Title: Book the Best Sanctuary SPA Resorts from CA $263 - Spa Hotels in Sanctuary, Sanibel | Expedia.ca [Vacation Rentals in Sanibel](https://expedia.ca/Sanibel-Vacation-Rentals.d9791.Travel-Guide-VacationRentals)[Flights to Sanibel](https://expedia.ca/Cheap-Flights-To-Sanibel.d9791.Travel-Guide-Flights)[Things to do in Sanibel](https://expedia.ca/Things-To-Do-In-Sanibel.d9791.Travel-Guide-Activities)[Sanctuary Car Rentals](https://expedia.ca/Car-Rentals-In-Sanctuary.d553248635976469368.Car-Rental-Guide)[Sanctuary Vacations](https://expedia.ca/Sanctuary.d553248635976469368.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/pool.jpeg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Sanctuary, Sanibel from CA $263 ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Sanctuary Spa Hotels Tonight [Sep 28 - Sep 29](https://www.expedia.ca/Hotel-Search?regionId=553248635976469368&startDate=2025-09-28&endDate=2025-09-29&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 29 - Sep 30](https://www.expedia.ca/Hotel-Search?regionId=553248635976469368&startDate=2025-09-29&endDate=2025-09-30&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=553248635976469368&startDate=2025-10-03&endDate=2025-10-05&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248635976469368&startDate=2025-10-10&endDate=2025-10-12&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Sanctuary Spa Hotels ![Massages](https://images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/2dcc8d7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/b4312f5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/1051a5d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/w3998h2821x0y0-a77e6574.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Margaritaville Beach Resort Fort Myers Fort Myers Beach 9.0/10 Wonderful (1505) "Great stay, accommodations, location" CA $192 CA $269 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Fort-Myers-Beach-Hotels-Margaritaville-Beach-Resort-Fort-Myers.h95126992.Hotel-Information) ![Couples treatment rooms, sauna, steam room, body treatments](https://images.trvl-media.com/lodging/1000000/10000/3100/3079/ae1f7d62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/3100/3079/89736118.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![On the beach, white sand, kayaking, motor boating](https://images.trvl-media.com/lodging/1000000/10000/3100/3079/ac9a3a07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, 3 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/10000/3100/3079/17d9d33f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Marriott Sanibel Harbour Resort & Spa Punta Rassa 8.4/10 Very good (1017) "Love the pool" CA $263 CA $328 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Fort-Myers-Hotels-Marriott-Sanibel-Harbour-Resort-Spa.h3079.Hotel-Information) ![Outdoor pool, open 8:00 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/3000000/2730000/2721900/2721880/d961205e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Bedrooms, Non Smoking, River View (Balcony)](https://images.trvl-media.com/lodging/3000000/2730000/2721900/2721880/43311ff7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2730000/2721900/2721880/4aba0d83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/3000000/2730000/2721900/2721880/1175676c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Westin Cape Coral Resort At Marina Village Pelican 9.0/10 Wonderful (1010) "It was absolutely a beautiful place!!!" CA $188 CA $263 total includes taxes & fees Oct 2 - Oct 3 [](https://www.expedia.ca/Fort-Myers-Hotels-The-Westin-Cape-Coral-Resort-At-Marina-Village.h2721880.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/180000/170800/170769/a5c54d2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee/tea maker](https://images.trvl-media.com/lodging/1000000/180000/170800/170769/a7398ba1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/180000/170800/170769/b4d8e8fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private beach, kayaking, fishing](https://images.trvl-media.com/lodging/1000000/180000/170800/170769/560da633.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tween Waters Island Resort & Spa Captiva 8.6/10 Excellent (1005) "We had an amazing stay at the Captiva Island! The place is great, the service was excellent. We truly enjoyed every moment and will definitely come back again. Highly recommended!" CA $399 CA $494 total includes taxes & fees Sep 30 - Oct 1 [](https://www.expedia.ca/Fort-Myers-Hotels-Tween-Waters-Island-Resort-Spa.h170769.Hotel-Information) ![Couples treatment rooms, body treatments, deep-tissue massages](https://images.trvl-media.com/lodging/1000000/10000/2000/1939/159252c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/10000/2000/1939/62d93321.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily cooked-to-order breakfast for a fee](https://images.trvl-media.com/lodging/1000000/10000/2000/1939/c6ba33ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/2000/1939/f4e5c65a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sundial Beach Resort & Spa Sanibel 8.6/10 Excellent (2578) "The ocean view 1 minute to the beach" CA $432 CA $666 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Sanibel-Hotels-Sundial-Beach-Resort-Spa.h1939.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-12&endDate=2025-10-13®ionId=553248635976469368&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top Sanctuary Hotel Reviews ![DiamondHead Beach Resort](//images.trvl-media.com/lodging/1000000/210000/200700/200632/814c4388_y.jpg) ### DiamondHead Beach Resort 10/10 Excellent "Overall very pleasant experience " [](https://expedia.ca/Fort-Myers-Hotels-DiamondHead-Beach-Resort.h200632.Hotel-Information) ![Tween Waters Island Resort & Spa](//images.trvl-media.com/lodging/1000000/180000/170800/170769/a5c54d2c_y.jpg) ### Tween Waters Island Resort & Spa 10/10 Excellent "Friendly staff. Lovely beach and pool" [](https://expedia.ca/Fort-Myers-Hotels-Tween-Waters-Island-Resort-Spa.h170769.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway](//images.trvl-media.com/lodging/1000000/20000/11200/11134/b06bf9be_y.jpg) ### La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway 10/10 Excellent "Newly renovated property just finishing the last upgrades like new exterior tiles. Lobby was spacious, staff helpful & check in prompt. Room was newly upgraded, excellent WiFi, great pool and breakfast was outstanding continental with hot options like sausages, scrambled egg, omelettes and waffle maker. Overall a great stay and would stay again." [](https://expedia.ca/Fort-Myers-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Ft-Myers-Sanibel-Gateway.h11134.Hotel-Information) ![Doubletree by Hilton Fort Myers at Bell Tower Shops](//images.trvl-media.com/lodging/1000000/20000/12400/12375/704cf90c_y.jpg) ### Doubletree by Hilton Fort Myers at Bell Tower Shops 10/10 Excellent "Great location. " [](https://expedia.ca/Fort-Myers-Hotels-Doubletree-By-Hilton-Fort-Myers-At-Bell-Tower-Shops.h12375.Hotel-Information) ![Pink Shell Beach Resort and Marina](//images.trvl-media.com/lodging/1000000/20000/15700/15603/5f038ed2_y.jpg) ### Pink Shell Beach Resort and Marina 10/10 Excellent "Great place to stay. Town is a 10 minute walk with Tram and golf cart if you prefer not to walk. Events for the kids every morning. Italian restaurant on property is delicious. Plenty of other food options so you don’t need to leave. " [](https://expedia.ca/Fort-Myers-Hotels-Pink-Shell-Beach-Resort-And-Marina.h15603.Hotel-Information) ![Hilton Garden Inn Ft Myers](//images.trvl-media.com/lodging/1000000/850000/848800/848740/d8bd559a_y.jpg) ### Hilton Garden Inn Ft Myers 10/10 Excellent "Safe, quiet, and clean" [](https://expedia.ca/Fort-Myers-Hotels-Hilton-Garden-Inn-Ft-Myers.h848740.Hotel-Information) ![Homewood Suites by Hilton - Fort Myers](//images.trvl-media.com/lodging/1000000/70000/63300/63247/6feb2ef6_y.jpg) ### Homewood Suites by Hilton - Fort Myers 10/10 Excellent "Breakfast was phenomenal. Very clean hotel, it has everything you could ever want or need to offer. Very friendly staff also." [](https://expedia.ca/Fort-Myers-Hotels-Homewood-Suites-By-Hilton-Fort-Myers.h63247.Hotel-Information) ![Marriott Sanibel Harbour Resort & Spa](//images.trvl-media.com/lodging/1000000/10000/3100/3079/ac9a3a07_y.jpg) ### Marriott Sanibel Harbour Resort & Spa 10/10 Excellent "Top notch resort with amazing pool and bayfront views of Sanibel!" [](https://expedia.ca/Fort-Myers-Hotels-Marriott-Sanibel-Harbour-Resort-Spa.h3079.Hotel-Information) ![The Lighthouse Resort Inn & Suites](//images.trvl-media.com/lodging/1000000/810000/800800/800715/w2800h1779x0y3-dbc2bfa3_y.jpg) ### The Lighthouse Resort Inn & Suites 10/10 Excellent "The room was excellent. It was very comfortable. We were glad that on a Thursday night the loud music in the bar stopped at 10pm." [](https://expedia.ca/Fort-Myers-Hotels-The-Lighthouse-Resort-Inn-Suites.h800715.Hotel-Information) ## Frequently asked questions ### Looking to vacation at a spa hotel in Sanctuary? > Treat yourself to some time in a luxurious spa hotel and you won't regret it. Spa hotels are a great way to break out of your daily routine and add a layer of luxury to your vacation. ### What's there to see and do in Sanctuary? > Enjoy Sanctuary with a stop at J. N. Ding Darling National Wildlife Refuge, Key West Express, and Blind Pass Beach. If you have a little extra time during your trip, you might want to check out Bowman's Beach and Captiva Beach. ### What is a Sanctuary spa hotel? > Spa hotels in Sanctuary have full on-site spas offering services including massages and a selection of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. 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