Title: Book the Best Santa Cruz LUXURY Hotels - Upscale Hotels in Santa Cruz | Expedia.ca [Santa Cruz Travel Guide](https://expedia.ca/Santa-Cruz.dx6053940)[Hotels in Santa Cruz](https://expedia.ca/Santa-Cruz-Hotels.d6053940.Travel-Guide-Hotels)[Vacation Rentals in Santa Cruz](https://expedia.ca/Santa-Cruz-Vacation-Rentals.d6053940.Travel-Guide-VacationRentals)[Flights to Santa Cruz](https://expedia.ca/Cheap-Flights-To-Santa-Cruz.d6053940.Travel-Guide-Flights)[Things to do in Santa Cruz](https://expedia.ca/Things-To-Do-In-Santa-Cruz.d6053940.Travel-Guide-Activities)[Santa Cruz Car Rentals](https://expedia.ca/Car-Rentals-In-Santa-Cruz.d6053940.Car-Rental-Guide)[Santa Cruz Vacation Packages](https://expedia.ca/Santa-Cruz.d6053940.Destination-Travel-Guides) ![Santa Cruz showing a city](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/115000/115559-Santa-Cruz.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Santa Cruz ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santa Cruz Luxury Hotels Tonight [Oct 9 - Oct 10](https://www.expedia.ca/Hotel-Search?regionId=6053940&startDate=2025-10-09&endDate=2025-10-10&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 10 - Oct 11](https://www.expedia.ca/Hotel-Search?regionId=6053940&startDate=2025-10-10&endDate=2025-10-11&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6053940&startDate=2025-10-10&endDate=2025-10-12&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6053940&startDate=2025-10-17&endDate=2025-10-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Santa Cruz Luxury Hotels ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/bb34bb1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/9bf66d6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/c96e3d06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/7d01dcfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel Santa Cruz 9.0/10 Wonderful (333) "Hotel was excellent. Staff excellent, check in good and bar resturant really good. room was good and clean " CA $165 CA $165 total Oct 17 - Oct 18 [](https://www.expedia.ca/Santa-Cruz-Hotels-Los-Tajibos-Hotel-And-Convention-Center.h18758.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-23&endDate=2025-10-24®ionId=6053940&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Santa Cruz ### Santa Cruzand its attractions for luxury travelers Santa Cruz, Bolivia, is a vibrant city that offers a unique blend of culture, luxury, and adventure for discerning travellers. Begin your exploration at the stunning Biocentro Güembé, where you can enjoy luxurious spa treatments amidst lush gardens and pools, perfect for unwinding after a day of exploration. For art enthusiasts, the Museo de Arte Contemporáneo offers an impressive collection of modern works, showcasing the region's artistic flair. A visit to the historic Plaza 24 de Septiembre is a must, where you can relax in elegant cafes while soaking up the local atmosphere and vibrant street life. Adventure seekers can take a day trip to the nearby Amboró National Park, where guided luxury tours reveal breathtaking landscapes and unique wildlife, ensuring an unforgettable experience. For accommodation, the exclusive Zona Equipetrol area is highly recommended, featuring upscale hotels that provide exceptional service and amenities. Here, you can enjoy exquisite dining options and vibrant nightlife, all within a stone's throw of your luxurious lodgings, making it an ideal base for a lavish Santa Cruz getaway. ### Find the best luxury hotels and resorts in Santa Cruz For travellers seeking a luxurious experience in Santa Cruz, Bolivia, these top hotels offer exceptional amenities and unmatched comfort, ensuring a splendid stay. [Hampton by Hilton Santa Cruz/Equipetrol, Bolivia](https://www.expedia.ca/Santa-Cruz-Hotels-Hampton-By-Hilton-Santa-Cruz.h13179436.Hotel-Information) - **Why it's great for a luxury retreat:** The Hampton by Hilton Santa Cruz/Equipetrol is perfect for luxury seekers, featuring a popular guest review rating of 9.2. This hotel provides room service and a warm fireplace, creating a cozy and inviting atmosphere for guests. With a dedicated concierge service, every need is anticipated, ensuring a seamless stay for all travellers. - **Other amenities:** Guests can enjoy a complimentary buffet breakfast each morning, along with accessible off-street parking. The hotel also features a fitness centre for those looking to stay active. Additional offerings include a grocery shopping service, a snack bar, and accessibility features, making it a well-rounded choice for luxury travel. - **Nearby attractions:** Santa Cruz Zoo - 1.8 km, Patio Design LifeStyle Center - 1.6 km, Ventura Mall - 0.7 km [Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel](https://www.expedia.ca/Santa-Cruz-Hotels-Los-Tajibos-Hotel-And-Convention-Center.h18758.Hotel-Information) - **Why it's great for a luxury retreat:** Located in the heart of Santa Cruz, Los Tajibos stands out with a remarkable guest review rating of 9.0. This luxurious hotel features a 24-hour restaurant and room service, ensuring guests can enjoy a delightful dining experience at their convenience. With premium bedding, guests can expect restful nights, complemented by the attentive concierge service that meets every traveller's desire. - **Other amenities:** The hotel also offers a range of spa services, including hydrotherapy treatments, body scrubs, and couples treatment rooms, enhancing the overall luxury experience. Other features include a hot tub, private balconies, and a fitness centre for those who wish to maintain their routine. Additional conveniences such as free buffet breakfast, self-parking, and nearby shopping districts elevate the level of comfort for guests. - **Nearby attractions:** Santa Cruz Zoo - 1.4 km, Patio Design LifeStyle Center - 1.4 km, Ventura Mall - 2.3 km [Marriott Santa Cruz de la Sierra Hotel](https://www.expedia.ca/Santa-Cruz-Hotels-Marriott-Santa-Cruz-De-La-Sierra-Hotel.h21490226.Hotel-Information) - **Why it's great for a luxury retreat:** The Marriott Santa Cruz de la Sierra Hotel epitomises luxury, a stellar review rating of 9.0. Featuring spacious executive rooms with access to an exclusive lounge, guests can enjoy enhanced privacy and comfort. The onsite spa offers a variety of treatments, while room service ensures dining can be enjoyed in the comfort of your own space. - **Other amenities:** The hotel also features an outdoor pool with sun loungers, tennis courts for an active lifestyle, and beautiful rooftop gardens for relaxation. Additional benefits include housekeeping services, free toiletries, fitness facilities, and self-parking, all designed to provide a straightforward experience for discerning travellers. - **Nearby attractions:** Santa Cruz Zoo - 2.4 km, Patio Design LifeStyle Center - 1.9 km, Ventura Mall - 0.7 km [Camino Real Hotel](https://www.expedia.ca/Santa-Cruz-Hotels-Camino-Real-Hotel.h444475.Hotel-Information) - **Why it's great for a luxury retreat:** The Camino Real Hotel is a splendid choice for luxury travellers, an impressive guest review rating of 8.8. With a stunning poolside bar and a swim-up bar, guests can indulge in refreshing cocktails while basking in the sun. The hotel also features a beautifully designed garden-view restaurant, perfect for enjoying exquisite meals in a serene environment, complemented by 24-hour room service and a dedicated concierge to cater to every need. - **Other amenities:** Guests can unwind in the onsite spa with treatment rooms offering massage services, or relax in the indoor and outdoor pools, complete with hydromassage showerheads and pool umbrellas. The hotel also provides an array of conveniences such as free buffet breakfast, airport transportation, and babysitting services, making it ideal for both relaxation and convenience. With a shopping district nearby, guests can easily explore local offerings. - **Nearby attractions:** Santa Cruz Zoo - 2 km, Patio Design LifeStyle Center - 2.2 km, Ventura Mall - 0.8 km [Sun Hotel](https://www.expedia.ca/Santa-Cruz-Hotels-Sun-Hotel.h12836211.Hotel-Information) - **Why it's great for a luxury retreat:** The Sun Hotel is an excellent option for luxury travellers, with an excellent guest review rating of 8.2. This hotel offers 24-hour room service and designer toiletries, ensuring guests feel pampered throughout their stay. With a concierge on hand, all requests can be accommodated, making this hotel an appealing choice for those seeking a refined experience. - **Other amenities:** Guests can indulge in spa services, including manis and pedis, reflexology, and body treatments. The outdoor pool and hot tub provide a perfect setting for relaxation, while the hotel also offers free buffet breakfast. Other conveniences include airport transportation, a sauna, and a beautiful garden area for leisurely strolls. - **Nearby attractions:** Play Land Amusement Park - 2.6 km, Univalle - 8.8 km ## Top Santa Cruz Hotel Reviews ![Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel](//images.trvl-media.com/lodging/1000000/20000/18800/18758/bb34bb1f_y.jpg) ### Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel 10/10 Excellent "Hotel was excellent. Staff excellent, check in good and bar resturant really good. room was good and clean " [](https://expedia.ca/Santa-Cruz-Hotels-Los-Tajibos-Hotel-And-Convention-Center.h18758.Hotel-Information) ## Frequently asked questions ### Are you looking for a luxury hotel for your Santa Cruz vacation? > Fly into Santa Cruz (VVI-Viru Viru Intl.) Airport and then pamper yourself by staying at one of 7 Santa Cruz luxury hotels. Santa Cruz has some interesting things to see and do including Plaza 24 de Septiembre and Ramon Tahuichi Aguilera Stadium, so you might want to take in the local sights during your visit. ### What's the best luxury hotel in Santa Cruz? > [Marriott Santa Cruz de la Sierra Hotel](https://www.expedia.ca/Santa-Cruz-Hotels-Marriott-Santa-Cruz-De-La-Sierra-Hotel.h21490226.Hotel-Information) is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travelers looking for an elegant place to stay. [Hampton by Hilton Santa Cruz/Equipetrol, Bolivia](https://www.expedia.ca/Santa-Cruz-Hotels-Hampton-By-Hilton-Santa-Cruz.h13179436.Hotel-Information) and [Camino Real Hotel](https://www.expedia.ca/Santa-Cruz-Hotels-Camino-Real-Hotel.h444475.Hotel-Information) are two other upscale options for your stay. ### How many luxury hotels will I find in Santa Cruz? > Lie in the lap of luxury during your getaway to Santa Cruz in one of Expedia's 7 luxury hotels. ### When can I expect good weather in Santa Cruz? > Planning for the weather is a good way to make your trip to Santa Cruz relaxing and enjoyable, especially when you're splurging. The hottest months are usually October and November with an average temp of 79°F, while the coldest months are June and July with an average of 70°F. Average annual precipitation for Santa Cruz is 48 inches. ### What's there to see and do in Santa Cruz? > Enjoy all that Santa Cruz has to offer when you visit Plaza 24 de Septiembre, Ramon Tahuichi Aguilera Stadium, and Cine Center. If you have a little extra time during your trip, you might want to make a stop at Santa Cruz Zoo and Ventura Mall. ### How can I get around Santa Cruz? > It's easier to get around town comfortably when you know your options. To see more of the larger area, hop on a train at Santa Cruz de la Sierra Station. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - [Family Hotels in Santa Cruz](https://www.expedia.ca/Destinations-In-Santa-Cruz-Family-Hotel.0-0-d6297178-tFamilyHotel.Hotel-Filter-Destinations) - [Santa Cruz Hotels](https://www.expedia.ca/Destinations-In-Santa-Cruz.d6297178.Hotel-Destinations) - [Hotels near El Trompillo](https://www.expedia.ca/El-Trompillo-Airport-Hotels.0-aSRZ-0.Travel-Guide-Filter-Hotels) - [Hotels with Free Airport Shuttle in La Guardia](https://www.expedia.ca/La-Guardia-Hotels-Hotels-With-Free-Airport-Shuttle.0-0-d6347124-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels) - [Flights from El Trompillo](https://www.expedia.ca/lp/airports/srz/flights-from-el-trompillo-airport) - [Flights from Eureka (ACV) to Santa Cruz (SRZ)](https://www.expedia.ca/lp/flights/acv/srz/eureka-to-santa-cruz) - [Flights from Adelaide (ADL) to Santa Cruz (SRZ)](https://www.expedia.ca/lp/flights/adl/srz/adelaide-to-santa-cruz) - 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[Flights from Edmonton (YEA) to Santa Cruz (SRZ)](https://www.expedia.ca/lp/flights/yea/srz/edmonton-to-santa-cruz) - [Flights from Edmonton (YEG) to Santa Cruz (SRZ)](https://www.expedia.ca/lp/flights/yeg/srz/edmonton-to-santa-cruz) - [Flights from Kelowna (YLW) to Santa Cruz (SRZ)](https://www.expedia.ca/lp/flights/ylw/srz/kelowna-to-santa-cruz) - [Flights from Ottawa (YRO) to Santa Cruz (SRZ)](https://www.expedia.ca/lp/flights/yro/srz/ottawa-to-santa-cruz) - [Flights from Montreal (YUL) to Santa Cruz (SRZ)](https://www.expedia.ca/lp/flights/yul/srz/montreal-to-santa-cruz) - [Flights from Vancouver (YVR) to Santa Cruz (SRZ)](https://www.expedia.ca/lp/flights/yvr/srz/vancouver-to-santa-cruz) - [Flights from Winnipeg (YWG) to Santa Cruz (SRZ)](https://www.expedia.ca/lp/flights/ywg/srz/winnipeg-to-santa-cruz) - [Flights from Saskatoon (YXE) to Santa Cruz (SRZ)](https://www.expedia.ca/lp/flights/yxe/srz/saskatoon-to-santa-cruz) - [Flights from Calgary (YYC) to Santa Cruz (SRZ)](https://www.expedia.ca/lp/flights/yyc/srz/calgary-to-santa-cruz) - [Flights from Victoria (YYJ) to Santa Cruz (SRZ)](https://www.expedia.ca/lp/flights/yyj/srz/victoria-to-santa-cruz) - [Flights from Toronto (YYZ) to Santa Cruz (SRZ)](https://www.expedia.ca/lp/flights/yyz/srz/toronto-to-santa-cruz) - [Plaza 24 de Septiembre](https://www.expedia.ca/Plaza-24-De-Septiembre-Santa-Cruz.d6098828.Vacation-Attraction)