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Santa Cruz Vacation Rentals

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Our top choices for Santa Cruz vacation rentals

1. Portal del Rodeo ApartaHotel - Arkadia Mall

Portal del Rodeo ApartaHotel - Arkadia Mall
3.5 star property
Medellín
9.2 out of 10, Wonderful, (298 reviews)
"Excellent place to stay with family and friends!"
Canada
Jose
The price is CA $88
CA $88 total
Oct 16 - Oct 17
Portal del Rodeo ApartaHotel - Arkadia Mall

2. Metropolitan Living by HOUSY

Metropolitan Living by HOUSY
4.0 star property
San Diego
9.0 out of 10, Wonderful, (92 reviews)
"Clean, good location, nice staff"
United States
Sau Yeng
The price is CA $61
CA $93 total
Nov 15 - Nov 16
Metropolitan Living by HOUSY

3. Go Living and Suites by Jalo

Go Living and Suites by Jalo
3.0 star property
El Poblado
9.2 out of 10, Wonderful, (139 reviews)
"Excellent Stay!"
United States
Esdras
The price is CA $74
CA $74 total
Oct 16 - Oct 17
Go Living and Suites by Jalo

4. Skyline Ecoliving

Skyline Ecoliving
3.0 star property
El Rosario
9.4 out of 10, Exceptional, (44 reviews)
"Good location with amazing views, a bit difficult finding . But overall great place to visit."
United States
Giovanni
The price is CA $84
CA $105 total
Oct 20 - Oct 21
Skyline Ecoliving

5. Travelers Rio Verde Living Suites

Travelers Rio Verde Living Suites
3.5 star property
Rionegro
8.2 out of 10, Very good, (495 reviews)
"Very clean and a good rear view of landscape"
United States
roberto
The price is CA $147
CA $147 total
Nov 14 - Nov 15
Travelers Rio Verde Living Suites

6. Kyux by Jalo

Kyux by Jalo
4.0 star property
Laureles
9.2 out of 10, Wonderful, (195 reviews)
"Great place to stay at"
United States
Miguel
The price is CA $71
CA $71 total
Oct 18 - Oct 19
Kyux by Jalo

7. Hotel Moore 45

Hotel Moore 45
4.0 star property
Buenos Aires
8.8 out of 10, Excellent, (5 reviews)
"I like the service and it’s really comfortable. And the people in their recession. Bety. Help. Take you guys. I Enjoy the State. I’m planning to Come Back. How old is go back to the hotel again!"
United States
Welinton
The price is CA $33
CA $33 total
Oct 21 - Oct 22
Hotel Moore 45

8. Amaranto Suites

Amaranto Suites
3.0 star property
Laureles - Estadio
9.8 out of 10, Exceptional, (7 reviews)
"Perfect"
United States
Alexander
The price is CA $43
CA $43 total
Oct 16 - Oct 17
Amaranto Suites

9. Edificio Helena

Edificio Helena
3.0 star property
Medellín
8.8 out of 10, Excellent, (75 reviews)
"Room was as expected, didn’t reward the fine print of cooling condition for the room , had a fan available in the room which helped. Appreciate the host, and the security of the building and room especially being I was a solo traveler"
United States
jocelyne
The price is CA $59
CA $59 total
Nov 13 - Nov 14
Edificio Helena

10. Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House

Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House
3.5 star property
Laureles
9.2 out of 10, Wonderful, (106 reviews)
"Excellent breakfast, good location "
United States
dickie
The price is CA $64
CA $64 total
Oct 18 - Oct 19
Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House

11. ONCE SUITES

ONCE SUITES
3.0 star property
Envigado
10.0 out of 10, Exceptional, (2 reviews)
"Todo fue perfecto!"
United States
Kevin J
The price is CA $69
CA $69 total
Nov 4 - Nov 5
ONCE SUITES

12. Origen Local Suites

Origen Local Suites
3.0 star property
Laureles
9.4 out of 10, Exceptional, (219 reviews)
"VERY CONVENIENT, CLOSE TO EVERYTHING AND SAFE."
United States
Rulph
The price is CA $82
CA $82 total
Oct 23 - Oct 24
Origen Local Suites

13. B 48 Living by B Rent

B 48 Living by B Rent
4.0 star property
Laureles - Estadio
9.8 out of 10, Exceptional, (26 reviews)
"Exceptionally friendly staff, the property is top notch. Cafe Soler is incredible."
United States
Frederick
The price is CA $75
CA $75 total
Oct 17 - Oct 18
B 48 Living by B Rent

14. Apartaestudios Zeni

Apartaestudios Zeni
2.0 star property
Laureles
10.0 out of 10, Exceptional, (1 review)
"It was very comfortable and accesible"
United States
Jose P
The price is CA $54
CA $54 total
Oct 29 - Oct 30
Apartaestudios Zeni

15. Factory Lofts

Factory Lofts
4.0 star property
Laureles - Estadio
9.6 out of 10, Exceptional, (146 reviews)
"The staff were terrific and helpful. The room was perfect in an ideal location."
United States
Amy
The price is CA $107
CA $147 total
Oct 20 - Oct 21
Factory Lofts

16. zenia

zenia
3.0 star property
Laureles
9.4 out of 10, Exceptional, (77 reviews)
"Great stay near everything. Free streaming services. Recommended!"
United States
Jonathan
The price is CA $50
CA $50 total
Oct 18 - Oct 19
zenia

17. Quadrato Studios

Quadrato Studios
3.0 star property
Laureles
9.4 out of 10, Exceptional, (116 reviews)
"Beautiful hotel great location great breakfast"
United States
gary
The price is CA $73
CA $73 total
Oct 16 - Oct 17
Quadrato Studios

18. HOUSY Laureles

HOUSY Laureles
4.0 star property
Laureles
9.2 out of 10, Wonderful, (111 reviews)
"The staff was helpfull"
United States
Elsje
The price is CA $64
CA $109 total
Nov 9 - Nov 10
HOUSY Laureles

19. Borbon Suites

Borbon Suites
3.0 star property
El Poblado
9.4 out of 10, Exceptional, (19 reviews)
"Great location across from the beach. Friendly and comfortable location. I will stay when I return."
United States
Calvin
The price is CA $73
CA $123 total
Oct 19 - Oct 20
Borbon Suites

20. PORTANOVA SUITES by ADVENTU

PORTANOVA SUITES by ADVENTU
3.0 star property
Rionegro
8.0 out of 10, Very good, (74 reviews)
"Great location, 10 mins from airport."
United States
Bilwa
The price is CA $74
CA $101 total
Oct 29 - Oct 30
PORTANOVA SUITES by ADVENTU
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

Find out more about Santa Cruz

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Santa Cruz. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, we offer vacation rentals close to popular attractions in Santa Cruz, or you can choose a more secluded option if you want a relaxing place to stay.

What's the top vacation rental in Santa Cruz?

6 Bedrooms House near Tourist Spots with backyard, Bar, Jacuzzi and heated pool: Visitors like this Santa Cruz vacation home rental. It offers an outdoor pool, a patio, and air-conditioning to help you feel perfectly comfortable in your new surroundings. It has 6 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family. You can relax into your vacation with a garden and a hot tub.

What’s there to see and do in Santa Cruz?

While exploring the area, visit family-friendly sights like Pueblito Paisa, or get outside and enjoy nature at Medellin Botanical Garden. In the larger area, you’ll find University of Antioquia and Arvi Park.

What’s a vacation rental in Santa Cruz like?

Vacation rentals are private properties where you can stay for a long or short time in Santa Cruz. Vacation rentals feature extras such as hot tubs, fire pits, and patios so you'll feel just like you're at home. If you're concerned about cleanliness, a vacation rental can offer a sense of safety away from public hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for families.