Santa Cruz Vacation Rentals

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Our top choices for Santa Cruz vacation rentals

Almaia 17

Almaia 17
3.0 star property
Rionegro
The price is CA $72
CA $170 total
May 10 - May 11
Almaia 17

Casagrande

Casagrande
2.0 star property
Rionegro
10.0 out of 10, Exceptional, (1 review)
"Very nice large room with king size bed, very low noise beautiful Mountain View’s. It was a little cold for pool but, various shopping centers close to property and public transport passes right in front. Awesome place to stay."
United States
Alex
The price is CA $73
CA $73 total
Apr 19 - Apr 20
Casagrande

PORTANOVA SUITES by ADVENTU

PORTANOVA SUITES by ADVENTU
3.0 star property
Rionegro
8.4 out of 10, Very good, (52 reviews)
"Room was very clean and apt is very quiet and close to the hospital "
United States
FERNANDO
The price is CA $59
CA $82 total
May 4 - May 5
PORTANOVA SUITES by ADVENTU

Skyline Ecoliving

Skyline Ecoliving
3.0 star property
El Rosario
9.2 out of 10, Wonderful, (42 reviews)
"Super impressive mountain view directly visible as soon as you open your eyes in the morning. "
United States
Antranik
The price is CA $92
CA $111 total
Apr 22 - Apr 23
Skyline Ecoliving

Mali Experience

Mali Experience
3.0 star property
Rionegro
10.0 out of 10, Exceptional, (2 reviews)
"My room was a well-equipped luxury studio apartment that included a washer/dryer (what a treat) and a great small kitchen and a large walk-in shower. Absolutely loved my accommodation. And for you gringos and gringas out there with shaky Spanish, your host, Juan, not only speaks impeccable English but is so very helpful. Highly recommend!"
United States
Gabrielle
The price is CA $101
CA $101 total
May 4 - May 5
Mali Experience

hotel civitas medellin

hotel civitas medellin
2.5 star property
La Candelaria
10.0 out of 10, Exceptional, (1 review)
"Hotel in a good location, comfortable and has a great staff."
United States
Valencia
The price is CA $35
CA $35 total
Apr 27 - Apr 28
hotel civitas medellin

Hotel Moore 45

Hotel Moore 45
4.0 star property
Buenos Aires
8.0 out of 10, Very good, (1 review)
The price is CA $34
CA $34 total
Apr 27 - Apr 28
Hotel Moore 45

Shabbat Hotel Boutique

Shabbat Hotel Boutique
4.0 star property
San Vicente
10.0 out of 10, Exceptional, (2 reviews)
"Excelente Servicio y facilidades. 100% recomendado"
United States
william
The price is CA $167
CA $167 total
Apr 21 - Apr 22
Shabbat Hotel Boutique

Travelers Rio Verde Living Suites

Travelers Rio Verde Living Suites
3.5 star property
Rionegro
8.4 out of 10, Very good, (473 reviews)
"GOOD PLACE TO STAY THE NIGHT NEAR THE AIRPORT"
United States
Robert
The price is CA $100
CA $100 total
Apr 19 - Apr 20
Travelers Rio Verde Living Suites

Praia Apartaestudios

Praia Apartaestudios
4.5 star property
Sabaneta
8.0 out of 10, Very good, (15 reviews)
"It nice and comfortable. "
United States
DENIS
The price is CA $48
CA $48 total
May 1 - May 2
Praia Apartaestudios

Hotel Rioverde- 5 minutos de cercanía al aeropuerto

Hotel Rioverde- 5 minutos de cercanía al aeropuerto
4.5 star property
Rionegro
7.4 out of 10, Good, (60 reviews)
"Clean room and good amenities. Close to the airport which was useful after a long flight "
Australia
DAVID
The price is CA $136
CA $136 total
Apr 20 - Apr 21
Hotel Rioverde- 5 minutos de cercanía al aeropuerto

Royal Living Poblado

Royal Living Poblado
4.0 star property
El Poblado
9.0 out of 10, Wonderful, (67 reviews)
"Great"
United States
Ryan
The price is CA $79
CA $79 total
May 18 - May 19
Royal Living Poblado

zenia

zenia
3.0 star property
Laureles
9.4 out of 10, Exceptional, (47 reviews)
"Wonderful place. Brilliant staff."
United States
Moriah
The price is CA $41
CA $41 total
Apr 21 - Apr 22
zenia

Candelaria Campestre

Candelaria Campestre
2.0 star property
El Carmen de Viboral
The price is CA $91
CA $125 total
Apr 19 - Apr 20
Candelaria Campestre

Edificio Helena

Edificio Helena
3.0 star property
Medellín
9.2 out of 10, Wonderful, (59 reviews)
"For being a last minute stay, this place was better than expected and highly recommended. The rooftop is has a spectacular view of Medellin. "
United States
Michael
The price is CA $50
CA $50 total
Apr 19 - Apr 20
Edificio Helena

Sites Hotel

Sites Hotel
4.0 star property
El Poblado
9.2 out of 10, Wonderful, (1,144 reviews)
"Everything was great, and the staff were so helpful and nice all the time, will definitely be back. "
United States
Romulo
The price is CA $127
CA $127 total
Apr 24 - Apr 25
Sites Hotel

Miracle Building

Miracle Building
3.5 star property
El Poblado
8.8 out of 10, Excellent, (26 reviews)
"Great place will definitely stay again"
United States
justin ryan
The price is CA $64
CA $98 total
Apr 19 - Apr 20
Miracle Building

Apto muy bien ubicado- Home ARIS 401

Apto muy bien ubicado- Home ARIS 401
3.5 star property
La Candelaria
10.0 out of 10, Exceptional, (1 review)
"O apartamento é muito bem localizado e organizado, Dona Iolanda muito prestativa e atenciosa."
Brazil
Ricardo
The price is CA $38
CA $73 total
Apr 19 - Apr 20
Apto muy bien ubicado- Home ARIS 401

Portal del Rodeo ApartaHotel - Arkadia Mall

Portal del Rodeo ApartaHotel - Arkadia Mall
3.5 star property
Medellín
9.2 out of 10, Wonderful, (271 reviews)
"the staff was very friendly good food and the room is so nice highly recomended"
United States
Astrid
The price is CA $89
CA $89 total
May 11 - May 12
Portal del Rodeo ApartaHotel - Arkadia Mall

Hotel Santa Ana

Hotel Santa Ana
4.0 star property
El Poblado
8.8 out of 10, Excellent, (21 reviews)
"Very clean and comfortable. Close to public transportation. Great food with lots of choices. Great staff and service. "
United States
Juan Vicente
The price is CA $73
CA $73 total
Apr 29 - Apr 30
Hotel Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

Find out more about Santa Cruz

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Santa Cruz. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, we offer vacation rentals close to popular attractions in Santa Cruz, or you can choose a more secluded option if you want a relaxing place to stay.

What's the top vacation rental in Santa Cruz?

8 BR Luxury 6000 S.F. Mansion , 2 Bars Hot Tub, Bbq and Ac : Visitors like this Santa Cruz vacation home rental. It offers a patio, a pool table, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 9 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a hot tub.

What’s there to see and do in Santa Cruz?

While exploring the area, visit family-friendly sights like Pueblito Paisa, or get outside and enjoy nature at Medellin Botanical Garden. In the larger area, you’ll find University of Antioquia and Arvi Park.

What’s a vacation rental in Santa Cruz like?

Vacation rentals are private properties where you can stay for a long or short time in Santa Cruz. Vacation rentals feature extras such as hot tubs, fire pits, and patios so you'll feel just like you're at home. If you're concerned about cleanliness, a vacation rental can offer a sense of safety away from public hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for families.