Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured San Luis Obispo Business Hotels

See all 357 Hotels in San Luis Obispo
Historic Santa Maria Inn

Historic Santa Maria Inn

801 S Broadway, Santa Maria
3.5 out of 5.0
4.1 out of 5 (620 reviews)
close to amenities, shoppingstaff were friendly, breakfast buffet was substantial, room was small but adequate
  20 Oct 2017

C$120

C$120
Embassy Suites by Hilton San Luis Obispo

Embassy Suites by Hilton San Luis Obispo

333 Madonna Road, San Luis Obispo
3.0 out of 5.0
4.0 out of 5 (621 reviews)
The shower was too tricky to turn on we had to call for help to get it started but the help came in a timely manner a sign needs to be posted on how to do it
  11 Oct 2017

C$124

C$124
Holiday Inn Hotel and Suites Santa Maria

Holiday Inn Hotel and Suites Santa Maria

2100 N Broadway, Santa Maria
3.0 out of 5.0
3.9 out of 5 (466 reviews)
Close to where we needed to beThe room was very nice and comfortable; the dining room was convenient but the food was average. and service was slow.
  11 Oct 2017

C$123

C$123
Best Western Plus Colony Inn

Best Western Plus Colony Inn

3600 El Camino Real, Atascadero
2.5 out of 5.0
4.1 out of 5 (137 reviews)
I was there for a quilt retreat. I liked that I could get a good cup of coffee first thing in the morning!
  13 Oct 2017

C$107

C$107
Radisson Hotel Santa Maria

Radisson Hotel Santa Maria

3455 Skyway Dr, Santa Maria
3.5 out of 5.0
4.0 out of 5 (300 reviews)
Just One ProblemThe facility is nice, the staff is very friendly, the onsite restaurant is really good. Everything was going well until I turned the bed down and found a bug in the bed. It wasn’t a small bug and it wasn’t a gpbig bug but it was big enough to give me a more uncomfortable feeling about staying in ...
  15 Oct 2017

C$136

C$136
Inn At Morro Bay

Inn At Morro Bay

60 State Park Rd, Morro Bay
3.5 out of 5.0
3.6 out of 5 (945 reviews)
We only stayed one night, but it was very nice. It is located within a State Park, so the grounds around the area are beautiful!
  13 Oct 2017

C$115

C$115
La Quinta Inn & Suites Paso Robles

La Quinta Inn & Suites Paso Robles

2615 Buena Vista Drive, Paso Robles
2.5 out of 5.0
4.6 out of 5 (345 reviews)
Easily accessible hotelReally enjoyed my stay at this excellent hotel. Very clean, comfortable room, friendly employees and great breakfast. Looking forward to a return visit.
  20 Oct 2017

C$126

C$126
La Cuesta Inn

La Cuesta Inn

2074 Monterey Street, San Luis Obispo
2.5 out of 5.0
4.1 out of 5 (235 reviews)
Team hotelI made reservations for my volleyball team here, and the rooms were the perfect size to have four athletes to a room, clean, cozy, the breakfast was just what we needed at the hour we needed (6am), and at a great price.
  31 Aug 2017

C$139

C$139
Candlewood Suites Santa Maria

Candlewood Suites Santa Maria

2079 N. Roemer Court, Santa Maria
2.5 out of 5.0
4.2 out of 5 (88 reviews)
close to interstatecheck in was quick, room was spacious and clean, free laundry on site
  26 May 2017

C$129

C$129
Oxford Suites Pismo Beach

Oxford Suites Pismo Beach

651 Five Cities Dr, Pismo Beach
2.5 out of 5.0
4.2 out of 5 (779 reviews)
I really have no complaints, everyone was very nice it was affordable. Rooms were clean as well as the pools. I would come back again.
  15 Oct 2017

C$123

C$123
Map

Recently booked San Luis Obispo hotels

Avila Lighthouse Suites
3.5 out of 5.0
Last booking: 11 minutes ago
Sands Inn & Suites
2.5 out of 5.0
Last booking: 19 minutes ago
Holiday Inn Express Grover Beach
2.5 out of 5.0
Last booking: 20 minutes ago
Madonna Inn
3.5 out of 5.0
Last booking: 25 minutes ago
SeaCrest OceanFront Hotel
3.5 out of 5.0
Last booking: 25 minutes ago
Springhill Suites by Marriott Paso Robles Atascadero
3.0 out of 5.0
Last booking: 30 minutes ago
Sundown Inn
2.5 out of 5.0
Last booking: 34 minutes ago
Cottage Inn By The Sea
3.0 out of 5.0
Last booking: 39 minutes ago
La Serena Inn
2.5 out of 5.0
Last booking: 42 minutes ago

Business Hotel Guide in San Luis Obispo

Work, play, and everything in between: Combine the best of every world with our selection of business hotels in San Luis Obispo. Inspired by the needs of the most discerning business traveler, these so-luxe spots provide everything you require to focus on your work and relax after a long afternoon of conference calls and face-to-face meetings.

You’ll get access to high-tech amenities, comfortable meeting rooms and a bevy of just-for-you services. Plus, when the day’s work is done, you can unwind in business class style with the upscale restaurants, in-room amenities, and top entertainment options.

Whether you’re searching for the sleekest executive business hotel in San Luis Obispo or want to find an unassuming spot near the office, our discounts and cheap deals will help you choose the perfect location for your unique needs. Browse our offerings to learn more about each business travel hotel in San Luis Obispo, and then pack your briefcase for a productive — and surprisingly fun — work trip.