Title: Book The Best Hotels in Santa María Tlalixtac for 2026 - Fully Refundable Options - Hotels.com - Expedia.ca

[Vacation Rentals in Santa María Tlalixtac](https://expedia.ca/Santa-Maria-Tlalixtac-Vacation-Rentals.d553248635640668814.Travel-Guide-VacationRentals)[Santa María Tlalixtac Car Rentals](https://expedia.ca/Car-Rentals-In-Santa-Maria-Tlalixtac.d553248635640668814.Car-Rental-Guide)[Santa María Tlalixtac Vacation Packages](https://expedia.ca/Santa-Maria-Tlalixtac.d553248635640668814.Destination-Travel-Guides)

![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg)  
###  
Change your mind  
Book hotels with free cancellation
- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg)  
###  
Treat yourself  
Sign in to save 10% or more on thousands of hotels  
[Sign in](https://www.expedia.ca/login)
- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg)  
###  
Be picky  
Search almost a million properties worldwide

## Check prices for these dates

Tonight

[Feb 17 - Feb 18](https://www.expedia.ca/Hotel-Search?regionId=553248635640668814&startDate=2026-02-17&endDate=2026-02-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 18 - Feb 19](https://www.expedia.ca/Hotel-Search?regionId=553248635640668814&startDate=2026-02-18&endDate=2026-02-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Feb 20 - Feb 22](https://www.expedia.ca/Hotel-Search?regionId=553248635640668814&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Feb 27 - Mar 1](https://www.expedia.ca/Hotel-Search?regionId=553248635640668814&startDate=2026-02-27&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh)

## 

The Annual Vacation Sale 

Members save up to 40% on hotels and homes. Plan this year’s big trip and save. 

[Book now](https://expedia.ca/deals?rfrr=HTG_SPRING_PROMO_553248635640668814)

![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg)

Save an average of 15% on thousands of hotels when you're signed in

[Sign in

](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Maria-Tlalixtac-Hotels.d553248635640668814.Travel-Guide-Hotels)[

Sign up, it's free

](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Maria-Tlalixtac-Hotels.d553248635640668814.Travel-Guide-Hotels)

## Top Santa María Tlalixtac Hotel Reviews

![Rustic House in the Tehuacan-Cuicatlan Biosphere Reserve](https://images.trvl-media.com/lodging/113000000/112230000/112220600/112220550/488ae3ea_y.jpg)

### Rustic House in the Tehuacan-Cuicatlan Biosphere Reserve

4/10 Poor

"I booked this house in November and paid the full price then. When I contacted the host the day before we arrived she told me her family was staying there and didn't remember my reservation. Then she said we could share the house with her family. We had no other option for accommodation and had a rental car and planned to explore the area for 4 days. When we arrived the family was not there, but I had paid for the entire house and two separate bedrooms. One was locked and we had to sleep in the same room. There were no windows, only a screened opening in the bedroom and it is right on the highway so traffic noise was really loud. Dogs barked all night and it was very difficult to sleep, and we got dozens of mosquito bites. The woman who greeted us was very nice, as was the woman who brought us tasty meals, because the town is very poor and partly abandoned and we could only find beer and soft drinks and poor quality food to buy for the kitchen. Vrbo does not allow sharing a house so it did not really qualify as a Vrbo rental. The host offered us an extra day but we had reservations in Oaxaca and had to return the rental car and didn't want to stay any longer. I was offered a partial refund but after we left I never heard from the host again and she did not respond to a number of messages from Vrbo or me. It was very expensive for a place with only a long table and plastic chairs for furnishing. The screens have cardboard over them. I can't recommend staying here"

[](https://expedia.ca/Santa-Maria-Tecomavaca-Hotels-Vrbo-Property.h112220550.Hotel-Information)

## More cheap stays in Santa María Tlalixtac

![Casa Rustica Reserva Biosfera Tehuacan Cuicatlan](https://images.trvl-media.com/lodging/92000000/91630000/91626200/91626110/ab9c8444_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Casa Rustica Reserva Biosfera Tehuacan Cuicatlan

 Santa María Tecomavaca OAX

[Get rates](https://expedia.ca/Hotel-Search?startDate=03%2F03%2F2026&endDate=04%2F03%2F2026&selected=91626110&PinnedHotelID=91626110&HadPinnedHotel=true&regionId=553248635640668814)

[](https://expedia.ca/Santa-Maria-Tecomavaca-Hotels-Casa-Rustica-Reserva-Biosfera-Tehuacan-Cuicatlan.h91626110.Hotel-Information)

## Frequently asked questions

### What is the best area to stay in Santa María Tlalixtac?

> This area is the heart of the community, offering a genuine glimpse into local life. The Zócalo is typically surrounded by the municipal palace, the church, and local markets, creating a focal point for daily activities. Streets here are often pedestrian-friendly and provide easy access to small, family-run eateries and artisan shops.
> 
>   
> Couples looking for a quiet retreat will appreciate this area. It provides a peaceful base to experience local customs, enjoy traditional Oaxacan cuisine, and explore the natural beauty of the surrounding hills without the bustle of a larger city.

### When is the best time to go to Santa María Tlalixtac?

> This period typically offers pleasant weather with warm, sunny days and cooler evenings, making it ideal for exploring the natural beauty of the region and participating in outdoor activities. You'll find less humidity and a lower chance of rain, which is superb for hiking, visiting local farms, or simply enjoying the village's surroundings.
> 
>   
> Couples looking for a peaceful escape will appreciate the dry season. The clear skies and comfortable temperatures are superb for romantic walks through the fields or enjoying a quiet evening under the stars. It's also a good time to experience local festivals that often occur around harvest times.
> 
>   
> Solo travellers will also find the dry season suitable for their explorations. The stable weather conditions make it easier to plan day trips to nearby natural attractions or to engage with local communities without the disruption of heavy rains.

### Can I cancel my hotel reservation on Expedia?

### How can I save on a Santa María Tlalixtac hotel booking with Expedia?

### How much is the nightly rate at a Santa María Tlalixtac hotel?

## Explore a world of travel with Expedia

- Lodging
- Flights
- Packages
- Cars
- Vacation Rental
- Other
- More ways to book

- [3 Star Hotels in San Juan Bautista Cuicatlán ](https://www.expedia.ca/3Star-San-Juan-Bautista-Cuicatlan-Hotels.s30-0-d553248635640632624.Travel-Guide-Filter-Hotels)
- [Abejones Hotels ](https://www.expedia.ca/Abejones-Hotels.d553248635640661944.Travel-Guide-Hotels)
- [Asunción Nochixtlán Hotels ](https://www.expedia.ca/Asuncion-Nochixtlan-Hotels.d6299360.Travel-Guide-Hotels)
- [Ayotzintepec Hotels ](https://www.expedia.ca/Ayotzintepec-Hotels.d553248635640691950.Travel-Guide-Hotels)
- [Capulálpam de Méndez Hotels ](https://www.expedia.ca/Capulalpam-De-Mendez-Hotels.d3000425501.Travel-Guide-Hotels)
- [Eloxochitlán de Flores Magón Hotels ](https://www.expedia.ca/Eloxochitlan-De-Flores-Magon-Hotels.d553248635640677753.Travel-Guide-Hotels)
- [Huautla de Jiménez Hotels ](https://www.expedia.ca/Huautla-De-Jimenez-Hotels.d553248635640694310.Travel-Guide-Hotels)
- [Ixtlán de Juárez Hotels ](https://www.expedia.ca/Ixtlan-De-Juarez-Hotels.d553248635640667316.Travel-Guide-Hotels)
- [Lgbt Friendly Hotels in Jalatlaco ](https://www.expedia.ca/Jalatlaco-Oaxaca-Hotels-LGBT-Friendly-Hotel.0-n553248635976399654-0-tLGBTFriendlyHotel.Travel-Guide-Filter-Hotels)
- [Magdalena Apasco Hotels ](https://www.expedia.ca/Magdalena-Apasco-Hotels.d553248635640675660.Travel-Guide-Hotels)
- [Lgbt Friendly Hotels in Oaxaca Centro ](https://www.expedia.ca/Oaxaca-Centro-Oaxaca-Hotels-LGBT-Friendly-Hotel.0-n6286955-0-tLGBTFriendlyHotel.Travel-Guide-Filter-Hotels)
- [All Inclusive Resorts and in Oaxaca ](https://www.expedia.ca/Oaxaca-Hotels-All-Inclusive-Hotel.0-0-d2631-tAllInclusiveHotel.Travel-Guide-Filter-Hotels)
- [Mountain Hotels in Oaxaca ](https://www.expedia.ca/Oaxaca-Hotels-Mountain-Hotels.0-0-d2631-tMountainHotels.Travel-Guide-Filter-Hotels)
- [Pueblo Nuevo Hotels ](https://www.expedia.ca/Pueblo-Nuevo-Hotels.d553248635975859239.Travel-Guide-Hotels)
- [Lgbt Friendly Hotels in Reforma ](https://www.expedia.ca/Reforma-Oaxaca-Hotels-LGBT-Friendly-Hotel.0-n553248635976007657-0-tLGBTFriendlyHotel.Travel-Guide-Filter-Hotels)
- [San Felipe Usila Hotels ](https://www.expedia.ca/San-Felipe-Usila-Hotels.d6299435.Travel-Guide-Hotels)
- [San Juan Atepec Hotels ](https://www.expedia.ca/San-Juan-Atepec-Hotels.d553248635640694497.Travel-Guide-Hotels)
- [Lgbt Friendly Hotels in San Juan Bautista Tuxtepec ](https://www.expedia.ca/San-Juan-Bautista-Tuxtepec-Hotels-LGBT-Friendly-Hotel.0-0-d6336123-tLGBTFriendlyHotel.Travel-Guide-Filter-Hotels)
- [San Juan Bautista Tuxtepec Hotels ](https://www.expedia.ca/San-Juan-Bautista-Tuxtepec-Hotels.d6336123.Travel-Guide-Hotels)
- [San Juan Bautista Valle Nacional Hotels ](https://www.expedia.ca/San-Juan-Bautista-Valle-Nacional-Hotels.d6299456.Travel-Guide-Hotels)
- [San Lucas Ojitlán Hotels ](https://www.expedia.ca/San-Lucas-Ojitlan-Hotels.d553248635640673112.Travel-Guide-Hotels)
- [San Martín Toxpalan Hotels ](https://www.expedia.ca/San-Martin-Toxpalan-Hotels.d553248635640631485.Travel-Guide-Hotels)
- [San Mateo Yetla Hotels ](https://www.expedia.ca/San-Mateo-Yetla-Hotels.d3000464167.Travel-Guide-Hotels)
- [San Miguel Santa Flor Hotels ](https://www.expedia.ca/San-Miguel-Santa-Flor-Hotels.d553248635640679651.Travel-Guide-Hotels)
- [San Pablo Huitzo Hotels ](https://www.expedia.ca/San-Pablo-Huitzo-Hotels.d553248635640633619.Travel-Guide-Hotels)
- [San Pedro Coxcaltepec Cántaros Hotels ](https://www.expedia.ca/San-Pedro-Coxcaltepec-Cantaros-Hotels.d553248635640691874.Travel-Guide-Hotels)
- [San Pedro Ixcatlán Hotels ](https://www.expedia.ca/San-Pedro-Ixcatlan-Hotels.d553248635640665948.Travel-Guide-Hotels)
- [San Pedro Yaneri Hotels ](https://www.expedia.ca/San-Pedro-Yaneri-Hotels.d553248635640640530.Travel-Guide-Hotels)
- [Cottages in Santa Catarina Lachatao ](https://www.expedia.ca/Santa-Catarina-Lachatao-Cottages.d6320274-aaCottages.Travel-Guide-Accommodation)
- [Santa María Jaltianguis Hotels ](https://www.expedia.ca/Santa-Maria-Jaltianguis-Hotels.d553248635640666030.Travel-Guide-Hotels)
- [Santa María Pápalo Hotels ](https://www.expedia.ca/Santa-Maria-Papalo-Hotels.d553248635640634854.Travel-Guide-Hotels)
- [Santa María Tecomavaca Hotels ](https://www.expedia.ca/Santa-Maria-Tecomavaca-Hotels.d553248635640676421.Travel-Guide-Hotels)
- [Santiago Apoala Hotels ](https://www.expedia.ca/Santiago-Apoala-Hotels.d553248635640634931.Travel-Guide-Hotels)
- [Tanetze de Zaragoza Hotels ](https://www.expedia.ca/Tanetze-De-Zaragoza-Hotels.d553248635640705180.Travel-Guide-Hotels)
- [Teotitlán de Flores Magón Hotels ](https://www.expedia.ca/Teotitlan-De-Flores-Magon-Hotels.d553248635640632888.Travel-Guide-Hotels)
- [Tlacotepec Plumas Hotels ](https://www.expedia.ca/Tlacotepec-Plumas-Hotels.d553248635640691895.Travel-Guide-Hotels)
- [Valerio Trujano Hotels ](https://www.expedia.ca/Valerio-Trujano-Hotels.d553248635640665901.Travel-Guide-Hotels)
- [Yanhuitlan Hotels ](https://www.expedia.ca/Yanhuitlan-Hotels.d6354831.Travel-Guide-Hotels)

- [Flights to Oaxaca ](https://www.expedia.ca/Cheap-Flights-To-Oaxaca.d2631.Travel-Guide-Flights)
- [Flights to San Juan Bautista Tuxtepec ](https://www.expedia.ca/Cheap-Flights-To-San-Juan-Bautista-Tuxtepec.d6336123.Travel-Guide-Flights)
- [Flights to San Miguel Amatlan ](https://www.expedia.ca/Cheap-Flights-To-San-Miguel-Amatlan.d6320273.Travel-Guide-Flights)
- [Flights from Toronto to Oaxaca ](https://www.expedia.ca/lp/flights/178314/2631/toronto-to-oaxaca)
- [Flights from Vancouver to Oaxaca ](https://www.expedia.ca/lp/flights/178315/2631/vancouver-to-oaxaca)
- [Flights from Edmonton to Oaxaca ](https://www.expedia.ca/lp/flights/180002/2631/edmonton-to-oaxaca)
- [Flights from Moncton to Oaxaca ](https://www.expedia.ca/lp/flights/4051/2631/moncton-to-oaxaca)
- [Flights from Victoria to Oaxaca ](https://www.expedia.ca/lp/flights/4138/2631/victoria-to-oaxaca)
- [Flights from Winnipeg to Oaxaca ](https://www.expedia.ca/lp/flights/6141041/2631/winnipeg-to-oaxaca)
- [Flights from San Juan Bautista Tuxtepec ](https://www.expedia.ca/lp/flights/6336123/flights-from-san-juan-bautista-tuxtepec)

- [Andador de Macedonia Alcala ](https://www.expedia.ca/Andador-De-Macedonia-Alcala-Ruta-Independencia.d6320307.Vacation-Attraction)
- [Visit Asunción Nochixtlán ](https://www.expedia.ca/Asuncion-Nochixtlan.dx6299360)
- [Basilica of Our Lady of Solitude ](https://www.expedia.ca/Basilica-Of-Our-Lady-Of-Solitude-Oaxaca-Centro.d553248621532977515.Vacation-Attraction)
- [Benito Juarez National Park ](https://www.expedia.ca/Benito-Juarez-National-Park-Oaxaca.d6000806.Vacation-Attraction)
- [El Llano Park ](https://www.expedia.ca/El-Llano-Park-Oaxaca-Centro.d6299885.Vacation-Attraction)
- [Ex-Convento de Santa Catalina ](https://www.expedia.ca/Ex-Convento-De-Santa-Catalina-Oaxaca.d553248621532629979.Vacation-Attraction)
- [Visit Ixtlán de Juárez ](https://www.expedia.ca/Ixtlan-De-Juarez.dx553248635640667316)
- [Macedonio Alcalá Theater ](https://www.expedia.ca/Macedonio-Alcala-Theater-Oaxaca-Centro.d6113660.Vacation-Attraction)
- [Visit Magdalena Apasco ](https://www.expedia.ca/Magdalena-Apasco.dx553248635640675660)
- [Visit Calzada Madero ](https://www.expedia.ca/Oaxaca-Calzada-Madero.dx553248635976398535)
- [Oaxaca Centro Vacations ](https://www.expedia.ca/Oaxaca-Centro.d6286955.Destination-Travel-Guides)
- [Visit Jalatlaco ](https://www.expedia.ca/Oaxaca-Jalatlaco.dx553248635976399654)
- [Visit Reforma ](https://www.expedia.ca/Oaxaca-Reforma.dx553248635976007657)
- [Visit Ruta Independencia ](https://www.expedia.ca/Oaxaca-Ruta-Independencia.dx553248635976399573)
- [Visit San Andrés Huayapan ](https://www.expedia.ca/Oaxaca-San-Andres-Huayapan.dx3000008736)
- [Visit San Felipe del Agua ](https://www.expedia.ca/Oaxaca-San-Felipe-Del-Agua.dx6049169)
- [Visit Santa Maria Atzompa ](https://www.expedia.ca/Oaxaca-Santa-Maria-Atzompa.dx6337481)
- [Visit Tlalixtac de Cabrera ](https://www.expedia.ca/Oaxaca-Tlalixtac-De-Cabrera.dx6320275)
- [Oaxaca Vacations ](https://www.expedia.ca/Oaxaca.d2631.Destination-Travel-Guides)
- [Visit Oaxaca ](https://www.expedia.ca/Oaxaca.dx2631)
- [Plaza Bella Oaxaca ](https://www.expedia.ca/Plaza-Bella-Oaxaca-Oaxaca.d553248634245951665.Vacation-Attraction)
- [Visit San Agustin Etla ](https://www.expedia.ca/San-Agustin-Etla.dx6347651)
- [Visit San Andrés Lagunas ](https://www.expedia.ca/San-Andres-Lagunas.dx553248635640637082)
- [Visit San Andrés Zautla ](https://www.expedia.ca/San-Andres-Zautla.dx553248635640667478)
- [Visit San Felipe Jalapa de Diaz ](https://www.expedia.ca/San-Felipe-Jalapa-De-Diaz.dx6320671)
- [Visit San Jerónimo Sosola ](https://www.expedia.ca/San-Jeronimo-Sosola.dx553248635640657921)
- [Visit San Juan Bautista Tuxtepec ](https://www.expedia.ca/San-Juan-Bautista-Tuxtepec.dx6336123)
- [Visit San Juan Bautista Valle Nacional ](https://www.expedia.ca/San-Juan-Bautista-Valle-Nacional.dx6299456)
- [Visit San Lorenzo Cacaotepec ](https://www.expedia.ca/San-Lorenzo-Cacaotepec.dx6299372)
- [Visit San Miguel Yotao ](https://www.expedia.ca/San-Miguel-Yotao.dx553248635640641451)
- [Visit San Pablo Etla ](https://www.expedia.ca/San-Pablo-Etla.dx6299480)
- [Visit San Pablo Huitzo ](https://www.expedia.ca/San-Pablo-Huitzo.dx553248635640633619)
- [Visit San Pedro Ixcatlán ](https://www.expedia.ca/San-Pedro-Ixcatlan.dx553248635640665948)
- [Visit Santa Catarina Ixtepeji ](https://www.expedia.ca/Santa-Catarina-Ixtepeji.dx553248635640676883)
- [Santa Catarina Lachatao Vacations ](https://www.expedia.ca/Santa-Catarina-Lachatao.d6320274.Destination-Travel-Guides)
- [Visit Santa María Chilchotla ](https://www.expedia.ca/Santa-Maria-Chilchotla.dx553248635640696545)
- [Visit Santa María Ixcatlán ](https://www.expedia.ca/Santa-Maria-Ixcatlan.dx553248635640639883)
- [Visit Santa María Jacatepec ](https://www.expedia.ca/Santa-Maria-Jacatepec.dx553248635640633023)
- [Visit Santa María Jaltianguis ](https://www.expedia.ca/Santa-Maria-Jaltianguis.dx553248635640666030)
- [Visit Santiago Apoala ](https://www.expedia.ca/Santiago-Apoala.dx553248635640634931)
- [Visit Santiago Camotlán ](https://www.expedia.ca/Santiago-Camotlan.dx553248635640670498)
- [Visit Teococuilco de Marcos Pérez ](https://www.expedia.ca/Teococuilco-De-Marcos-Perez.dx553248635640694719)
- [Visit Villa de Etla ](https://www.expedia.ca/Villa-De-Etla.dx553248635640631158)
- [Visit Villa Talea de Castro ](https://www.expedia.ca/Villa-Talea-De-Castro.dx553248635640694168)

- [Car rental Oaxaca ](https://www.expedia.ca/Car-Rentals-In-Oaxaca.d2631.Car-Rental-Guide)
- [Car rentals near San Carlos ](https://www.expedia.ca/Car-Rentals-In-San-Carlos.d553248635976398127.Car-Rental-Guide)
- [Car rental Santa Ana Yareni ](https://www.expedia.ca/Car-Rentals-In-Santa-Ana-Yareni.d553248635640673179.Car-Rental-Guide)
- [Car rentals near Santo Domingo ](https://www.expedia.ca/Car-Rentals-In-Santo-Domingo.d553248635975867463.Car-Rental-Guide)

- [Oaxaca Vacation Rentals ](https://www.expedia.ca/Oaxaca-Vacation-Rentals.d2631.Travel-Guide-VacationRentals)
- [San Juan Bautista Tuxtepec Vacation Rentals ](https://www.expedia.ca/San-Juan-Bautista-Tuxtepec-Vacation-Rentals.d6336123.Travel-Guide-VacationRentals)

- [Things to do in Oaxaca ](https://www.expedia.ca/Things-To-Do-In-Oaxaca.d2631.Travel-Guide-Activities)
- [Things to do in Santa Catarina Lachatao ](https://www.expedia.ca/Things-To-Do-In-Santa-Catarina-Lachatao.d6320274.Travel-Guide-Activities)

- [Book Hotels in Santa María Tlalixtac on Expedia.mx ](https://www.expedia.mx/Santa-Maria-Tlalixtac-Hoteles.d553248635640668814.Guia-Viajes-Hoteles)

![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg)

## Go further with the Expedia app

Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go.

Scan the QR code with your device camera and download our app