Title: Book the Best ADVENTURE Hotels in Santee in 2026 | Expedia.ca [Santee Travel Guide](https://expedia.ca/Santee.dx9953)[Hotels in Santee](https://expedia.ca/Santee-Hotels.d9953.Travel-Guide-Hotels)[Vacation Rentals in Santee](https://expedia.ca/Santee-Vacation-Rentals.d9953.Travel-Guide-VacationRentals)[Flights to Santee](https://expedia.ca/Cheap-Flights-To-Santee.d9953.Travel-Guide-Flights)[Santee Car Rentals](https://expedia.ca/Car-Rentals-In-Santee.d9953.Car-Rental-Guide)[Santee Vacation Packages](https://expedia.ca/Santee.d9953.Destination-Travel-Guides) ![Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels & Resorts for Couples in Santee, SC from CA $224 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santee Hotels & Resorts for Couples Tonight [Dec 18 - Dec 19](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-12-18&endDate=2025-12-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 19 - Dec 20](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-12-19&endDate=2025-12-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Santee adventure hotels ![Terrace/patio](https://images.trvl-media.com/lodging/95000000/94850000/94846800/94846723/f4d74712.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/95000000/94850000/94846800/94846723/d7126112_edited_d996.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Miscellaneous](https://images.trvl-media.com/lodging/95000000/94850000/94846800/94846723/25be5d48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, hair dryer, towels, soap](https://images.trvl-media.com/lodging/95000000/94850000/94846800/94846723/8e450cea_edited_f3d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tranquil Getaways W/Heated Pool and Fishing [](https://www.expedia.ca/Santee-Hotels-Tranquil-Studio-Cottage-With-Heated-Pool-And-Fishing-Access.h94846723.Hotel-Information) Elloree 8.4/10 Very good (6) "Great property the pool was so fun! Mostly stayed on the property and lounged around for a nice relaxing stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tori P. CA $122 CA $292 total includes taxes & fees Jan 2 - Jan 3, 2026 [](https://www.expedia.ca/Santee-Hotels-Tranquil-Studio-Cottage-With-Heated-Pool-And-Fishing-Access.h94846723.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/108000000/107480000/107471600/107471514/14910802.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/108000000/107480000/107471600/107471514/c80eacb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/108000000/107480000/107471600/107471514/3c5e3a43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/108000000/107480000/107471600/107471514/224b7c6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing! [](https://www.expedia.ca/Santee-Hotels-Peaceful-Condo-On-Lake-Marion-In-Santee.h107471514.Hotel-Information) Santee 10/10 Exceptional (11) "Nice place great location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeffrey H. CA $241 CA $594 total includes taxes & fees Jan 12 - Jan 13, 2026 [](https://www.expedia.ca/Santee-Hotels-Peaceful-Condo-On-Lake-Marion-In-Santee.h107471514.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/77000000/76600000/76591800/76591706/38650b86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/77000000/76600000/76591800/76591706/00cecc0b_edited_986a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/77000000/76600000/76591800/76591706/aff09b01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/77000000/76600000/76591800/76591706/b53af47a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301 [](https://www.expedia.ca/Beautiful-Country-Cottage-With-Ease-Of-Access-Minutes-To-I-26.h76591706.Hotel-Information) Bowman 10/10 Exceptional (30) "Will stay again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Robert B. CA $105 CA $224 total includes taxes & fees Dec 20 - Dec 21 [](https://www.expedia.ca/Beautiful-Country-Cottage-With-Ease-Of-Access-Minutes-To-I-26.h76591706.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-01&endDate=2026-01-02®ionId=9953&adults=2&nearby_group=recreation&sort=RECOMMENDED&openPlayBack=true) ## Top Santee Hotel Reviews ![Hampton Inn Santee-I-95](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/5f0a1276_y.jpg) ### Hampton Inn Santee-I-95 10/10 Excellent "the breakfast was fresh. handicap parking close to entry" [](https://expedia.ca/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information) ![Red Roof Inn Santee](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/4686cd8f_y.jpg) ### Red Roof Inn Santee 10/10 Excellent "Yes and and prompt check in" [](https://expedia.ca/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information) ## Frequently asked questions ### How much do hotels for couples in Santee cost? ### What are the best hotels for couples in Santee? ### How many hotels for couples are there in Santee? ### What are the best cheap hotels for couples in Santee? ### Why book your hotel for couples in Santee with Expedia? ### How can I find cheap hotels for couples in Santee? ### What is there to do in Santee near my hotel for couples? ## Explore a world of travel with Expedia - 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