Title: Book The Best Hotels in Santiago del Río for 2026 from CA $43 - Fully Refundable Options - Expedia.ca [Santiago del Río Travel Guide](https://expedia.ca/Santiago-Del-Rio.dx553248635640665145)[Vacation Rentals in Santiago del Río](https://expedia.ca/Santiago-Del-Rio-Vacation-Rentals.d553248635640665145.Travel-Guide-VacationRentals)[Santiago del Río Car Rentals](https://expedia.ca/Car-Rentals-In-Santiago-Del-Rio.d553248635640665145.Car-Rental-Guide)[Santiago del Río Vacation Packages](https://expedia.ca/Santiago-Del-Rio.d553248635640665145.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels in Santiago del Río from CA $43 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Dec 10 - Dec 11](https://www.expedia.ca/Hotel-Search?regionId=553248635640665145&startDate=2025-12-10&endDate=2025-12-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 11 - Dec 12](https://www.expedia.ca/Hotel-Search?regionId=553248635640665145&startDate=2025-12-11&endDate=2025-12-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=553248635640665145&startDate=2025-12-12&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248635640665145&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSantiago-Del-Rio-Hotels.d553248635640665145.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSantiago-Del-Rio-Hotels.d553248635640665145.Travel-Guide-Hotels) ## More cheap stays in Santiago del Río ![HOTEL POSADA DON MATIAS](https://images.trvl-media.com/lodging/110000000/109630000/109623100/109623058/cd4c38fa_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### HOTEL POSADA DON MATIAS 316 C. de Ignacio Aldama Centro Oaxaca OAX CA $36 CA $43 total Dec 11 - Dec 12 includes taxes & fees 9/10 Wonderful! (189 reviews) [](https://expedia.ca/Oaxaca-Hotels-HOTEL-POSADA-DON-MATIAS.h109623058.Hotel-Information) ![HOTEL BIULÚ](https://images.trvl-media.com/lodging/91000000/90950000/90946300/90946251/7f6d4e14_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### HOTEL BIULÚ BOULEVARD BENITO JUAREZ, 22 Santa María Huatulco OAX CA $103 CA $122 total Dec 13 - Dec 14 includes taxes & fees 8.8/10 Excellent! (132 reviews) [](https://expedia.ca/Santa-Maria-Huatulco-Hotels-HOTEL-BIULU.h90946251.Hotel-Information) ![Hotel Posada El Cid](https://images.trvl-media.com/lodging/12000000/11600000/11592000/11591984/05e73c87_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Posada El Cid Pino Suarez 903, Colonia Centro Oaxaca OAX CA $103 CA $124 total Dec 24 - Dec 25 includes taxes & fees 7.8/10 Good! (69 reviews) [](https://expedia.ca/Oaxaca-Hotels-Posada-Del-Cid.h11591984.Hotel-Information) ![Casona Oaxaca Historia y Paz](https://images.trvl-media.com/lodging/108000000/107620000/107611700/107611619/49b3b44d_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Casona Oaxaca Historia y Paz Trujano 206 Oaxaca Oax. CA $112 CA $133 total Dec 11 - Dec 12 includes taxes & fees 9.2/10 Wonderful! (161 reviews) [](https://expedia.ca/Oaxaca-Hotels-Casona-Oaxaca-Historia-Y-Paz.h107611619.Hotel-Information) ![Blater Hotel](https://images.trvl-media.com/lodging/16000000/15260000/15251800/15251774/a74d6916_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Blater Hotel Calle Del Morro S/N Col. Santa Maria Santa Maria Colotepec Oaxaca CA $180 CA $214 total Jan 9 - Jan 10, 2026 includes taxes & fees 9.2/10 Wonderful! (62 reviews) [](https://expedia.ca/Santa-Maria-Colotepec-Hotels-Blater-Hotel.h15251774.Hotel-Information) ![Happy Express Hotel](https://images.trvl-media.com/lodging/10000000/9590000/9587300/9587247/820d5b66_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Happy Express Hotel Diaz Ordaz 312 Oaxaca OAX CA $68,478 CA $81,489 total Dec 12 - Dec 13 includes taxes & fees 9/10 Wonderful! (318 reviews) [](https://expedia.ca/Oaxaca-Hotels-Happy-Express-Hotel.h9587247.Hotel-Information) ## Frequently asked questions ### What is the best area to stay in Santiago Del Río? > This neighbourhood is the heart of Santiago Del Río and is very walkable. It's centred around the Zócalo, the main square, which is surrounded by the Cathedral and the Government Palace. The streets branching off the Zócalo, particularly Avenida Independencia and Calle Macedonio Alcalá (a pedestrian-only street), are lined with shops, restaurants, and galleries housed in historic buildings. > > > Couples will find the Historic Centre particularly appealing. You'll be within easy walking distance of cultural sites like the Templo de Santo Domingo de Guzmán and the Museo de las Culturas de Oaxaca. Many hotels in this area offer beautiful courtyards and rooftop terraces, superb for enjoying the city's atmosphere in the evenings. > > > For those looking for a slightly more residential feel while still being very central, the Reforma neighbourhood is an excellent option. It's just a short taxi ride or a pleasant walk north of the Historic Centre. Reforma offers a good selection of modern hotels and a more relaxed pace, with pleasant tree-lined streets and a variety of dining options. ### When is the best time to go to Santiago Del Río? > During these months, you'll experience pleasant, warm days with clear skies and very little rain. The average daytime temperatures hover around 25-30°C (77-86°F), making it comfortable for exploring the outdoors and enjoying the local sights. The evenings are cooler, often dropping to around 15-20°C (59-68°F), so a light jacket or jumper is a good idea. > > > This period is ideal for travellers who want to make the most of Santiago Del Río's natural beauty and cultural offerings without the interruption of heavy downpours. It's superb for hiking in the nearby mountains, visiting coffee plantations, or simply enjoying the town's charming streets and plazas. You'll find it easier to get around, and outdoor activities like market visits and al fresco dining are much more enjoyable. > > > While the dry season is generally considered the best, it's also the most popular, so you might find more visitors and slightly higher prices, especially around major holidays like Christmas and Easter. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Santiago del Río hotel booking with Expedia? ### How much is the nightly rate at a Santiago del Río hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [3 Star Hotels in San Juan Bautista Cuicatlán ](https://www.expedia.ca/3Star-San-Juan-Bautista-Cuicatlan-Hotels.s30-0-d553248635640632624.Travel-Guide-Filter-Hotels) - [Asunción Nochixtlán Hotels ](https://www.expedia.ca/Asuncion-Nochixtlan-Hotels.d6299360.Travel-Guide-Hotels) - [Calihualá Hotels ](https://www.expedia.ca/Calihuala-Hotels.d553248635640632815.Travel-Guide-Hotels) - [Chalcatongo de Hidalgo Hotels ](https://www.expedia.ca/Chalcatongo-De-Hidalgo-Hotels.d553248635640677829.Travel-Guide-Hotels) - [Huajuapan Hotels ](https://www.expedia.ca/Huajuapan-Hotels.d6245105.Travel-Guide-Hotels) - [Ixpantepec Nieves Hotels ](https://www.expedia.ca/Ixpantepec-Nieves-Hotels.d553248635640640405.Travel-Guide-Hotels) - [Mariscala de Juárez Hotels ](https://www.expedia.ca/Mariscala-De-Juarez-Hotels.d553248635640704411.Travel-Guide-Hotels) - [Putla Villa de Guerrero Hotels ](https://www.expedia.ca/Putla-Villa-De-Guerrero-Hotels.d553248635640677765.Travel-Guide-Hotels) - [San Jorge Nuchita Hotels ](https://www.expedia.ca/San-Jorge-Nuchita-Hotels.d553248635640681158.Travel-Guide-Hotels) - [San Juan Bautista Tlachichilco Hotels ](https://www.expedia.ca/San-Juan-Bautista-Tlachichilco-Hotels.d553248635640658855.Travel-Guide-Hotels) - [San Juan Cacahuatepec Hotels ](https://www.expedia.ca/San-Juan-Cacahuatepec-Hotels.d553248635640656455.Travel-Guide-Hotels) - [San Juan Teposcolula Hotels ](https://www.expedia.ca/San-Juan-Teposcolula-Hotels.d553248635640662104.Travel-Guide-Hotels) - [San Lorenzo Victoria Hotels ](https://www.expedia.ca/San-Lorenzo-Victoria-Hotels.d553248635640642582.Travel-Guide-Hotels) - [San Miguel Achiutla Hotels ](https://www.expedia.ca/San-Miguel-Achiutla-Hotels.d553248635640633425.Travel-Guide-Hotels) - [San Miguel el Grande Hotels ](https://www.expedia.ca/San-Miguel-El-Grande-Hotels.d553248635640667354.Travel-Guide-Hotels) - [Hotels near San Pedro y San Pablo Teposcolula Catholic Church ](https://www.expedia.ca/San-Pedro-Y-San-Pablo-Teposcolula-Catholic-Church-Hotels.0-l553248635976234903-0.Travel-Guide-Filter-Hotels) - [San Pedro y San Pablo Teposcolula Hotels ](https://www.expedia.ca/San-Pedro-Y-San-Pablo-Teposcolula-Hotels.d553248635640657811.Travel-Guide-Hotels) - [San Sebastián Tecomaxtlahuaca Hotels ](https://www.expedia.ca/San-Sebastian-Tecomaxtlahuaca-Hotels.d553248635640660876.Travel-Guide-Hotels) - [San Simón Zahuatlán Hotels ](https://www.expedia.ca/San-Simon-Zahuatlan-Hotels.d553248635640671156.Travel-Guide-Hotels) - [Santa María Yolotepec Hotels ](https://www.expedia.ca/Santa-Maria-Yolotepec-Hotels.d553248635640679610.Travel-Guide-Hotels) - [Santa María Zacatepec Hotels ](https://www.expedia.ca/Santa-Maria-Zacatepec-Hotels.d553248635640694662.Travel-Guide-Hotels) - [Santiago Juxtlahuaca Hotels ](https://www.expedia.ca/Santiago-Juxtlahuaca-Hotels.d553248635640672179.Travel-Guide-Hotels) - [Santiago Miltepec Hotels ](https://www.expedia.ca/Santiago-Miltepec-Hotels.d553248635640644121.Travel-Guide-Hotels) - [Santiago Tamazola Hotels ](https://www.expedia.ca/Santiago-Tamazola-Hotels.d553248635640637097.Travel-Guide-Hotels) - [Santiago Yucuyachi Hotels ](https://www.expedia.ca/Santiago-Yucuyachi-Hotels.d553248635640633085.Travel-Guide-Hotels) - [Tamazulapam Hotels ](https://www.expedia.ca/Tamazulapam-Hotels.d6320679.Travel-Guide-Hotels) - [Tlacotepec Plumas Hotels ](https://www.expedia.ca/Tlacotepec-Plumas-Hotels.d553248635640691895.Travel-Guide-Hotels) - [Tlaxiaco Hotels ](https://www.expedia.ca/Tlaxiaco-Hotels.d3000367158.Travel-Guide-Hotels) - [Yanhuitlan Hotels ](https://www.expedia.ca/Yanhuitlan-Hotels.d6354831.Travel-Guide-Hotels) - [Yutanduchi de Guerrero Hotels ](https://www.expedia.ca/Yutanduchi-De-Guerrero-Hotels.d553248635640676414.Travel-Guide-Hotels) - [Zapotitlán Lagunas Hotels ](https://www.expedia.ca/Zapotitlan-Lagunas-Hotels.d553248635640678078.Travel-Guide-Hotels) - [Flights to Huajuapan ](https://www.expedia.ca/Cheap-Flights-To-Huajuapan.d6245105.Travel-Guide-Flights) - [Flights to Pinotepa Nacional ](https://www.expedia.ca/Cheap-Flights-To-Pinotepa-Nacional.d3000449713.Travel-Guide-Flights) - [Flights to Santiago Juxtlahuaca ](https://www.expedia.ca/Cheap-Flights-To-Santiago-Juxtlahuaca.d553248635640672179.Travel-Guide-Flights) - [Visit Asunción Nochixtlán ](https://www.expedia.ca/Asuncion-Nochixtlan.dx6299360) - [Visit Chalcatongo de Hidalgo ](https://www.expedia.ca/Chalcatongo-De-Hidalgo.dx553248635640677829) - [Visit Magdalena Apasco ](https://www.expedia.ca/Magdalena-Apasco.dx553248635640675660) - [Visit Pinotepa Nacional ](https://www.expedia.ca/Pinotepa-Nacional.dx3000449713) - [Visit Putla Villa de Guerrero ](https://www.expedia.ca/Putla-Villa-De-Guerrero.dx553248635640677765) - [Visit San Andrés Huaxpaltepec ](https://www.expedia.ca/San-Andres-Huaxpaltepec.dx553248635640665955) - [Visit San Andrés Lagunas ](https://www.expedia.ca/San-Andres-Lagunas.dx553248635640637082) - [Visit San Andrés Zautla ](https://www.expedia.ca/San-Andres-Zautla.dx553248635640667478) - [Visit San Jerónimo Sosola ](https://www.expedia.ca/San-Jeronimo-Sosola.dx553248635640657921) - [Visit San Juan Bautista Tlachichilco ](https://www.expedia.ca/San-Juan-Bautista-Tlachichilco.dx553248635640658855) - [Visit San Juan Mixtepec Distrito 08 ](https://www.expedia.ca/San-Juan-Mixtepec-Distrito-08.dx553248635640658582) - [Visit San Lorenzo Victoria ](https://www.expedia.ca/San-Lorenzo-Victoria.dx553248635640642582) - [Visit San Martín Peras ](https://www.expedia.ca/San-Martin-Peras.dx553248635640694317) - [Visit San Mateo Yucutindoo ](https://www.expedia.ca/San-Mateo-Yucutindoo.dx553248635640676828) - [Visit San Pablo Huitzo ](https://www.expedia.ca/San-Pablo-Huitzo.dx553248635640633619) - [Visit San Pablo Tijaltepec ](https://www.expedia.ca/San-Pablo-Tijaltepec.dx553248635640698804) - [Visit San Sebastián Nicananduta ](https://www.expedia.ca/San-Sebastian-Nicananduta.dx553248635640633633) - [Visit San Sebastián Tecomaxtlahuaca ](https://www.expedia.ca/San-Sebastian-Tecomaxtlahuaca.dx553248635640660876) - [Visit Santa Cruz Tacache de Mina ](https://www.expedia.ca/Santa-Cruz-Tacache-De-Mina.dx553248635640668519) - [Visit Santa María Ixcatlán ](https://www.expedia.ca/Santa-Maria-Ixcatlan.dx553248635640639883) - [Visit Santiago Apoala ](https://www.expedia.ca/Santiago-Apoala.dx553248635640634931) - [Visit Santiago Juxtlahuaca ](https://www.expedia.ca/Santiago-Juxtlahuaca.dx553248635640672179) - [Visit Santiago Yolomécatl ](https://www.expedia.ca/Santiago-Yolomecatl.dx553248635640671015) - [Visit Santiago Yosondúa ](https://www.expedia.ca/Santiago-Yosondua.dx553248635640642062) - [Visit Santo Domingo Teojomulco ](https://www.expedia.ca/Santo-Domingo-Teojomulco.dx553248635640678296) - [Visit Santo Tomás Ocotepec ](https://www.expedia.ca/Santo-Tomas-Ocotepec.dx553248635640676897) - [Visit Santos Reyes Tepejillo ](https://www.expedia.ca/Santos-Reyes-Tepejillo.dx553248635640671563) - [Visit Santos Reyes Yucuná ](https://www.expedia.ca/Santos-Reyes-Yucuna.dx553248635640659560) - [Car rental Santiago Juxtlahuaca ](https://www.expedia.ca/Car-Rentals-In-Santiago-Juxtlahuaca.d553248635640672179.Car-Rental-Guide) - [Fox Rental Cars Rental Cars in San Pedro y San Pablo Tequixtepec ](https://www.expedia.ca/Fox-Rental-Cars-Car-Rentals-In-San-Pedro-Y-San-Pablo-Tequixtepec.d553248635640641988-c19.Car-Rental-Guide-Suppliers) - [Book Hotels in Santiago del Río on Expedia.mx ](https://www.expedia.mx/Santiago-Del-Rio-Hoteles.d553248635640665145.Guia-Viajes-Hoteles) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app