Title: Book the Best Sanibel Isles SPA Resorts from CA $264 - Spa Hotels in Sanibel Isles, Sanibel | Expedia.ca [Vacation Rentals in Sanibel](https://expedia.ca/Sanibel-Vacation-Rentals.d9791.Travel-Guide-VacationRentals)[Flights to Sanibel](https://expedia.ca/Cheap-Flights-To-Sanibel.d9791.Travel-Guide-Flights)[Things to do in Sanibel](https://expedia.ca/Things-To-Do-In-Sanibel.d9791.Travel-Guide-Activities)[Sanibel Isles Car Rentals](https://expedia.ca/Car-Rentals-In-Sanibel-Isles.d553248635976477245.Car-Rental-Guide)[Sanibel Isles Vacations](https://expedia.ca/Sanibel-Isles.d553248635976477245.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/9/6748f9f3d5a0dfbe5d878db6bfe88052.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Sanibel Isles, Sanibel from CA $264 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Sanibel Isles Spa Hotels Tonight [Oct 24 - Oct 25](https://www.expedia.ca/Hotel-Search?regionId=553248635976477245&startDate=2025-10-24&endDate=2025-10-25&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 25 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635976477245&startDate=2025-10-25&endDate=2025-10-26&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635976477245&startDate=2025-10-24&endDate=2025-10-26&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248635976477245&startDate=2025-10-31&endDate=2025-11-02&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Sanibel Isles Spa Hotels ![Massages](https://images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/2dcc8d7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/0153ec95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/w3998h2821x0y0-a77e6574.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/1051a5d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Margaritaville Beach Resort Fort Myers Fort Myers Beach 9.0/10 Wonderful (1560) "Loved everything about our stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $178 CA $269 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Fort-Myers-Beach-Hotels-Margaritaville-Beach-Resort-Fort-Myers.h95126992.Hotel-Information) ![Outdoor pool, open 8:00 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/3000000/2730000/2721900/2721880/d961205e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/3000000/2730000/2721900/2721880/b069fb2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/3000000/2730000/2721900/2721880/1175676c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Bedrooms, Non Smoking, River View (Balcony)](https://images.trvl-media.com/lodging/3000000/2730000/2721900/2721880/43311ff7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Westin Cape Coral Resort At Marina Village Pelican 9.0/10 Wonderful (1000) "Clean room and lobby very helpful and friendly staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James CA $189 CA $264 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Fort-Myers-Hotels-The-Westin-Cape-Coral-Resort-At-Marina-Village.h2721880.Hotel-Information) ![Couples treatment rooms, sauna, steam room, body treatments](https://images.trvl-media.com/lodging/1000000/10000/3100/3079/ae1f7d62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/3100/3079/89736118.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/3100/3079/39279b5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, 3 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/10000/3100/3079/17d9d33f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Marriott Sanibel Harbour Resort & Spa Punta Rassa 8.4/10 Very good (1004) "It is a beautiful resort! It had everything, dining , pool, very relaxing. The staff and rooms were incredible." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christine CA $225 CA $286 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Fort-Myers-Hotels-Marriott-Sanibel-Harbour-Resort-Spa.h3079.Hotel-Information) ![Couples treatment rooms, body treatments, deep-tissue massages](https://images.trvl-media.com/lodging/1000000/10000/2000/1939/159252c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/10000/2000/1939/5481c209.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/10000/2000/1939/62d93321.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily cooked-to-order breakfast for a fee](https://images.trvl-media.com/lodging/1000000/10000/2000/1939/c6ba33ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sundial Beach Resort & Spa Mid Island 8.6/10 Excellent (2579) "Thank you for a great stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jessica CA $465 CA $594 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Sanibel-Hotels-Sundial-Beach-Resort-Spa.h1939.Hotel-Information) ![Body treatments, aromatherapy, hot stone massages, deep-tissue massages](https://images.trvl-media.com/lodging/1000000/800000/792100/792025/c3c44ae2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 outdoor pools](https://images.trvl-media.com/lodging/1000000/800000/792100/792025/311e3874.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Poolside bar](https://images.trvl-media.com/lodging/1000000/800000/792100/792025/449f7ba3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hair dryer, towels](https://images.trvl-media.com/lodging/1000000/800000/792100/792025/53643806.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Coconut Point Resort & Spa Bonita Springs 9.0/10 Wonderful (1008) "Pool and water slides were great!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard CA $393 CA $508 total includes taxes & fees Nov 17 - Nov 18 [](https://www.expedia.ca/Naples-Hotels-Hyatt-Regency-Coconut-Point-Resort-Spa.h792025.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/180000/170800/170769/a5c54d2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/180000/170800/170769/b4d8e8fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dock](https://images.trvl-media.com/lodging/1000000/180000/170800/170769/24a52d40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee/tea maker](https://images.trvl-media.com/lodging/1000000/180000/170800/170769/a7398ba1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tween Waters Island Resort & Spa Captiva 8.6/10 Excellent (1001) "Stunning Beach View great Staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Robert CA $267 CA $347 total includes taxes & fees Oct 30 - Oct 31 [](https://www.expedia.ca/Fort-Myers-Hotels-Tween-Waters-Island-Resort-Spa.h170769.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-07&endDate=2025-11-08®ionId=553248635976477245&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top Sanibel Isles Hotel Reviews ![Hyatt Vacation Club at Coconut Cove, Bonita Springs](//images.trvl-media.com/lodging/1000000/1000000/991200/991114/7c494168_y.jpg) ### Hyatt Vacation Club at Coconut Cove, Bonita Springs 10/10 Excellent "Very good " [](https://expedia.ca/Bonita-Springs-Hotels-Hyatt-Vacation-Club-At-Coconut-Cove.h991114.Hotel-Information) ![The Lighthouse Resort Inn & Suites](//images.trvl-media.com/lodging/1000000/810000/800800/800715/w2800h1779x0y3-dbc2bfa3_y.jpg) ### The Lighthouse Resort Inn & Suites 10/10 Excellent "Absolutely enjoyed our 1 week stay. Can’t wait to come back. Staff members were friendly and courteous " [](https://expedia.ca/Fort-Myers-Hotels-The-Lighthouse-Resort-Inn-Suites.h800715.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway](//images.trvl-media.com/lodging/1000000/20000/11200/11134/b06bf9be_y.jpg) ### La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway 10/10 Excellent "Clean room by the pool. Very quiet. Lovely warm pool. Nice breakfast served with lots of variety. Convenient location. The bed was very comfortable. Miss this place already!" [](https://expedia.ca/Fort-Myers-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Ft-Myers-Sanibel-Gateway.h11134.Hotel-Information) ![DiamondHead Beach Resort](//images.trvl-media.com/lodging/1000000/210000/200700/200632/814c4388_y.jpg) ### DiamondHead Beach Resort 10/10 Excellent "It was our first time visiting Fort Myers Beach. DiamondHead resort provided a great place to stay. Clean room, comfortable beds, great shower, overall a very nice place. Restaurants were great. The beach chairs and umbrella was a definite plus. Close enough to walk to Times Square area (but golf cart taxi service is also available at a reasonable rate). Note: some unit’s have a little stove top ours did not. We had bought some eggs before arriving and ended up giving them to a staff member. Next time we visit we plan on staying here again. " [](https://expedia.ca/Fort-Myers-Hotels-DiamondHead-Beach-Resort.h200632.Hotel-Information) ![Embassy Suites by Hilton Fort Myers Estero](//images.trvl-media.com/lodging/2000000/1320000/1312700/1312669/40e94d44_y.jpg) ### Embassy Suites by Hilton Fort Myers Estero 10/10 Excellent "Staff helpful, bed comfy & room was big. " [](https://expedia.ca/Fort-Myers-Hotels-Embassy-Suites-By-Hilton-Fort-Myers-Estero.h1312669.Hotel-Information) ![Pink Shell Beach Resort and Marina](//images.trvl-media.com/lodging/1000000/20000/15700/15603/5f038ed2_y.jpg) ### Pink Shell Beach Resort and Marina 10/10 Excellent "We would go again - nice for families with kids" [](https://expedia.ca/Fort-Myers-Hotels-Pink-Shell-Beach-Resort-And-Marina.h15603.Hotel-Information) ![Marriott Sanibel Harbour Resort & Spa](//images.trvl-media.com/lodging/1000000/10000/3100/3079/ac9a3a07_y.jpg) ### Marriott Sanibel Harbour Resort & Spa 10/10 Excellent "The grounds were beautiful and it was wonderful to sit on the balcony and watch the water and boats coming and going. My only negative is that there is no option for coffee until 7:00. So being an early riser, that was disappointing. " [](https://expedia.ca/Fort-Myers-Hotels-Marriott-Sanibel-Harbour-Resort-Spa.h3079.Hotel-Information) ![Doubletree by Hilton Fort Myers at Bell Tower Shops](//images.trvl-media.com/lodging/1000000/20000/12400/12375/704cf90c_y.jpg) ### Doubletree by Hilton Fort Myers at Bell Tower Shops 10/10 Excellent "Best hotel I would always stay there when I visit my family . Friendly staff warm cookies and hot coffee . Great job!" [](https://expedia.ca/Fort-Myers-Hotels-Doubletree-By-Hilton-Fort-Myers-At-Bell-Tower-Shops.h12375.Hotel-Information) ![Trianon Bonita Bay](//images.trvl-media.com/lodging/1000000/50000/40900/40858/a9620a82_y.jpg) ### Trianon Bonita Bay 10/10 Excellent "Everything was good " [](https://expedia.ca/Naples-Hotels-Trianon-Bonita-Bay.h40858.Hotel-Information) ## Frequently asked questions ### Looking for a spa hotel in Sanibel Isles? > Forget the stress of everyday life and book yourself a lush spa hotel. Hotels with spas are the perfect way to break out of your daily routine and add a layer of luxury to your vacation. ### What's there to see and do in Sanibel Isles? > Enjoy Sanibel Isles and visit Key West Express, Periwinkle Way, and Sanibel Island Northern Beach. If you have some spare time during your trip, you might want to check out Sanibel Island Lighthouse and Sanibel Island Southern Beach. ### What is a Sanibel Isles spa hotel? > Spa hotels in Sanibel Isles have on-site spas which offer services like therapies and a choice of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. 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