Title: Book the Best Sanderson LUXURY Hotels - Upscale Hotels in Sanderson, FL | Expedia.ca [Hotels in Sanderson](https://expedia.ca/Sanderson-Hotels.d6185900.Travel-Guide-Hotels)[Vacation Rentals in Sanderson](https://expedia.ca/Sanderson-Vacation-Rentals.d6185900.Travel-Guide-VacationRentals)[Sanderson Car Rentals](https://expedia.ca/Car-Rentals-In-Sanderson.d6185900.Car-Rental-Guide)[Sanderson Vacation Packages](https://expedia.ca/Sanderson.d6185900.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Sanderson, FL - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Sanderson Luxury Hotels Tonight [Nov 2 - Nov 3](https://www.expedia.ca/Hotel-Search?regionId=6185900&startDate=2025-11-02&endDate=2025-11-03&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Nov 3 - Nov 4](https://www.expedia.ca/Hotel-Search?regionId=6185900&startDate=2025-11-03&endDate=2025-11-04&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6185900&startDate=2025-11-07&endDate=2025-11-09&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) In two weeks [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=6185900&startDate=2025-11-14&endDate=2025-11-16&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Sanderson Luxury Hotels ## Top Sanderson Hotel Reviews ![Comfort Suites Lake City](//images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/4977ae81_y.jpg) ### Comfort Suites Lake City 10/10 Excellent "Clean and large rooms." [](https://expedia.ca/Lake-City-Hotels-Comfort-Suites-Lake-City.h2479520.Hotel-Information) ![Americas Best Value Inn Lake City](//images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/1bfc5692_y.jpg) ### Americas Best Value Inn Lake City 10/10 Excellent "Reasonably priced, nice and clean, easy access to I 75" [](https://expedia.ca/Lake-City-Hotels-Americas-Best-Value-Inn-Lake-City.h1039754.Hotel-Information) ![Palms Garden Inn](//images.trvl-media.com/lodging/1000000/50000/40800/40753/c251e287_y.jpg) ### Palms Garden Inn 10/10 Excellent "Nice clean room with a big bed Good AC" [](https://expedia.ca/Lake-City-Hotels-Palms-Garden-Inn.h40753.Hotel-Information) ![Days Inn by Wyndham Lake City I-10](//images.trvl-media.com/lodging/1000000/90000/85000/84936/90-8d4a781e_y.jpg) ### Days Inn by Wyndham Lake City I-10 10/10 Excellent "Friendly staff, quiet, convenient, easy parking, clean" [](https://expedia.ca/Lake-City-Hotels-Days-Inn-By-Wyndham-Lake-City-I-10.h84936.Hotel-Information) ![Super 8 by Wyndham Lake City](//images.trvl-media.com/lodging/1000000/910000/909400/909334/add6c913_y.jpg) ### Super 8 by Wyndham Lake City 10/10 Excellent "Great.. the breakfast was real good, used fresh eggs..friendly staff." [](https://expedia.ca/Lake-City-Hotels-Super-8-By-Wyndham-Lake-City.h909334.Hotel-Information) ## Frequently asked questions ### Are you looking for a luxury hotel for your stay in Sanderson? > Use Expedia to arrange your flight to Jacksonville International Airport (JAX) airport, and then choose from a variety of places to stay that will deliver the luxury you seek. Amenities are an important consideration when you plan a trip, so we make it easy to find what you need to make your stay relaxing and comfortable. If you want a posh hotel with a spa, an indoor pool, or luxury bedding, Expedia can help you find the best luxury hotel experience that Sanderson offers. Sanderson has some interesting things to see and do including Okefenokee National Wildlife Refuge and Osceola National Forest, so you might want to take in the local sights during your visit. ### When can I expect good weather in Sanderson? > Planning for the weather is an important factor for making your trip to Sanderson a success, especially when you're splurging. The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 59°F. Average annual precipitation for Sanderson is 52 inches. ### What's there to see and do in Sanderson? > Take in the sights and attractions that Sanderson offers with a visit to Okefenokee National Wildlife Refuge, Osceola National Forest, and Olustee Battlefield Historic State Park. 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