Title: Santee Vacation Home Rentals from CA $294: Search Top Private Vacation Homes for Rent | Expedia.ca [Santee Travel Guide](https://expedia.ca/Santee.dx9953)[Hotels in Santee](https://expedia.ca/Santee-Hotels.d9953.Travel-Guide-Hotels)[Vacation Rentals in Santee](https://expedia.ca/Santee-Vacation-Rentals.d9953.Travel-Guide-VacationRentals)[Flights to Santee](https://expedia.ca/Cheap-Flights-To-Santee.d9953.Travel-Guide-Flights)[Santee Car Rentals](https://expedia.ca/Car-Rentals-In-Santee.d9953.Car-Rental-Guide)[Santee Vacation Packages](https://expedia.ca/Santee.d9953.Destination-Travel-Guides) ![Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates In two weeks [Mar 20 - Mar 22](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2026-03-20&endDate=2026-03-22&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [May 1 - May 3](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2026-05-01&endDate=2026-05-03&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [May 29 - May 31](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2026-05-29&endDate=2026-05-31&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [Jun 26 - Jun 28](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2026-06-26&endDate=2026-06-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Santee vacation homes ![Smart TV, offices](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/c321e70e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/431d124d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, offices](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/61772a9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/f5487ae6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95! [](https://www.expedia.ca/Santee-Hotels-This-House-Is-A-3-Bedroom.h91788460.Hotel-Information) Santee 10/10 Exceptional (39 reviews) "This home was perfect for our Thanksgiving family getaway. We really enjoyed everything about the house, especially the fenced yard for the dogs. I would definitely stay here again. The house was exceptionally clean. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kelly C. CA $126 CA $437 total includes taxes & fees Mar 9 - Mar 10 [](https://www.expedia.ca/Santee-Hotels-This-House-Is-A-3-Bedroom.h91788460.Hotel-Information) ![TV, table tennis](https://images.trvl-media.com/lodging/120000000/119470000/119463700/119463617/b1457367.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/120000000/119470000/119463700/119463617/d950643a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/120000000/119470000/119463700/119463617/85826adc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Game room](https://images.trvl-media.com/lodging/120000000/119470000/119463700/119463617/1dfe7a45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Turtle Cove - Lake Living on Lake Marion [](https://www.expedia.ca/Summerton-Hotels-Turtle-Cove-Lake-Living-On-Lake-Marion.h119463617.Hotel-Information) Summerton CA $171 CA $586 total includes taxes & fees Mar 8 - Mar 9 [](https://www.expedia.ca/Summerton-Hotels-Turtle-Cove-Lake-Living-On-Lake-Marion.h119463617.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/105000000/104530000/104523100/104523088/fe01674b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/105000000/104530000/104523100/104523088/4a84e798.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 bedrooms, iron/ironing board, internet, bed sheets](https://images.trvl-media.com/lodging/105000000/104530000/104523100/104523088/8aaa8970.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/105000000/104530000/104523100/104523088/5eedc4b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sweet Marion - Dock + Boat Ramp + Hot Tub! [](https://www.expedia.ca/Summerton-Hotels-Sweet-Marion-Dock-Boat-Ramp-Hot-Tub.h104523088.Hotel-Information) Summerton 8.6/10 Excellent (19 reviews) "Nice comfortable place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dylan H. CA $198 CA $680 total includes taxes & fees Mar 8 - Mar 9 [](https://www.expedia.ca/Summerton-Hotels-Sweet-Marion-Dock-Boat-Ramp-Hot-Tub.h104523088.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/20000000/20000000/19993600/19993568/ec7cddf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Marina](https://images.trvl-media.com/lodging/20000000/20000000/19993600/19993568/431a876d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/20000000/20000000/19993600/19993568/9b1fe174.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/20000000/20000000/19993600/19993568/0949138a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable [](https://www.expedia.ca/Summerton-Hotels-SANITIZED-Lake-Marion-Lakefront-Sandy-Beach.h19993568.Hotel-Information) Summerton 9.6/10 Exceptional (249 reviews) "We had a great family retreat " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ernestine C. CA $342 CA $686 total includes taxes & fees Mar 22 - Mar 23 [](https://www.expedia.ca/Summerton-Hotels-SANITIZED-Lake-Marion-Lakefront-Sandy-Beach.h19993568.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/124000000/123610000/123609000/123608930/62aee6da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/124000000/123610000/123609000/123608930/4a09493e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchen](https://images.trvl-media.com/lodging/124000000/123610000/123609000/123608930/w1057h775x63y0-6c79090c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/124000000/123610000/123609000/123608930/2ac0ad5e_edited_fd03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Tee Vee Cove is the place to be located near great golfing, fishing and food [](https://www.expedia.ca/Elloree-Hotels-The-Tee-Vee-Cove-Is-The-Place-To-Be-Located-Near-Great-Golfing.h123608930.Hotel-Information) Elloree CA $184 CA $354 total includes taxes & fees Mar 8 - Mar 9 [](https://www.expedia.ca/Elloree-Hotels-The-Tee-Vee-Cove-Is-The-Place-To-Be-Located-Near-Great-Golfing.h123608930.Hotel-Information) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/113000000/112530000/112528200/112528151/w1198h1600x0y0-8fa30947.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/113000000/112530000/112528200/112528151/92a17159.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/113000000/112530000/112528200/112528151/c0703344.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112530000/112528200/112528151/w1197h1600x0y0-a4a4fa86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beautiful brick home w/ large porch and 3 bedrooms [](https://www.expedia.ca/Beautiful-Brick-Home-W-Large-Porch-And-3-Bedrooms.h112528151.Hotel-Information) Bowman 9.2/10 Wonderful (5 reviews) "Nice and quiet property. It served us well for the weekend " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mick S. CA $203 CA $385 total includes taxes & fees Mar 6 - Mar 7 [](https://www.expedia.ca/Beautiful-Brick-Home-W-Large-Porch-And-3-Bedrooms.h112528151.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/114000000/113030000/113026400/113026382/716e2146.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/114000000/113030000/113026400/113026382/838e215b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/114000000/113030000/113026400/113026382/897763a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/114000000/113030000/113026400/113026382/fab3138f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Reel Haven on the Water: Modern + Comfy Home! [](https://www.expedia.ca/Eutawville-Hotels-Reel-Haven-On-The-Water-Modern-Comfy-Home.h113026382.Hotel-Information) Eutawville 6.8/10 (5 reviews) "Perfect place for a weekend fishing trip. Owner was responsive. Slept 6 easily. Only stayed one night but was a perfect fit" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) brandon h. CA $178 CA $596 total includes taxes & fees Mar 8 - Mar 9 [](https://www.expedia.ca/Eutawville-Hotels-Reel-Haven-On-The-Water-Modern-Comfy-Home.h113026382.Hotel-Information) ![1 bedroom, in-room safe, WiFi, bed sheets](https://images.trvl-media.com/lodging/88000000/87980000/87972600/87972565/fb69157a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/88000000/87980000/87972600/87972565/5115418d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, hair dryer, bathrobes, towels](https://images.trvl-media.com/lodging/88000000/87980000/87972600/87972565/fe737fd1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/88000000/87980000/87972600/87972565/w449h683x287y0-8c43cd49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Private entrance charming room with clawfoot tub. [](https://www.expedia.ca/Elloree-Hotels-Private-Entrance-Charming-Room-With-Clawfoot-Tub.h87972565.Hotel-Information) Elloree 4.0/10 (1 review) "This pains me to write because this could’ve been a great little stopping point, however the bathtub was actually filthy. It smelled like urine and there is a dark grey film that needs to be scrubbed off. I get that old tubs can have stains but these are not stains and could’ve been removed with cleaner and elbow grease. I had camped for a week and just wanted to take a nice hot bath; I did not get to take one. Also I would add a sign for the cottage because it was confusing as to which door it... ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gregory P. CA $205 CA $292 total includes taxes & fees Mar 8 - Mar 9 [](https://www.expedia.ca/Elloree-Hotels-Private-Entrance-Charming-Room-With-Clawfoot-Tub.h87972565.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-03-19&endDate=2026-03-20®ionId=9953&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.ca/deals?rfrr=AA_SPRING_PROMO_9953) ## Find vacation rentals that suit your style Cabins [](https://www.expedia.ca/Hotel-Search?destination=Santee%2C+South+Carolina%2C+United+States+of+America®ionId=9953&latLong=33.487602%2C-80.476242&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=CABIN) Cottages [](https://www.expedia.ca/Hotel-Search?destination=Santee%2C+South+Carolina%2C+United+States+of+America®ionId=9953&latLong=33.487602%2C-80.476242&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=COTTAGE) Private vacation homes [](https://www.expedia.ca/Hotel-Search?destination=Santee%2C+South+Carolina%2C+United+States+of+America®ionId=9953&latLong=33.487602%2C-80.476242&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=VACATION_HOME) Condos [](https://www.expedia.ca/Hotel-Search?destination=Santee%2C+South+Carolina%2C+United+States+of+America®ionId=9953&latLong=33.487602%2C-80.476242&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=CONDO) Aparthotels [](https://www.expedia.ca/Hotel-Search?destination=Santee%2C+South+Carolina%2C+United+States+of+America®ionId=9953&latLong=33.487602%2C-80.476242&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=APART_HOTEL) Apartments [](https://www.expedia.ca/Hotel-Search?destination=Santee%2C+South+Carolina%2C+United+States+of+America®ionId=9953&latLong=33.487602%2C-80.476242&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=APARTMENT) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSantee-Private-Vacation-Homes.d9953-aaPrivateVacationHomes.Travel-Guide-Accommodation)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSantee-Private-Vacation-Homes.d9953-aaPrivateVacationHomes.Travel-Guide-Accommodation) ## Top Santee Hotel Reviews ![Fairfield Inn & Suites by Marriott Santee](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb_y.jpg) ### Fairfield Inn & Suites by Marriott Santee 10/10 Excellent "It was a fantastic stay. That’s why we stayed there before. " [](https://expedia.ca/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) ![Comfort Inn & Suites Santee](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/fc94b516_y.jpg) ### Comfort Inn & Suites Santee 10/10 Excellent "Hotel was a little dated but clean." [](https://expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) ![Red Roof Inn Santee](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/8136c59d_y.jpg) ### Red Roof Inn Santee 2/10 Terrible "I haven’t be returned my $50 security yet " [](https://expedia.ca/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information) ![Travelodge by Wyndham Orangeburg](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/bfdc100f_y.jpg) ### Travelodge by Wyndham Orangeburg 8/10 Good "Conveniently located just off I26, this motel is very clean and beds are comfortable and rooms are quiet. Rooms could use some updating but can’t complain for the price. Lots of restaurants around to choose from and motel supplies coffee and cereal for breakfast in front dining area. " [](https://expedia.ca/Orangeburg-Hotels-Travelodge-By-Wyndham-Orangeburg.h17380261.Hotel-Information) ![Baymont by Wyndham Santee](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/d2da67e4_y.jpg) ### Baymont by Wyndham Santee 8/10 Good "Older hotel but very clean. Easy on/off access to I95" [](https://expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Best Western Plus Santee Inn](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/93ba5eb3_y.jpg) ### Best Western Plus Santee Inn 10/10 Excellent "Clean but a bit worn" [](https://expedia.ca/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) ![Holiday Inn Santee by IHG](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/278d9dc3_y.jpg) ### Holiday Inn Santee by IHG 8/10 Good "Staff was amazing — but they were very short staffed so the one person at the bar/restaurant (Dee) and the one person at the desk did the job of 3 people each!! Place is being renovated so not quite there yet but clean and good stay. And again incredible staff!!! " [](https://expedia.ca/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information) ![Tru by Hilton Orangeburg](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/99c8fb35_y.jpg) ### Tru by Hilton Orangeburg 6/10 Okay "Room seemed new but cheap( Shower trim was already rusty)Body wash in shower was empty. When do you think I found that out. Front desk staff when checking in was great, nobody present at desk for check out so was not able to inform of soap being empty. Hopefully the housekeeper catches it for the next guest" [](https://expedia.ca/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information) ![Ramada by Wyndham Santee I-95](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/d34bd120_y.jpg) ### Ramada by Wyndham Santee I-95 8/10 Good "Clean room and good staff" [](https://expedia.ca/Orangeburg-Hotels-Clarion-Inn-Santee-I-95.h11623.Hotel-Information) ## Find out more about Santee ## Santee Vacation Homes information | Number of reviews | 313 | | ----------------- | ----------------- | | Accommodation | 76 Vacation Homes | | Lowest Price | CA $294 | | Highest Price | CA $686 | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [5 Star Hotels in Manning ](https://www.expedia.ca/5Star-Manning-Hotels.s50-0-d8454.Travel-Guide-Filter-Hotels) - [B&B in Bowman ](https://www.expedia.ca/Bowman-Bed-And-Breakfast.d553248634998681915-aaBedAndBreakfast.Travel-Guide-Accommodation) - 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