Title: Book the Best Santa Cruz Island LUXURY Hotels - Upscale Hotels in Santa Cruz Island | Expedia.ca [Santa Cruz Island Travel Guide](https://expedia.ca/Santa-Cruz-Island.dx6053670)[Hotels in Santa Cruz Island](https://expedia.ca/Santa-Cruz-Island-Hotels.d6053670.Travel-Guide-Hotels)[Vacation Rentals in Santa Cruz Island](https://expedia.ca/Santa-Cruz-Island-Vacation-Rentals.d6053670.Travel-Guide-VacationRentals)[Flights to Santa Cruz Island](https://expedia.ca/Cheap-Flights-To-Santa-Cruz-Island.d6053670.Travel-Guide-Flights)[Things to do in Santa Cruz Island](https://expedia.ca/Things-To-Do-In-Santa-Cruz-Island.d6053670.Travel-Guide-Activities)[Santa Cruz Island Car Rentals](https://expedia.ca/Car-Rentals-In-Santa-Cruz-Island.d6053670.Car-Rental-Guide)[Santa Cruz Island Vacation Packages](https://expedia.ca/Santa-Cruz-Island.d6053670.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/04d5e478ee175ffd174b1e23d51916f4.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Santa Cruz Island ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santa Cruz Island Luxury Hotels Tonight [Sep 21 - Sep 22](https://www.expedia.ca/Hotel-Search?regionId=6053670&startDate=2025-09-21&endDate=2025-09-22&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 22 - Sep 23](https://www.expedia.ca/Hotel-Search?regionId=6053670&startDate=2025-09-22&endDate=2025-09-23&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Sep 26 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=6053670&startDate=2025-09-26&endDate=2025-09-28&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6053670&startDate=2025-10-03&endDate=2025-10-05&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Santa Cruz Island Luxury Hotels ## Our top choices for Santa Cruz Island luxury hotels ![Exterior](https://images.trvl-media.com/lodging/11000000/10090000/10087200/10087137/08eca00e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/11000000/10090000/10087200/10087137/7d701bfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Beach nearby, white sand](https://images.trvl-media.com/lodging/11000000/10090000/10087200/10087137/bf30a401.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Double Beds](https://images.trvl-media.com/lodging/11000000/10090000/10087200/10087137/d196b036.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Ninfa Puerto Ayora 8.4/10 Very good (209) "Great hotel to use as your base while exploring Galapagos, and a lovely pool, hot tub and bar to come home to at the end of the day" CA $184 CA $184 total Oct 22 - Oct 23 [](https://www.expedia.ca/Puerto-Ayora-Hotels-Hotel-Ninfa.h10087137.Hotel-Information) ![Breakfast, lunch, dinner served; international cuisine, ocean views ](https://images.trvl-media.com/lodging/3000000/2060000/2057800/2057779/4a332d25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/3000000/2060000/2057800/2057779/92acdc7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite Signature | Bathroom](https://images.trvl-media.com/lodging/3000000/2060000/2057800/2057779/09b4fe48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite Signature](https://images.trvl-media.com/lodging/3000000/2060000/2057800/2057779/a7defe75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Blu Galapagos Sustainable Waterfront Lodge Puerto Ayora 8.8/10 Excellent (115) "We had a great stay at Blu Galapagos. Loved the location and our room was perfect - Great view, well maintained and had a king bed. Even if the description says queen bed and the picture looks like a king, you can trust the picture. Morning breakfast with iguanas and seals, and all day Galapagos coffee availability made this stay special. " CA $227 CA $250 total Oct 9 - Oct 10 [](https://www.expedia.ca/Puerto-Ayora-Hotels-Galapagos-Habitat-By-Eco-Luxury-Group.h2057779.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1870000/1862600/1862515/62b50762.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Boating](https://images.trvl-media.com/lodging/2000000/1870000/1862600/1862515/1802a44b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Double Room](https://images.trvl-media.com/lodging/2000000/1870000/1862600/1862515/w2236h1687x0y0-81876455.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/2000000/1870000/1862600/1862515/75f9c54d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Finch Bay Galapagos Hotel Puerto Ayora 9.2/10 Wonderful (87) "Beautiful resort, impeccably clean, very kind and enthusiastic staff. Delicious restaurant. 5 stars all around, we will definitely return!" CA $734 CA $818 total Oct 14 - Oct 15 [](https://www.expedia.ca/Puerto-Ayora-Hotels-Finch-Bay-Galapagos-Hotel.h1862515.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-05&endDate=2025-10-06®ionId=6053670&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Santa Cruz Island ### Santa Cruz Islandand its attractions for luxury travelers Santa Cruz Island in the Galápagos is a paradise for luxury travellers seeking a unique blend of adventure and comfort. Begin your exploration at the Charles Darwin Research Station, where you can learn about the conservation efforts for the iconic Galápagos tortoises while enjoying the lush surroundings. For exquisite diving experiences, head to the underwater marvels of Devil's Crown, where you can swim alongside vibrant marine life in crystal-clear waters. The stunning white sands of Tortuga Bay offer a serene escape, perfect for sunbathing or kayaking in a picturesque setting. Indulge in gourmet dining at local high-end restaurants that serve fresh seafood and local delicacies, with many breathtaking ocean views. A stay in the upscale area of Puerto Ayora provides luxurious hotel options with personalised services, allowing you to unwind after a day of exploration. Hotels here often feature spacious suites, infinity pools, and spa treatments, ensuring that your needs are met with the utmost care and attention. ## Top Santa Cruz Island Hotel Reviews ![Blu Galapagos Sustainable Waterfront Lodge](//images.trvl-media.com/lodging/3000000/2060000/2057800/2057779/4a332d25_y.jpg) ### Blu Galapagos Sustainable Waterfront Lodge 10/10 Excellent "We had a great stay at Blu Galapagos. Loved the location and our room was perfect - Great view, well maintained and had a king bed. Even if the description says queen bed and the picture looks like a king, you can trust the picture. Morning breakfast with iguanas and seals, and all day Galapagos coffee availability made this stay special. " [](https://expedia.ca/Puerto-Ayora-Hotels-Galapagos-Habitat-By-Eco-Luxury-Group.h2057779.Hotel-Information) ![Hotel Ninfa](//images.trvl-media.com/lodging/11000000/10090000/10087200/10087137/08eca00e_y.jpg) ### Hotel Ninfa 10/10 Excellent "Excellent location a short walk from the pier. Staff is friendly and helpful. The room was very clean and comfortable and they even included a small gift. Definitely will stay here if I return. " [](https://expedia.ca/Puerto-Ayora-Hotels-Hotel-Ninfa.h10087137.Hotel-Information) ![Finch Bay Galapagos Hotel](//images.trvl-media.com/lodging/2000000/1870000/1862600/1862515/62b50762_y.jpg) ### Finch Bay Galapagos Hotel 10/10 Excellent "Beautiful resort, impeccably clean, very kind and enthusiastic staff. Delicious restaurant. 5 stars all around, we will definitely return!" 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