Santiago Vacation Packages

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Your Santiago Vacation

Enjoy the urban city of Santiago with a tailor-made Santiago vacation package and immerse yourself in all it can offer. From its rich history and cultural experiences to its lively atmosphere, prepare to fall for the unique charms of this vibrant destination. Parque Acuatico Italia Guadalupe Panama, Catedral of Santiago Apostol and Plaza Banconal are just some of the sights you'll want to see during your trip to Santiago. A few quick clicks is all it takes to put together the perfect Santiago vacation on Expedia.

Top Santiago Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Hotel Panamonte

Hotel Panamonte

3.5 out of 5
Price was CA $2,212, price is now CA $1,412 per person
CA $1,412
per person
Nov 23 - Nov 30
found 1 day ago
Roundtrip flight included
Montreal (YUL) to Panama City (PTY)
9.4/10 Exceptional! (112 reviews)
This is a classic, elegant property that lives up to its reputation. Quality in every regard. On par with some of the finest historic hotels in the country (and I’ve stayed at a few).

Reviewed on Sep. 4, 2025

Casa Fofo Family House

Casa Fofo Family House

3 out of 5
Price was CA $3,022, price is now CA $1,683 per person
CA $1,683
per person
Nov 23 - Nov 30
found 1 day ago
Roundtrip flight included
Montreal (YUL) to Panama City (PTY)
No reviews
Central Hotel Bocas del Toro

Central Hotel Bocas del Toro

3 out of 5
Price was CA $5,250, price is now CA $2,939 per person
CA $2,939
per person
Nov 17 - Nov 24
found 1 day ago
Roundtrip flight included
Toronto (YYZ) to Panama City (PTY)
No reviews
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was CA $3,290, price is now CA $2,022 per person
CA $2,022
per person
Nov 19 - Nov 26
found 1 day ago
Roundtrip flight included
Edmonton (YEG) to Panama City (PTY)
9/10 Wonderful! (986 reviews)
The hotel is so beautiful, the people are very friendly and helpful!

Reviewed on Sep. 2, 2025

La Coralina Island House

La Coralina Island House

3.5 out of 5
Price was CA $2,625, price is now CA $1,723 per person
CA $1,723
per person
Oct 18 - Oct 25
found 1 day ago
Roundtrip non-stop flight included
Toronto (YYZ) to Panama City (PTY)
9.4/10 Exceptional! (85 reviews)
Beautiful grounds and love the included yoga, meditation, and work outs. They provided free cooked to order breakfast with coffee and juice. Staff was friendly and helpful

Reviewed on Aug. 30, 2025

Ready to book your vacation to Santiago?

 

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Santiago Hotel Deals

Hotel Gran David

Hotel Gran David

3.5 out of 5
Vía Interamericana, Santiago, Veraguas
Fully refundableReserve now, pay when you stay
The price is CA $96 per night from Sep 7 to Sep 8
CA $96
CA $107 total
Sep 7 - Sep 8
includes taxes & fees
Hotel Gran David
HOTEL PLAZA COROTÚ

HOTEL PLAZA COROTÚ

2 out of 5
Carr. Panamericana, Santiago, Provincia de Veraguas
Get rates
HOTEL PLAZA COROTÚ
Charming 2-bedroom house in amazing Santiago with AC, WiFi cable phone

Charming 2-bedroom house in amazing Santiago with AC, WiFi cable phone

2 out of 5
Santiago
Get rates
Charming 2-bedroom house in amazing Santiago with AC, WiFi cable phone
See all 12 properties in Santiago
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Discover the most popular places to visit in Santiago

Escuela Normal Juan Demostenes Arosemena

Explore the campus of Escuela Normal Juan Demostenes Arosemena, during your trip to Santiago. Stroll along the lakeside or visit the cathedral while you're in the area.

Escuela Normal Juan Demostenes Arosemena
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.