Title: Hotels by Independent in Sanctuary from CA $134 | Expedia.ca [Sanctuary Travel Guide](https://expedia.ca/Sanibel-Sanctuary.dx553248635976469368)[Vacation Rentals in Sanibel](https://expedia.ca/Sanibel-Vacation-Rentals.d9791.Travel-Guide-VacationRentals)[Flights to Sanibel](https://expedia.ca/Cheap-Flights-To-Sanibel.d9791.Travel-Guide-Flights)[Things to do in Sanibel](https://expedia.ca/Things-To-Do-In-Sanibel.d9791.Travel-Guide-Activities)[Sanctuary Car Rentals](https://expedia.ca/Car-Rentals-In-Sanctuary.d553248635976469368.Car-Rental-Guide)[Sanctuary Vacations](https://expedia.ca/Sanctuary.d553248635976469368.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Independent in Sanctuary from CA $134 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Nov 2 - Nov 3](https://www.expedia.ca/Hotel-Search?regionId=553248635976469368&startDate=2025-11-02&endDate=2025-11-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 3 - Nov 4](https://www.expedia.ca/Hotel-Search?regionId=553248635976469368&startDate=2025-11-03&endDate=2025-11-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=553248635976469368&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=553248635976469368&startDate=2025-11-14&endDate=2025-11-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Sanctuary Independent Hotels ![Suite with King Bed, Beachfront, Balcony | Terrace/patio](https://images.trvl-media.com/lodging/1000000/440000/438800/438796/b5b17142.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite with Two Doubles, Beachfront, Balcony](https://images.trvl-media.com/lodging/1000000/440000/438800/438796/2e8856cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/440000/438800/438796/767ba460.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Beachfront, Balcony, Two Doubles](https://images.trvl-media.com/lodging/1000000/440000/438800/438796/de245384.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lani Kai Beachfront Resort Fort Myers Beach 8.8/10 Excellent (1027) "All around great place to stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chris CA $240 CA $299 total includes taxes & fees Nov 6 - Nov 7 [](https://www.expedia.ca/Fort-Myers-Hotels-Lani-Kai-Beachfront-Resort.h438796.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/w3998h2821x0y0-a77e6574.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/0153ec95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/1051a5d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 restaurants, breakfast served](https://images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/abf6da91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Margaritaville Beach Resort Fort Myers Fort Myers Beach 9.0/10 Wonderful (1588) "Beautiful property, excellent food and friendly staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melissa CA $203 CA $297 total includes taxes & fees Nov 17 - Nov 18 [](https://www.expedia.ca/Fort-Myers-Beach-Hotels-Margaritaville-Beach-Resort-Fort-Myers.h95126992.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15700/15603/5f038ed2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15700/15603/82b672d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sundeck](https://images.trvl-media.com/lodging/1000000/20000/15700/15603/167b1a1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 Bedroom Captiva Villa,1 King Bed | View from room](https://images.trvl-media.com/lodging/1000000/20000/15700/15603/435d58a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pink Shell Beach Resort and Marina Fort Myers Beach 9.4/10 Exceptional (1135) "Great breakfast. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Betty CA $286 CA $412 total includes taxes & fees Dec 2 - Dec 3 [](https://www.expedia.ca/Fort-Myers-Hotels-Pink-Shell-Beach-Resort-And-Marina.h15603.Hotel-Information) ![2 outdoor pools](https://images.trvl-media.com/lodging/1000000/810000/800800/800715/w2800h1779x0y3-dbc2bfa3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/810000/800800/800715/35893057.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, 1 Bedroom | Private kitchen](https://images.trvl-media.com/lodging/1000000/810000/800800/800715/4ab0ecca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Studio Suite, 2 Double Beds](https://images.trvl-media.com/lodging/1000000/810000/800800/800715/c881a6b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Lighthouse Resort Inn & Suites Fort Myers Beach 8.6/10 Excellent (1522) "It was close to everything and I love their 2 bedroom suite options along with the Tiki Bar" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tricia CA $140 CA $184 total includes taxes & fees Nov 6 - Nov 7 [](https://www.expedia.ca/Fort-Myers-Hotels-The-Lighthouse-Resort-Inn-Suites.h800715.Hotel-Information) ![Apartment, Multiple Beds, Partial Ocean View | Beach/ocean view](https://images.trvl-media.com/lodging/12000000/11760000/11753200/11753200/fb0b7d7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 2 Bedrooms, Partial Ocean View](https://images.trvl-media.com/lodging/12000000/11760000/11753200/11753200/b348cef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio, 1 Queen Bed, Partial Ocean View](https://images.trvl-media.com/lodging/12000000/11760000/11753200/11753200/96081da3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Apartment, Multiple Beds, Beach View | Living room](https://images.trvl-media.com/lodging/12000000/11760000/11753200/11753200/1081c4bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Edison Beach House Fort Myers Beach 9.4/10 Exceptional (1544) "All around great place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $269 CA $342 total includes taxes & fees Nov 4 - Nov 5 [](https://www.expedia.ca/Fort-Myers-Hotels-Edison-Beach-House.h11753200.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1640000/1632700/1632691/faba246e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1640000/1632700/1632691/1b9c29fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1640000/1632700/1632691/e917c234.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Porch](https://images.trvl-media.com/lodging/2000000/1640000/1632700/1632691/23e15eaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dolphin Key Resort Caloosahatchee 8.8/10 Excellent (1188) "We have stayed here a few times and they never disappoint. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joseph CA $140 CA $156 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Fort-Myers-Hotels-Dolphin-Key-Resort.h1632691.Hotel-Information) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/430000/421600/421546/0be36f55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/430000/421600/421546/a638e8b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/430000/421600/421546/98f0aac3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/430000/421600/421546/693ea816.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Allure Suites McGregor 7.6/10 Good (1005) "Was clean staff was very nice" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard J CA $120 CA $134 total includes taxes & fees Nov 7 - Nov 8 [](https://www.expedia.ca/Fort-Myers-Hotels-Allure-Suites.h421546.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40800/40711/55e96d4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, premium bedding, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/50000/40800/40711/09cc3103.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/50000/40800/40711/0f55ab5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Condo, 2 Bedrooms, Balcony, Partial Ocean View | Private kitchen](https://images.trvl-media.com/lodging/1000000/50000/40800/40711/7fccca0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sanibel Inn East End 9.0/10 Wonderful (1004) "The reception was welcoming and the room we stayed in was excellent." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steven CA $394 CA $521 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Fort-Myers-Hotels-Sanibel-Inn.h40711.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/180000/170800/170769/a5c54d2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private beach, kayaking, fishing](https://images.trvl-media.com/lodging/1000000/180000/170800/170769/560da633.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dock](https://images.trvl-media.com/lodging/1000000/180000/170800/170769/24a52d40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee/tea maker](https://images.trvl-media.com/lodging/1000000/180000/170800/170769/a7398ba1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tween Waters Island Resort & Spa Captiva 8.6/10 Excellent (1001) "Stunning Beach View great Staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Robert CA $285 CA $367 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Fort-Myers-Hotels-Tween-Waters-Island-Resort-Spa.h170769.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/3000000/2670000/2665100/2665085/fc463bf9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/3000000/2670000/2665100/2665085/a62366ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/3000000/2670000/2665100/2665085/2a7931b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/3000000/2670000/2665100/2665085/e46c7f87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Matanzas Inn Bayside Resort and Marina Fort Myers Beach 9.2/10 Wonderful (1004) "Great location for park the car and walk to the beach restaurants bars shopping. The staff excellent. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) DANIEL CA $344 CA $419 total includes taxes & fees Nov 5 - Nov 6 [](https://www.expedia.ca/Fort-Myers-Hotels-Matanzas-Inn-Bayside-Resort-And-Marina.h2665085.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-16&endDate=2025-11-17®ionId=553248635976469368&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSanctuary-Sanibel-Hotels-Independent.0-n553248635976469368-0--bIndependent.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSanctuary-Sanibel-Hotels-Independent.0-n553248635976469368-0--bIndependent.Travel-Guide-Filter-Hotels) ## Top Sanctuary Hotel Reviews ![Lani Kai Beachfront Resort](//images.trvl-media.com/lodging/1000000/440000/438800/438796/b5b17142_y.jpg) ### Lani Kai Beachfront Resort 10/10 Excellent "Nice remodeled room." [](https://expedia.ca/Fort-Myers-Hotels-Lani-Kai-Beachfront-Resort.h438796.Hotel-Information) ![Pink Shell Beach Resort and Marina](//images.trvl-media.com/lodging/1000000/20000/15700/15603/5f038ed2_y.jpg) ### Pink Shell Beach Resort and Marina 10/10 Excellent "I comeback next year" [](https://expedia.ca/Fort-Myers-Hotels-Pink-Shell-Beach-Resort-And-Marina.h15603.Hotel-Information) ![DiamondHead Beach Resort](//images.trvl-media.com/lodging/1000000/210000/200700/200632/814c4388_y.jpg) ### DiamondHead Beach Resort 10/10 Excellent "Easy check in , clean and beautiful view. " [](https://expedia.ca/Fort-Myers-Hotels-DiamondHead-Beach-Resort.h200632.Hotel-Information) ![Edison Beach House](//images.trvl-media.com/lodging/12000000/11760000/11753200/11753200/fb0b7d7c_y.jpg) ### Edison Beach House 10/10 Excellent "It was nice elevator didn’t work and that was a lot of steps to get to the 4th floor while. carrying luggage. " [](https://expedia.ca/Fort-Myers-Hotels-Edison-Beach-House.h11753200.Hotel-Information) ![Sanibel Island Beach Resort](//images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/w2247h1500x326y0-2ea06bb5_y.jpg) ### Sanibel Island Beach Resort 10/10 Excellent "The property was clean and well maintained. The staff was all very friendly and helpful. The restaurant and tiki bar food and drinks were good. " [](https://expedia.ca/Fort-Myers-Hotels-Sanibel-Island-Beach-Resort.h17298818.Hotel-Information) ![Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway](//images.trvl-media.com/lodging/1000000/560000/551900/551886/8158a459_y.jpg) ### Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway 10/10 Excellent "Everyone was so nice checked in on me occasionally to see how my stay was going." [](https://expedia.ca/Fort-Myers-Beach-Hotels-Hampton-Inn-Suites-Fort-Myers-BeachSanibel-Gateway.h551886.Hotel-Information) ![Doubletree by Hilton Fort Myers at Bell Tower Shops](//images.trvl-media.com/lodging/1000000/20000/12400/12375/704cf90c_y.jpg) ### Doubletree by Hilton Fort Myers at Bell Tower Shops 10/10 Excellent "Excellent all around " [](https://expedia.ca/Fort-Myers-Hotels-Doubletree-By-Hilton-Fort-Myers-At-Bell-Tower-Shops.h12375.Hotel-Information) ![Margaritaville Beach Resort Fort Myers ](//images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/w3998h2821x0y0-a77e6574_y.jpg) ### Margaritaville Beach Resort Fort Myers 10/10 Excellent "Clean room, excellent housekeeping, staff from check-in to checkout was fantastic! Wonderful view of the beach and our balcony was spectacular!" [](https://expedia.ca/Fort-Myers-Beach-Hotels-Margaritaville-Beach-Resort-Fort-Myers.h95126992.Hotel-Information) ![Homewood Suites by Hilton - Fort Myers](//images.trvl-media.com/lodging/1000000/70000/63300/63247/6feb2ef6_y.jpg) ### Homewood Suites by Hilton - Fort Myers 10/10 Excellent "Wow what an incredible stay we had! The staff was very professional and friendly.The hotel grounds were so clean. Our suite was very spacious and so clean. Breakfast choices were amazing. We plan to stay here again. " [](https://expedia.ca/Fort-Myers-Hotels-Homewood-Suites-By-Hilton-Fort-Myers.h63247.Hotel-Information) ## Find out more about Sanctuary ## Sanctuary Hotels Guide Expedia.ca offers a selection of 12730 hotels in Sanctuary. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Sanctuary. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Sanctuary neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Sanctuary, Sanibel now! ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [La Quinta Inn & Suites Hotels in Bonita Bay](https://www.expedia.ca/Bonita-Bay-Bonita-Springs-Hotels-La-Quinta-Inn-Suites.0-n553248635976470574-0--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [La Quinta Inn & Suites Hotels in Bonita Shores](https://www.expedia.ca/Bonita-Shores-Bonita-Springs-Hotels-La-Quinta-Inn-Suites.0-n553248635976474586-0--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [Best Western Hotels in Bonita Springs](https://www.expedia.ca/Bonita-Springs-Hotels-Best-Western.0-0-d6403--bBestWestern.Travel-Guide-Filter-Hotels) - [Hotels near Bowman's Beach](https://www.expedia.ca/Bowmans-Beach-Hotels.0-l6296151-0.Travel-Guide-Filter-Hotels) - [Best Western Hotels in Cape Coral](https://www.expedia.ca/Cape-Coral-Hotels-Best-Western.0-0-d6521--bBestWestern.Travel-Guide-Filter-Hotels) - 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