Title: Book the Best Santa Susana LUXURY Hotels - Upscale Hotels in Santa Susana, Simi Valley | Expedia.ca [Vacation Rentals in Simi Valley](https://expedia.ca/Simi-Valley-Vacation-Rentals.d6894.Travel-Guide-VacationRentals)[Flights to Simi Valley](https://expedia.ca/Cheap-Flights-To-Simi-Valley.d6894.Travel-Guide-Flights)[Things to do in Simi Valley](https://expedia.ca/Things-To-Do-In-Simi-Valley.d6894.Travel-Guide-Activities)[Santa Susana Car Rentals](https://expedia.ca/Car-Rentals-In-Santa-Susana.d6340842.Car-Rental-Guide)[Santa Susana Vacations](https://expedia.ca/Santa-Susana.d6340842.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/9/b896caa52309cedbebd5afbd9a25ceff.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Luxury Hotels in Santa Susana, Simi Valley ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santa Susana Luxury Hotels Tonight [Oct 23 - Oct 24](https://www.expedia.ca/Hotel-Search?regionId=6340842&startDate=2025-10-23&endDate=2025-10-24&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Oct 24 - Oct 25](https://www.expedia.ca/Hotel-Search?regionId=6340842&startDate=2025-10-24&endDate=2025-10-25&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6340842&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6340842&startDate=2025-10-31&endDate=2025-11-02&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Santa Susana Luxury Hotels ## Top Santa Susana Hotel Reviews ![Holiday Inn Express Van Nuys by IHG](//images.trvl-media.com/lodging/1000000/30000/21600/21558/4a5612d3_y.jpg) ### Holiday Inn Express Van Nuys by IHG 10/10 Excellent "Fresh, clean, great selection. " [](https://expedia.ca/Los-Angeles-Hotels-Holiday-Inn-Express-Van-Nuys.h21558.Hotel-Information) ![Hotel Angeleno](//images.trvl-media.com/lodging/1000000/30000/21900/21848/7bddbf3f_y.jpg) ### Hotel Angeleno 10/10 Excellent "Simply excellent " [](https://expedia.ca/Los-Angeles-Hotels-Hotel-Angeleno.h21848.Hotel-Information) ![Best Western Valencia/Six Flags Inn & Suites](//images.trvl-media.com/lodging/1000000/910000/908700/908621/99775826_y.jpg) ### Best Western Valencia/Six Flags Inn & Suites 10/10 Excellent "It was a great stay " [](https://expedia.ca/Los-Angeles-Hotels-Best-Western-ValenciaSix-Flags-Inn-Suites.h908621.Hotel-Information) ![The Anza - A Calabasas Hotel](//images.trvl-media.com/lodging/1000000/10000/4000/3917/80cbfa59_y.jpg) ### The Anza - A Calabasas Hotel 10/10 Excellent "We only booked our stay for one night haven't really settled in yet because we went out to eat but I was very very impressed so far with the quality of the rooms the bathroom and the beds definitely will be returning" [](https://expedia.ca/Los-Angeles-Hotels-The-Anza-A-Calabasas-Hotel.h3917.Hotel-Information) ![Sheraton Agoura Hills Hotel](//images.trvl-media.com/lodging/1000000/30000/23000/22940/eae14a8c_y.jpg) ### Sheraton Agoura Hills Hotel 10/10 Excellent "quiet location, easy access to everything I needed, free parking was a bonus. Most of the staff were very friendly and helpful. I was wondering why the bathrooms did not have functioning vents( exhaust) . Made the rooms steamy and had a wet musky smell when we entered the room." [](https://expedia.ca/Los-Angeles-Hotels-Sheraton-Agoura-Hills-Hotel.h22940.Hotel-Information) ![Hilton Garden Inn Calabasas](//images.trvl-media.com/lodging/1000000/890000/889300/889222/6b3ea089_y.jpg) ### Hilton Garden Inn Calabasas 10/10 Excellent "It was nice. It’s not a 5 star resort but that’s what i knew going in there. It’s a good value for the money. My only wish was that someone told me that i could order things like pancakes and French toast for breakfast. I thought it was just the scrambled eggs and bacon for breakfast. " [](https://expedia.ca/Los-Angeles-Hotels-Hilton-Garden-Inn-Calabasas.h889222.Hotel-Information) ![Palm Garden Hotel](//images.trvl-media.com/lodging/1000000/20000/10300/10241/54ccf1fa_y.jpg) ### Palm Garden Hotel 10/10 Excellent "Will stay here again next time in 1000 Oaks." [](https://expedia.ca/Los-Angeles-Hotels-Palm-Garden-Hotel.h10241.Hotel-Information) ![Motel 6 Thousand Oaks, CA](//images.trvl-media.com/lodging/1000000/990000/983700/983645/feff5327_y.jpg) ### Motel 6 Thousand Oaks, CA 10/10 Excellent "Gteat" [](https://expedia.ca/Los-Angeles-Hotels-Motel-6-Thousand-Oaks.h983645.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Santa Clarita - Valencia](//images.trvl-media.com/lodging/2000000/1560000/1550200/1550158/9847c5b2_y.jpg) ### La Quinta Inn & Suites by Wyndham Santa Clarita - Valencia 10/10 Excellent "Room was very quiet beds were comfortable " [](https://expedia.ca/Los-Angeles-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Santa-Clarita-Valencia.h1550158.Hotel-Information) ## Frequently asked questions ### Are you looking for a luxury hotel for your stay in Santa Susana? > Expedia can help you get a flight to Van Nuys, CA (VNY) airport or Santa Paula, CA (SZP) airport, and then you can select from a variety of places to stay that will deliver the luxury you seek. Amenities are an important consideration when you plan a vacation, so we make it easy to find what you'd like to make your stay special. If you want a posh hotel that has a spa, an indoor pool, or luxury bedding, Expedia can help you find the best luxury hotel experience that Santa Susana offers. Santa Susana has some interesting things to see and do including Bottle Village, so you might want to take in the local sights during your visit. ### What's there to see and do in Santa Susana? > Enjoy Santa Susana with a stop at Six Flags Magic Mountain, Simi Valley Town Center, and Ronald Reagan Presidential Library. 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[Hotels with Kitchenettes in Waterfront](https://www.expedia.ca/Waterfront-Los-Angeles-Hotels-Hotels-With-Kitchenettes.0-n553248635976007924-0-tHotelswithKitchenettes.Travel-Guide-Filter-Hotels) - [Oceanfront Hotels in Waterfront](https://www.expedia.ca/Waterfront-Los-Angeles-Hotels-Oceanfront-Hotels.0-n553248635976007924-0-tOceanfrontHotels.Travel-Guide-Filter-Hotels) - [Cheap Hotels in West Hills](https://www.expedia.ca/West-Hills-Hotels-Cheap-Hotels.0-0-d553248635074842962-tCheapHotels.Travel-Guide-Filter-Hotels) - [Green Hotels in West Hills](https://www.expedia.ca/West-Hills-Hotels-Green-Sustainable.0-0-d553248635074842962-tGreenSustainable.Travel-Guide-Filter-Hotels) - [Hotels with Kitchenettes in West Hills](https://www.expedia.ca/West-Hills-Hotels-Hotels-With-Kitchenettes.0-0-d553248635074842962-tHotelswithKitchenettes.Travel-Guide-Filter-Hotels) - [Spa Hotels in West Hills](https://www.expedia.ca/West-Hills-Hotels-Spa-Hotel.0-0-d553248635074842962-tSpaHotel.Travel-Guide-Filter-Hotels) - [Book Hotels in Santa Susana on Expedia.com](https://www.expedia.com/Santa-Susana-Simi-Valley-Hotels-Luxury-Hotel.0-n6340842-0-tLuxuryHotel.Travel-Guide-Filter-Hotels)