Title: Hotels by Independent in Sanctuary | Expedia.ca [Sanctuary Travel Guide](https://expedia.ca/Sanibel-Sanctuary.dx553248635976469368)[Vacation Rentals in Sanibel](https://expedia.ca/Sanibel-Vacation-Rentals.d9791.Travel-Guide-VacationRentals)[Flights to Sanibel](https://expedia.ca/Cheap-Flights-To-Sanibel.d9791.Travel-Guide-Flights)[Things to do in Sanibel](https://expedia.ca/Things-To-Do-In-Sanibel.d9791.Travel-Guide-Activities)[Sanctuary Car Rentals](https://expedia.ca/Car-Rentals-In-Sanctuary.d553248635976469368.Car-Rental-Guide)[Sanctuary Vacations](https://expedia.ca/Sanctuary.d553248635976469368.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Independent in Sanctuary ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 18 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635976469368&startDate=2025-10-18&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 19 - Oct 20](https://www.expedia.ca/Hotel-Search?regionId=553248635976469368&startDate=2025-10-19&endDate=2025-10-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635976469368&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248635976469368&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Sanctuary Independent Hotels ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSanctuary-Sanibel-Hotels-Independent.0-n553248635976469368-0--bIndependent.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSanctuary-Sanibel-Hotels-Independent.0-n553248635976469368-0--bIndependent.Travel-Guide-Filter-Hotels) ## Top Sanctuary Hotel Reviews ## Find out more about Sanctuary ## Sanctuary Hotels Guide Expedia.ca offers a selection of 12638 hotels in Sanctuary. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Sanctuary. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Sanctuary neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Sanctuary, Sanibel now! ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [La Quinta Inn & Suites Hotels in Bonita Bay](https://www.expedia.ca/Bonita-Bay-Bonita-Springs-Hotels-La-Quinta-Inn-Suites.0-n553248635976470574-0--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [La Quinta Inn & Suites Hotels in Bonita Shores](https://www.expedia.ca/Bonita-Shores-Bonita-Springs-Hotels-La-Quinta-Inn-Suites.0-n553248635976474586-0--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [Best Western Hotels in Bonita Springs](https://www.expedia.ca/Bonita-Springs-Hotels-Best-Western.0-0-d6403--bBestWestern.Travel-Guide-Filter-Hotels) - [Hotels near Bowman's Beach](https://www.expedia.ca/Bowmans-Beach-Hotels.0-l6296151-0.Travel-Guide-Filter-Hotels) - [Best Western Hotels in Cape Coral](https://www.expedia.ca/Cape-Coral-Hotels-Best-Western.0-0-d6521--bBestWestern.Travel-Guide-Filter-Hotels) - 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N. 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