Santiago Vacation Packages

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Your Santiago Vacation

Enjoy the urban city of Santiago with a tailor-made Santiago vacation package and immerse yourself in all it can offer. From its rich history and cultural experiences to its lively atmosphere, prepare to fall for the unique charms of this vibrant destination. Parque Acuatico Italia Guadalupe Panama, Catedral of Santiago Apostol and Plaza Banconal are just some of the sights you'll want to see during your trip to Santiago. A few quick clicks is all it takes to put together the perfect Santiago vacation on Expedia.

Top Santiago Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Villa Botero By Casa Mojito B&B

Villa Botero By Casa Mojito B&B

3 out of 5
Price was CA $1,703, price is now CA $1,155 per person
CA $1,155
per person
May 4 - May 10
found 1 day ago
Roundtrip non-stop flight included
Toronto (YYZ) to Panama City (PTY)
9.8/10 Exceptional! (64 reviews)
excellent breakfast every day and varied menu. nice room, had a a fridge and coffee maker, sitting area and very clean pool. walkable to beach and few restaurants - beach was very nice.

Reviewed on Mar 22, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was CA $3,281, price is now CA $2,020 per person
CA $2,020
per person
May 9 - May 16
found 1 day ago
Roundtrip non-stop flight included
Edmonton (YEG) to Panama City (PTY)
9/10 Wonderful! (1,000 reviews)
Such a beautiful hotel!!! I chose it because of the stair case but was floored when I saw it in person. Gorgeous, peaceful.It was a dream fantasy come to fruition!!! The location perfect. Few feet away from the presidential plaza. There was something happening everyday right outside the hotel all the time. The staff so welcoming, breakfast was delicious. The city the people. I cannot say enough Panama and its people. So welcoming. I will definitely stay there again and longer. It was like staying in a movie. I see why our people move there and why citizens rarely move out this country

Reviewed on Mar 20, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was CA $2,562, price is now CA $1,737 per person
CA $1,737
per person
May 9 - May 16
found 1 day ago
Roundtrip non-stop flight included
Edmonton (YEG) to Panama City (PTY)
8.4/10 Very Good! (1,448 reviews)
Love love this hotel…. Points to note, the room lighting is really dim(can’t take a good picture in the room itself) and the pool closes at 8pm not 10pm

Reviewed on Mar 26, 2026

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was CA $2,046, price is now CA $1,435 per person
CA $1,435
per person
May 9 - May 16
found 1 day ago
Roundtrip non-stop flight included
Edmonton (YEG) to Panama City (PTY)
9/10 Wonderful! (5,100 reviews)
Breakfast was fresh with many options

Reviewed on Mar 26, 2026

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
San Francisco
Price was CA $2,036, price is now CA $1,509 per person
CA $1,509
per person
May 9 - May 16
found 1 day ago
Roundtrip non-stop flight included
Edmonton (YEG) to Panama City (PTY)
9/10 Wonderful! (1,017 reviews)
Excelente precio -calidad

Reviewed on Mar 25, 2026

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Santiago Hotel Deals

Hotel Gran David

Hotel Gran David

3.5 out of 5
Vía Interamericana Santiago Veraguas
Fully refundableReserve now, pay when you stay
The price is CA $92 per night from Apr 2 to Apr 3
CA $92
CA $103 total
Apr 2 - Apr 3
includes taxes & fees
Hotel Gran David
Minutes from downtown Santiago, Chicho Fábrega hospital and Universidad Latina.

Minutes from downtown Santiago, Chicho Fábrega hospital and Universidad Latina.

Panama Panamá
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Minutes from downtown Santiago, Chicho Fábrega hospital and Universidad Latina.
HOTEL PLAZA COROTÚ

HOTEL PLAZA COROTÚ

2 out of 5
Carr. Panamericana Santiago Provincia de Veraguas
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HOTEL PLAZA COROTÚ
See all 16 properties in Santiago
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Discover the most popular places to visit in Santiago

Escuela Normal Juan Demostenes Arosemena

Explore the campus of Escuela Normal Juan Demostenes Arosemena, during your trip to Santiago. Stroll along the lakeside or visit the cathedral while you're in the area.

Escuela Normal Juan Demostenes Arosemena

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.