Title: Book the Best Sanibel Isles Adults Only Resorts & Hotels in 2025 from CA $106 | Expedia.ca [Vacation Rentals in Sanibel](https://expedia.ca/Sanibel-Vacation-Rentals.d9791.Travel-Guide-VacationRentals)[Flights to Sanibel](https://expedia.ca/Cheap-Flights-To-Sanibel.d9791.Travel-Guide-Flights)[Things to do in Sanibel](https://expedia.ca/Things-To-Do-In-Sanibel.d9791.Travel-Guide-Activities)[Sanibel Isles Car Rentals](https://expedia.ca/Car-Rentals-In-Sanibel-Isles.d553248635976477245.Car-Rental-Guide)[Sanibel Isles Vacations](https://expedia.ca/Sanibel-Isles.d553248635976477245.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/9/6748f9f3d5a0dfbe5d878db6bfe88052.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Adults Only Resorts & Hotels in Sanibel Isles, FL from CA $106 ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Sanibel Isles Adults Only Resorts & Hotels Tonight [Oct 6 - Oct 7](https://www.expedia.ca/Hotel-Search?regionId=553248635976477245&startDate=2025-10-06&endDate=2025-10-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 7 - Oct 8](https://www.expedia.ca/Hotel-Search?regionId=553248635976477245&startDate=2025-10-07&endDate=2025-10-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248635976477245&startDate=2025-10-10&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635976477245&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Sanibel Isles Adults Only Resorts & Hotels We don't have any properties that match your exact search [See all properties in Sanibel Isles](https://expedia.ca/Hotel-Search?startDate=2025-10-20&endDate=2025-10-21®ionId=553248635976477245&adults=2) ## Recommended hotels in Sanibel Isles ![Lobby](https://images.trvl-media.com/lodging/1000000/160000/159000/158967/2bbde5c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/160000/159000/158967/1d4afbb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/1000000/160000/159000/158967/fbf201ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/160000/159000/158967/c08f3667.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Bonita Springs Naples N. Bonita Shores 9.0/10 Wonderful (1151) "Spacious room, very clean, and friendly staff." CA $135 CA $151 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Naples-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Bonita-Springs-Naples-N.h158967.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/50000/40900/40858/a9620a82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily to-go breakfast for a fee](https://images.trvl-media.com/lodging/1000000/50000/40900/40858/d254153a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Balcony](https://images.trvl-media.com/lodging/1000000/50000/40900/40858/a0f722c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40900/40858/7d170878.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Trianon Bonita Bay Bonita Bay 9.2/10 Wonderful (1672) "Great location , very nice place , good restaurants" CA $122 CA $137 total includes taxes & fees Oct 7 - Oct 8 [](https://www.expedia.ca/Naples-Hotels-Trianon-Bonita-Bay.h40858.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/49000000/48990000/48980100/48980077/98e32444.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/49000000/48990000/48980100/48980077/2da48eb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 7:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/49000000/48990000/48980100/48980077/e26fbeff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/49000000/48990000/48980100/48980077/00a97ad2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Fort Myers Airport by IHG Daniels Corridor 9.6/10 Exceptional (1003) "Great place to stay." CA $130 CA $145 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Fort-Myers-Hotels-Holiday-Inn-Express-Suites-Fort-Myers-Southeast.h48980077.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/30000/28400/28397/0af0c975.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Accessible (Roll-In Shower)](https://images.trvl-media.com/lodging/1000000/30000/28400/28397/657b9b9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/1000000/30000/28400/28397/e558da0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/28400/28397/946d6fb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Bonita Springs/Naples-North Bonita Springs 9.0/10 Wonderful (1005) "Always a great stay!" CA $138 CA $154 total includes taxes & fees Oct 16 - Oct 17 [](https://www.expedia.ca/Naples-Hotels-Hampton-Inn-By-Hilton-Bonita-Springs-Naples-North.h28397.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/97000000/96930000/96929600/96929542/a2675737.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/97000000/96930000/96929600/96929542/9b2fb814.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/97000000/96930000/96929600/96929542/b9eaf5b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Studio, 2 Queen Beds, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/97000000/96930000/96929600/96929542/ce7db9d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Extended Stay America Premier Suites - Fort Myers - Airport Daniels Corridor 8.8/10 Excellent (707) "Great place to stay nice and clean" CA $95 CA $106 total includes taxes & fees Oct 7 - Oct 8 [](https://www.expedia.ca/Fort-Myers-Hotels-Extended-Stay-America-Premier-Suites-Fort-Myers-Airport.h96929542.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/3000000/2630000/2625800/2625745/83cb6bb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/3000000/2630000/2625800/2625745/e00a9bae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/3000000/2630000/2625800/2625745/5f2e6784.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/3000000/2630000/2625800/2625745/2c14a98f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Residence Inn by Marriott Fort Myers Sanibel Fort Myers 8.6/10 Excellent (1004) "We loved the staff attitude and the excellent breakfast." CA $144 CA $160 total includes taxes & fees Oct 7 - Oct 8 [](https://www.expedia.ca/Fort-Myers-Hotels-Residence-Inn-By-Marriott-Fort-Myers-Sanibel.h2625745.Hotel-Information) ![3 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/1000000/991200/991114/7c494168.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/1000000/991200/991114/77b83b7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Beach volleyball](https://images.trvl-media.com/lodging/1000000/1000000/991200/991114/01798210.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/1000000/991200/991114/10e34bd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Vacation Club at Coconut Cove, Bonita Springs Bonita Springs 9.2/10 Wonderful (652) "Amazing place" CA $163 CA $237 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Bonita-Springs-Hotels-Hyatt-Vacation-Club-At-Coconut-Cove.h991114.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/96000000/95380000/95374500/95374467/ed747e8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/96000000/95380000/95374500/95374467/a15d6af6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/96000000/95380000/95374500/95374467/42c1a856.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/96000000/95380000/95374500/95374467/d2845050.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Fort Myers Downtown Fort Myers River District 9.2/10 Wonderful (732) "Beautiful stay. " CA $159 CA $177 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Fort-Myers-Hotels-Hampton-Inn-Fort-Myers-Downtown.h95374467.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1750000/1746300/1746276/2deb021c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1750000/1746300/1746276/eec3b567.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/2000000/1750000/1746300/1746276/b9d6a513.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Food court](https://images.trvl-media.com/lodging/2000000/1750000/1746300/1746276/295168d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Airport Daniels Corridor 8.8/10 Excellent (1085) "Excellent place to stay" CA $103 CA $115 total includes taxes & fees Oct 8 - Oct 9 [](https://www.expedia.ca/Fort-Myers-Hotels-Comfort-Inn-Suites-Airport.h1746276.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/800000/798500/798422/16c0566c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/800000/798500/798422/a4826c5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/800000/798500/798422/039cd0a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/800000/798500/798422/953f373d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park Daniels Corridor 7.8/10 Good (1434) "Everything was great This was our 2nd stay and counting " CA $97 CA $108 total includes taxes & fees Oct 7 - Oct 8 [](https://www.expedia.ca/Fort-Myers-Hotels-Days-Inn-Suites-By-Wyndham-Fort-Myers-Near-JetBlue-Park.h798422.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. 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[Oceanfront Hotels in Shell Harbor](https://www.expedia.ca/Shell-Harbor-Sanibel-Hotels-Oceanfront-Hotels.0-n553248635976472731-0-tOceanfrontHotels.Travel-Guide-Filter-Hotels) - [Business Hotels in South Florida](https://www.expedia.ca/South-Florida-Hotels-Business-Hotel.0-0-d6233792-tBusinessHotel.Travel-Guide-Filter-Hotels) - [Hotels & Resorts for Couples in South Florida](https://www.expedia.ca/South-Florida-Hotels-Couples-Resorts-Hotels.0-0-d6233792-tCouplesResortsHotels.Travel-Guide-Filter-Hotels) - [Historic Hotels in South Florida](https://www.expedia.ca/South-Florida-Hotels-Historic-Hotel.0-0-d6233792-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Honeymoon Resorts and in South Florida](https://www.expedia.ca/South-Florida-Hotels-Honeymoon-Hotels.0-0-d6233792-tHoneymoonHotels.Travel-Guide-Filter-Hotels) - [Hotels with Early Check-in in South Florida](https://www.expedia.ca/South-Florida-Hotels-Hotel-With-Early-Check-In.0-0-d6233792-thotelwithearlycheckin.Travel-Guide-Filter-Hotels) - 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[Luxury Hotels in Southeast Florida](https://www.expedia.ca/Southeast-Florida-Hotels-Luxury-Hotel.0-0-d6047949-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Oceanfront Hotels in Southeast Florida](https://www.expedia.ca/Southeast-Florida-Hotels-Oceanfront-Hotels.0-0-d6047949-tOceanfrontHotels.Travel-Guide-Filter-Hotels) - [Romantic Hotels in Southeast Florida](https://www.expedia.ca/Southeast-Florida-Hotels-Romantic-Hotel.0-0-d6047949-tRomanticHotel.Travel-Guide-Filter-Hotels) - [Scuba Diving Hotels in Southeast Florida](https://www.expedia.ca/Southeast-Florida-Hotels-Scuba-Diving-Vacations.0-0-d6047949-tscubadivingvacations.Travel-Guide-Filter-Hotels) - [Spa Hotels in Southeast Florida](https://www.expedia.ca/Southeast-Florida-Hotels-Spa-Hotel.0-0-d6047949-tSpaHotel.Travel-Guide-Filter-Hotels) - [Waterpark Hotels in Southeast Florida](https://www.expedia.ca/Southeast-Florida-Hotels-Waterpark-Hotels.0-0-d6047949-tWaterparkHotels.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in The Dunes](https://www.expedia.ca/The-Dunes-Sanibel-Hotels-Beach-Hotel.0-n553248635976473424-0-tBeachHotel.Travel-Guide-Filter-Hotels) - [Hotels with Bar in Venice](https://www.expedia.ca/Venice-Hotels-Hotels-With-Bar.0-0-d10285-tHotelswithBar.Travel-Guide-Filter-Hotels) - [Hotels with Free Airport Shuttle in Venice](https://www.expedia.ca/Venice-Hotels-Hotels-With-Free-Airport-Shuttle.0-0-d10285-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels) - [Hotels with Tennis Courts in Venice](https://www.expedia.ca/Venice-Hotels-Hotels-With-Tennis-Courts.0-0-d10285-tHotelswithTennisCourts.Travel-Guide-Filter-Hotels) - [Lake Hotels in Venice](https://www.expedia.ca/Venice-Hotels-Lake-Hotels.0-0-d10285-tLakeHotels.Travel-Guide-Filter-Hotels) - [Mountain Hotels in Venice](https://www.expedia.ca/Venice-Hotels-Mountain-Hotels.0-0-d10285-tMountainHotels.Travel-Guide-Filter-Hotels) - [Shopping Hotels in Venice](https://www.expedia.ca/Venice-Hotels-Shopping-Hotel.0-0-d10285-tShoppingHotel.Travel-Guide-Filter-Hotels) - [Winery Hotels in Venice](https://www.expedia.ca/Venice-Hotels-Winery-Hotel.0-0-d10285-tWineryHotel.Travel-Guide-Filter-Hotels) - 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