Title: Book the Best BUSINESS Hotels in San Luis Obispo Wine Country in 2026 | Expedia.ca [San Luis Obispo Wine Country Travel Guide](https://expedia.ca/San-Luis-Obispo-Wine-Country.dx553248621593965865)[Hotels in San Luis Obispo Wine Country](https://expedia.ca/San-Luis-Obispo-Wine-Country-Hotels.d553248621593965865.Travel-Guide-Hotels)[Vacation Rentals in San Luis Obispo Wine Country](https://expedia.ca/San-Luis-Obispo-Wine-Country-Vacation-Rentals.d553248621593965865.Travel-Guide-VacationRentals)[Flights to San Luis Obispo Wine Country](https://expedia.ca/Cheap-Flights-To-San-Luis-Obispo-Wine-Country.d553248621593965865.Travel-Guide-Flights)[San Luis Obispo Wine Country Car Rentals](https://expedia.ca/Car-Rentals-In-San-Luis-Obispo-Wine-Country.d553248621593965865.Car-Rental-Guide)[San Luis Obispo Wine Country Vacation Packages](https://expedia.ca/San-Luis-Obispo-Wine-Country.d553248621593965865.Destination-Travel-Guides) ![#Hiking along the coast of Avila Beach in California. While hiking in this area, BEWARE, because on your left from this spot, is the Nude Beach. Yup, it's the only nude beach that I know of that still exist in California. P.s. It was an accidental find for us, and no, we didn't go. #Waterlust #WeekendGetaway](https://images.trvl-media.com/place/11911/da9298a6-d014-4db2-a780-5eb15f4e4aae.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Anthony Hilario # Find Business Hotels in San Luis Obispo Wine Country, CA from CA $109 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on San Luis Obispo Wine Country Business Hotels Tonight [Dec 15 - Dec 16](https://www.expedia.ca/Hotel-Search?regionId=553248621593965865&startDate=2025-12-15&endDate=2025-12-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Dec 16 - Dec 17](https://www.expedia.ca/Hotel-Search?regionId=553248621593965865&startDate=2025-12-16&endDate=2025-12-17&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248621593965865&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248621593965865&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for San Luis Obispo Wine Country business-friendly hotels ![Aerial view](https://images.trvl-media.com/lodging/1000000/40000/39500/39435/f5438f41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast area](https://images.trvl-media.com/lodging/1000000/40000/39500/39435/1e66a09e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 9:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/40000/39500/39435/880cde75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/40000/39500/39435/cd19526e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apple Farm [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Apple-Farm.h39435.Hotel-Information) San Luis Obispo 9.0/10 Wonderful (1571) "Love the rooms, great atmosphere for a fun trip. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) R [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Apple-Farm.h39435.Hotel-Information) ![Family Studio Suite](https://images.trvl-media.com/lodging/1000000/50000/42000/41941/488fecb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42000/41941/27e8ce9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42000/41941/e7d3c4b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/42000/41941/83cec734.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vagabond Inn San Luis Obispo [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Vagabond-Inn-San-Luis-Obispo.h41941.Hotel-Information) San Luis Obispo 8.4/10 Very good (1185) "Clean and friendly staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carlos CA $82 CA $109 total includes taxes & fees Dec 16 - Dec 17 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Vagabond-Inn-San-Luis-Obispo.h41941.Hotel-Information) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/28000000/27200000/27194600/27194534/99fa5dc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/28000000/27200000/27194600/27194534/51fe5539.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/28000000/27200000/27194600/27194534/d050f4c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/28000000/27200000/27194600/27194534/b8f67749.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham San Luis Obispo Downtown [](https://www.expedia.ca/San-Luis-Obispo-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Luis-Obispo-Downtown.h27194534.Hotel-Information) San Luis Obispo 9.0/10 Wonderful (1806) "Staff was very friendly. Room was clean and location was great. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer CA $154 CA $175 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Luis-Obispo-Downtown.h27194534.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/2000000/1380000/1379200/1379138/b29cd20f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1380000/1379200/1379138/aed1ca39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor wedding area](https://images.trvl-media.com/lodging/2000000/1380000/1379200/1379138/b6c6cc26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/2000000/1380000/1379200/1379138/4bf058d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Avila Lighthouse Suites [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Avila-Lighthouse-Suites.h1379138.Hotel-Information) Avila Beach 9.4/10 Exceptional (1000) "Excellent place to enjoy with family and friends " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) RAUL CA $207 CA $311 total includes taxes & fees Dec 16 - Dec 17 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Avila-Lighthouse-Suites.h1379138.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-29&endDate=2025-12-30®ionId=553248621593965865&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top San Luis Obispo Wine Country Hotel Reviews ![Apple Farm](https://images.trvl-media.com/lodging/1000000/40000/39500/39435/f5438f41_y.jpg) ### Apple Farm 10/10 Excellent "Beautiful location and lovely rooms! Enjoy " [](https://expedia.ca/San-Luis-Obispo-Hotels-Apple-Farm.h39435.Hotel-Information) ![Hampton Inn & Suites San Luis Obispo](https://images.trvl-media.com/lodging/5000000/4860000/4857100/4857071/893b69cd_y.jpg) ### Hampton Inn & Suites San Luis Obispo 10/10 Excellent "Everything was terrific. Very clean. Great breakfast. " [](https://expedia.ca/San-Luis-Obispo-Hotels-Hampton-Inn-And-Suites-San-Luis-Obispo.h4857071.Hotel-Information) ![Madonna Inn](https://images.trvl-media.com/lodging/2000000/1200000/1191000/1190976/1ea42b7b_y.jpg) ### Madonna Inn 10/10 Excellent "Always such a joy" [](https://expedia.ca/San-Luis-Obispo-Hotels-Madonna-Inn.h1190976.Hotel-Information) ![Spyglass Inn](https://images.trvl-media.com/lodging/1000000/50000/41300/41235/44c3350f_y.jpg) ### Spyglass Inn 10/10 Excellent "View was amazing, large clean room" [](https://expedia.ca/San-Luis-Obispo-Hotels-Spyglass-Inn.h41235.Hotel-Information) ![La Cuesta Inn, BW Signature Collection](https://images.trvl-media.com/lodging/1000000/20000/14400/14372/f5b74a44_y.jpg) ### La Cuesta Inn, BW Signature Collection 10/10 Excellent "Clean room, large suites, quiet, helpful staff. Breakfast was good too with lots of options." [](https://expedia.ca/San-Luis-Obispo-Hotels-La-Cuesta-Inn.h14372.Hotel-Information) ![Sands Inn & Suites](https://images.trvl-media.com/lodging/3000000/2210000/2202700/2202688/b3e0f714_y.jpg) ### Sands Inn & Suites 10/10 Excellent "Bed very comfortable and a very beautiful room." [](https://expedia.ca/San-Luis-Obispo-Hotels-Sands-Inn-Suites.h2202688.Hotel-Information) ![Quality Suites Downtown San Luis Obispo](https://images.trvl-media.com/lodging/1000000/10000/3200/3138/9ac45291_y.jpg) ### Quality Suites Downtown San Luis Obispo 10/10 Excellent "The suites were very spacious and the beds comfortable, even the pull out. The location is excellent. " [](https://expedia.ca/San-Luis-Obispo-Hotels-Quality-Suites-Downtown-San-Luis-Obispo.h3138.Hotel-Information) ![Embassy Suites by Hilton San Luis Obispo](https://images.trvl-media.com/lodging/1000000/20000/15500/15406/48c2929b_y.jpg) ### Embassy Suites by Hilton San Luis Obispo 10/10 Excellent "Customer service, clean rooms and cocktail hour" [](https://expedia.ca/San-Luis-Obispo-Hotels-Embassy-Suites-By-Hilton-San-Luis-Obispo.h15406.Hotel-Information) ![Avila Village Inn](https://images.trvl-media.com/lodging/2000000/1180000/1178000/1177942/d33bd7d9_y.jpg) ### Avila Village Inn 10/10 Excellent "Everything about my staff was wonderful wish I had time to stay longer however I will be back " [](https://expedia.ca/San-Luis-Obispo-Hotels-Avila-Village-Inn.h1177942.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in San Luis Obispo Wine Country cost? ### What are the best business-friendly hotels in San Luis Obispo Wine Country? ### How many business-friendly hotels are there in San Luis Obispo Wine Country? ### What are the top business-friendly motels in San Luis Obispo Wine Country? ### Are there any family-friendly hotels in San Luis Obispo Wine Country that are also business friendly? ### Are there any 5-star business-friendly hotels in San Luis Obispo Wine Country? ### Why book your business-friendly hotel in San Luis Obispo Wine Country with Expedia? ### How can I find cheap business-friendly hotels in San Luis Obispo Wine Country? ### What is there to do in San Luis Obispo Wine Country near my business-friendly hotel? ## Explore a world of travel with Expedia - 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[Car rentals near Johnson Ranch Open Space ](https://www.expedia.ca/Car-Rentals-In-Johnson-Ranch-Open-Space.d553248635118921978.Car-Rental-Guide) - [Rental cars San Luis Obispo County Regional airport ](https://www.expedia.ca/Car-Rentals-In-San-Luis-Obispo-County-Regional.d6031729.Car-Rental-Guide) - [Dollar Rent A Car Rental Cars in San Luis Obispo County Regional ](https://www.expedia.ca/Dollar-Rent-A-Car-Car-Rentals-In-San-Luis-Obispo-County-Regional.d6031729-c43.Car-Rental-Guide-Suppliers) - [Enterprise Rental Cars in San Luis Obispo County Regional ](https://www.expedia.ca/Enterprise-Car-Rentals-In-San-Luis-Obispo-County-Regional.d6031729-c15.Car-Rental-Guide-Suppliers) - [National Car Rental Rental Cars in San Luis Obispo County Regional ](https://www.expedia.ca/National-Car-Rental-Car-Rentals-In-San-Luis-Obispo-County-Regional.d6031729-c42.Car-Rental-Guide-Suppliers) - [Sixt Rental Cars in San Luis Obispo County Regional ](https://www.expedia.ca/Sixt-Car-Rentals-In-San-Luis-Obispo-County-Regional.d6031729-c35.Car-Rental-Guide-Suppliers) - [Things to do in San Luis Obispo ](https://www.expedia.ca/Things-To-Do-In-San-Luis-Obispo.d6046822.Travel-Guide-Activities) - [Book Business Hotels in San Luis Obispo Wine Country on Expedia.com ](https://www.expedia.com/San-Luis-Obispo-Wine-Country-Hotels-Business-Hotel.0-0-d553248621593965865-tBusinessHotel.Travel-Guide-Filter-Hotels)