Title: Santee Vacation Home Rentals from CA $302: Search Top Private Vacation Homes for Rent | Expedia.ca [Santee Travel Guide](https://expedia.ca/Santee.dx9953)[Hotels in Santee](https://expedia.ca/Santee-Hotels.d9953.Travel-Guide-Hotels)[Vacation Rentals in Santee](https://expedia.ca/Santee-Vacation-Rentals.d9953.Travel-Guide-VacationRentals)[Flights to Santee](https://expedia.ca/Cheap-Flights-To-Santee.d9953.Travel-Guide-Flights)[Santee Car Rentals](https://expedia.ca/Car-Rentals-In-Santee.d9953.Car-Rental-Guide)[Santee Vacation Packages](https://expedia.ca/Santee.d9953.Destination-Travel-Guides) ![Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Santee Vacation Rentals - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Next weekend [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-12-05&endDate=2025-12-07&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-12-12&endDate=2025-12-14&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In one month [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-12-26&endDate=2025-12-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Jan 23 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2026-01-23&endDate=2026-01-25&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Browse Select Santee Vacation Homes ![Smart TV, offices](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/dc99579a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/339c1207.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/10896652.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/431d124d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95! Santee 10/10 Exceptional (36) "Amazing host, comfy furniture, the fenced in yard was perfect for our fur babies! Hope to stay here again. 1.2 miles away from I-95! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lauren B. CA $141 CA $458 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Santee-Hotels-This-House-Is-A-3-Bedroom.h91788460.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/110000000/109530000/109522600/109522588/4470744c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/110000000/109530000/109522600/109522588/61053f61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, printers](https://images.trvl-media.com/lodging/110000000/109530000/109522600/109522588/cf36fe26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, printers](https://images.trvl-media.com/lodging/110000000/109530000/109522600/109522588/0dbecbd3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming 2-bedroom townhome with AC and WiFi in peaceful Summerton Summerton CA $195 CA $425 total includes taxes & fees Dec 1 - Dec 2 [](https://www.expedia.ca/Summerton-Hotels-Charming-2-Bedroom-Townhome-With-AC-And-WiFi-In-Peaceful-Summerton.h109522588.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/55000000/54180000/54171600/54171514/cebbaa06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/55000000/54180000/54171600/54171514/959f5275.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/55000000/54180000/54171600/54171514/0ddde0a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/55000000/54180000/54171600/54171514/7f847335.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Lake House at Turtle Cove: Cozy relaxing lake home with dock on wooded lot. Eutawville 10/10 Exceptional (39) "Excellent place to stay. Nice and cozy spot. Neighbors are very nice as well. Very clean and neat place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Devin W. [](https://www.expedia.ca/Eutawville-Hotels-Vrbo-Property.h54171514.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/105000000/104530000/104523100/104523088/fe01674b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/105000000/104530000/104523100/104523088/a30c8a2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/105000000/104530000/104523100/104523088/dd305957.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/105000000/104530000/104523100/104523088/c4f232ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sweet Marion - Dock + Boat Ramp + Hot Tub! Summerton 8.6/10 Excellent (18) "Group of us older guys went for a golf weekend at Santee. The house was great and we really enjoyed our stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chris D. CA $175 CA $660 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Summerton-Hotels-Sweet-Marion-Dock-Boat-Ramp-Hot-Tub.h104523088.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/113000000/112530000/112528200/112528151/d8b442d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/113000000/112530000/112528200/112528151/w1199h1600x1y0-b1f9af42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/113000000/112530000/112528200/112528151/w1200h1600x1y0-32d57d04.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112530000/112528200/112528151/w1197h1600x0y0-a4a4fa86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beautiful brick home w/ large porch and 3 bedrooms Bowman 9.0/10 Wonderful (4) "Nice and quiet property. It served us well for the weekend " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mick S. CA $208 CA $394 total includes taxes & fees Nov 28 - Nov 29 [](https://www.expedia.ca/Beautiful-Brick-Home-W-Large-Porch-And-3-Bedrooms.h112528151.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/120000000/119470000/119463700/119463617/df0d5860.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, table tennis](https://images.trvl-media.com/lodging/120000000/119470000/119463700/119463617/b1457367.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Game room](https://images.trvl-media.com/lodging/120000000/119470000/119463700/119463617/d3922896.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/120000000/119470000/119463700/119463617/85826adc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Turtle Cove - Lake Living on Lake Marion Summerton CA $173 CA $598 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Summerton-Hotels-Turtle-Cove-Lake-Living-On-Lake-Marion.h119463617.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/114000000/113030000/113026400/113026382/bd88e0b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/114000000/113030000/113026400/113026382/09c89483.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/114000000/113030000/113026400/113026382/fab3138f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/114000000/113030000/113026400/113026382/df3c924b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Reel Haven on the Water: Modern + Comfy Home! Eutawville 6.8/10 (5) "Perfect place for a weekend fishing trip. Owner was responsive. Slept 6 easily. Only stayed one night but was a perfect fit" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) brandon h. CA $167 CA $583 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Eutawville-Hotels-Reel-Haven-On-The-Water-Modern-Comfy-Home.h113026382.Hotel-Information) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/119000000/118860000/118855900/118855890/ea2b2ead.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/119000000/118860000/118855900/118855890/347463eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/119000000/118860000/118855900/118855890/53e826e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/119000000/118860000/118855900/118855890/6b4ae984.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 4BD | 3BTH | Pool | HotTub | Games |5Miles to I-95 Elloree CA $216 CA $747 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Elloree-Hotels-4BD-3BTH-Pool-HotTub-Games-5Miles-To-I-95.h118855890.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/123000000/122220000/122212100/122212081/ab949c34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/123000000/122220000/122212100/122212081/ffeab226.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/123000000/122220000/122212100/122212081/0d0cadcb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 bedrooms, iron/ironing board, internet, bed sheets](https://images.trvl-media.com/lodging/123000000/122220000/122212100/122212081/e2d4bd94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Marvelous Manning - 4Bdr + Game Room +Waterfront! Shad Moss village CA $489 CA $1,148 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Manning-Hotels-Marvelous-Manning-4Bdr-Game-Room-Waterfront.h122212081.Hotel-Information) ![1 bedroom, in-room safe, WiFi, bed sheets](https://images.trvl-media.com/lodging/88000000/87980000/87972600/87972565/fb69157a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/88000000/87980000/87972600/87972565/w449h683x287y0-8c43cd49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, hair dryer, bathrobes, towels](https://images.trvl-media.com/lodging/88000000/87980000/87972600/87972565/w449h683x288y0-8fb90fc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, hair dryer, bathrobes, towels](https://images.trvl-media.com/lodging/88000000/87980000/87972600/87972565/fe737fd1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Private entrance charming room with clawfoot tub. Elloree 4.0/10 (1) "This pains me to write because this could’ve been a great little stopping point, however the bathtub was actually filthy. It smelled like urine and there is a dark grey film that needs to be scrubbed off. I get that old tubs can have stains but these are not stains and could’ve been removed with cleaner and elbow grease. I had camped for a week and just wanted to take a nice hot bath; I did not get to take one. Also I would add a sign for the cottage because it was confusing as to which door it... ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gregory P. CA $211 CA $302 total includes taxes & fees Dec 2 - Dec 3 [](https://www.expedia.ca/Elloree-Hotels-Private-Entrance-Charming-Room-With-Clawfoot-Tub.h87972565.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/123000000/122220000/122212100/122212064/313f1221.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/123000000/122220000/122212100/122212064/e8e56b06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/123000000/122220000/122212100/122212064/286ec07b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/123000000/122220000/122212100/122212064/2757f4f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Marvelous Manning: 4-Bdr + Studio + Waterfront Shad Moss village CA $533 CA $1,344 total includes taxes & fees Dec 2 - Dec 3 [](https://www.expedia.ca/Manning-Hotels-Marvelous-Manning-4-Bdr-Studio-Waterfront.h122212064.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-11&endDate=2025-12-12®ionId=9953&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_CA_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## Black Friday Sale Limited-time deals: save up to 50% on select hotels [Book now](https://expedia.ca/deals?rfrr=AA_BF_PROMO_9953) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSantee-Private-Vacation-Homes.d9953-aaPrivateVacationHomes.Travel-Guide-Accommodation)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSantee-Private-Vacation-Homes.d9953-aaPrivateVacationHomes.Travel-Guide-Accommodation) ## Top Santee Hotel Reviews ![Fairfield Inn & Suites by Marriott Santee](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb_y.jpg) ### Fairfield Inn & Suites by Marriott Santee 10/10 Excellent "Everything was great!" [](https://expedia.ca/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) ![Tru By Hilton Santee](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/5c693db6_y.jpg) ### Tru By Hilton Santee 10/10 Excellent "Clean room, friendly staff" [](https://expedia.ca/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) ![Baymont by Wyndham Santee](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3_y.jpg) ### Baymont by Wyndham Santee 10/10 Excellent "Check in was great. Latoya was wonderful she saw that I was pulling a trailer and made sure to tell me where I could park that was near my room. She was the sweetest lady. The room was clean. No bugs (big one for me). And although right off I95 it was very quiet. The rooms face outside so parking in front of your room. " [](https://expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Travelodge by Wyndham Santee](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/4ab49efd_y.jpg) ### Travelodge by Wyndham Santee 10/10 Excellent "Very comfortable beds and clean room!" [](https://expedia.ca/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information) ![Hampton Inn Santee-I-95](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/5f0a1276_y.jpg) ### Hampton Inn Santee-I-95 10/10 Excellent "Room was clean and smelled clean... not musty or perfumey. Staff was friendly. " [](https://expedia.ca/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information) ![Best Western Plus Santee Inn](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/6d1459c3_y.jpg) ### Best Western Plus Santee Inn 10/10 Excellent "Nice rooms and very good breakfast items." [](https://expedia.ca/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) ![Charming 2 Bedroom Waterfront Lake Marion Condo](https://images.trvl-media.com/lodging/113000000/112150000/112150000/112149977/c68f4c0f_y.jpg) ### Charming 2 Bedroom Waterfront Lake Marion Condo 10/10 Excellent "The host was attentive and responsive, even inviting us to check in earlier. The home was lovely, well-cared for and thoughtfully appointed. The small touches, such as a basket of coffee and filters along with some snacks allowed us to have coffee the next morning despite getting into town when the stores were closed. We will absolutely return to this property and feel comfortable recommending it others. " [](https://expedia.ca/Santee-Hotels-Charming-2-Bedroom-Waterfront-Lake-Marion-Condo.h112149977.Hotel-Information) ![Red Roof Inn Santee](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/4686cd8f_y.jpg) ### Red Roof Inn Santee 10/10 Excellent "It's a good stop for the price " [](https://expedia.ca/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information) ![Comfort Inn & Suites Santee](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/8e89959e_y.jpg) ### Comfort Inn & Suites Santee 10/10 Excellent "Everything was what we expected. " [](https://expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) ## Find out more about Santee ## Santee Vacation Homes information | Number of reviews | 97 | | --- | --- | | Accommodation | 76 Vacation Homes | | Lowest Price | CA $302 | | Highest Price | CA $1,344 | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [5 Star Hotels in Manning](https://www.expedia.ca/5Star-Manning-Hotels.s50-0-d8454.Travel-Guide-Filter-Hotels) - [B&B in Bowman](https://www.expedia.ca/Bowman-Bed-And-Breakfast.d553248634998681915-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Red Roof Inn Hotels in Bowman](https://www.expedia.ca/Bowman-Hotels-Red-Roof-Inn.0-0-d553248634998681915--bRedRoofInn.Travel-Guide-Filter-Hotels) - [Bowman Hotels](https://www.expedia.ca/Bowman-Hotels.d553248634998681915.Travel-Guide-Hotels) - [Apartments in Brookdale](https://www.expedia.ca/Brookdale-Apartments.d553248634999003908-aaApartments.Travel-Guide-Accommodation) - 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