Title: Book the Best BUSINESS Hotels in Sanibel in 2026 | Expedia.ca [Sanibel Travel Guide](https://expedia.ca/Sanibel.dx9791)[Hotels in Sanibel](https://expedia.ca/Sanibel-Hotels.d9791.Travel-Guide-Hotels)[Vacation Rentals in Sanibel](https://expedia.ca/Sanibel-Vacation-Rentals.d9791.Travel-Guide-VacationRentals)[Flights to Sanibel](https://expedia.ca/Cheap-Flights-To-Sanibel.d9791.Travel-Guide-Flights)[Things to do in Sanibel](https://expedia.ca/Things-To-Do-In-Sanibel.d9791.Travel-Guide-Activities)[Sanibel Car Rentals](https://expedia.ca/Car-Rentals-In-Sanibel.d9791.Car-Rental-Guide)[Sanibel Vacation Packages](https://expedia.ca/Sanibel.d9791.Destination-Travel-Guides) ![Sanibel Island Lighthouse which includes a sunset and a lighthouse](https://images.trvl-media.com/place/6123905/f29c3c57-bfa6-4f38-95ba-a11a95bd6896.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Sanibel, FL from CA $121 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Sanibel Business Hotels Tonight [Dec 17 - Dec 18](https://www.expedia.ca/Hotel-Search?regionId=9791&startDate=2025-12-17&endDate=2025-12-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Dec 18 - Dec 19](https://www.expedia.ca/Hotel-Search?regionId=9791&startDate=2025-12-18&endDate=2025-12-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=9791&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=9791&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Sanibel business-friendly hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/800000/798500/798422/16c0566c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/800000/798500/798422/953f373d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/800000/798500/798422/039cd0a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/800000/798500/798422/1fa522a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park [](https://www.expedia.ca/Fort-Myers-Hotels-Days-Inn-Suites-By-Wyndham-Fort-Myers-Near-JetBlue-Park.h798422.Hotel-Information) Daniels Corridor 8.0/10 Very good (1503) "Nice and beautiful place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maguenne CA $109 CA $121 total includes taxes & fees Dec 19 - Dec 20 [](https://www.expedia.ca/Fort-Myers-Hotels-Days-Inn-Suites-By-Wyndham-Fort-Myers-Near-JetBlue-Park.h798422.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1750000/1746300/1746276/2deb021c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1750000/1746300/1746276/0893d88f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Food court](https://images.trvl-media.com/lodging/2000000/1750000/1746300/1746276/295168d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1750000/1746300/1746276/eec3b567.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Fort Myers Airport [](https://www.expedia.ca/Fort-Myers-Hotels-Comfort-Inn-Suites-Airport.h1746276.Hotel-Information) Daniels Corridor 8.8/10 Excellent (1120) "Great staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alison CA $118 CA $131 total includes taxes & fees Dec 20 - Dec 21 [](https://www.expedia.ca/Fort-Myers-Hotels-Comfort-Inn-Suites-Airport.h1746276.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/19100/19063/907bbde1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/20000/19100/19063/23c34ff9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking (Mobility/Hearing Impaired)](https://images.trvl-media.com/lodging/1000000/20000/19100/19063/8daf0cf3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/19100/19063/4d6357af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Bonita Springs Naples North [](https://www.expedia.ca/Naples-Hotels-Baymont-By-Wyndham-Bonita-Springs-Naples-North.h19063.Hotel-Information) Bonita Springs 8.0/10 Very good (1001) "Great stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cherick CA $116 CA $130 total includes taxes & fees Dec 20 - Dec 21 [](https://www.expedia.ca/Naples-Hotels-Baymont-By-Wyndham-Bonita-Springs-Naples-North.h19063.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/w2247h1500x326y0-2ea06bb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/2ab8abc8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![On the beach, sun loungers, beach towels](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/86e902b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/aa9b23b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sanibel Island Beach Resort [](https://www.expedia.ca/Fort-Myers-Hotels-Sanibel-Island-Beach-Resort.h17298818.Hotel-Information) Mid Island 9.2/10 Wonderful (1471) "Great place." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $316 CA $387 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Fort-Myers-Hotels-Sanibel-Island-Beach-Resort.h17298818.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/50000/40900/40858/a9620a82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40900/40858/7d170878.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily to-go breakfast for a fee](https://images.trvl-media.com/lodging/1000000/50000/40900/40858/d254153a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40900/40858/bb6d486e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Trianon Bonita Bay [](https://www.expedia.ca/Naples-Hotels-Trianon-Bonita-Bay.h40858.Hotel-Information) Bonita Bay 9.2/10 Wonderful (1714) "The room was great as well as the amenities!!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Fernando CA $160 CA $179 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Naples-Hotels-Trianon-Bonita-Bay.h40858.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/160000/159000/158967/2bbde5c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/160000/159000/158967/ec833164.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/160000/159000/158967/c08f3667.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/1000000/160000/159000/158967/fbf201ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Bonita Springs Naples N. [](https://www.expedia.ca/Naples-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Bonita-Springs-Naples-N.h158967.Hotel-Information) Bonita Shores 9.0/10 Wonderful (1210) "Our stay was excellent! The room was clean, the area safe, great view, Walking to the restaurants" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Norman CA $134 CA $150 total includes taxes & fees Dec 20 - Dec 21 [](https://www.expedia.ca/Naples-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Bonita-Springs-Naples-N.h158967.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/480000/473200/473197/0a44581b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sundeck](https://images.trvl-media.com/lodging/1000000/480000/473200/473197/5a9e28b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/480000/473200/473197/037200b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/480000/473200/473197/70770f5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn & Suites by Wyndham Bonita Springs North Naples [](https://www.expedia.ca/Naples-Hotels-Days-Inn-Suites-By-Wyndham-Bonita-Springs-North-Naples.h473197.Hotel-Information) Bonita Springs 7.8/10 Good (1008) "Good place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rafael CA $109 CA $121 total includes taxes & fees Dec 19 - Dec 20 [](https://www.expedia.ca/Naples-Hotels-Days-Inn-Suites-By-Wyndham-Bonita-Springs-North-Naples.h473197.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/50000000/49160000/49152700/49152700/a69cd385.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/50000000/49160000/49152700/49152700/9ecc1017.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/50000000/49160000/49152700/49152700/088bfb58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/50000000/49160000/49152700/49152700/798de6a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG [](https://www.expedia.ca/Fort-Myers-Hotels-Holiday-Inn-Express-Suites-Ft-Myers-Beach-Sanibel-Gateway.h49152700.Hotel-Information) Fort Myers Beach 9.4/10 Exceptional (1001) "Great rooms, good staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dedan CA $150 CA $167 total includes taxes & fees Dec 20 - Dec 21 [](https://www.expedia.ca/Fort-Myers-Hotels-Holiday-Inn-Express-Suites-Ft-Myers-Beach-Sanibel-Gateway.h49152700.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/17200/17131/cebf36b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/17200/17131/42212932.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/20000/17200/17131/d9380a64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking, Microwave](https://images.trvl-media.com/lodging/1000000/20000/17200/17131/55b8bfc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Fort Myers Inn & Suites [](https://www.expedia.ca/Fort-Myers-Hotels-Best-Western-Fort-Myers-Inn-Suites.h17131.Hotel-Information) Fort Myers 8.8/10 Excellent (1107) "Clean room, friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mary CA $110 CA $123 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Fort-Myers-Hotels-Best-Western-Fort-Myers-Inn-Suites.h17131.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/110000000/109300000/109299300/109299203/w2868h1920x12y0-118022ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Non Smoking](https://images.trvl-media.com/lodging/110000000/109300000/109299300/109299203/d7c7e7e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/110000000/109300000/109299300/109299203/6a1456e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Non Smoking (Upgrade)](https://images.trvl-media.com/lodging/110000000/109300000/109299300/109299203/3b030475.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Fort Myers East I-75 [](https://www.expedia.ca/Fort-Myers-Hotels-Comfort-Suites.h109299203.Hotel-Information) Fort Myers 9.6/10 Exceptional (355) "Friendly staff, great breakfast, clean room. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shellie CA $141 CA $157 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Fort-Myers-Hotels-Comfort-Suites.h109299203.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-01&endDate=2026-01-02®ionId=9791&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Sanibel Hotel Reviews ![Sanibel Island Beach Resort](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/w2247h1500x326y0-2ea06bb5_y.jpg) ### Sanibel Island Beach Resort 10/10 Excellent "Room was clean, staff was nice, will Return!" [](https://expedia.ca/Fort-Myers-Hotels-Sanibel-Island-Beach-Resort.h17298818.Hotel-Information) ![Casa Ybel Resort](https://images.trvl-media.com/lodging/2000000/1070000/1060300/1060289/33a6cafb_y.jpg) ### Casa Ybel Resort 8/10 Good "Room was amazing! Their video on their site is pre Hurricane Ian so don’t expect it to be like that ! Lots of devistation but they are working to bring it back. Most staff was nice , the front office staff were snotty and not helpful at !! Location on the beach is amazing! Sanibel / Captiva have captured my heart and I can’t wait to return. I’d stay there again . " [](https://expedia.ca/Fort-Myers-Hotels-Casa-Ybel-Resort.h1060289.Hotel-Information) ![Kona Kai Motel](https://images.trvl-media.com/lodging/9000000/8080000/8078500/8078470/e1676e63_y.jpg) ### Kona Kai Motel 10/10 Excellent " very clean" [](https://expedia.ca/Sanibel-Hotels-Kona-Kai-Motel.h8078470.Hotel-Information) ![Sanibel Inn](https://images.trvl-media.com/lodging/1000000/50000/40800/40711/55e96d4f_y.jpg) ### Sanibel Inn 10/10 Excellent "We had a fantastic stay here!! Rooms were nice. It was off season which meant a lot of quiet days. The pool was always clean and the staff was excellent. Hannah took care of us poolside as well as at dauntes . " [](https://expedia.ca/Fort-Myers-Hotels-Sanibel-Inn.h40711.Hotel-Information) ![Sundial Beach Resort & Spa](https://images.trvl-media.com/lodging/1000000/10000/2000/1939/5481c209_y.jpg) ### Sundial Beach Resort & Spa 10/10 Excellent "What you want and expect on a beach trip, loved it" [](https://expedia.ca/Sanibel-Hotels-Sundial-Beach-Resort-Spa.h1939.Hotel-Information) ![Island Inn](https://images.trvl-media.com/lodging/2000000/1510000/1509800/1509747/57dffb5c_y.jpg) ### Island Inn 10/10 Excellent "We enjoyed our stay. I would highly recommend!" [](https://expedia.ca/Fort-Myers-Hotels-Island-Inn.h1509747.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Sanibel cost? ### What are the best business-friendly hotels in Sanibel? ### How many business-friendly hotels are there in Sanibel? ### What are the best cheap business-friendly hotels in Sanibel? ### Are there any family-friendly hotels in Sanibel that are also business friendly? ### Why book your business-friendly hotel in Sanibel with Expedia? ### How can I find cheap business-friendly hotels in Sanibel? ### What is there to do in Sanibel near my business-friendly hotel? ## Explore a world of travel with Expedia - Lodging - More ways to book - [Cheap Hotels in Downtown Fort Myers Beach ](https://www.expedia.ca/Downtown-Fort-Myers-Beach-Fort-Myers-Beach-Hotels-Cheap-Hotels.0-n904326898430316544-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Golf Hotels in Downtown Fort Myers Beach ](https://www.expedia.ca/Downtown-Fort-Myers-Beach-Fort-Myers-Beach-Hotels-Golf-Hotel.0-n904326898430316544-0-tGolfHotel.Travel-Guide-Filter-Hotels) - 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