Title: 10 Best Hotels in Santa Maria, Guayaquil for 2026 | Expedia.ca

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## Check prices for these dates

Tonight

[Jan 31 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=553248635976397555&startDate=2026-01-31&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 1 - Feb 2](https://www.expedia.ca/Hotel-Search?regionId=553248635976397555&startDate=2026-02-01&endDate=2026-02-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=553248635976397555&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=553248635976397555&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Recommended

Price (low to high)

Distance

Star rating

## Our top choices for Santa Maria hotels

![Outdoor spa tub](https://images.trvl-media.com/lodging/33000000/32050000/32048100/32048032/04063cb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/33000000/32050000/32048100/32048032/a936dba7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium Suite, 1 Bedroom, Ensuite, Ground Floor | Private kitchen](https://images.trvl-media.com/lodging/33000000/32050000/32048100/32048032/f1ade29c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/33000000/32050000/32048100/32048032/2cfaa3df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Luxury Suites Riverfront GYE

[](https://www.expedia.ca/Guayaquil-Hotels-Luxury-Suites-Riverfront-GYE.h32048032.Hotel-Information)

Puerto Santa Ana, 7.5 km from Santa Maria

9.4/10

Exceptional

(104 reviews)

"The property was very clean and well maintained. Lots of security. The building is on the riverfront with many excellent restaurants within a few steps. Vibrant night life which was unfortunately very noisy when trying to sleep. Within walking distance to many attractions."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Carolyn

CA $142

CA $143 total

Feb 11 - Feb 12

[](https://www.expedia.ca/Guayaquil-Hotels-Luxury-Suites-Riverfront-GYE.h32048032.Hotel-Information)

![Rooftop terrace](https://images.trvl-media.com/lodging/23000000/22660000/22652600/22652575/26611775.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/23000000/22660000/22652600/22652575/a69fa43d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/23000000/22660000/22652600/22652575/b3ec1eca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Garden](https://images.trvl-media.com/lodging/23000000/22660000/22652600/22652575/e4fb9cbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### River View suites Puerto Santa Ana gye

[](https://www.expedia.ca/Guayaquil-Hotels-River-View-Suites-Puerto-Santa-Ana-Gye.h22652575.Hotel-Information)

Puerto Santa Ana, 7.6 km from Santa Maria

8.8/10

Excellent

(46 reviews)

"Nice place to stay!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Aaliyah

CA $108

CA $109 total

Feb 1 - Feb 2

[](https://www.expedia.ca/Guayaquil-Hotels-River-View-Suites-Puerto-Santa-Ana-Gye.h22652575.Hotel-Information)

![Lobby lounge](https://images.trvl-media.com/lodging/13000000/12080000/12070900/12070859/536a4fbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/13000000/12080000/12070900/12070859/465ab7f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/13000000/12080000/12070900/12070859/3be7fa5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/13000000/12080000/12070900/12070859/d9e37e94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Mansión del Río

[](https://www.expedia.ca/Guayaquil-Hotels-Mansion-Del-Rio.h12070859.Hotel-Information)

Las Peñas, 7.8 km from Santa Maria

8.8/10

Excellent

(136 reviews)

"Breakfast was good. I enjoyed my scrambled eggs and toast "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Caitlin

CA $80

CA $89 total

Feb 1 - Feb 2

[](https://www.expedia.ca/Guayaquil-Hotels-Mansion-Del-Rio.h12070859.Hotel-Information)

![Reception](https://images.trvl-media.com/lodging/84000000/83920000/83919600/83919535/6a3f2cec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, towels, soap, shampoo](https://images.trvl-media.com/lodging/84000000/83920000/83919600/83919535/9f3eb4dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cooked-to-order breakfast on weekdays (USD 3.00 per person)](https://images.trvl-media.com/lodging/84000000/83920000/83919600/83919535/w1650h2440x0y0-e4b6bf85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Twin Room, 2 Double Beds | Room amenity](https://images.trvl-media.com/lodging/84000000/83920000/83919600/83919535/84846b7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hostal California Inn

[](https://www.expedia.ca/Guayaquil-Hotels-Hostal-California-Inn.h83919535.Hotel-Information)

7.4 km from Santa Maria

8.6/10

Excellent

(8 reviews)

"Me encantó, es muy cómoda, la habitación super amplia y limpia Si duda volveré "

![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg)

Anita

[](https://www.expedia.ca/Guayaquil-Hotels-Hostal-California-Inn.h83919535.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/19000000/18730000/18723200/18723150/c1ad2432.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/19000000/18730000/18723200/18723150/08d5e5eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily full breakfast](https://images.trvl-media.com/lodging/19000000/18730000/18723200/18723150/1d60ec28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/19000000/18730000/18723200/18723150/e6967dee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel La Ria Durán

[](https://www.expedia.ca/Guayaquil-Hotels-Hotel-La-Ria-Duran.h18723150.Hotel-Information)

9.8 km from Santa Maria

7.4/10

Good

(20 reviews)

"Muy buena experiencia"

![Ecuador](https://a.travel-assets.com/egds/marks/flags/ec.svg)

HERNAN

CA $65

CA $65 total

Feb 2 - Feb 3

[](https://www.expedia.ca/Guayaquil-Hotels-Hotel-La-Ria-Duran.h18723150.Hotel-Information)

![2 bars/lounges, lobby lounge](https://images.trvl-media.com/lodging/7000000/6320000/6312500/6312483/007eb40d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 restaurants, breakfast, lunch, dinner served; international cuisine](https://images.trvl-media.com/lodging/7000000/6320000/6312500/6312483/c2a9584b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/7000000/6320000/6312500/6312483/0ba4528e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/7000000/6320000/6312500/6312483/a510ee59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Wyndham Guayaquil Puerto Santa Ana

[](https://www.expedia.ca/Guayaquil-Hotels-Wyndham-Guayaquil.h6312483.Hotel-Information)

Puerto Santa Ana, 7.5 km from Santa Maria

9.2/10

Wonderful

(1,000 reviews)

"Clean rooms,great staff and very good food"

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Abel Patricio

CA $136

CA $153 total

Feb 17 - Feb 18

[](https://www.expedia.ca/Guayaquil-Hotels-Wyndham-Guayaquil.h6312483.Hotel-Information)

![Comfort Apartment, Kitchenette](https://images.trvl-media.com/lodging/115000000/114970000/114965400/114965387/e8be61a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Apartment, Kitchenette | Private kitchen](https://images.trvl-media.com/lodging/115000000/114970000/114965400/114965387/772ab89e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Apartment, Kitchenette | Living area](https://images.trvl-media.com/lodging/115000000/114970000/114965400/114965387/ca79cfec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Apartment, Kitchenette | Living area](https://images.trvl-media.com/lodging/115000000/114970000/114965400/114965387/92acdee5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Guayacan Apart Hotel 

[](https://www.expedia.ca/Guayaquil-Hotels-Guayacan-Apart-Hotel.h114965387.Hotel-Information)

Downtown Guayaquil, 7.6 km from Santa Maria

CA $54

CA $54 total

Feb 1 - Feb 2

[](https://www.expedia.ca/Guayaquil-Hotels-Guayacan-Apart-Hotel.h114965387.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/5000000/4900000/4897300/4897251/dc6e9b8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/5000000/4900000/4897300/4897251/7b979839.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Sundeck](https://images.trvl-media.com/lodging/5000000/4900000/4897300/4897251/81deefb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/5000000/4900000/4897300/4897251/7d38fccb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Murali Hostal Guayaquil

[](https://www.expedia.ca/Guayaquil-Hotels-Murali-Hostal-Guayaquil.h4897251.Hotel-Information)

Simón Bolívar, 5.2 km from Santa Maria

7.0/10

Good

(41 reviews)

"The hotel was clean. I never figured out the hot water, so took cold shower. Don't know if there wasn't any hot water or I didn't wait long enough for it to be hot. Hotel staff not very friendly. Breakfast was scrambled egg w/ white toast and coffee. Milk for coffee was curdled. We paid $66\. The hotel didn't have our reservation, so I was glad to have reservation printed out from internet. The cost of rooms at the desk was slightly higher. It was not worth the $66.00 paid, but it was not...

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Anonymous traveller

[](https://www.expedia.ca/Guayaquil-Hotels-Murali-Hostal-Guayaquil.h4897251.Hotel-Information)

![Daily buffet breakfast (USD 19 per person)](https://images.trvl-media.com/lodging/1000000/560000/556000/556000/d8d91fe6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/560000/556000/556000/43ee85e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/560000/556000/556000/9272e9d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, open 7:00 AM to 7:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/560000/556000/556000/68767ed7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Sheraton Guayaquil Hotel

[](https://www.expedia.ca/Guayaquil-Hotels-Sheraton-Guayaquil-Hotel.h556000.Hotel-Information)

Simón Bolívar, 4.8 km from Santa Maria

9.0/10

Wonderful

(617 reviews)

"Very nice place to stay ! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Diana

CA $121

CA $137 total

Feb 8 - Feb 9

[](https://www.expedia.ca/Guayaquil-Hotels-Sheraton-Guayaquil-Hotel.h556000.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/46000000/45180000/45173500/45173420/eeaef3a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/46000000/45180000/45173500/45173420/53f362a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/46000000/45180000/45173500/45173420/b6d5e5bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/46000000/45180000/45173500/45173420/cf049ad1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hostal Macaw

[](https://www.expedia.ca/Guayaquil-Hotels-Hostal-Macaw.h45173420.Hotel-Information)

Kennedy, 4.6 km from Santa Maria

10/10

Exceptional

(9 reviews)

"Wonderful hosts and felt like home "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tina

CA $94

CA $96 total

Feb 2 - Feb 3

[](https://www.expedia.ca/Guayaquil-Hotels-Hostal-Macaw.h45173420.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/18000000/17170000/17163300/17163266/4673b2dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business centre](https://images.trvl-media.com/lodging/18000000/17170000/17163300/17163266/e05bbd94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/18000000/17170000/17163300/17163266/572c82cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/18000000/17170000/17163300/17163266/b68d6fc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel del Parque

[](https://www.expedia.ca/Guayaquil-Hotels-Hotel-Del-Parque.h17163266.Hotel-Information)

7 km from Santa Maria

9.8/10

Exceptional

(109 reviews)

"Friendly staff. We arrived very early and they were ablemto accommodate an early check-in. The hotel is beautiful "

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Victor

CA $423

CA $465 total

Feb 6 - Feb 7

[](https://www.expedia.ca/Guayaquil-Hotels-Hotel-Del-Parque.h17163266.Hotel-Information)

![Economy Double Room](https://images.trvl-media.com/lodging/100000000/99980000/99979800/99979748/96f63d6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, free WiFi](https://images.trvl-media.com/lodging/100000000/99980000/99979800/99979748/8d5edaea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, free WiFi](https://images.trvl-media.com/lodging/100000000/99980000/99979800/99979748/9195a1a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, free WiFi](https://images.trvl-media.com/lodging/100000000/99980000/99979800/99979748/771f37a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Malecon Guesthouse

[](https://www.expedia.ca/Guayaquil-Hotels-Malecon-Guesthouse.h99979748.Hotel-Information)

River City, 7.9 km from Santa Maria

CA $19

CA $34 total

Feb 1 - Feb 2

[](https://www.expedia.ca/Guayaquil-Hotels-Malecon-Guesthouse.h99979748.Hotel-Information)

![Executive Suite, Kitchenette, City View | Private kitchen](https://images.trvl-media.com/lodging/105000000/104820000/104814100/104814029/51248e19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Room | Bathroom](https://images.trvl-media.com/lodging/105000000/104820000/104814100/104814029/ed09222f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/105000000/104820000/104814100/104814029/4c99206f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Executive Suite, Kitchenette, City View](https://images.trvl-media.com/lodging/105000000/104820000/104814100/104814029/47c22f24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Suitesecu Rentals Guayaquil

[](https://www.expedia.ca/Guayaquil-Hotels-Suitesecu-Guayaquil.h104814029.Hotel-Information)

Garzota, 5.1 km from Santa Maria

9.0/10

Wonderful

(10 reviews)

"You can walk to the airport."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Digna

[](https://www.expedia.ca/Guayaquil-Hotels-Suitesecu-Guayaquil.h104814029.Hotel-Information)

![Reception](https://images.trvl-media.com/lodging/5000000/4440000/4436100/4436047/aa3d78b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/5000000/4440000/4436100/4436047/8cd56277.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Gazebo](https://images.trvl-media.com/lodging/5000000/4440000/4436100/4436047/bd65b589.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/5000000/4440000/4436100/4436047/bc3ef4ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### TRYP by Wyndham Guayaquil Airport

[](https://www.expedia.ca/Guayaquil-Hotels-TRYP-By-Wyndham-Guayaquil.h4436047.Hotel-Information)

Simón Bolívar, 4.9 km from Santa Maria

9.0/10

Wonderful

(1,001 reviews)

"Excellent location, service, room and property. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Angela

CA $109

CA $123 total

Feb 1 - Feb 2

[](https://www.expedia.ca/Guayaquil-Hotels-TRYP-By-Wyndham-Guayaquil.h4436047.Hotel-Information)

![Children's activities](https://images.trvl-media.com/lodging/1000000/30000/23700/23682/104d895f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Sauna, hot tub, Turkish bath, body treatments, facials](https://images.trvl-media.com/lodging/1000000/30000/23700/23682/9f8e7902.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/23700/23682/7377f418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![5 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/30000/23700/23682/14b51792.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Oro Verde Guayaquil

[](https://www.expedia.ca/Guayaquil-Hotels-Oro-Verde-Guayaquil.h23682.Hotel-Information)

Downtown Guayaquil, 6.9 km from Santa Maria

9.4/10

Exceptional

(1,003 reviews)

"Nice hotel with great breakfast and dining"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Eulalia

CA $108

CA $122 total

Feb 8 - Feb 9

[](https://www.expedia.ca/Guayaquil-Hotels-Oro-Verde-Guayaquil.h23682.Hotel-Information)

![Indoor pool, open 8:00 AM to 10 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/17300/17245/86269c9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/1000000/20000/17300/17245/982860d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Superior Double Room](https://images.trvl-media.com/lodging/1000000/20000/17300/17245/081d671e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/20000/17300/17245/90ba4f12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Ramada

[](https://www.expedia.ca/Guayaquil-Hotels-Hotel-Ramada.h17245.Hotel-Information)

Downtown Guayaquil, 7.9 km from Santa Maria

8.0/10

Very good

(389 reviews)

"Great customer service, very kind staff, amazing location"

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Maria Lorena

[](https://www.expedia.ca/Guayaquil-Hotels-Hotel-Ramada.h17245.Hotel-Information)

![Restaurant](https://images.trvl-media.com/lodging/114000000/113770000/113765400/113765303/02d3f2d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Eco-friendly toiletries, hair dryer, slippers, towels](https://images.trvl-media.com/lodging/114000000/113770000/113765400/113765303/e4343470.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior detail](https://images.trvl-media.com/lodging/114000000/113770000/113765400/113765303/fe038750.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Building design](https://images.trvl-media.com/lodging/114000000/113770000/113765400/113765303/aafff4e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Río Guayas by Art Hotels Ecuador 

[](https://www.expedia.ca/Guayaquil-Hotels-Hotel-Rio-Guayas.h113765303.Hotel-Information)

Las Peñas, 7.9 km from Santa Maria

10/10

Exceptional

(3 reviews)

"The staff was very friendly and helpful. The hotel is new and modern, it is a good place to relax and work. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Richard

CA $526

CA $584 total

Feb 2 - Feb 3

[](https://www.expedia.ca/Guayaquil-Hotels-Hotel-Rio-Guayas.h113765303.Hotel-Information)

![Junior Suite, 1 Double Bed, Kitchenette](https://images.trvl-media.com/lodging/16000000/15830000/15824400/15824334/e31d844c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![42-inch plasma TV with cable channels, TV](https://images.trvl-media.com/lodging/16000000/15830000/15824400/15824334/22c0d46e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Gym](https://images.trvl-media.com/lodging/16000000/15830000/15824400/15824334/001711ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/16000000/15830000/15824400/15824334/a27d1c14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### San Francisco Apart Hotel

[](https://www.expedia.ca/Guayaquil-Hotels-San-Francisco-Apart-Hotel.h15824334.Hotel-Information)

La Atarazana, 6 km from Santa Maria

6.2/10

(23 reviews)

"Receptionist was very helpful finding us delivery food on arrival."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

William

CA $46

CA $47 total

Feb 5 - Feb 6

[](https://www.expedia.ca/Guayaquil-Hotels-San-Francisco-Apart-Hotel.h15824334.Hotel-Information)

![Ecotours](https://images.trvl-media.com/lodging/102000000/101760000/101750500/101750483/ca8ca9e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/102000000/101760000/101750500/101750483/dc579336.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/102000000/101760000/101750500/101750483/47dac461.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Twin Room, 2 Double Beds](https://images.trvl-media.com/lodging/102000000/101760000/101750500/101750483/16926df1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fortune Hotel 

[](https://www.expedia.ca/Guayaquil-Hotels-Fortune-Hotel.h101750483.Hotel-Information)

River City, 7.7 km from Santa Maria

8.0/10

Very good

(7 reviews)

"Very bad Hotel. Not using Expedia again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Bryan

CA $67

CA $68 total

Feb 2 - Feb 3

[](https://www.expedia.ca/Guayaquil-Hotels-Fortune-Hotel.h101750483.Hotel-Information)

![Deluxe Loft | Living area](https://images.trvl-media.com/lodging/97000000/96820000/96812600/96812586/bf18bfd0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Design Studio](https://images.trvl-media.com/lodging/97000000/96820000/96812600/96812586/f5aa049d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/97000000/96820000/96812600/96812586/c643cdd5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/97000000/96820000/96812600/96812586/a61d44ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### PRAGA APARTMENTS

[](https://www.expedia.ca/Guayaquil-Hotels-PRAGA-APARTMENTS.h96812586.Hotel-Information)

Urdesa, 4.2 km from Santa Maria

9.0/10

Wonderful

(15 reviews)

"Great place to stay at "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Eric

[](https://www.expedia.ca/Guayaquil-Hotels-PRAGA-APARTMENTS.h96812586.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-14&endDate=2026-02-15&regionId=553248635976397555&adults=2&sort=RECOMMENDED&openPlayBack=true)

## Where to stay in Santa Maria

Find the best Santa Maria areas and neighborhoods for the activities you enjoy most. 

- Ecuador
- Downtown Guayaquil
- Puerto Santa Ana
- Bolívar
- Kennedy

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=553248635976397513)

![Ecuador map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:%7E%60xLhvrfNgL%7DB%60BeFt%40BnAbAh%40ITPS%60%40pB%60BZYl%40Rg%40%5C%3FvB&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=ITAe6nXctcoLe9r_9tpkYiy1Tjw=)

### Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur. 

[See properties](https://www.expedia.ca/Hotel-Search?regionId=553248635976397513)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=6337572)

![Downtown Guayaquil map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:jfkLr%7BsfNws%40cOiEsJhA%7Bd%40vAcO%7EAoHqCi%40%7CMwf%40tWlJ%7Ch%40tO_YdgB&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=efYuk0Ril1wmcsuwYNvCseyS7mU=)

### Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like San Francisco Square and Central Market while you're in town. 

[See properties](https://www.expedia.ca/Hotel-Search?regionId=6337572)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=6338310)

![Puerto Santa Ana map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:%7CwgLbkpfN_GmS%7Cc%40%7BKdDvE%7DErUeZ%7CB&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=xj2tOWP-VhOsA14MKImU-pDvkUY=)

### Puerto Santa Ana

Well-liked for its restaurants and river views, you might stop by Santa Ana Hill and Numa Pompilio Llona Street while you're exploring Puerto Santa Ana and the surrounding neighborhoods. 

[See properties](https://www.expedia.ca/Hotel-Search?regionId=6338310)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=916425151487365120)

![Bolívar map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:jdmLtcsfNgm%40gMjCuSjp%40fEoFt%5B&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=asSonBXw-8et3K4FrN6CN5UpvUQ=)

### Bolívar

While Bolívar isn't home to many top sights, Malecon Mall and Civic Center are some notable places to visit nearby. 

[See properties](https://www.expedia.ca/Hotel-Search?regionId=916425151487365120)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=553248633981744623)

![Kennedy map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:d%7CbLxnufNu%40YkJUz%40oGdLwWrh%40kf%40fE%7BBjHaBhpAoBv_%40t%40bWhAuHp%5BjZaJxEfNQfDqCpAcNdL_RfH_FxFwSkE%7Dc%40aEiFkA%7BKo%40kYnI%7DUd%40yKbBmHBoB%60BmAN%7DAkAa%40_IeAiAqBU_A%7E%40c%40%60EwAbD%3F%7EFuCv%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=XWwvskPj7fazk3NWYmm490jAt1Q=)

### Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area. 

[See properties](https://www.expedia.ca/Hotel-Search?regionId=553248633981744623)

## Top Santa Maria Hotel Reviews

![Wyndham Guayaquil Puerto Santa Ana](https://images.trvl-media.com/lodging/7000000/6320000/6312500/6312483/79b2b000_y.jpg)

### Wyndham Guayaquil Puerto Santa Ana

10/10 Excellent

"Excelente localidad y excelente servicio "

[](https://expedia.ca/Guayaquil-Hotels-Wyndham-Guayaquil.h6312483.Hotel-Information)

![Holiday Inn Guayaquil Airport by IHG](https://images.trvl-media.com/lodging/6000000/5960000/5959100/5959068/15d3bf82_y.jpg)

### Holiday Inn Guayaquil Airport by IHG

10/10 Excellent

"Clean walking distance from airport. Great staff, good food "

[](https://expedia.ca/Guayaquil-Hotels-Holiday-Inn-Guayaquil-Airport.h5959068.Hotel-Information)

![Wyndham Garden Guayaquil](https://images.trvl-media.com/lodging/2000000/1280000/1273600/1273513/a22c50d5_y.jpg)

### Wyndham Garden Guayaquil

10/10 Excellent

"Everything was clean and the staff was great! "

[](https://expedia.ca/Guayaquil-Hotels-Wyndham-Garden-Guayaquil.h1273513.Hotel-Information)

![Hotel Puerto Pacifico Guayaquil Airport](https://images.trvl-media.com/lodging/49000000/48230000/48220700/48220680/188ae291_y.jpg)

### Hotel Puerto Pacifico Guayaquil Airport

10/10 Excellent

"Great stay and great staff!"

[](https://expedia.ca/Guayaquil-Hotels-Hotel-Puerto-Pacifico.h48220680.Hotel-Information)

![Harmonie](https://images.trvl-media.com/lodging/106000000/105890000/105884300/105884261/24d4b9c9_y.jpg)

### Harmonie

10/10 Excellent

"Staff was excellent, I believe her name was Melissa. Room had everything I needed, and was comfortable. Shower was very good!"

[](https://expedia.ca/Guayaquil-Hotels-Harmonie.h105884261.Hotel-Information)

![Courtyard by Marriott Guayaquil](https://images.trvl-media.com/lodging/3000000/2750000/2745100/2745088/e22d8e0e_y.jpg)

### Courtyard by Marriott Guayaquil

10/10 Excellent

"Amazing staff. Everyone was so attentive."

[](https://expedia.ca/Guayaquil-Hotels-Courtyard-By-Marriott-Guayaquil.h2745088.Hotel-Information)

![Oro Verde Guayaquil](https://images.trvl-media.com/lodging/1000000/30000/23700/23682/104d895f_y.jpg)

### Oro Verde Guayaquil

10/10 Excellent

"Upgrade was excellent as wss the complimentary airport transfers."

[](https://expedia.ca/Guayaquil-Hotels-Oro-Verde-Guayaquil.h23682.Hotel-Information)

![Grand Hotel Guayaquil, an Ascend Collection Hotel](https://images.trvl-media.com/lodging/7000000/6760000/6751000/6750908/1d447ff4_y.jpg)

### Grand Hotel Guayaquil, an Ascend Collection Hotel

10/10 Excellent

"Everything was perfect "

[](https://expedia.ca/Guayaquil-Hotels-Grand-Hotel-Guayaquil.h6750908.Hotel-Information)

![DC Suites Aeropuerto](https://images.trvl-media.com/lodging/18000000/17340000/17331400/17331318/2a010657_y.jpg)

### DC Suites Aeropuerto

10/10 Excellent

"Wonderful lady at the front desk. Rooms are clean and lovely. Bathroom is immaculate. Close to many local restaurants and a mall. "

[](https://expedia.ca/Guayaquil-Hotels-DC-Suites-Aeropuerto.h17331318.Hotel-Information)

## Frequently asked questions

### What is Santa Maria like?

### If I need to cancel my hotel reservation in Santa Maria, will I receive a refund?

### What can I see and do in this Guayaquil neighborhood?

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