Santiago Vacation Packages
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to CA $4,200 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Santiago Vacation
Enjoy the urban city of Santiago with a tailor-made Santiago vacation package and immerse yourself in all it can offer. From its rich history and cultural experiences to its lively atmosphere, prepare to fall for the unique charms of this vibrant destination. Parque Acuatico Italia Guadalupe Panama, Catedral of Santiago Apostol and Plaza Banconal are just some of the sights you'll want to see during your trip to Santiago. A few quick clicks is all it takes to put together the perfect Santiago vacation on Expedia.
Top Santiago Vacation Deals
Price found within the past 48 hours. Click for updated prices.
Central Hotel Panama Casco Viejo
Casco Viejo
Price was CA $2,111, price is now CA $1,245 per person
CA $1,245
per person
Aug 5 - Aug 9
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
9.2/10 Wonderful! (1,004 reviews)
Got in on a red eye. Wouldn’t let us check into a room until 3pm unless we wanted to pay for an extra night.
The rooms surrounding the lounge/dining area are loud. There is someone playing music from 7am throughout the entire day until late evening. The rooms in the back were quieter.
The food was good. Breakfast buffet also really good.
Reviewed on Jun 26, 2026
Megapolis Hotel Panamá
San Francisco
Price was CA $2,573, price is now CA $1,553 per person
CA $1,553
per person
Sep 10 - Sep 17
found 1 day ago
Roundtrip non-stop flight included
Montreal (YMQ) to Panama City (PTY)
8.4/10 Very good! (1,567 reviews)
La habitación bien, cómoda para una familia de 6 personas! La pasamos muy bien.
Reviewed on Jun 26, 2026
Riande Aeropuerto Hotel & Casino
Price was CA $1,900, price is now CA $1,301 per person
CA $1,301
per person
Aug 16 - Aug 22
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
8.4/10 Very good! (1,839 reviews)
Always a favorite place to stay the night before an international trip out of PTY. Love the reception area and tiki bar. Nice to have the small gift shop. Convenient shuttle runs every hour on the hour to the airport.
Reviewed on Jun 19, 2026
Villa Marina Hotel
Price was CA $1,894, price is now CA $1,343 per person
CA $1,343
per person
Jul 31 - Aug 6
found 11 hours ago
Roundtrip flight included
Toronto (YTO) to Panama City (PTY)
9/10 Wonderful! (162 reviews)
The room was spotless clean!
The staff was always helpful and ready to serve.
Breakfast and food in general was very tasty.
The Bar is quite complete
Reviewed on Jun 13, 2026
Decapolis Hotel Panama City
San Francisco
Price was CA $1,814, price is now CA $1,304 per person
CA $1,304
per person
Sep 7 - Sep 14
found 19 hours ago
Roundtrip non-stop flight included
Toronto (YTO) to Panama City (PTY)
8.6/10 Excellent! (1,689 reviews)
Lugar lindo y facil de estar
Reviewed on Jun 19, 2026
Santiago Hotel Deals
Hotel Gran David
Vía Interamericana Santiago Veraguas
Fully refundableReserve now, pay when you stay
The price is CA $83 per night from Jun 28 to Jun 29
CA $83
CA $91 total
Jun 28 - Jun 29
includes taxes & fees
8.6/10 Excellent! (408 reviews)
"Great place to stay. I would stay there again."
Reviewed on Jun 4, 2026
HOTEL CORPORATIVO PLAZA COROTÚ
Carr. Panamericana Santiago Provincia de Veraguas
Minutes from downtown Santiago, Chicho Fábrega hospital and Universidad Latina.
Panama Panamá
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Santiago attractions
Explore a world of travel with Expedia
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
