Title: Book the Best Sanibel Isles SPA Resorts from CA $268 - Spa Hotels in Sanibel Isles, Sanibel | Expedia.ca [Vacation Rentals in Sanibel](https://expedia.ca/Sanibel-Vacation-Rentals.d9791.Travel-Guide-VacationRentals)[Flights to Sanibel](https://expedia.ca/Cheap-Flights-To-Sanibel.d9791.Travel-Guide-Flights)[Things to do in Sanibel](https://expedia.ca/Things-To-Do-In-Sanibel.d9791.Travel-Guide-Activities)[Sanibel Isles Car Rentals](https://expedia.ca/Car-Rentals-In-Sanibel-Isles.d553248635976477245.Car-Rental-Guide)[Sanibel Isles Vacations](https://expedia.ca/Sanibel-Isles.d553248635976477245.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/9/6748f9f3d5a0dfbe5d878db6bfe88052.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Sanibel Isles, Sanibel from CA $268 ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Sanibel Isles Spa Hotels Tonight [Sep 30 - Oct 1](https://www.expedia.ca/Hotel-Search?regionId=553248635976477245&startDate=2025-09-30&endDate=2025-10-01&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 1 - Oct 2](https://www.expedia.ca/Hotel-Search?regionId=553248635976477245&startDate=2025-10-01&endDate=2025-10-02&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=553248635976477245&startDate=2025-10-03&endDate=2025-10-05&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248635976477245&startDate=2025-10-10&endDate=2025-10-12&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Sanibel Isles Spa Hotels ![Massages](https://images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/2dcc8d7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/0153ec95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/1051a5d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/b4312f5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Margaritaville Beach Resort Fort Myers Fort Myers Beach 9.0/10 Wonderful (1507) "Great stay, accommodations, location" CA $191 CA $268 total includes taxes & fees Oct 7 - Oct 8 [](https://www.expedia.ca/Fort-Myers-Beach-Hotels-Margaritaville-Beach-Resort-Fort-Myers.h95126992.Hotel-Information) ![Outdoor pool, open 8:00 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/3000000/2730000/2721900/2721880/d961205e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/3000000/2730000/2721900/2721880/1175676c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2730000/2721900/2721880/4aba0d83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/3000000/2730000/2721900/2721880/b069fb2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Westin Cape Coral Resort At Marina Village Pelican 9.0/10 Wonderful (1011) "It was absolutely a beautiful place!!!" CA $199 CA $275 total includes taxes & fees Oct 1 - Oct 2 [](https://www.expedia.ca/Fort-Myers-Hotels-The-Westin-Cape-Coral-Resort-At-Marina-Village.h2721880.Hotel-Information) ![Couples treatment rooms, sauna, steam room, body treatments](https://images.trvl-media.com/lodging/1000000/10000/3100/3079/ae1f7d62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/3100/3079/89736118.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![On the beach, white sand, kayaking, motor boating](https://images.trvl-media.com/lodging/1000000/10000/3100/3079/ac9a3a07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, 3 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/10000/3100/3079/17d9d33f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Marriott Sanibel Harbour Resort & Spa Punta Rassa 8.4/10 Very good (1022) "Had a wonderful visit. Will return soon hopefully! " CA $263 CA $328 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Fort-Myers-Hotels-Marriott-Sanibel-Harbour-Resort-Spa.h3079.Hotel-Information) ![Body treatments, aromatherapy, hot stone massages, deep-tissue massages](https://images.trvl-media.com/lodging/1000000/800000/792100/792025/c3c44ae2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Poolside bar](https://images.trvl-media.com/lodging/1000000/800000/792100/792025/449f7ba3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/800000/792100/792025/325331d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 outdoor pools](https://images.trvl-media.com/lodging/1000000/800000/792100/792025/311e3874.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Coconut Point Resort & Spa Bonita Springs 9.0/10 Wonderful (1011) "Wonderful location, very quiet and definitely will be returning " CA $390 CA $504 total includes taxes & fees Oct 14 - Oct 15 [](https://www.expedia.ca/Naples-Hotels-Hyatt-Regency-Coconut-Point-Resort-Spa.h792025.Hotel-Information) ![Couples treatment rooms, body treatments, deep-tissue massages](https://images.trvl-media.com/lodging/1000000/10000/2000/1939/159252c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/10000/2000/1939/5481c209.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/2000/1939/f4e5c65a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/10000/2000/1939/62d93321.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sundial Beach Resort & Spa Sanibel 8.6/10 Excellent (2578) "The ocean view 1 minute to the beach" CA $436 CA $670 total includes taxes & fees Oct 2 - Oct 3 [](https://www.expedia.ca/Sanibel-Hotels-Sundial-Beach-Resort-Spa.h1939.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/180000/170800/170769/a5c54d2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/180000/170800/170769/b4d8e8fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee/tea maker](https://images.trvl-media.com/lodging/1000000/180000/170800/170769/a7398ba1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dock](https://images.trvl-media.com/lodging/1000000/180000/170800/170769/24a52d40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tween Waters Island Resort & Spa Captiva 8.6/10 Excellent (1000) "We had an amazing stay at the Captiva Island! The place is great, the service was excellent. We truly enjoyed every moment and will definitely come back again. Highly recommended!" CA $413 CA $510 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Fort-Myers-Hotels-Tween-Waters-Island-Resort-Spa.h170769.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-14&endDate=2025-10-15®ionId=553248635976477245&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top Sanibel Isles Hotel Reviews ![The Lighthouse Resort Inn & Suites](//images.trvl-media.com/lodging/1000000/810000/800800/800715/w2800h1779x0y3-dbc2bfa3_y.jpg) ### The Lighthouse Resort Inn & Suites 10/10 Excellent "The rooms are newly renovated and are very spacious. We were disappointed the pool was not open and waiting for an inspection. " [](https://expedia.ca/Fort-Myers-Hotels-The-Lighthouse-Resort-Inn-Suites.h800715.Hotel-Information) ![Hyatt Vacation Club at Coconut Cove, Bonita Springs](//images.trvl-media.com/lodging/1000000/1000000/991200/991114/7c494168_y.jpg) ### Hyatt Vacation Club at Coconut Cove, Bonita Springs 10/10 Excellent "Very nice clean rooms, great service and a very nice quiet area" [](https://expedia.ca/Bonita-Springs-Hotels-Hyatt-Vacation-Club-At-Coconut-Cove.h991114.Hotel-Information) ![Hilton Garden Inn Fort Myers Airport/FGCU](//images.trvl-media.com/lodging/3000000/2810000/2803700/2803658/c005265d_y.jpg) ### Hilton Garden Inn Fort Myers Airport/FGCU 10/10 Excellent "Clean-very friendly staff. " [](https://expedia.ca/Fort-Myers-Hotels-Hilton-Garden-Inn-Fort-Myers-AirportFGCU.h2803658.Hotel-Information) ![Trianon Bonita Bay](//images.trvl-media.com/lodging/1000000/50000/40900/40858/a9620a82_y.jpg) ### Trianon Bonita Bay 10/10 Excellent "great place at great price. friendly staff " [](https://expedia.ca/Naples-Hotels-Trianon-Bonita-Bay.h40858.Hotel-Information) ![Embassy Suites by Hilton Fort Myers Estero](//images.trvl-media.com/lodging/2000000/1320000/1312700/1312669/40e94d44_y.jpg) ### Embassy Suites by Hilton Fort Myers Estero 10/10 Excellent "Very good" [](https://expedia.ca/Fort-Myers-Hotels-Embassy-Suites-By-Hilton-Fort-Myers-Estero.h1312669.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway](//images.trvl-media.com/lodging/1000000/20000/11200/11134/b06bf9be_y.jpg) ### La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway 10/10 Excellent "Newly renovated property just finishing the last upgrades like new exterior tiles. Lobby was spacious, staff helpful & check in prompt. Room was newly upgraded, excellent WiFi, great pool and breakfast was outstanding continental with hot options like sausages, scrambled egg, omelettes and waffle maker. Overall a great stay and would stay again." [](https://expedia.ca/Fort-Myers-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Ft-Myers-Sanibel-Gateway.h11134.Hotel-Information) ![Doubletree by Hilton Fort Myers at Bell Tower Shops](//images.trvl-media.com/lodging/1000000/20000/12400/12375/704cf90c_y.jpg) ### Doubletree by Hilton Fort Myers at Bell Tower Shops 10/10 Excellent "Great location. " [](https://expedia.ca/Fort-Myers-Hotels-Doubletree-By-Hilton-Fort-Myers-At-Bell-Tower-Shops.h12375.Hotel-Information) ![Pink Shell Beach Resort and Marina](//images.trvl-media.com/lodging/1000000/20000/15700/15603/5f038ed2_y.jpg) ### Pink Shell Beach Resort and Marina 10/10 Excellent "Great place to stay. Town is a 10 minute walk with Tram and golf cart if you prefer not to walk. Events for the kids every morning. Italian restaurant on property is delicious. Plenty of other food options so you don’t need to leave. " [](https://expedia.ca/Fort-Myers-Hotels-Pink-Shell-Beach-Resort-And-Marina.h15603.Hotel-Information) ![Hilton Garden Inn Ft Myers](//images.trvl-media.com/lodging/1000000/850000/848800/848740/d8bd559a_y.jpg) ### Hilton Garden Inn Ft Myers 10/10 Excellent "Safe, quiet, and clean" [](https://expedia.ca/Fort-Myers-Hotels-Hilton-Garden-Inn-Ft-Myers.h848740.Hotel-Information) ## Frequently asked questions ### Looking for a spa hotel in Sanibel Isles? > Forget the stress of everyday life and book yourself a lush spa hotel. Hotels with spas are the perfect way to break out of your daily routine and add a layer of luxury to your vacation. ### What's there to see and do in Sanibel Isles? > Enjoy Sanibel Isles and visit Key West Express, Periwinkle Way, and Sanibel Island Northern Beach. If you have some spare time during your trip, you might want to check out Sanibel Island Lighthouse and Sanibel Island Southern Beach. ### What is a Sanibel Isles spa hotel? > Spa hotels in Sanibel Isles have on-site spas which offer services like therapies and a choice of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. 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