/2057662/4d77a964.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Golf](https://images.trvl-media.com/lodging/3000000/2060000/2057700/2057662/559ecd87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Steam room, body treatments, aromatherapy, hot stone massages](https://images.trvl-media.com/lodging/3000000/2060000/2057700/2057662/17f7b7e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lake](https://images.trvl-media.com/lodging/3000000/2060000/2057700/2057662/w2877h1919x0y0-94bdbba4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Mission Resort and Club [](https://www.expedia.ca/Leesburg-Hotels-Mission-Inn-Resort-Club.h2057662.Hotel-Information) Howey-in-the-Hills 8.8/10 Excellent (727) "Great place to stay ! We came for a wedding and it was fantastic!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Yasunari [](https://www.expedia.ca/Leesburg-Hotels-Mission-Inn-Resort-Club.h2057662.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/330000/328900/328816/52240e0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/330000/328900/328816/e1f1cafd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/330000/328900/328816/6b6467c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/330000/328900/328816/6d9517fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Microtel Inn & Suites by Wyndham Leesburg/Mt Dora [](https://www.expedia.ca/Leesburg-Hotels-Microtel-Inn-Suites-By-Wyndham-LeesburgMt-Dora.h328816.Hotel-Information) Leesburg 8.4/10 Very good (1006) "Excellent Services!!!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Myrna CA $99 CA $110 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Leesburg-Hotels-Microtel-Inn-Suites-By-Wyndham-LeesburgMt-Dora.h328816.Hotel-Information) ![Suite, 1 King Bed with Sofa bed | Private kitchenette](https://images.trvl-media.com/lodging/43000000/42070000/42069200/42069165/1b1de007.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/43000000/42070000/42069200/42069165/76a7d873.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/43000000/42070000/42069200/42069165/9fba0205.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/43000000/42070000/42069200/42069165/3b3f1b38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Brownwood Hotel & Spa [](https://www.expedia.ca/Leesburg-Hotels-Brownwood-Hotel-Spa.h42069165.Hotel-Information) Wildwood 9.8/10 Exceptional (1073) "Clean room, beautiful hotel. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) albert [](https://www.expedia.ca/Leesburg-Hotels-Brownwood-Hotel-Spa.h42069165.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1280000/1273500/1273403/acbbaec3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio, 1 King Bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/2000000/1280000/1273500/1273403/31676daa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1280000/1273500/1273403/d422f3d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1280000/1273500/1273403/44358362.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Lady Lake/The Villages [](https://www.expedia.ca/Leesburg-Hotels-Hampton-Inn-Suites-Lady-LakeThe-Villages.h1273403.Hotel-Information) Lady Lake 9.0/10 Wonderful (1000) "Room was great, staff was very friendly, breakfast was spot on. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Beth CA $157 CA $168 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/Leesburg-Hotels-Hampton-Inn-Suites-Lady-LakeThe-Villages.h1273403.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1800000/1790600/1790521/ada4fd28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Room](https://images.trvl-media.com/lodging/2000000/1800000/1790600/1790521/bca24cbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1800000/1790600/1790521/4dc98f06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 8:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/2000000/1800000/1790600/1790521/8a0caa27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Waterfront Inn [](https://www.expedia.ca/Leesburg-Hotels-The-Waterfront-Inn.h1790521.Hotel-Information) Lake Sumter Landing 9.2/10 Wonderful (1297) "Great hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) sherry [](https://www.expedia.ca/Leesburg-Hotels-The-Waterfront-Inn.h1790521.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/1000000/30000/27200/27152/62f99e87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/30000/27200/27152/9f32775e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/30000/27200/27152/97e02533.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/1000000/30000/27200/27152/0fcdbbf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Equus Inn Ocala [](https://www.expedia.ca/Ocala-Hotels-Equus-Inn-Ocala.h27152.Hotel-Information) Ocala 9.0/10 Wonderful (1771) "We had a good stay , the breakfast is a lifesaver " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) arlet CA $113 CA $126 total includes taxes & fees Dec 29 - Dec 30 [](https://www.expedia.ca/Ocala-Hotels-Equus-Inn-Ocala.h27152.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/1000/997/e4e6dd29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/10000/1000/997/a14d006f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/10000/1000/997/6e4c80bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/1000000/10000/1000/997/372b4887.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### avid Hotel Ocala Downtown by IHG [](https://www.expedia.ca/Ocala-Hotels-Avid-Hotels-Ocala-Downtown.h997.Hotel-Information) Ocala 8.8/10 Excellent (779) "Nice, clean affordable hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Barbara CA $117 CA $130 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Ocala-Hotels-Avid-Hotels-Ocala-Downtown.h997.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1200000/1199200/1199197/0cf84473.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1200000/1199200/1199197/6814ee26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/2000000/1200000/1199200/1199197/36e4aa3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/2000000/1200000/1199200/1199197/af1a9632.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn and Suites - Ocala / Belleview [](https://www.expedia.ca/Ocala-Hotels-Sleep-Inn-And-Suites-Ocala-Belleview.h1199197.Hotel-Information) Ocala 8.0/10 Very good (1000) "Very nice room very clean very welcome and staffing" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) william CA $111 CA $124 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Ocala-Hotels-Sleep-Inn-And-Suites-Ocala-Belleview.h1199197.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-07&endDate=2026-01-08®ionId=553248635976471427&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Santo Domingo Hotel Reviews ![Best Western Ocala Park Centre](https://images.trvl-media.com/lodging/1000000/430000/429400/429339/fbb41ad1_y.jpg) ### Best Western Ocala Park Centre 10/10 Excellent "Customer service was top notch! Every employee we encountered was super polite and knowledgeable. Our room was clean and stocked with what we needed. Breakfast was great too!! " [](https://expedia.ca/Ocala-Hotels-Best-Western-Ocala-Park-Centre.h429339.Hotel-Information) ![Comfort Suites Lady Lake - The Villages](https://images.trvl-media.com/lodging/2000000/1180000/1180000/1179917/37208c0a_y.jpg) ### Comfort Suites Lady Lake - The Villages 10/10 Excellent "Easy check -in. The front desk attendant "Joyce", let me and my dog check in early. She took an interest in "Ryder",and made him feel comfortable. The manager contacted me before and after to inquire about my stay. Kudos and adulation to all. Will return again." [](https://expedia.ca/Leesburg-Hotels-Comfort-Suites-The-Villages.h1179917.Hotel-Information) ![Hilton Ocala](https://images.trvl-media.com/lodging/1000000/30000/24300/24277/e365e01a_y.jpg) ### Hilton Ocala 10/10 Excellent "Overall experience was great." [](https://expedia.ca/Ocala-Hotels-Hilton-Ocala.h24277.Hotel-Information) ![Microtel Inn & Suites by Wyndham Leesburg/Mt Dora](https://images.trvl-media.com/lodging/1000000/330000/328900/328816/52240e0d_y.jpg) ### Microtel Inn & Suites by Wyndham Leesburg/Mt Dora 10/10 Excellent "Excellent Services!!!!" [](https://expedia.ca/Leesburg-Hotels-Microtel-Inn-Suites-By-Wyndham-LeesburgMt-Dora.h328816.Hotel-Information) ![The Waterfront Inn](https://images.trvl-media.com/lodging/2000000/1800000/1790600/1790521/adafc576_y.jpg) ### The Waterfront Inn 10/10 Excellent "For me cleanliness, helpful staff, and a comfortable bed and pillows - a good night sleep is super important - are the main things I look for in a hotel. The Waterfront Inn delivers in all three areas. My family and I enjoy staying here whenever we visit the Villages. It is in such a great location and the sunsets, and sunrises are stunning over the water." [](https://expedia.ca/Leesburg-Hotels-The-Waterfront-Inn.h1790521.Hotel-Information) ![Holiday Inn Hotel and Suites Ocala Conference Center by IHG](https://images.trvl-media.com/lodging/2000000/1700000/1698700/1698619/92033a63_y.jpg) ### Holiday Inn Hotel and Suites Ocala Conference Center by IHG 10/10 Excellent "Absolutely perfect " [](https://expedia.ca/Ocala-Hotels-Holiday-Inn-Hotel-And-Suites-Ocala-Conference-Center.h1698619.Hotel-Information) ![Equus Inn Ocala](https://images.trvl-media.com/lodging/1000000/30000/27200/27152/8ea1560b_y.jpg) ### Equus Inn Ocala 10/10 Excellent "We had a good stay , the breakfast is a lifesaver " [](https://expedia.ca/Ocala-Hotels-Equus-Inn-Ocala.h27152.Hotel-Information) ![Hampton Inn & Suites Lady Lake/The Villages](https://images.trvl-media.com/lodging/2000000/1280000/1273500/1273403/acbbaec3_y.jpg) ### Hampton Inn & Suites Lady Lake/The Villages 10/10 Excellent "While I can't remember her name, she was on duty the night we checked in and she was originally from PA. She was so helpful and made us feel very welcomed to the property." [](https://expedia.ca/Leesburg-Hotels-Hampton-Inn-Suites-Lady-LakeThe-Villages.h1273403.Hotel-Information) ![Mission Resort and Club](https://images.trvl-media.com/lodging/3000000/2060000/2057700/2057662/76bb6715_y.jpg) ### Mission Resort and Club 10/10 Excellent "It was very nice" [](https://expedia.ca/Leesburg-Hotels-Mission-Inn-Resort-Club.h2057662.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - More ways to book - [Beach Hotel Hotels in Central Florida ](https://www.expedia.ca/Central-Florida-Hotels-Beach-Hotel.0-0-d6048177-tBeachHotel.Travel-Guide-Filter-Hotels) - [Hotels & Resorts for Couples in De La Vista ](https://www.expedia.ca/De-La-Vista-Lady-Lake-Hotels-Couples-Resorts-Hotels.0-n553248635976471956-0-tCouplesResortsHotels.Travel-Guide-Filter-Hotels) - [Hotel Wedding Venues Hotels in De La Vista ](https://www.expedia.ca/De-La-Vista-Lady-Lake-Hotels-Wedding-Hotels.0-n553248635976471956-0-tWeddingHotels.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Del Mar ](https://www.expedia.ca/Del-Mar-Lady-Lake-Hotels-Boutique-Hotel.0-n553248635976479781-0-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - 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