Title: Book the Best Sanctuary LUXURY Hotels - Upscale Hotels in Sanctuary, Sanibel | Expedia.ca [Vacation Rentals in Sanibel](https://expedia.ca/Sanibel-Vacation-Rentals.d9791.Travel-Guide-VacationRentals)[Flights to Sanibel](https://expedia.ca/Cheap-Flights-To-Sanibel.d9791.Travel-Guide-Flights)[Things to do in Sanibel](https://expedia.ca/Things-To-Do-In-Sanibel.d9791.Travel-Guide-Activities)[Sanctuary Car Rentals](https://expedia.ca/Car-Rentals-In-Sanctuary.d553248635976469368.Car-Rental-Guide)[Sanctuary Vacations](https://expedia.ca/Sanctuary.d553248635976469368.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Luxury Hotels in Sanctuary, Sanibel ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Sanctuary Luxury Hotels Tonight [Oct 14 - Oct 15](https://www.expedia.ca/Hotel-Search?regionId=553248635976469368&startDate=2025-10-14&endDate=2025-10-15&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 15 - Oct 16](https://www.expedia.ca/Hotel-Search?regionId=553248635976469368&startDate=2025-10-15&endDate=2025-10-16&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635976469368&startDate=2025-10-17&endDate=2025-10-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635976469368&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Sanctuary Luxury Hotels ## Top Sanctuary Hotel Reviews ![Lani Kai Beachfront Resort](//images.trvl-media.com/lodging/1000000/440000/438800/438796/b5b17142_y.jpg) ### Lani Kai Beachfront Resort 10/10 Excellent "Liked that all rooms are gulf view and have balconys." [](https://expedia.ca/Fort-Myers-Hotels-Lani-Kai-Beachfront-Resort.h438796.Hotel-Information) ![Marriott Sanibel Harbour Resort & Spa](//images.trvl-media.com/lodging/1000000/10000/3100/3079/ac9a3a07_y.jpg) ### Marriott Sanibel Harbour Resort & Spa 10/10 Excellent "It is a beautiful resort! It had everything, dining , pool, very relaxing. The staff and rooms were incredible." [](https://expedia.ca/Fort-Myers-Hotels-Marriott-Sanibel-Harbour-Resort-Spa.h3079.Hotel-Information) ![Pink Shell Beach Resort and Marina](//images.trvl-media.com/lodging/1000000/20000/15700/15603/5f038ed2_y.jpg) ### Pink Shell Beach Resort and Marina 10/10 Excellent "View was excellent from balcony. Room was very clean. Staff went out of their way to accommodate us." [](https://expedia.ca/Fort-Myers-Hotels-Pink-Shell-Beach-Resort-And-Marina.h15603.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway](//images.trvl-media.com/lodging/1000000/20000/11200/11134/b06bf9be_y.jpg) ### La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway 10/10 Excellent "We were greeted by Roopa who was very nice! We explained how the hotel was hard to find by gps. She explained that if you add service Rd to the address it will guide you correctly. Parking was easy. There was a circle K next door & a publix down the road along with a Gator Bites Pub which we decided on for dinner after our late arrival. Our room was clean & spacious. A comfy, clean bed. I would have liked more down pillows. There were like 5 pillows so plenty to choose from. I prefer down so you can fluff it as neccessary. There was a love seat and side table which was adequate for a drink, snack etc. There really wasn't enough dresser space for our week long stay but it was sufficient for a couple of nights. The room was cleaned daily. The free breakfast was good. I made self waffles. Tea & coffee were available 24/7. The pool is hugh! It's great for laps. The hotel is located on a quieter street so that was nice. It was also located nearby to main streets for easy access. We went to Bunche Beach preserve nearby which was great for a walk & I found some nice 🐚 shells. We were able to feed gators while mini golfing at Smugglers Cove. We had breakfast twice at Sunflower Cafe after waking up too late for the free breakfast. It was delicious, the staff was friendly & the service was fast. We would definately stay at this LaQuinta again!" [](https://expedia.ca/Fort-Myers-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Ft-Myers-Sanibel-Gateway.h11134.Hotel-Information) ![DiamondHead Beach Resort](//images.trvl-media.com/lodging/1000000/210000/200700/200632/814c4388_y.jpg) ### DiamondHead Beach Resort 10/10 Excellent " Nice, large room. This hotel on the beach has everything: on the beach, great views, nice pool/hot tubs, food/bar, and some entertainment. Needs a sit down breakfast option." [](https://expedia.ca/Fort-Myers-Hotels-DiamondHead-Beach-Resort.h200632.Hotel-Information) ![The Westin Cape Coral Resort At Marina Village](//images.trvl-media.com/lodging/3000000/2730000/2721900/2721880/d961205e_y.jpg) ### The Westin Cape Coral Resort At Marina Village 10/10 Excellent "Great space and great location. Staff extremely helpful." [](https://expedia.ca/Fort-Myers-Hotels-The-Westin-Cape-Coral-Resort-At-Marina-Village.h2721880.Hotel-Information) ![The Lighthouse Resort Inn & Suites](//images.trvl-media.com/lodging/1000000/810000/800800/800715/w2800h1779x0y3-dbc2bfa3_y.jpg) ### The Lighthouse Resort Inn & Suites 10/10 Excellent "our first time staying at the lighthouse . we really enjoyed our stay and actually extended one more nite , and have already booked another stay. sad to see all the extended damage from storm's But we found a new location to visit . We LOVE ft.Myers Beach " [](https://expedia.ca/Fort-Myers-Hotels-The-Lighthouse-Resort-Inn-Suites.h800715.Hotel-Information) ![Homewood Suites by Hilton - Fort Myers](//images.trvl-media.com/lodging/1000000/70000/63300/63247/6feb2ef6_y.jpg) ### Homewood Suites by Hilton - Fort Myers 10/10 Excellent "Everything was excellent. Will definitely stay here again in the future." [](https://expedia.ca/Fort-Myers-Hotels-Homewood-Suites-By-Hilton-Fort-Myers.h63247.Hotel-Information) ## Frequently asked questions ### Are you searching for a great accommodation for your luxury getaway to Sanctuary? > Use Expedia to arrange your flight to Southwest Florida Intl. Airport (RSW) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are an important consideration when you plan a vacation, so we make it easy to find what you want to make your stay relaxing and comfortable. If you want a posh hotel that has a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Sanctuary offers. Sanctuary has some interesting things to see and do including J. N. Ding Darling National Wildlife Refuge, so you might want to take in the local sights during your visit. ### What's there to see and do in Sanctuary? > When you're in Sanctuary, enjoy exploring the sights and attractions here including J. N. Ding Darling National Wildlife Refuge, Key West Express, and Blind Pass Beach. If you have extra time while you're in the area, you might want to stop by Turner Beach and Bowman's Beach. ## Explore a world of travel with Expedia - Lodging - Packages - More ways to book - [Hotels near Bowman's Beach](https://www.expedia.ca/Bowmans-Beach-Hotels.0-l6296151-0.Travel-Guide-Filter-Hotels) - [Hotels near Captiva Beach](https://www.expedia.ca/Captiva-Beach-Hotels.0-l6296288-0.Travel-Guide-Filter-Hotels) - [Cottages in Captiva](https://www.expedia.ca/Captiva-Cottages.d86452-aaCottages.Travel-Guide-Accommodation) - [All Inclusive Resorts and in Captiva](https://www.expedia.ca/Captiva-Hotels-All-Inclusive-Hotel.0-0-d86452-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Captiva](https://www.expedia.ca/Captiva-Hotels-Beach-Hotel.0-0-d86452-tBeachHotel.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Captiva](https://www.expedia.ca/Captiva-Hotels-Boutique-Hotel.0-0-d86452-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Hotels with a Lazy River in Captiva](https://www.expedia.ca/Captiva-Hotels-Hotels-With-A-Lazy-River.0-0-d86452-tHotelswithaLazyRiver.Travel-Guide-Filter-Hotels) - 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[Hotels with Free Airport Shuttle in Venice](https://www.expedia.ca/Venice-Hotels-Hotels-With-Free-Airport-Shuttle.0-0-d10285-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels) - [Hotels with Tennis Courts in Venice](https://www.expedia.ca/Venice-Hotels-Hotels-With-Tennis-Courts.0-0-d10285-tHotelswithTennisCourts.Travel-Guide-Filter-Hotels) - [Lake Hotels in Venice](https://www.expedia.ca/Venice-Hotels-Lake-Hotels.0-0-d10285-tLakeHotels.Travel-Guide-Filter-Hotels) - [Mountain Hotels in Venice](https://www.expedia.ca/Venice-Hotels-Mountain-Hotels.0-0-d10285-tMountainHotels.Travel-Guide-Filter-Hotels) - [Shopping Hotels in Venice](https://www.expedia.ca/Venice-Hotels-Shopping-Hotel.0-0-d10285-tShoppingHotel.Travel-Guide-Filter-Hotels) - [Winery Hotels in Venice](https://www.expedia.ca/Venice-Hotels-Winery-Hotel.0-0-d10285-tWineryHotel.Travel-Guide-Filter-Hotels) - [Bowman's Beach](https://www.expedia.ca/Bowmans-Beach-Sanibel.d6296151.Vacation-Attraction) - [Captiva Vacations](https://www.expedia.ca/Captiva.d86452.Destination-Travel-Guides) - [Mccarthy's Marina](https://www.expedia.ca/McCarthys-Marina-Captiva.d6182960.Vacation-Attraction) - [Visit Wulfert](https://www.expedia.ca/Wulfert.dx3000748774) - [Book Hotels in Sanctuary on Expedia.com](https://www.expedia.com/Sanctuary-Sanibel-Hotels-Luxury-Hotel.0-n553248635976469368-0-tLuxuryHotel.Travel-Guide-Filter-Hotels)