Title: Santiago Este Vacation Rentals : Short-Term Rentals for 2026 | Expedia.ca [Santiago Este Travel Guide](https://expedia.ca/Santiago-Este.dx829297293743108096)[Hotels in Santiago Este](https://expedia.ca/Santiago-Este-Hotels.d829297293743108096.Travel-Guide-Hotels)[Santiago Este Car Rentals](https://expedia.ca/Car-Rentals-In-Santiago-Este.d829297293743108096.Car-Rental-Guide)[Santiago Este Vacation Packages](https://expedia.ca/Santiago-Este.d829297293743108096.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Santiago Este Vacation Rentals - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Dec 25 - Dec 26](https://www.expedia.ca/Hotel-Search?regionId=829297293743108096&startDate=2025-12-25&endDate=2025-12-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 26 - Dec 27](https://www.expedia.ca/Hotel-Search?regionId=829297293743108096&startDate=2025-12-26&endDate=2025-12-27&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=829297293743108096&startDate=2025-12-26&endDate=2025-12-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=829297293743108096&startDate=2026-01-02&endDate=2026-01-04&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSantiago-Este-Vacation-Rentals.d829297293743108096.Travel-Guide-VacationRentals)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSantiago-Este-Vacation-Rentals.d829297293743108096.Travel-Guide-VacationRentals) ## Top Santiago Este Hotel Reviews ![Hotel Galería](https://images.trvl-media.com/lodging/28000000/27580000/27570800/27570722/7a530baa_y.jpg) ### Hotel Galería 10/10 Excellent "Clean room, comfy bed. Great restaurant with a free breakfast. What more could two weary travelers want. " [](https://expedia.ca/Santiago-Hotels-Hotel-Galeria.h27570722.Hotel-Information) ![Hotel Mykonos Panama](https://images.trvl-media.com/lodging/6000000/5280000/5270400/5270392/cdb98b1d_y.jpg) ### Hotel Mykonos Panama 10/10 Excellent "Everything was great!" [](https://expedia.ca/Santiago-Hotels-Hotel-Mykonos-Panama.h5270392.Hotel-Information) ![HOTEL VISTA LAGO](https://images.trvl-media.com/lodging/96000000/95680000/95675300/95675257/4e3dd11f_y.jpg) ### HOTEL VISTA LAGO 10/10 Excellent "Wow! I can’t say enough about this place, it’s a hidden gem in Boquete. The view is spectacular, beautiful private room, very comfortable bed, spotless everything. Daniel and Andrea are very friendly and proud of their property, they have thought of every detail.Thank you for making us the most amazing breakfast on the terrace, can’t wait to come back, congratulations!!" [](https://expedia.ca/Nuevo-Santiago-Hotels-HOTEL-VISTA-LAGO.h95675257.Hotel-Information) ![Hotel Gran David](https://images.trvl-media.com/lodging/13000000/12010000/12003400/12003378/5966cf9c_y.jpg) ### Hotel Gran David 10/10 Excellent "Everything was very good" [](https://expedia.ca/Santiago-Hotels-Hotel-Gran-David.h12003378.Hotel-Information) ![HOTEL PLAZA COROTÚ](https://images.trvl-media.com/lodging/112000000/111280000/111276700/111276682/1a9e698d_y.jpg) ### HOTEL PLAZA COROTÚ 10/10 Excellent "They will wash and laundry for a reasonable fee." [](https://expedia.ca/Santiago-Hotels-HOTEL-PLAZA-COROTU.h111276682.Hotel-Information) ## Find out more about Santiago Este You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded. As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Santiago Este. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true. It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do. ## Explore a world of travel with Expedia - Trending destinations on Expedia.ca ### Trending destinations on Expedia.ca - [Canmore Vacation Rentals ](https://www.expedia.ca/Canmore-Vacation-Rentals.d10131.Travel-Guide-VacationRentals) - [Maui Vacation Rentals ](https://www.expedia.ca/Maui-Vacation-Rentals.d180073.Travel-Guide-VacationRentals) - [Kelowna Vacation Rentals ](https://www.expedia.ca/Kelowna-Vacation-Rentals.d3997.Travel-Guide-VacationRentals) - [Whistler Vacation Rentals ](https://www.expedia.ca/Whistler-Vacation-Rentals.d4115.Travel-Guide-VacationRentals) - [Florida Vacation Rentals ](https://www.expedia.ca/Destinations-In-Florida.d211.Vacation-Rental-Destinations) - [Victoria Vacation Rentals ](https://www.expedia.ca/Victoria-Vacation-Rentals.d4138.Travel-Guide-VacationRentals) - [Vancouver Vacation Rentals ](https://www.expedia.ca/Vancouver-Vacation-Rentals.d178315.Travel-Guide-VacationRentals) - [Palm Springs Vacation Rentals ](https://www.expedia.ca/Palm-Springs-Vacation-Rentals.d180676.Travel-Guide-VacationRentals) - [Tofino Vacation Rentals ](https://www.expedia.ca/Tofino-Vacation-Rentals.d6094955.Travel-Guide-VacationRentals) - [Calgary Vacation Rentals ](https://www.expedia.ca/Calgary-Vacation-Rentals.d178245.Travel-Guide-VacationRentals) - [Costa Rica Vacation Rentals ](https://www.expedia.ca/Destinations-In-Costa-Rica.d42.Vacation-Rental-Destinations) - [Vancouver Island Vacation Rentals ](https://www.expedia.ca/Vancouver-Island-Vacation-Rentals.d6058387.Travel-Guide-VacationRentals) - [Puerto Vallarta Vacation Rentals ](https://www.expedia.ca/Puerto-Vallarta-Vacation-Rentals.d180016.Travel-Guide-VacationRentals) - [Hawaii Vacation Rentals ](https://www.expedia.ca/Destinations-In-Hawaii.d213.Vacation-Rental-Destinations) - [Toronto Vacation Rentals ](https://www.expedia.ca/Toronto-Vacation-Rentals.d178314.Travel-Guide-VacationRentals) - [Banff Vacation Rentals ](https://www.expedia.ca/Banff-Vacation-Rentals.d10550.Travel-Guide-VacationRentals) - [Penticton Vacation Rentals ](https://www.expedia.ca/Penticton-Vacation-Rentals.d4135.Travel-Guide-VacationRentals) - [Osoyoos Vacation Rentals ](https://www.expedia.ca/Osoyoos-Vacation-Rentals.d181782.Travel-Guide-VacationRentals) - [Mont Tremblant Vacation Rentals ](https://www.expedia.ca/Mont-Tremblant-Vacation-Rentals.d55374.Travel-Guide-VacationRentals) - [Big White Ski Resort Vacation Rentals ](https://www.expedia.ca/Big-White-Ski-Resort-Vacation-Rentals.d6058319.Travel-Guide-VacationRentals) - [Ontario Vacation Rentals ](https://www.expedia.ca/Destinations-In-Ontario.d11178.Vacation-Rental-Destinations) - [British Columbia Vacation Rentals ](https://www.expedia.ca/Destinations-In-British-Columbia.d11117.Vacation-Rental-Destinations) - [Prince Edward Island Vacation Rentals ](https://www.expedia.ca/Destinations-In-Prince-Edward-Island.d6058122.Vacation-Rental-Destinations) - [Québec Vacation Rentals ](https://www.expedia.ca/Quebec-Vacation-Rentals.d180017.Travel-Guide-VacationRentals) ## Frequently asked questions ### Can I find vacation rentals in Santiago Este? ### What are some of the best vacation home rentals that Santiago Este has to offer? ### What’s there to see and do in Santiago Este? ### What’s a vacation rental in Santiago Este like? ### Expedia's Latest Trends Hotels - [Hotels with Free Airport Shuttle in Panama City](https://expedia.ca/Panama-City-Hotels-Hotels-With-Free-Airport-Shuttle.0-0-d2897-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels) - [Hotels in Almirante](https://expedia.ca/Almirante-Hotels.d6245958.Travel-Guide-Hotels) - [Hotels near Banff National Park](https://expedia.ca/Banff-National-Park-Hotels.0-l602291-0.Travel-Guide-Filter-Hotels) - [Hotels in Panama City](https://expedia.ca/Panama-City-Hotels.d2897.Travel-Guide-Hotels) - [All Inclusive Resorts and Hotels in Rio Hato](https://expedia.ca/Rio-Hato-Hotels-All-Inclusive-Hotel.0-0-d6246042-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Hotels in Bocas del Toro](https://expedia.ca/Bocas-Del-Toro-Hotels.d6023445.Travel-Guide-Hotels) Flights - [Flights to Italy](https://expedia.ca/Destinations-In-Italy.d86.Flight-Destinations) - [Flights from Kitchener to Calgary](https://expedia.ca/lp/flights/ykf/yyc/kitchener-to-calgary) - [Flights to Colon](https://expedia.ca/Cheap-Flights-To-Colon.d601867.Travel-Guide-Flights) - [Flights to Boca Chica](https://expedia.ca/Cheap-Flights-To-Boca-Chica.d6198033.Travel-Guide-Flights) - [Flights to Chepo](https://expedia.ca/Cheap-Flights-To-Chepo.d553248622834396118.Travel-Guide-Flights) - [Flights to Toronto](https://expedia.ca/Cheap-Flights-To-Toronto.d178314.Travel-Guide-Flights) - [Flights from Mumbai to Toronto](https://expedia.ca/lp/flights/bom/yyz/mumbai-to-toronto) - [Flights to Rio Hato](https://expedia.ca/Cheap-Flights-To-Rio-Hato.d6246042.Travel-Guide-Flights) - [Flights to Panama City](https://expedia.ca/Cheap-Flights-To-Panama-City.d2897.Travel-Guide-Flights) - [Flights to Bocas del Toro](https://expedia.ca/Cheap-Flights-To-Bocas-Del-Toro.d6023445.Travel-Guide-Flights) Cars - [Car rentals in Panama City](https://expedia.ca/Car-Rentals-In-Panama-City.d2897.Car-Rental-Guide) - [Car rentals in Rio Hato](https://expedia.ca/Car-Rentals-In-Rio-Hato.d6246042.Car-Rental-Guide) - [Car rentals in David](https://expedia.ca/Car-Rentals-In-David.d500195.Car-Rental-Guide) Activities - [Things to do in Santa Clara](https://expedia.ca/Things-To-Do-In-Santa-Clara.d553248623287315690.Travel-Guide-Activities) - [Things to do in Panama City](https://expedia.ca/Things-To-Do-In-Panama-City.d2897.Travel-Guide-Activities) - [Things to do in Bocas del Toro](https://expedia.ca/Things-To-Do-In-Bocas-Del-Toro.d6023445.Travel-Guide-Activities) - [Things to do in Colon](https://expedia.ca/Things-To-Do-In-Colon.d601867.Travel-Guide-Activities) - [Things to do in Rio Hato](https://expedia.ca/Things-To-Do-In-Rio-Hato.d6246042.Travel-Guide-Activities) Packages - [Bocas del Toro Vacations](https://expedia.ca/Bocas-Del-Toro.d6023445.Destination-Travel-Guides) - [Rio Hato Vacations](https://expedia.ca/Rio-Hato.d6246042.Destination-Travel-Guides) - [Panama City Vacations](https://expedia.ca/Panama-City.d2897.Destination-Travel-Guides) General - [Visit Boquete](https://expedia.ca/Boquete.dx500194) - [Visit El Valle de Anton](https://expedia.ca/El-Valle-De-Anton.dx6053180) - [Visit Panama City](https://expedia.ca/Panama-City.dx2897) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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